Novel anti-cancer drugs with improved potency and acitivity against drug resistant cells

Invention Antimetabolites and antineoplastic agents have been chemically modified to render them active against resistant as well as sensitive cancer cells The Need The major reason for chemotherapy failure in cancer treatment is the emergence of cells that are resistant to therapeutic agents Potential Applications Cancer Chemotherapy Advantages These new chemical entities have a substantial therapeutic advantage over existing anti-cancer agents as they are active against resistant cancer cells. The chemical modification is applicable to a range of chemotherapeutics.

Stage Compounds have been synthesized that exhibit anticancer activity in vitro and in vivo against sensitive as well as resistant cell lines Patent Pending Tech Transfer Officer Ms. Irit Ben-Chlouch Office: +972-3-6406601 Fax: +972-3-6406675 Mail: [email protected]

Inventor(s): Ada Rephaeli, Abraham Nudelman

Type of Offer: Licensing



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