Identification and Use of Peptide Inhibitors of Protein Synthesis
The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit.
LLANO-SOTELO BEATRIZ [US]; MANKIN ALEXANDER S [US]; KLEPACKI DOROTA [US]
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