Enediyne Compounds

TECH FIELD(S)
Medical-therapeutic

FEATURES
The potent antitumor activity of the enediyne natural product antibiotics such as calicheamicin, dynemicin, esperamicin, and neocarzinostatin has fostered interest in the development of simple enediynes with low thermal barriers to the formation of the lethal intermediate.

The invention provides novel tetradentate enediyne ligands that are thermally stable, yet react under photothermal conditions or thermally at about room temperature when complexed with metal ions. Moreover, the invention provides a method of prophylactically or therapeutically treating cancer by administering a therapeutically effective amount of the compound. The compound can be administered alone or as a composition that includes a therapeutically acceptable carrier. The free uncomplexed ligand can be administered such that the ligand contacts a metal in vivo and forms a metal complex. Alternatively, a metal complex can be administered so as to prophylactically or therapeutically treat cancer.

BENEFITS
* Formation of the metal complex under physiological conditions

Patents:
US 6,987,132
US 6,514,995

Inventor(s): Jeffrey M. Zaleski and Diwan S. Rawat

Type of Offer: Licensing



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