Delivery of Therapeutic Agents Using Oligonucleotide-modified Nanoparticles As Carriers
Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide molecules in a ratio to therapeutic agent molecules to allow a sufficient transportation of the therapeutic agent molecules into a cell. The therapeutic agents include both hydrophobic and hydrophilic. Different attachments of therapeutic agents in a composition are also described.
MIRKIN CHAD A [US]; GILJOHANN DAVID A [US]; DANIEL WESTON L [US]
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