Enhancing Gene Transfer

Described herein are methods of improving the efficiency of gene transfer for a wide range of applications. Specifically provided are methods of increasing expression of an exogenous gene in a cell by contacting the cell with a vector comprising the exogenous gene and contacting the cell with a proteasome inhibitor, a lysosomal protease inhibitor and/or a microtubule inhibitor. Also provided are methods of delivering an antigen delivery vector to a cell or a subject. Provided are antigen delivery systems and kits comprising an antigen delivery vector and a proteasome inhibitor, a lysosomal protease and/or a microtuhulc inhibitor.

Attached files:
US 20110081317.jpg

Patents:
US 20,110,081,317

Inventor(s): DEWHURST STEPHEN [US]; ZANGHI CHRISTINE N [US]; VOLCY KETNA [US]; SCHLESINGER JACOB J [US]

Type of Offer: Licensing



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