Human Single-chain T Cell Receptors
A soluble human single-chain T cell receptor (TCR) having the structure: Va2-L-Vss or Vss-L-Va2, wherein L is a linker peptide that links Vss with Va, Vss is a TCR variable ss region, and Va2 is a TCR variable a region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.
KRANZ DAVID M [US]; AGGEN DAVID H [US]
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