Substrate-mimetic Akt Inhibitor
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue were characterized. Functionally homologous non-peptide groups were substituted for the amino acids of the GSK-3 creating a hybrid peptide-non-peptide and non-peptide compounds capable of binding to Akt. The non-peptide compounds show increased stability and rigidity compared to peptide counterparts and are less susceptible to degradation. The bound non-peptide compounds exhibit an inhibitory effect on Akt, similar to peptide-based Akt inhibitors.
US 9,453,049 issued 2016-09-27 [MORE INFO
US 9,896,668 issued 2018-02-20 [MORE INFO
SEBTI SAID M [US]; CHENG JIN Q [US]; HAMILTON ANDREW D [US]; KAYSER-BRICKER KATHERINE [US]
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