Bisphosphonate-prostatic Acid Phosphatase Inhibitor Conjugates to Treat Prostate Cancer Bone Metastasis
The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid.
KIRSCHENBAUM ALEXANDER [US]; LEVINE ALICE C [US]; REGEN STEVEN L [US]; JANOUT VACLAV [US]
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