Cancer Stem Cells, Kits, and Methods
The present invention provides a cancer stem cell that has, inter alia, the properties of asymmetrical cell division, tumor initiating capacity, and metastatic competence. This cancer stem cell population is phenotypically characterized by the lack of major histocompatibility antigens and differentiation markers (e.g., cytokeratins, androgen receptor, etc.) and evidence of activation of self-renewal/developmental pathways (e.g., WNT/ss-catenin, NOTCH and Hedgehog). The identification of this cancer stem cell population has important clinical implications in diagnostic and predictive laboratory assays, as well as for development of novel therapeutic strategies specifically targeting the cancer stem cell.
CORDON-CARDO CARLOS [US]; PETRYLAK DANIEL [US]; DOMENECH JOSEP [US]; MARTIN MIREIA CASTILLA [US]
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