Minimized Small Peptides with High Affinity for Factor VIII and Factor VIII-like Proteins

The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present invention relates to the synthesis and optimization of compounds comprising small peptides and peptide derivatives with affinity to coagulation Factor VIII and/or Factor VIII-like polypeptides and/or domains thereof. These compounds are useful for labeling, detecting, identifying, isolating and preferably for purifying, stabilizing and enhancing the activity of Factor VIII, Factor VIII-like polypeptides or domains thereof from physiological and non-physiological solutions comprising same. Further, these compounds may be used as ligands, which bind Factor VIII, Factor VIII-like polypeptides or domains thereof in methods of the present invention.

Patents:
US 2,010,099,113   [MORE INFO]

Inventor(s): KNOER SEBASTIAN [DE]; KESSLER HORST [DE]; HAUSER CHARLOTTE [DE]; SAENKO EVGUENI [RU]; KHRENOV ALEXEY [US]

Type of Offer: Sale



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