Fluorescence Resonance Energy Transfer Assays for Sarco/endoplasmic Reticulum Calcium Atpase and Phospholamban

Provided herein are methods for identifying molecules capable of modulating SERCA, the SERCA-PLB complex or the microenvironment of the complex. An exemplary assay provided herein is fluorescence resonance energy transfer (FRET). Also provided herein are FRET assays that are optimized for high-throughput screening (HTS) for identifying small molecules that modulate SERCA or the SERCA-PLB complex. Further provided are kits for carrying out said methods for identifying molecules.

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Patents:
WO 2,010,085,514

Inventor(s): THOMAS DAVID D [US]; CORNEA RAZVAN L [US]; ZSEBO KRISZTINA M [US]

Type of Offer: Licensing



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