Method of Generating ?0 Cells

Described is a method of the generation of ? DEG cells using a mitochondrial targeted restriction endonuclease. This method comprises (a) transfecting cells with an expression vector containing a gene encoding a fusion protein comprising a mitochondrial targeting sequence (MTS) and a restriction endonuclease operatively linked to a suitable promoter; (b) culturing the transfected cells over a sufficient period of time; and (c) selecting ? DEG cells, e.g., via FACS analysis.

Patents:
WO 2,009,074,337

Inventor(s): SEIBEL PETER [DE]

Type of Offer: Sale



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