Anti-hmg Monoclonal Antibodies and Compositions Containing the Same

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

Patents:
IL 158,643

Inventor(s): TRACEY KEVIN J [US]; YANG HUAN [US]; WARREN HOWLAND SHAW JR [US]; FINK MITCHELL P [US]

Type of Offer: Licensing



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