Reversible Platelet Inhibition

The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention further relates to von Willebrand Factor (VWF) inhibitors, and antidotes therefore, and to methods of using same.

Patents:
US 20,110,118,187

Inventor(s): SULLENGER BRUCE [US]; NIMJEE SHAHID [US]; ONEY SABAH [US]; QUE-GEWIRTH NANETTE [US]

Type of Offer: Licensing



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