Prevention of Receptor Desensitization

PROBLEM TO BE SOLVED: To provide a method for treatment of diseases relating to G protein receptor kinase activity or patients under pathological conditions of the same. ; SOLUTION: The desensitization of a receptor controlling the diseases can be prevented by inhibition of the G protein receptor kinase. This is applicable to patients with, e.g., cardiac failure, attached with a left ventricle cardiac device or a cardiac pump after surgical operation or those immediately before the surgical operation, and under high risk of the cardiac phenomena, or administered with an opiate or with opiate intoxication, or with a cystic fibrosis or a chronic rheumatoid arthritis. ; COPYRIGHT: (C)2010,JPO&INPIT

Patents:
JP 2,010,159,307

Inventor(s): STAMLER JONATHAN S; LEFKOWITZ ROBERT J; WHALEN ERIN J; KOCH WALTER J; PIANTADOSI CLAUDE A

Type of Offer: Licensing



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