Serum-based, Diagnostic, Biological Assay to Predict Pregnancy Disorders

The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum samples from such subjects exhibit an ability to disrupt the architecture involving fetal trophoblasts and maternal endothelial cells in a three-dimensional, dual cell co-culture system provided herein, in contrast to normal pregnancy serum samples. Based on these distinctions, the assays are employed to predict pregnancy outcomes as early as first trimester.

Attached files:
US 20110059904.jpg

Patents:
US 20,110,059,904

Inventor(s): SHARMA SURENDRA [US]; KALKUNTE SATYAN [US]

Type of Offer: Licensing

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