Polyamine Inhibitors for the Treatment and Prevention of Parkinson's Disease

Disclosed herein are methods for treating a disease involving a-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce a-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce a-synucleic aggregation; or (3) a compound which inhibits a- synucleic aggregation in an amount effective to reduce a-synucleic aggregation. Also disclosed are methods for reducing the amount of a-synucleic aggregation in a brain cell using (1) a compound which reduces the amount of polyamines in an amount effective to reduce a-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce a-synucleic aggregation; or (3) a compound which inhibits a-synucleic aggregation in an amount effective to reduce a-synucleic aggregation. Disclosed herein are also compounds which can be used in the above described methods.

Patents:
WO 2,010,098,886

Inventor(s): SMALL SCOTT A [US]; LEWANDOWSKI NICOLE [US]; LANDRY DONALD W [US]; DENG SHI-XIANG [US]

Type of Offer: Licensing



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