Aptamer-mediated Drug Release
The present invention relates to aptamer/drug conjugate complexes and the use of such complexes, together with a trigger compound, to inducibly release a drug. Through these complexes, the present invention provides a means for establishing a drug reservoir in a subject, whereby drug may be released as needed. One specific embodiment of the invention provides an aptamer/insulin conjugate complex from which insulin may be released by an inoocuous, orally administrable trigger, such as quinine.
STOJANOVIC MILAN N [US]; PEI RENJUN [US]; TAYLOR STEVEN MICHAEL FORNA [US]
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