Glycan Markers of Hepatocellular Carcinoma

TECH FIELD(S)
Medical Biomarkers

FEATURES Hepatocellular Carcinoma (HCC) is a worldwide health problem. Serum alpha-fetoprotein, the current marker for HCC, is not effective for early diagnosis. It would be advantageous to develop markers for early detection of HCC. The inventors employed MALDI-TOF mass spectrometry for analysis of N-glycans in patient serum samples. The N-glycan analysis was performed by the solid phase permethylation technique described in IURTC Tech ID No. 05061.

BENEFITS A set of three N-glycans was identified that is sufficient for detection of HCC.

Inventor(s): Milos V. Novotny, Ph.D., Yehia Mechref, Ph.D., Radoslav Goldman, Ph.D., Habtom W. Ressom, Ph.D.

Type of Offer: Licensing



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