Methods of Modifying P53 Acetylation and Treating Cancer Using Avra

The present invention relates to methods and compositions for the treatment of cancer. The methods and compositions involve the use of the Salmonella effector protein AvrA, as well as variants or fragments thereof, or encoding nucleic acids. The AvrA effector protein is demonstrated to enhance p53 acetylation, disrupt the cell cycle progression in treated cells, and enhance the killing of cancer cells. In this way, the methods and compositions can treat cancerous conditions either alone or in combination with other therapies.

WO 2,010,101,886

Inventor(s): SUN JUN [US]

Type of Offer: Licensing

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