A Method and Composition Using a Dual Specificity Protein Tyrosine Phosphatase As an Antimalarial Drug Target

Phosphotyrosine phosphatase (PTP) encoded by PF13_0027 is a desirable drug target for the human malaria parasite Plasmodium falciparum. This PTP is critical for intraerythrocytic parasite development and invasion of erythrocytes by malaria merozoites. Mutation of the PF13_0027 gene or blocking expression of PTP function to create a PTP-null parasite severely attenuates the malaria parasite's ability to survive, making the PTP-null parasite suitable as an attenuated blood-stage parasite vaccine.

Attached files:


Patents:
WO 2,010,108,177

Inventor(s): ADAMS JOHN H [US]; BALU BHARATH [US]; MAHER STEVEN P [US]; CAMPBELL CHRIS [US]; MANETSCH ROMAN [US]

Type of Offer: Licensing



« More Medical Patents

---