Methods of Synthesizing γ-AApeptides and Libraries to Inhibit Aβ Protein Aggregates

Researchers have developed an efficient method of making and screening a γ-AApeptide library. This screening method can identify ligands to a target compound, which is helpful in the identification of new molecular probes and drug candidates. Furthermore, this
technology also includes a method of protein synthesis that allows many ligands to be synthesized easily and efficiently. Also developed were methods of inhibiting the toxicity of Aβ aggregates towards N2a neuroblastoma cells, as well as methods and compounds for treating Alzheimer's disease and other neurodegenerative diseases that exhibit Aβ protein aggregates.

US 9,645,155 issued 2017-05-09   [MORE INFO]

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