Multicomponent Degradable Cationic Polymers
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000TM, FUGENE TM , or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
GREEN JORDAN J [US]; SUNSHINE JOEL C [US]; BHISE NUPURA S [US]; SHMUELI RON B [US]; TZENG STEPHANY Y [US]
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