Methods for the Treatment of Infections and Tumors

PD-I antagonists are disclosed that can be used to reduce the expression or activity of PD-I in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-I antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-I antagonists. In addition, subjects with tumors can be treated using the PD-I antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-I antagonist. Methods are also disclosed for determining the efficacy of a PD-I antagonist in a subject administered the PD-I antagonist.; In some embodiments, these methods include measuring proliferation of memory B cells in a sample from a subject administered the PD-I antagonist.

Patents:
WO 2,010,063,011

Inventor(s): AHMED RAFI [US]; AMARA RAMA [US]; VELU VIJAYAKUMAR [US]; TITANJI KEHMIA [US]; FREEMAN GORDON [US]

Type of Offer: Licensing



« More Medical Patents

---