Controlled Release of Actives in Skin.

Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is - C - R - C - or - C -; Z is between 2 and about 100, inclusive; R1 is CH=CH or (CH2),, wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.

Patents:
MX 2,009,008,030

Inventor(s): KOHN JOACHIM B [US]; MICHNIAK BOZENA; DEVORE DAVID; SHEIHET LARISA; CHANDRA PRAFULLA; BATHEJA PRIYA

Type of Offer: Licensing



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