Methods and Compositions for Regulating Th2 and Th17 Responses

Methods are provided for treating diseases, such as asthma, inflammatory bowel disease, autoimmune disease and cancers in which IL-6 production by dendritic cells is elevated. Dendritic cell c-Kit signaling is implicated herein in the production of IL-6 and an elevated TH17 response, such as an elevated TH2/TH17 response. Inhibition of c-Kit activity can reduce the elevated IL-6 production via a pathway that involves stem cell factor (KIT ligand), PI3 kinase p110d and the Notch ligand Jagged-2. Compositions and drug products useful in treatment of those diseases also are provided. Methods of identifying compounds that target c-Kit activity in the production or overproduction of IL-6 also are provided.

Attached files:


Patents:
WO 2,009,135,001

Inventor(s): RAY ANURADHA [US]; RAY PRABIR [US]; KRISHNAMOOTHY NANDINI [US]

Type of Offer: Licensing



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