Diagnostics and Therapeutics for Glaucoma
The invention provides methods and compositions for diagnosing and treating glaucoma by detecting alterations in the Wnt signaling pathway-including changes in the level or bioactivity of frizzled related protein. The invention further provides methods for screening for anti-glaucomatous compounds by detecting a Wnt pathway component such as a frizzled related protein, as well as methods for predicting or diagnosing glaucoma based upon the detection of a genetic alteration in a Wnt pathway component gene.
CLARK ABBOT F [US]; FINGERT JOHN [US]; MCNATT LORETTA [US]; STONE EDWIN M [US]; WANG WAN-HENG [US]
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