Method for Confirming a Diagnosis of Rolandic Epilepsy

A strong association between variants in Elongator Protein Complex 4, (ELP4) (specifically single nucleotide polymorphisms, SNPs) at the 11p13 locus on chromosome 11 and the centrotemporal sharp wave trait (CTS) has been discovered, which association has diagnostic significance for rolandic epilepsy. It has further been discovered that the 11p13 locus has a pleiotropic role in the development of speech motor praxis and CTS, which supports a neurodevelopmental origin for classic rolandic epilepsy (RE).

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Patents:
WO 2,010,071,881

Inventor(s): PAL DEB KUMAR [GB]; STRUG LISA JOANNA [CA]

Type of Offer: Licensing



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