Pharmaceutical Patents for Sale or License

Notify me of New Entries on this Page

You can receive an email whenever a new patent is added to this category. You can unsubscribe at any time.

Enzymes for Inhibiting Growth of Biofilms and Degrading Same

Enzymes for inhibiting growth of biofilms and degrading biofilms. The enzymes comprise glycosyl hydrolases capable of degrading biofilms. The enzymes are formulated in compositions with and without antimicrobial agents. The enzymes with and without the antimicrobial agents are delivered to biofilms ...
...

Methods for Prevention and/or Treatment of Capsular Contracture

J&E Solutions holds a US patent for the prevention and/or treatment of capsular contracture utilizing a repositioned topical ointment. The patent also encompasses the use of the product on fibrotic tissue with other etiologies as its formative basis. The topical composition is comprised of a pharmac...
...

Holistic Breast Patch: Device for Postpartum Women to Aid in the Relief from Breast Engorgement Pain and Suppresses Breast Milk Production

Lactation Suppression: “The Forgotten Aspect of Women Postpartum Care.” Currently, there is no drug approved by the Food Drug Administration (FDA), to safely provide relief from breast engorgement pain and/or breast milk suppression. According to data from the National Vital ...
...

Oxygen Sensors and their Uses

Brief description Novel oxygen sensors for use in product packaging for storing products under oxygen-free conditions. Basic principle Our novel sensors are based upon a unique synthetic platform technology that enables specific manipulation of oxo-hydroxide materials modified with organic li...
...

Cytotoxin compounds and methods of isolation

The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell l...
...

Oral Antidepressant Formulation

TriRima® Product Profile Summary TriRima® is an optimized, specific, high affinity, reversible inhibitor of monoamine oxidase-A (RIMA) potentially useful as monotherapy in the treatment of major depressive disorder. TriRima was designed and developed specifically to maximize RIMA efficacy while ...
...

Metadichol ® Nano particle and applications ( patent pending)

Metadichol®*(anagram METHODICAL) is a product produced from the waste of our agricultural industry and is present in small amounts in our foods we consume on a daily basis as most of it is lost in our food processing. We suffer from diseases because our immune system gets weakened over time and  l...
...

Hydroxy Ceramides and analogs thereof and their use for Preventing or Treating Cancer

Disclosed are compounds, compositions, methods of treatment and synthetic methods for making compounds related to stereoisomers of 2-hydroxy-ceramides and the use of 2-hydroxy-ceramides and their analogs....
...

Intelligent Temperature Indicator Label and Method

Our Smart Labels or Time Temperature Indicators (TTI) are researched and designed for use in Cold Chain . The labels provide information regarding the Products Integrity. They monitor whether or not the products have been stored or maintained at the proper temperature and tim...
...

Intelligent Temperature Indicator Label and Method

Our Smart Labels or Time Temperature Indicators (TTI) are researched and designed for use in Cold Chain . The labels provide information regarding the Products Integrity. They monitor whether or not the products have been stored or maintained at the proper temperature and tim...
...

Biodegradable Self-Expanding Drug-Eluting Prosthesis

Implantable radially expandable medical prostheses for treatment of vascular diseases through percutaneous deployment....
...

Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents

Radiotherapy is the treatment of cancer and other diseases with ionizing radiation. Radiotherapy is used in curative therapy, palliative therapy, adjuvant therapy after or before surgery, simultaneous radio-chemotherapy, etc. Radiotherapy is successful because ionizing radiation kills dividing cells...
...

Device for Organizing the Administration of Pills At Predetermined Time Intervals

A device for organizing the administration of pills at predetermined time intervals, characterized in that it has a main body used as an individual tissue ring with an opening, through which tissues can be inserted, and that the main body includes at least one compartment (4,4',4''), which can hold ...
...

Unit Dosage of Apadenoson

The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging....
...

Pyridinone Diketo Acids: Inhibitors of HIV Replication in Combination Therapy.

A new class of diketo acids constructed on pyridinone scaffolds, designed as inhibitors of HTV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, o...
...

2'-fluoro-6'-methylene Carbocyclic Nucleosides and Methods of Treating Viral Infections

The present invention relates to 2'-Fluoro-6'-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis ...
...

Antimicrobial Composition and Use

Antimicrobial compositions are provided comprising a pharmaceutically acceptable organic acid and a pharmaceutically acceptable surfactant. This synergistic combination allows compositions to be formulated at low concentrations that have efficacy in reducing bacterial counts by greater than 3 log wi...
...

Vaccine for Runting-stunting Syndrome

The present invention includes polypeptides, polynucleotides, antibodies, and vaccines associated with Runting Stunting Syndrome (RSS) in poultry. The present invention also includes methods of protecting poultry, including chickens, against RSS by immunization with such polypeptides and vaccines....
...

Composition À Base De Mycoplasma Gallisepticum

The present invention provides a formulation that prevents virulent Mycoplasma galHsepticum infection in birds of the order GaIHf ormes. The formulation comprises live Mycoplasma galHsepticum strain K5831 or derivatives thereof in a pharmaceutically acceptable carrier. A vaccine that prevents virule...
...

Methods and Compositions for Ophthalmic Treatment of Fungal and Bacterial Infections

The present invention provides methods and compositions for use in the methods for contacting an eye of a patient with an effective amount of therapeutic composition comprising a pharmaceutically acceptable chelating agent, a pharmaceutically acceptable pH buffering agent, and an antimicrobial agent...
...

Dose of an Angiogenic Factor and Method of Administering to Improve Myocardial Blood Flow

The present invention has multiple aspects. In one aspect, the present invention is directed to a unit dose pharmaceutical composition comprising from about 5 ng/dose to less than 135,000 ng of an angiogenic agent, typically from 5 ng to 67,500 ng. Preferably, the angiogenic agent is FGF, more prefe...
...

Aptamer Inhibitors of Osteopontin and Methods of Use Thereof

The present invention polynucleotide aptamers that selectively bind to and inhibit the function of osteopontin, pharmaceutical compositions comprising the same, and methods of use for diagnostics and treatment of diseases and disorders associated with osteopontin....
...

Anti-CD19 Antibodies and Uses in Oncology

The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies, using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The pre...
...

Use of Ranolazine for Non-cardiovascular Disorders

Disclosed is a method of treating a non-cardiovascular disorder characterized by an abnormal persistent sodium current in a subject in need of treatment thereof, said method comprising administering to the subject an effective amount of a compound of Formula (I): wherein: m is 1 or 2; R1, R2, R3, R4...
...

Geranylgeranyl Transferase Inhibitors and Methods of Making and Using the Same

The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same....
...

Indoles, Derivatives, and Analogs Thereof and Uses Thereof

Indole derivatives and analog compounds and pharmaceutical compositions comprising the same are provided. Also provided are methods of using these compounds to inhibit tubulin polymerization in a cell associated with a proliferative disease or to treat a cancer....
...

Methods and Compositions for Modulating Drug-polymer Architecture, Pharmacokinetics and Biodistribution

Drug-polymer chemotherapeutics are provided having improved therapeutic efficacy and reduced dose-limiting toxicity. Methods are also provided for modulating the architecture, pharmacokinetics and biodistribution of drug-polymers and for reducing the dependence of transition temperature on concentra...
...

Method of modulating the activity of a nucleic acid molecule

The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid molecules in a sequence independent manner and modulate (e.g., inhibit or reverse) their activity. ...
...

Substituted Porphyrins

Discloses are compounds according to Formula I. Further provided are methods of reducing oxidative stress in a cell, methods of treating a disease including cancer, and methods of treating a subject with a disorder associated with oxidative stress, the methods including administering a compound acco...
...

Manassantin Compounds and Methods of Making and Using Same

Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further provided are pharmaceutical compositions comprising compounds according to Formula I. Also provided are me...
...

Aromatic C16-C20 Substituted Tetrahydro Prostaglandins Useful As FP Agonists

PROBLEM TO BE SOLVED: To provide a new PGF analogs, particularly compounds useful for the treatment of various diseases and conditions such as bone disorders and glaucoma, to provide pharmaceutical compositions comprising these compounds, and further to provide the methods for treatment of bone diso...
...

TRPC6 Involved in Glomerulonephritis

Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion channel protein Transient Receptor P...
...

Inhibiting Eph B-3 Kinase

EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such a...
...

Methods and Systems for Treating Cell Proliferation Disorders with Psoralen Derivatives

Psoralen compounds of Formula (I): wherein (N+Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: (iv), wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 t...
...

Substituted Porphyrins

PROBLEM TO BE SOLVED: To provide a method for modulating physiological and pathological processes, and in particular, to provide a method for modulating the intracellular levels of oxidants and thereby modulating the processes in which such oxidants are a participant, and to provide a compound and c...
...

Biomolecule Polymer Conjugates and Methods for Making the Same

Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from defined sites on the biomolecule. The conjugates may have desirable pharmacological properties and may ...
...

Peptide Adjuvants, Vaccines, and Methods of Use

Provided herein are peptides that have activity as mast cell activating proteins (MCAP), as well as compositions, adjuvant compositions, vaccines, and pharmaceutical formulations that include the peptides. Also provided are methods of using the peptides, including methods for eliciting an immune res...
...

Prochelators Useful for Inhibiting Metal-associated Toxicity

Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same....
...

CD20-specific Antibody and Method of Employing the Same

The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention further provides methods of using the monoclonal antibodies, antigen-binding fragments, and pharmaceuti...
...

Compositions, Methods, and Kits for Determining an Alkyl Transferase

The present invention relates to novel compounds as well as to compositions, methods, and kits comprising the compounds for determining an alkyltransferase (ATase), in particular an alkylguanine-DNA alkyl transferase (AGT). In general, the novel compounds provide for determining ATase levels, in par...
...

Bisphosphonate Compositions and Methods for Treating Heart Failure

The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof....
...

Betulinic Acid Derivatives As Anti-HIV Agents

The present invention provides compounds of the general structure: which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of treating viral infections employing the same....
...

Polyvalent Vaccine

The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets...
...

Compositions and Methods Relating to Heat Shock Transcription Factor Activating Compounds and Targets Thereof

The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both R and S enantiomeric forms and racemic mixture...
...

Nanoparticle Targeted Drug Delivery to the Lungs Using Extra-testicular Sertoli Cells

A method of delivering a compound of interest to the lungs of a subject by the intravenous injection of Sertoli cells loaded with a plurality of chitosan nanoparticles coupled with the compound of interest is provided. Testis-derived rat Sertoli cells were pre-loaded with chitosan nanoparticles coup...
...

Derivative N-thiolated 2-oxazolidinone Antibiotics

This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, incl...
...

Polyphenol proteasome inhibitors, synthesis, and methods of use

The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes a...
...

Novel Polymorph of Acetylsalicylic Acid, and Methods of Making and Using the Same

A polymorph of aspirin is provided by the present invention. Methods of making and using the same are also provided....
...

Compositions Comprising Anti-icam-1 Antibodies

There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV ...
...

Antibacterial S-heterosubstituted Disulfides

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and c...
...

Pharmaceutical Co-Crystal Compositions

A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester...
...

Fish-ribosyn for antibiotic susceptibility testing

The subject invention concerns materials and methods for evaluating the susceptibility of bacterial cells to an antibiotic or other antimicrobial compound or agent. In one embodiment, a sample comprising a microbial population is exposed to an antibiotic of interest. The sample is then processed usi...
...

Broad Spectrum Vaccine Against Non-typhoidal Salmonella

The present invention is drawn to attenuated Salmonella serovar strains S. Typhimurium and S. Enteritidis, conjugate vaccines derived from these attenuated strains of S. Typhimurium and S. Enteritidis, comprising an O polysaccharide covalently linked to a flagellin protein, and methods for inducing ...
...

Mutual Prodrugs and Methods to Treat Cancer.

Mutual prodrugs comprising retinoids and histone deacetylase inhibitors, methods for production of the mutual prodnigs, and methods of treatment comprising administration of the mutual prodrugs. The retinoids include all-trans retinoic acid, 13-cis retinoic acid, and retinoic acid analogs that have ...
...

P53 Activator Peptides

The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides as well as methods of treating abnormal conditions, such as ma...
...

Kynurenine-aminotransferase Inhibitors

Compounds of formula (I) : prodrug derivatives and/or pharmaceutically acceptable salt thereof, selectively inhibit the enzyme kynurenine aminotransferase, thereby reducing the synthesis of kynurenic acid. The compounds are used for the treatment of psychiatric and neurological diseases which benefi...
...

Attenuated Salmonella Enterica Serovar Paratyphi a and Uses Thereof

The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccine, and methods of using these strains and conjugate vaccine....
...

Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-associated Immunogens

Vaccine formulations effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment, prevention and prophylaxis of Staphylococcus aureus infections in a subject....
...

Multivalent Live Vector Vaccine Against Clostridium Difficile-associated Disease

The invention relates to a multivalent Clostridium difficile vaccine comprising a Salmonella Typhi live vector comprising the cell binding domain of TcdA toxin (CBD/A) of Clostridium difficile or an antigenic fragment thereof and the cell binding domain of TcdB toxin (CBD/B) of Clostridium difficile...
...

Sulfated Psyllium Derivative for Reducing the Risk of Chronic Human Diseases and Method for Preparing the Same

The invention is directed to a method for preparing sulfated psyllium derivatives for use to reduce the risk of chronic human diseases. The sulfation of psyllium was carried out with sulfur, trioxide, pyridine, dimethylformamide and chlorosulfonic acid in pyridine. Six total sulfated psyllium deriva...
...

Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities

Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, deriv...
...

Kainate Receptor-Selective Epimeric Analogs of Dysiherbaine

Disclosed are compounds, pharmaceutical compositions, methods of treatment, and methods for selectively antagonizing a GluR5 receptor, a GluR6 receptor, or both receptors. The pharmaceutical compositions include and the methods utilize compounds that are analogs and stereoisomers of dysiherbaine and...
...

Selective Poly-n-substituted Glycine Antibiotics

Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively....
...

Vaccine Compositons for Inducing Immune Responses Against Components of Drusen

Disclosed are compositions and methods for treating or preventing the formation of drusen in a patient in need thereof. The compositions include an effective amount of at least one polypeptide present in drusen, or an immunogenic fragment or variant thereof that induces an immune response against th...
...

Treatment of Amyotrophic Lateral Sclerosis

The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds....
...

Compositions and Methods of Vitamin E Administration

The present invention relates to compositions and methods of vitamin E administration. In particular, the present invention provides opposing effects, relative to inflammation, from the administration of two major forms of vitamin E ([alpha]-tocopherol and [gamma]-tocopherol)....
...

Targeted Schiff Base Complexes

The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof....
...

Pyrimidine-2,4,6-triones for Use in the Treatment of Amyotrophic Lateral Sclerosis

The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the...
...

Cyclohexane-1,3-diones for Use in the Treatment of Amyotrophic Lateral Sclerosis

The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the pro...
...

Vaccine Compositions and Uses Thereof

The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems comprising an antigen and a dendritic cell-targeting peptide. Such compositions target vaccines to dendr...
...

Pharmacological Treatment for Sleep Apnea

The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity....
...

Use of Specifically Engineered Enzymes to Enhance the Efficacy of Prodrugs

The invention provides methods for enhancing efficiency of prodrugs by specifically engineered enzymes with altered or enhanced activity and broader substrate specificity towards nucleoside analogs used in cancer chemotherapy, and delivering the enzymes to specific target cells in a patient. The inv...
...

Ecteinascidins

The present invention is directed to several newly discovered ecteinascidin (Et) species, designated herein as Et 731, Et 815, Et 808, and Et 594. The physical properties of these compounds, their preparation and therapeutic properties are also reported....
...

Non-simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus.

Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage cells are described as having a capability of supporting infectivity and reproduction by PRRSV. Cells ...
...

Liposome Formulation Having Hydrophilic and Hydrophobic Pharmaceutical Compounds Co-encapsulated Therein

The present invention features liposomal formulations composed of at least one hydrophilic pharmaceutical compound loaded in the aqueous core of the liposome and at least one hydrophobic pharmaceutical compound in the bilayer of the liposome; and a method for producing the same. In so far as the pha...
...

Enzyme Inhibiting Compounds and Methods

The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for exampl...
...

Portable Active Fluid Powered Ankle-foot Orthosis

A portable active pneumatically-powered ankle foot orthosis. A lower leg mount and a foot bed are pivotally coupled at or proximate to an ankle position. A pneumatically powered rotary actuator is configured to receive power from a wearable fluid power source and provide controlled force and resista...
...

Method of Regulating Cell Growth Using a Proteasome Inhibitor

This invention provides methods and pharmaceutical compositions for regulating cell growth or inducing apoptosis in a cell, particularly a mammalian tumor cell. Specifically, the invention provides methods for inducing apoptosis in a tumor cell comprising contacting the tumor cell with a proteasome ...
...

Compositions and Methods for Treating Neurodegenerating Diseases

This invention provides agents, compositions, pharmaceutical compositions and methods for treating or slowing the progression of a neurodegenerating disease, such as Alzheimer's disease and a demyelinating disease....
...

Synergistic Antibiotic Combinations and Derivatives

Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions comprising the improved analogs and the synergistic combinations, and methods for their production and use. The synergi...
...

Agr-mediated Inhibition of Methicillin Resistant Staphylococcus Aureus

The present invention involves the use of activators of bacterial Agrquoroum-sensing systems to prevent or reverse biofilm formation in methicillin resistant Staphylococcus aureus (MRSA), or to restore sensitivity of MRSA bio films to antibiotics....
...

2,4,6-trisubstituted Phenols Having Anesthetic Properties

Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed....
...

Cellulose Capsules and Methods for Making Them

Disclosed are cellulose capsules, methods for preparing a cellulose capsule, and compositions comprising cellulose capsules, including sustained- or controlled-release dosage forms comprising cellulose capsules....
...

Methods of Improving Vaccine Immunogenicity

The present invention provides a process called "Immune Banking" that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular markers recognized by an existing antibody response. This recognition of the tagged vaccine components en...
...

Inhibitors of Phosphodiesterase Type 5A for Treating or Preventing Muscle Disease or the Symptoms Thereof in a Patient

Disclosed are pharmaceutical compositions and methods for treating or preventing muscle diseases or the symptoms thereof. The compositions typically include and the methods typically utilize phosphodiesterase type 5A inhibitors....
...

Producing polyelectrolyte hydrogel bodies, useful e.g. as soft tissue implants, comprises filling a semi-permeable membrane-forming liquid and a coagulation medium in a hollow template to form hollow

Producing dimensionally stable polyelectrolyte hydrogel bodies (2) with defined three-dimensional shape, comprises: filling a semi-permeable membrane-forming liquid in a hollow template (1); separating a liquid film adhered on the template; filling a coagulation medium, preferably water or alcohol i...
...

Analgesic Agents

he invention provides a compound of formula (I) or a salt thereof, as well as compositions comprising such compounds. The compounds and compositions are useful as analgesics....
...

Triptolide Prodrugs

The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the ...
...

STREPTOCOCCAL C5a PEPTIDASE VACCINE

Novel vaccines for use against beta -hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also disclosed is a method of protecting a susceptible mammal against beta -hemolytic Streptococcus colo...
...

Methods of Administering Porcine B-domainless FVIII

The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective protection to su...
...

Nucleoside Derivatives for Treatment of Caliciviridae Infections, Including Norovirus Infections

A method and composition for treating a host infected with a Caliciviridae virus, such as a Norovirus, comprising administering an effective treatment amount of a described modified nucleoside or a pharmaceutically acceptable salt thereof, is provided....
...

Non-myelosuppressive Compounds, Pharmaceutical Compositions Thereof, and Methods of Treatment

The present invention provides microtubule targeting compounds that are myelo-sparing. Particularly, the MTCs of the invention are structurally designed to exhibit specificity for inhibiting ss-tubulin isotypes that are not related to the myelosuppression associated with other known MTCs. The invent...
...

Steroid Analogues for Neuroprotection

Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the...
...

2'-fluoronucleosides

The 2'-fluoronucleoside is provided to treat hepatitis type B, hepatitis type C, HIV(human immunodeficiency virus), and abnormal cell proliferation including tumor and cancer. The pharmaceutical composition for treating hepatitis type B in human comprises the 2'-fluoro-beta-D-nucleoside represented ...
...

Branched Diepoxide Compounds for the Treatment of Inflammatory Disorders

The present invention provides certain diepoxide carbocyclic compounds wherein at least one carbocyclic ring carbon includes two non-epoxide substituents, and pharmaceutical compositions containing the same, for the treatment or prophylaxis of inflammatory, autoimmune and hyper- or abnormally prolif...
...

Cyanine-containing Compounds for Cancer Imaging and Treatment

This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the i...
...

Methods and Compositions for Improved Delivery of Therapeutic and Diagnostic Agents

Among other things, this disclosure provides for compounds having a targeting moiety linked to a therapeutic moiety and/or a diagnostic moiety; the synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and, methods for treating or diagnosing disorders. Som...
...

Catecholamine Derivatives for Obesity and Neurological Disorders

Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing a catecholamine backbone and pharmaceutically acceptable salts, prodrugs, and deri...
...

Compounds, Compositions, Methods of Synthesis, and Methods of Treatment

Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodime...
...

Subunit Selective NMDA Receptor Potentiators for the Treatment of Neurological Conditions

Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologi...
...

Methods of Neuroprotection Using Neuroprotective Steroids and a Vitamin D

Described herein are compositions and methods for treating or preventing nervous system injury. In particular, the methods and compositions relate to the use of at least one neuroprotective steroid, such as progesterone, and vitamin D....
...

ENANTIOMERICALLY PURE beta -D-DIOXOLANE-NUCLEOSIDES

A method and composition for the treatment of humans infected with HIV that includes the administration of an HIV treatment amount of an enantiomerically pure (beta)-D-dioxolanyl purine nucleoside of formula (I), wherein R is OH, Cl, NH2, or H, or a pharmaceutically acceptable salt or derivative of ...
...

MVA Expressing Modified HIV Envelope, Gag, and Pol Gene

PROBLEM TO BE SOLVED: To control pathogenic immunodeficiency virus. ; SOLUTION: There is provided a pharmaceutical composition comprising a recombinant MVA virus expressing an HIV env, gag, and pol gene or modified gene thereof for production of an HIV Env, Gag, and Pol antigen by expression from th...
...

Conjugates of Noscapine and Folic Acid and their Use in Treating Cancer

The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs), where the folic acid is conjugated to noscapine or the noscapine analog at the 9-position on the isoquinol...
...

Small-molecule Inhibitors of HIF and Angiogenesis

Inhibitors of Hypoxia Inducible Factor (HIF) and angiogenesis, for example 2,2-dimethylbenzopyran compounds and derivatives thereof, and methods of their use including treatment of cancer, disorders leading to ischemia (e.g., stroke and ischemic heart disease), and non-cancerous angiogenic diseases ...
...

NMDA Receptor Antagonists for Neuroprotection.

Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Form...
...

Use of Imipramine Blue and Analogs Thereof in Treating Cancers

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, infla...
...

Treating Various Disorders Using TrkB Agonists

Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four six-membered rings and a substituted or unsubstituted C5 or C6 heteroaryl or hetero-cycloalkyl ring and ph...
...

Noscapine and Noscapine Analogs and their Use in Treating Infectious Diseases By Tubulin Binding Inhibition

Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. The compositions include various noscapine analogs, which are capable of blocking the movement of vir...
...

NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders.

Provided are pharmaceutical compositions and methods of treatment or prophylaxis of certain neuropsychiatric conditions, in particular mood disorders. The compounds are of the general Formula I-V as described herein....
...

Systems Biology Approach Predicts Immunogenicity of Vaccines

A major challenge in vaccinology is to prospectively determine vaccine efficacy. Disclosed herein are methods and compositions for identifying early expression "signatures" that predicted immune responses in humans vaccinated with a vaccine....
...

Synergistic Induction of Humoral and Cellular Immunity By Combinatorial Activation of Toll-like Receptors

Described herein are compositions that include a selected antigen, a TLR4 ligand and a TLR7/TLR8 ligand, wherein the antigen and TLR ligands are encapsulated in nanoparticles. Co-administration of both a TLR4 ligand and a TLR7/TLR8 ligand results in the synergistic induction of humor and cellular im...
...

Compositions and Methods for Treating MIV-infection, and Preventing and Treating Mlv-initiated Diseases

Compositions and methods for inhibiting infection by XMRV or other MLV are disclosed. Also disclosed are methods for treating cancers resulting from infection by XMRV or other MLV, and for preventing such cancers. The anti- XMRV/anti-MLV compounds are predominantly integrase inhibitors, such as glob...
...

Recombinant Antibodies Against H1N1 Influenza

Antibodies that bind with high affinity to swine H1N1 virus are described. In vivo experiments showed that one such antibody is able to fully protect mice challenged with a lethal dose of swine H1N1 virus. The antibody is also able to cure mice in a therapeutic setting when treated as late as up to ...
...

Polymers for Delivering a Substance Into a Cell

Disclosed herein are polymers that can be made cationic and used to deliver a substance into a cell. Also disclosed are pharmaceutical compositions comprising the polymers and methods of using the polymers....
...

Anti-cancer Vaccine Composition

Combinations of anti-cancer vaccines and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The vaccines may be isolated antigens, groups of antigens, or whole tumor cells. The inhibitory antibodies may be generated in an animal by injection of fragments of CD223. Antibod...
...

Spiperone Derivatives and Methods of Treating Disorders

Described herein are spiperone derivative compounds which have been found to be useful in methods of stimulating CaCC and treating disorders (or symptoms thereof) associated with CaCC including cystic fibrosis, wherein a compound of the invention is administered to a subject....
...

Compositions and Methods for Treatment of Neurodegenerative Disease

Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed....
...

Thermostabilization of Proteins.

Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining wheth...
...

Inhibitors of Mre11, Rad50 And/or Nbs1

The invention provides, inter alia, compositions comprising an inhibitor of MRE11, RAD50 and/or NBSl and methods of using such inhibitor for modulating the cellular response to DNA damage, arresting the cell cycle, and/or treatment of cancer. The inhibitor is, e.g., a compound of formula I:...
...

Pharmaceutical Composition Comprising a Proton Pump Inhibitor and Protein Component

The present disclosure relates to, inter alia, pharmaceutical compositions comprising a H+,K+-ATPase proton pump inhibitor and a protein component; to methods for manufacture of such compositions, and to use of such compositions in treating and preventing diseases and/or disorders....
...

Compounds for Treatment of Copper Overload

The present invention provides compounds, pharmaceutical compositions, and methods that can be used to treat pathologies that are due to copper overload or to the presence of reactive oxygen species....
...

Novel substituted benzimidazole dosage forms and method of using same

The invention provides a solid oral pharmaceutical composition in capsule or powder dosage form comprising: a) omeprazole or a single enantiomer thereof, including a salt or other derivative thereof; and b) sodium bicarbonate; wherein the dosage form is not enteric coated or time-released, and the c...
...

E3 Ligase Inhibitors

The present invention provides, e.g., compounds having the structure of formula (I): The present invention also provides pharmaceutical compositions that include such compounds, and methods for modulating murine double minute 2 protein (Mdm2) E3 ligase activity, particularly the Mdm2-MdmX hetero-com...
...

Compounds that Inhibit Production of sAPPB and AB and Uses Thereof

The present invention relates to compounds with activity as inhibitors of sAPP[beta] and A[beta] production, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease and pharmaceutical compositions containing such candidate compounds....
...

Rage Fusion Proteins and Methods of Use

Disclosed are RAGE fusion proteins comprising RAGE polypeptide of soluble human sRAGE fragment with the certain amino acid sequence and non-RAGE polypeptide linked thereto. Said protein is used for treatment of diabetes and complications connected with diabetes....
...

Agents for preventing and treating disorders involving modulation of the RyR receptors

The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds...
...

Novel Curcumin Derivatives and their Pharmaeutical Uses Thereof

Disclosed are methods relating to analogues, derivatives, and metabolites of curcumin. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention...
...

Vaccine Against Botulism

The invention relates to novel DNA and protein vaccines against Clostridium botulinum. The DNA vaccine includes a DNA molecule that includes a first segment encoding a fragment of a heavy chain region of a Clostridium botulinum neurotoxin, wherein the first segment is codon-enhanced to improve expre...
...

Method and Compositions for Treatment Or Prevention of Inflammatory Conditions

Pharmaceutical compositions and methods for treating or preventing an inflammatory condition in a patient are disclosed. The pharmaceutical compositions and methods include the use of vincamine or a vincamine derivative, either alone or in combination with one or more additional therapeutic agents, ...
...

Respiratory Syncytial Virus Vaccine Based on Chimeric Papillomavirus Virus-like Particles Or Capsomeres

The present invention is directed to a chimeric papillomavirus virus- like particle (VLP) or capsomere including an Ll polypeptide and, optionally, an L2 polypeptide, and a respiratory syncytial virus (RSV) protein or polypeptide fragment thereof comprising a first epitope, where the RSV protein or ...
...

Use of Electrophilic Compounds for Inducing Platelet Production Or Maintaining Platelet Function

The present invention is directed to a method of inducing platelet production that includes contacting a megakaryocyte with an electrophilic compound under conditions effective to induce platelet production by the contacting megakaryocyte. Methods of treating a patient for low platelet levels, incre...
...

Systems and Methods for Enhancing Vaccine Efficacy

Pharmaceutical compositions of the invention include an antigen or a nucleic acid molecule encoding the antigen; one or both of a PPAR ligand and an RxR ligand; and a pharmaceutically suitable carrier. The pharmaceutical composition can optionally include a mitogen or other additives. Also disclosed...
...

Compounds and Methods for Altering Lifespan of Eukaryotic Organisms

Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1...
...

Phenazine Derivatives and Uses Thereof

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same....
...

Biocompatible Polysaccharide-based Hydrogels

Modified polysaccharides and crosslinked modified polysaccharide compositions are described. Methods of using the crosslinked modified polysaccharide compositions to deliver proteins, oligonucleotides, or pharmaceutical agents are also disclosed....
...

Phosphopeptides As Melanoma Vaccines

We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were e...
...

Antifungal Agents As Neuroprotectants

Provided herein are compounds, compositions and methods for protecting neuronal and glial cells....
...

Vaccines Targeting Cellular Death Receptors

The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding dea...
...

Antitumor Agents

The invention provides compounds of formula I as described herein wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, inter...
...

Dendrimers for Sustained Release of Compounds

Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa....
...

Topical Steroidal Formulations

The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula I or II, and glucocorticoids, and methods for reducing side effects from glucocorticoid treatment by co-...
...

Substituted Styryl Benzylsulfones for Treating Proliferative Disorders

Styryl benzylsulfones of formula (I) are useful as antiproliferative agents, including, for example, anticancer agents. In said formula, (a) (i) at least three of R1, R2, R3, R4 and R5 are independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl,...
...

Manipulating Sp1 Activity to Improve Therapeutic Cloning

The observed over-expression of Sp1 target genes has inspired inventors to formulate a specific strategy for correcting many gene expression defects, and thus improve clone development. The invention is based on the belief that manipulating Sp1 activity can improve cloning. Inventors believe that cl...
...

Suppression of Postoperative Ileus

The invention provides a method for suppressing postoperative ileus in connection with the performance of a surgical procedure on a patient. In accordance with the inventive method, interleukin-10 (IL-10), glycine, a COX-2 inhibitor and a mast cell stabilizer are administered to the patient undergoi...
...

Cyclic Adenosine Monophosphates for Reducing the Formation of Adhesions

Provided herein are methods of reducing adhesion formation in a subject, for example, post-surgical abdominal and pelvic adhesions. The methods comprise administering to the subject a compound chosen from one or both of 2',3' cyclic adenosine monophosphate, or an analogue or pharmaceutically accepta...
...

Compounds for the Treatment of Pathologies Associated with Aging and Degenerative Disorders

The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an effective amount of one or more of the compounds as set forth herein. "Inhibiting a sign of aging or...
...

Prediction and Prevention of Preeclampsia

The present disclosure relates to methods for assessing increased risk of preeclampsia in a pregnant woman. The methods described herein employ measuring relaxin levels, and optionally measuring C-reactive protein levels in a biological sample of a pregnant woman. The disclosure further encompasses ...
...

Anticancer Vaccine and Diagnostic Methods and Reagents

The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the patient. The invention further provides a method of identifying tumor antigens....
...

Bicyclic Compounds Having Antimitotic And/or Antitumor Activity and Methods of Use Thereof

The present invention provides bicyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensiti...
...

Tricyclic Compounds Having Antimitotic And/or Antitumor Activity and Methods of Use Thereof

The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and r...
...

Novel Compunds, Pharmaceutical Compositions Containing Same, and Methods of Use for Same

A pharmaceutical composition comprising a phamaceurtical diluent and a compound of formula IV wherein R21= H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, -CH2OR25, -C(O)R25, -CO(O)R25, -C(O)NR25R26, -CH2C(O)R25, or ûCH2C(O)NHR25, where R25 and R26 are each independently H, C1-C...
...

Method for Treatment of Tumors Using Nordihydrogualaretic Acid Derivatives

Pharmaceutical compositions comprising nordihydroguaiaretic derivatives and uses thereof to suppress Spl regulated promoter activity, arrest cell growth, stimulate apoptosis, and treat tumors....
...

Chimeric Vaccines

The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether th...
...

Antithrombotic Agents and Methods of Use Thereof

The instant invention provides methods and compositions for the treatment, prevention and diagnosis of for example, platelet aggregation or clot formation in a subject. The invention inhibits the activity of decreases the amount of neutrophils in the subject by inhibiting the activity or production ...
...

Fused Diimidazodiazepine Compounds and Methods of Use and Manufacture Thereof

he invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing di...
...

Inhibitors of Human Methionine Aminopeptidase 1 and Methods of Treating Disorders

Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject....
...

N-acyloxysulfonamide and N-hydroxy-n-acylsulfonamide Derivatives

The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such co...
...

Bis-acylated Hydroxylamine Derivatives

The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical ...
...

Trioxane Dimer Sulfur Compounds

The disclosure provides novel trioxane sulfur dimers having Formula I: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer, proliferative disorders, and/or malaria using these compounds and/or compositions....
...

Pharmaceutical Formulation for Regulating the Timed Release of Biologically Active Compounds Based on a Polymer Matrix

A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the polymer forming hydrolytic degradation products that promote the release of the biologically active compo...
...

Soybean Oil Based Oxygen Carrying Emulsion for Massive Blood Loss

VivaSure is a new treatment for shock from massive blood loss. It is based on soybean oil and is therefore biodegradable. It refills lost vascular volume, protects from free radicals, absorbs toxins and provides nutrition to cells. Also it can deliver oxygen, nitric oxide or other gases to tissues. ...
...

Therapeutic Compounds.

he invention provides compounds of formula (I) wherein A, B, R, F, G, n, n' and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents....
...

Solubilized Topoisomerase Poison Agents

The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compound...
...

Multiple Phase Cross-linked Compositions and Uses Thereof

The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid a...
...

Pharmaceutical Preparations Having Individualized Dosage and Structure

A manufacturing device capable of creating individualized dosages of pharmaceutical preparations in which a metering system and a means of performing non-destructive chemical analysis of individual manufactured units are controlled by a microprocessor to precisely control the content and structure o...
...

Methylenedioxybenzo [i] Phenanthridine Derivatives Used to Treat Cancer

The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase med...
...

Type 5 Adenylyl Cyclase Inhibitors for Providing Cardiac Protection

The invention provides a method of treating a cardiac disease by administering a pharmaceutically effective amount of at least one compound capable of inhibiting AC5 to a patient. The compound capable of inhibiting AC5 may be administered singly or in combination with another agent, such as, for ins...
...

Therapeutic Compounds

The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents....
...

Compositions and Methods Modulating Mg29 for the Treatment of Diabetes

Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the com...
...

Antimicrobial Agents

The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1- R12 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents....
...

Cytomegalovirus Vaccines and Methods of Production.

Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epith...
...

Inhibition of Glycerol-3-phosphate Acyltransferase (gpat) and Associated Enzymes for Treatment of Viral Infections

A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme...
...

Antibiotic Compounds

Methods for identifying prodrug antibiotic compounds and direct inhibitory antibiotic compounds utilizing various screens are provided. Also provided are methods for treating infections using these compounds....
...

Compositions for Treating Bacterial Infections

The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are useful as antibiotic compounds....
...

Inhibitors of Fructose 1,6-bisphosphatase and Methods of Use Thereof

The invention is directed to a compound according to formula (I). The compounds of formula (I) include prodrugs, pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof. The invention is also directed to a pharmaceutical composition comprising a compound according to formul...
...

Novel Hetero Pyrrole Analogs Acting on Cannapinoid Receptors

Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor antagonists, having selectivity for the CB 1...
...

Methods and Compositions for Inhibiting Atherosclerosis and Vascular Inflammation

Disclosed herein are compositions and methods for reducing inflammation associated with atherosclerosis and/or vascular inflammatory disease. The methods include administering to a subject in need of treatment for atherosclerosis and/or vascular inflammation a pharmaceutically effective amount of an...
...

Cholera Vaccines

The methods and compositions of the present invention are directed to a vaccine against Vibrio cholerae comprised of V. cholerae outer membrane vesicles (OMVs). Such vaccines are relatively stable, facilitating distribution. Inventive methods generally include administration of a vaccine against Vib...
...

Small Molecule Antagonists of Phosphatidylinositol-3, 4, 5-triphosphate (pip3) and Uses Thereof

Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3 -dependent signaling events in vitro and exert significant anti-tumor activity in vivo. The small molecule ...
...

Method and Composition for Inhibiting Multi-drug Resistance By Hyaluronan Oligomer

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating multi-drug resistant cell. ; SOLUTION: The pharmaceutical composition includes a competing agent of hyaluronan interaction with an effective dosage in order to reduce the cellular tolerance against a pharmacologic agent. As t...
...

Methods and Compositions for Spore-based Vaccines

Methods for immunizing a subject to an infectious agent are provided, using vegetative cytoplasmic expression of an antigen encoding an infectious agent or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both with or witho...
...

Indole Compounds and Methods of Use Thereof

Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds....
...

Antifungal Formulation and Method of Preparation

A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said peptide has an amino acid sequence of at least 8 amino acids selected from the group of amino acid ...
...

Compositions and Methods for the Treatment of Cystic Fibrosis

The invention is directed to novel pharmaceutical compositions comprising chemicals agents that are useful in the treatment and prevention of cystic fibrosis and the prevention of signs and symptoms of this disease. These pharmaceutical compositions are surprisingly successful in the treatment disor...
...

Tetrahydropyranonaphthyridines Derivatives, Pharmaceutical Compositions and Therapeutic Treatment Thereof

This invention relates to tetrahydropyranonaphthyridines derivatives having formula (III) or IV: and analogues of the tetrahydropyranonaphthyridines derivatives. The invention also relates to pharmaceutical compositions comprising these compounds and methods for treatment of tuberculosis using these...
...

Human Antibodies Against Hepatitis C Virus (hcv) Uses Thereof.

Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotyp...
...

Reagents for Recombinogenic Engineering and Use Thereof

The present invention features homologous recombination methods and systems. The methods and systems promote highly efficient homologous recombination in cells (e.g., in prokaryotic cells). The methods and systems are useful, for example, in pharmaceutical drug development, vaccine development and c...
...

Antibodies to Treat Cancer

Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polyn...
...

Espfu Nucleic Acids and Proteins and Uses Thereof

Disclosed are EspFU (EspF-like polypeptide encoded by a gene of the cryptic prophage CP-933U of enterohemorrhagic E. coli) polypeptides, fragments thereof, nucleic acids that encode EspFU polypeptides, or fragments thereof, and cells including the polypeptides, fragments, and/or nucleic acids. Also ...
...

Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections

Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical composit...
...

Compositions with Enhanced Bioavailability and Fast Acting Inhibitor of Gastric Acid Secretion

The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination a...
...

Methods of Treating Cancer and Other Conditions Or Disease States Using Lfmau and Ldt

The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states: Where X is H or F; R1 and R2 are independently H, an acyl group, a C1-C20 alkyl or ether group, a ph...
...

Anti-inflammatory compounds and uses thereof

The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF- B-dependent target gen...
...

Immunogenic Epitopes As Targets for Universal Cancer Vaccines

The present invention provides a peptide having an amino acid sequence as set forth in SEQ ID NOs: 1 through 95 and any combination there of. The peptide or combination of peptides possess 0CT4 specific inducibility. The peptide or combination of peptides can further be used as a vaccine....
...

Anti-inflammatory Compounds and Uses Thereof

The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-[kappa]B-dependent targ...
...

Anti-hepatitis C Activity of Meso-tetrakis-porphyrin Analogues

The present invention relates to porphyrin analogues, their use in pharmaceutical compositions alone, or combination with other agents and in the treatment and/or prophylaxis of flaviviridae viral infections, especially hepatitis C viral infection, and secondary disease states and/or conditions asso...
...

Mif Modulators

The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression....
...

Use of Hsp90 Protein Inhibiting Compounds and Pharmaceutical Composition Intended for Anti-tumour Therapy

The invention relates to a method for designing an individual anti-tumour therapy for a patient based on the detection of the levels of the Hsp90 protein responsible for resistance to a drug or a mixture of anti-tumour drugs that inhibit receptors IGF1R/KIT. The invention also relates to the use of ...
...

Method for Marking and Identifying Manufactured Articles, Substances and Organisms, and Uses Thereof

The present invention comprises a method for marking and identifying manufactured articles, substances and organisms (referred to below as "products"), based on the addition to the product to be marked of a known mixture of two or more isotropic profiles of a single chemical element that are enriche...
...

Spiropiperidyl Rifamycins for the Treatment of Microbacterial Infections

The compounds of formula (1), their pharmaceutically acceptable salts and their solvates, wherein R 1 is a radical selected between hydrogen and alkyl; R 2 is selected from hydroxyalkyl, phenyl, phenyl mono-substituted and phenyl di-substituted in positions 3 and 4; R 3 is selected from phenyl, phen...
...

Deuterated Tapazole and Derivatives, Preparation Method Therefor and Use of Same

The invention relates to deuterated compounds having formula (I) in which R1, R2 and R3 represent independently a hydrogen atom or a C1-C4alkyl group, optionally substituted with: a -OR4 group, R4 representing a hydrogen atom or a C1-C3 alkyl group optionally substituted with phenyl; a -NR5R6 group,...
...

Recombinant Antigen

The invention relates to a recombinant peptide of the catalytic subunit of the serine/threonine protein phosphatase of Angiostrongylus costaricensis and active peptides used in the production of an intranasal anthelmintic vaccine....
...

Peptides for the Treatment of Ocular Hypertension And/or Glaucoma

The invention relates to peptide compounds with the amino acid sequence having formula (I): Tyr-Ala-Arg-Ala-Ala-Ala-Arg-Gln-Ala-Arg-Ala-(X)-Ser-Asp-Gly-Gly-pTyr-Met- Asp-Met-Ser (I), wherein (X) is none, one or more amino acid spacer residues and pTyr is a phosphorylated tyrosine, and variants and d...
...

Bisthiazole Compounds That Can Be Used to Treat Cancer

The invention relates to compounds having formula (I), the pharmaceutically acceptable salts thereof, or the solvates of same, wherein: Ri is selected from phenyl, optionally mono-, di- or tri-substituted with a radical independently selected from F, Cl, Br, I, (C1C4)-alkyl, N,N-(C1,C4)-alkylamino, ...
...

Triterpenoid Derivatives Useful As Antiproliferative Agents

Formule (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, for preventing and/or inhibiting tumor growth and for treating cancer and ot...
...

Method for Screening Compounds for the Treatment Or Prevention of Colon Cancer

The invention is in the field of molecular medicine, more in particular in the field of identifying new compounds for the treatment or prevention of colorectal cancer. The invention provides a method for the screening and/or identification of compounds that are capable of preventing or ameliorating ...
...

Antagonistic Peptides for Frizzled-1 and Frizzled-2

The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled-1and/or frizzled-2 receptors which may be useful in molecular imaging of the wound healing process after myocardial infarction and in therapeutic intervention into wound healing after remodeling of t...
...

Method for the Treatment of Ischemia Reperfusion Injury

The invention is in the field of thrombosis, haemostasis, cardiology, medicinal chemistry and/or pharmacology. More particularly, it relates to the use of a mutant activated protein C (APC) for the treatment of ischemia reperfusion injury. A method is provided for treating or preventing reperfusion ...
...

A3 Adenosine Receptor Allosteric Modulators

The present invention relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM),for the preparation of pharmaceutical compositions for modulating the A3AR in a subject, as well as pharmaceutical compositions comprising the ...
...

Compounds and Uses

The invention relates to a compound having the formula of structure (I): or a pharmaceutically acceptable salt thereof, for use in treating a LH receptor-related condition....
...

Novel Antimalarial 3-azabicyclo[3.2.2]nonane Derivatives

The present invention relates to novel 3-azabicyclo[3.2.2]nonane derivatives of the general formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined in the specification. The novel 3-azabicyclo[3.2.2]nonane derivatives are particular...
...

Tryptamine-derived Compounds As Antibacterial Agents

The present invention relates to a compound according to formula I, a pharmaceutically acceptable salt and/or N-oxide thereof for use as an antibacterial agent....
...

Water Soluble Curcumin Compositions for Use in Anti-cancer and Anti-inflammatory Therapy

The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumour and/or anti-inflammatory activity, and improved physico-chemical properties. In a...
...

Method for Generating Islet Beta Cells from Dedifferentiated Exocrine Pancreatic Cells

The present invention relates to an in vitro method for generating insulin-producing beta cells from a population of mammalian cells comprising dedifferentiated exocrine pancreatic cells. The method comprises the step of culturing said dedifferentiated exocrine pancreatic cells in a culture medium i...
...

In Vitro Cultivation of Helicobacter Species.

The present invention relates to media and methods for the isolation and cultivation of "Candidatus Helicobacter suis" and isolates of "Candidatus Helicobacter suis" obtainable by these methods. The present invention further relates to the use of these bacteria for the manufacture of antigen prepara...
...

Novel Vaccine Against Trypanosoma Cruzi Infection

The present invention relates to a vaccine against Trypanosoma cruzi infection, useful in the prevention and/or treatment of the Chagas disease. More specifically, the present invention relates to a recombinant mutant trans-sialidase enzyme that can be used as an efficient vaccine, without side effe...
...

Immediate Release Pharmaceutical Granule Compositions and a Continuous Process for Making Them

A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.5% to 20% by weight of the composition, and excip...
...

Vitamin D3 Analogues for the Prevention and Treatment of Bone Disorders

Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis...
...

Streptococcus Pneumoniae Vaccines

Streptococcus pneumoniae is a major cause of pneumoniae, meningitis, and major cause of morbidity and mortality throughout the world by bacterial otitis media, pneumoniae, meningitis, and bacteraemia. It is an important agent of disease in man especially among infants, the elderly and immunocompromi...
...

Novel Bicyclic Heterocycles

The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also ...
...

Morpholine Derivatives Used As Antifungal Compounds

The present invention relates to a series of novel compounds (I) which have been shown to possess antifungal activity. The invention therefore relates to the new compounds, methods for their preparation, pharmaceutical compositions comprising them and to the compounds for use as a medicament, more i...
...

Indole Amide Derivatives and Related Compounds for Use in the Treatment of Neurodegenerative Diseases

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised...
...

Anti-viral Pyrimidine Nucleoside Derivatives

A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alk...
...

Synthesis of Resorcylic Acid Lactones Useful As Therapeutic Agents.

Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and ...
...

Oral Galenic Form, Polymer Production Method and Use of Same

The polymers according to the invention comprise a polysaccharide block (17) and several hydrophobic polyacrylic blocks (18) enabling the polymer to remain intact until it reaches the colon. The polysaccharide block is degraded by the colonic microflora irrespective of the pH, while the polyacrylic ...
...

Hydroxy-bisphosphonic Acid Derivatives As Vector for Targeting Bone Tissue

The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: - n and m denote, independently of one another, an integer ranging from 1 to 4, - X denotes an oxygen atom or an N-R3 group, - R1 and R3 denote, independently of one another, a lin...
...

Piperidine derivatives, process for their preparation and pharmaceutical compositions containing them

Phenyl-carbamic acid piperidin-3-yl ester compounds (I) and their enantiomers, and addition salts with an acid or a base are new. Phenyl-carbamic acid piperidin-3-yl ester compounds of formula (I) and their enantiomers, and addition salts with an acid or a base are new. R 1> : H or methyl group; and...
...

ANXIOLYTIC COMPOSITION CONTAINING ALPHAs-CASEIN -DERIVED PEPTIDES

The invention relates to pharmaceutical compositions and food products containing peptides derived from the as1-casein in milk and having benzodiazepine-type activity and particularly, anxiolytic activity....
...

Stambomycin and Derivatives, their Production and their Use As Drugs

The present invention relates to Stambomycin compounds, their derivatives and their pharmaceutically acceptable salt thereof....
...

Casein-Derived Peptides having Anxiolytic Activity

The invention relates to peptides and, in particular, heptapeptides derived from milk casein [alpha]s1 and having anxiolytic activity. The invention also relates to pharmaceutical and food compositions containing said peptides and to the preparation methods thereof....
...

Peptides Modulating the Activity of IGF-1 and the Applications of Said Peptides

The invention relates to peptides that can modulate the activity of IGF-1, to a pharmaceutical composition containing said peptides, and to the applications thereof as medicaments and agents for the in vitro modulation of cellular proliferation....
...

Analogs of Temporin-sha, and Uses Thereof

The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions including said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said n...
...

Nitrogen Heterocycle Derivatives As Proteasome Modulators

The instant invention relates to the use of at least one nitrogen heterocycle derivative of formula (I): as proteasome activity modulator in the manufacture of a pharmaceutical composition intended to prevent and/or treat a disease condition mediated by the proteasome activity....
...

Viral Encoded Pellino Protein and Its Uses

This invention relates to a pharmaceutical composition. In particular, it relates to a virally encoded form of a Pellino protein and its use in the regulation of signalling pathways that are associated with immune disorders....
...

Guanidine Based Compounds

The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into a and ss subclasses. The adrenoceptors have important roles in regulating a myriad of physiological conditions and their malfunction has been implicated in the pathophysiology of anumber of diseases. Dis...
...

Modified Helicobacter Protein

A vaccine comprising a structurally modified AhpC protein for inducing immunoreactivity against Helicobacter pylori. The structurally modified AhpC protein may have a molecular weight of between about 3OkDa to about 5OkDa. A modified AhpC protein with enhanced immunogenicity and antibodies raised ag...
...

Treatment of Microbial Infections

The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present inventi...
...

Efficient Aspirin Prodrugs

Aspirin is one of the most widely used drugs in the treatment of inflammation, pain and fever. It has more recently found application in the prevention of heart attacks and stroke and is being studied as a cancer chemopreventative agent. Despite its value aspirin continues to be underutilized becaus...
...

Soluble Influenza Vaccine

The invention provides fusion proteins comprising: (i) a first portion comprising an influenza A M2e polypeptide, and (ii) a second portion comprising a rotaviral NSP4 polypeptide. The fusion proteins mimics the native tetrameric structure of native M2 protein. Additionally it is highly soluble and ...
...

PDZ Domain Modulators

This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions....
...

Vaccine

The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis (M. ptb) substantially free of whole organisms of that species either dead or alive. The secreted protein may be obtained from a culture of M. ptb with the microorganisms being remove...
...

Multi-component Compositions and Methods for Delivery of Anti-cancer Agents

The present invention relates to a composition for the treatment or prevention of cancer, the composition comprising 5-fluorouracil, or a pharmaceutically acceptable salt or analogue thereof; folinic acid, or a pharmaceutically acceptable salt thereof, oxaliplatin and a cyclodextrin or a pharmaceuti...
...

Group a Streptococcus Pharmaceutical Compositions and Methods Thereof

Isolated proteins and immunogenic fragments thereof, for use in the treatment and prevention of a Group A Streptococcus infection are provided. In particular, the invention provides pharmaceutical compositions and methods of prophylactic and/or therapeutic treatment of a Group A Streptococcus infect...
...

Compositions and Methods for Delivery of Anti-cancer Agents

The present invention relates to compositions comprising 5-fluorouracil, or a pharmaceutically acceptable salt or analogue thereof, folinic acid, or a pharmaceutically acceptable salt thereof and a cyclodextrin, or a pharmace utically acceptable salt or derivative thereof. The invention also relates...
...

Antimicrobial Compounds

The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of Gram-negative bacterial infections....
...

Compositions and Methods for the Treatment of Disease

The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of disease associated with fibrosis in a vertebrate, said composition comprising at least one activin antagonist, and optionally a pharmaceutically acceptable carrier, adjuvant and/or diluent. The inven...
...

A Method for Treating Obesity

A method and pharmaceutical composition for treating a disease or condition associated with elevated hypothalamic T cell protein tyrosine phosphatase (TCPTP) such as obesity, weight gain, type 2 diabetes mellitus, insulin sensitivity, impaired glucose tolerance, and inflammation is disclosed. The me...
...

2-ARYLPYRAZOLO[L,5-alpha]PYRIMIDIN-3-YL ACETAMIDE DERIVATIVES AS LIGANDS FOR TRANSLOCATOR PROTEIN(18 KDA)

The invention provides compounds of formula (I) radiolabelled with 18F, 123I, 76Br, 124I or75Br and salts thereof, and a method of imaging translocator protein (18kDa) (TSPO) in a subject comprising administering a compound of formula (I) radiolabelled with 18F, 123I, 76Br, 124I or 75Br or a pharmac...
...

Administrable Compositions

The present invention relates to a composition suitable for administration to a subject, the composition comprising pharmacologically acceptable particulate material dispersed throughout a pharmacologically acceptable liquid carrier, the particulate material being maintained in the dispersed state b...
...

Halogenated Analogues of Anti-fibrotic Agents

The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrqtic agents. The present invention also relates to methods for their preparation....
...

Porous Silica Shell-mediated Assembly of Macromolecular Capsules

The present invention relates to a process of preparing macromolecular capsules. In particular, the invention relates to the use of a template with a permeable shell and an impermeable core for preparing macromolecular capsules. The process of the present invention relates to infiltrating macromolec...
...

A Temperature Sensitive Vaccine Strain of Mycoplasma Hyopneumoniae and Uses Thereof

The present invention relates to a Mycoplasma hyopneumoniae vaccine strain comprising a mutation in at least one of the genes listed or as deposited with the National Measurements Institute (Australia) under accession number NM04/41259, which strain is temperature sensitive and attenuated, a vaccine...
...

Polypeptides et polynucleotides de phorphorymonas gingivalis

The present invention relates to isolated Porphorymonas gingivalis polypeptides and nucleotides. The polypeptides include; an amino acid sequence selected from the group consisting of SEQ. ID. NO. 265 to SEQ. ID. NO. 528, SEQ. ID. NO. 531 and SEQ. ID. NO. 532; or an amino acid sequence at least 85%,...
...

A Synthetic Vaccine Component

The present invention relates generally to the field of synthetic vaccines, components thereof and methods for producing same. More particularly, the present invention provides a component of synthetic vaccines and its use in a modular approach to vaccine production....
...

Dinuclear, Quadruply-stranded Compounds Comprising Palladium Or Platinum

The invention relates to a compound of formula (M2L4 where: M = a palladium or platinum metal ion; L = X = -O-, -S-, -NH-, or (-CH2-)n, where n = 1, 2 or 3; R2, R4, R5, R6 are each independently selected from -H, -F, -Cl, -Br, -I, -methyl, -ethyl, -propyl, -O-methyl, -OH, -CH2OH, and - CH2CH2OH, R7,...
...

Anti-cancer Composition Comprising Alginate

The present invention relates to a biologically acceptable composition for the prophylaxis and/or treatment of colorectal cancer comprising an iron chelator, wherein the composition is adapted for the selective targeting of the iron chelator to the colon....
...

Use of Pharmaceutical Compound Containing Crotoxin for the Treatment of Muscle Dystonias

The present invention is related to the use of a pharmaceutical compound containing a toxin extracted from the rattlesnake (Crotalus durissus terrificus) venom, known as crotoxin, which can act as an agent provoking muscular paralysis. Medical uses of this invention formulation are described, which ...
...

Methods for Synthesizing Glycinols, Glyceollins I and Ii, Compositions of Selected Intermediates, and Therapeutic Uses Thereof

Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures a...
...

Therapeutic Aryl-am I Do-aryl Compounds and their Use

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, are (selective) retinoic acid receptor a (RARa...
...

Hot-melt Extrusion of Modified Release Multi-particulates

The present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates into a polymeric or wax-like matrix. The modified release multi-particulates comprise an effective amou...
...

Use of Riboflavin in the Treatment of Hypertension.

The invention provides the use of riboflavin in the manufacture of a medicament for the treatment or prophylaxis of elevated blood pressure in a subject homozygous or heterozygous for the MTHFR C677T polymorphism. The invention also provides a pharmaceutical product for the treatment or prophylaxis ...
...

Combinations Comprising Epothilone Derivatives and Alkylating Agents and Pharmaceutical Compositions Comprising Them

The invention relates to a pharmaceutical combination which comprises (a) an alkylating agent and (b) an epothilone derivative of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond. Said combination can be useful for t...
...

P53 Tumor Suppressor Protein Activating

The invention provides a compound of formula (I), wherein X, L1-4 and R1-4 are as defined herein, with the proviso that the compound is not (i) 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester; (ii) 4-(2,5-difluorobenzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester); (iii) ...
...

Pyrimide Derivatives and their Pharmaceutical Use

The invention provides a compound according to formula (I): wherein: X is O or S; Y is O or S; each Ar and Ar' is independently a mono-, bi- or tricyclic aryl or heteroaryl group optionally substituted with one or more substituents selected from halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino,...
...

SingleC-9 Binding Agents

The present invention relates to agents capable of binding sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) and their use in the treatment of cell proliferation and differentiation disorders. Furthermore, the present invention provides associated pharmaceutical formulations and methods....
...

Use of Tiamulin As an Antiviral Agent

The invention relates to an antiviral medicament produced using an antibiotic. The invention relates to the use of an antibiotic in the preparation an antiviral medicament. The invention also relates to a method of treating a viral infection comprising administering an antibiotic to a subject hav...
...

Methods for Identification

The invention relates to methods for the discovery of new chemical entities and pharmaceutical compositions with broad-spectrum chemokine inhibitor (BSCI) activity, together with the use of such agents as anti-inflammatory medicaments. In one aspect the method for the identification of a compound or...
...

Improved Methods for Identification

The invention relates to methods for the discovery of new chemical entities and pharmaceutical compositions with broad-spectrum chemokine inhibitor (BSCI) activity, together with the use of such agents as anti-inflammatory medicaments. In one aspect, there is provided a method for the identification...
...

Fusion Polypeptide Comprising S-antigen Repeat Units

The present invention relates to a fusion polypeptide comprising a) at least one fragment of the Plasmodium falciparum S-antigen or a variant thereof, wherein the fragment comprises one or a plurality of Plasmodium falciparum S-antigen repeat unit(s) or variant(s) thereof and b) at least one antigen...
...

Anti-inflammatory Compositions and Combinations

Use of broad-spectrum chemokine inhibitors (BSCIs), and in particular members of the acylaminolactam class of pharmaceutical agents, for the prevention, prophylaxis, treatment or amelioration of symptoms of inflammatory diseases. In particular, improved compositions consisting of BSCI agents combine...
...

Anti-inflammatory composition

The invention relates to 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one, and its pharmaceutical compositions and its use for preparing a medicament intended to prevent or treat inflammatory disorders....
...

Dimethylthiofoxins and azafoxins which may be useful as ligands for G-protein coupled receptors

The invention provides compounds of general formulae (II) or (III), or pharmaceutically acceptable salts thereof. X is -CO-(Y)k-(Z)nor -SO2-(Y)k-(Z)nwherein k is 0 or 1, each Y is a cycloalkyl, polycycloalkyl, cycloalkenyl or polycycloalkenyl group, n is an integer from 1 to the maximum number of su...
...

Novel Antibiotic Compositions

This invention is directed to antibiotic compositions comprising a targeting moiety covalently linked to an antibiotic moiety. This invention is also directed to pharmaceutical compositions comprising the antibiotic compositions of the invention and methods of making and using the antibiotic composi...
...

Anti-inflammatory agents

The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder, but excluding (S)-3-(1'-methylcyclohexylcarbonylamino)-caprolactam; wherein z is 1,2,3 or 4; A ...
...

Magnetically-controlled micro-fluid system for e.g. 'lab-on-chip' system for determination of presence of bio-molecules, virus, biological cells

A micro-fluid system transports tiny particulate quantities of a biological or pharmaceutical liquid sample through a channel exposed to the effect of a magnetic force generated nearby. The channel is exposed to two or more magnetic sources, each separated from the other. - The magnetic force is gen...
...

Quantitative Screening Assay for Protein Surface Changes

Isis Project No 3849 A new Quantitative Profiling Of biotinylation Patterns (Q-POP) assay, to enable screening for protein surface changes following protein-protein interaction. Potential applications include normal, cancer or pathogen cell function research; enabling identification of new treatment...
...

High-throughput Screening of Membrane Proteins

Isis Project No 3329 A novel method for producing synthetic biological membranes has potential in new high-throughput screens of membrane protein function and drug interactions. Marketing Opportunity Membrane proteins such as G-protein coupled receptors and ion-channels represent around 60% of ...
...

Improved Physical Methods for Increasing Stereoselectivity

BACKGROUND: Since 1988, the Food & Drug Administration has required that the enantiomeric composition of all drugs be known, making stereoselective reactions essential for the pharmaceuticals industry. However, the reactions used to establish chirality at one or more stereocenters often are not suff...
...

Bifunctional Catalysts and Methods for Synthesis of Impermeable and Semipermeable Coatings

BACKGROUND: Fields that involve the handling of sensitive materials, such as electronics, chemicals, and biological agents need a means of safely isolating these items to protect them or the outside environment from contamination. Current methods for coating, sealing, or encapsulating these materia...
...

One-Pot Organocopper Chemistry and Stereospecific Nucleoside Formation

A researcher at the University of California has made several inventions related to organic syntheses involving higher-order cuprates. Higher-order organocuprates are reagents containing copper atoms to which are bound multiple negatively-charged ligands in ethereal solvents, and have been successfu...
...

DNA Binding Compounds for Genetic Regulation and Medical Diagnosis and Therapy

Compounds that bind to DNA could be used to target drugs to DNA and to regulate expression of genes. Indeed, many compounds have been discovered (e.g. Distamycin) which bind to the minor groove of DNA, but the bond is too weak for reliable medical application. Scientists at the University of Cal...
...

RNA Nano-Constructions for Cell Detection and Drug Delivery

BACKGROUND: RNA has been previously demonstrated to assemble into nanoparticles of various shapes and sizes. These nanoparticles are able to carry various non-RNA components, including molecules for specific cell recognition, image detection and therapeutic treatment, making them ideal drug delivery...
...

Multiplexing Protein Binding Microarrays for Genetic Analysis

BACKGROUND: Our ability to understand and practically benefit from the control logic encoded in the human genome is currently limited by a lack of accurate information regarding promoter regulation. Gene regulatory proteins play critical roles in converting the genome into the complex ensemble of ex...
...

Novel Agents that act in Steroid-like signaling pathways in Medicine and Agriculture

BACKGROUND: The END-2 protein of the nematode Caenorhabditis elegans is a member of the nuclear hormone receptor family. Classically, nuclear hormone receptors are thought to be localized in the cytoplasm and nucleus of the cell. Steroids or steroid-like molecules, such as retinoids, diffuse across...
...

Methods for Identifying Novel Therapeutics and Diagnostics in the p53 Pathway

BACKGROUND: Current non-surgical cancer therapies rely on the use of compounds or radiation doses that are non-specific for the tumor cells and are highly toxic to humans. Although these treatments are particularly effective against tumor cells, they are also destructive to the surrounding normal ce...
...

Safe and Potent Synthetic Lung Surfactant for Treating RDS and Acute Asthma

BACKGROUND: The use of lung surfactant dispersions, based on lipid and protein components extracted from animal lung tissue, has significantly reduced mortality and morbidity from respiratory distress syndrome (RDS) in premature infants in the past decade. However, existing lung surfactants are not ...
...

Enzyme for Antimicrobial and Vaccine Development

Scientists at the University of California have shown that a specific enzyme is an essential regulator of Salmonella virulence. This enzyme is prevalent in many organisms including most enterobacteria, certain gram negative and gram positive bacteria, as well as archaebacteria. It is expected that t...
...

Initiators for Block-Copolypeptide Synthesis

BACKGROUND: Amino acid-N-carboxyanhydride (NCA) polymerizations employing conventional initiators (e.g. hexylamine or sodium methoxide) are plagued by chain-breaking transfer and termination reactions which prevent the formation of block copolymers. The mechanisms of NCA polymerization have been und...
...

Tools for the Genetic Manipulation of Fusobacterium Nucleatum

BACKGROUND: Fusobatcerium nucleatum is an anaerobic Gram-negative microorganism that is commonly found in the mouth. For example, Fusobacterium nucleatum is the most frequently isolated pathogen from periodontal disease sites and is believed to be an initiator of periodontal diseases. Moreover, thi...
...

BPM-3, a Negataive Determinant of Bone Density

BACKGROUND: Bone morphogenetic proteins (BMPs) are members of the TGFb superfamily, a large family of growth factors with varied functions. BMPs induce the formation of cartilage and bone by influencing cell proliferation, differentiation, morphogenesis and apoptosis. BMP signaling activity is regul...
...

EPLIN, a marker for human Cancer

BACKGROUND: EPLIN, a novel gene not previously described encodes a protein expressed in human epithelial cells. EPLIN is of significant importance because its expression is diminished in many forms of human cancers including breast and prostate cancer. Restoring the expression of EPLIN in cancer cel...
...

A Novel Tumor Suppressor Gene

BACKGROUND: Tumor suppressor genes are genes that, when damaged, fail to suppress tumorigenesis. Typically, tumor suppressor genes are genes that, in their wild-type alleles, express proteins that suppress abnormal cellular proliferation. When the gene coding for a tumor suppressor protein is mutat...
...

Antibody Fusion Proteins for treating Cancer

University of California researchers have developed a family of antibody fusion proteins with a potential for various therapeutic applications. These inventions represent both novel technologies and products with novel applications. These UC fusion proteins combine an antibody with various cytoki...
...

High-Speed, High-Resolution Impedance Sensor

BACKGROUND: While there has been extensive work in developing radio-frequency probes for measuring proximal impedances in air, these probes have been limited to applications using good conductors as their proximal impedance source. For electrolytic and biological samples, lower frequency probes have...
...

A Novel Mechanism and Target for Asthma Intervention

The Challenge Asthma is a chronic inflammatory disorder of the airways characterized by an obstruction of airflow, usually caused by mucus overproduction. Currently, most treatments for mucus hyper secretion (corticosteroids) have limited efficacy and are largely non-specific, indicating a clea...
...

Linker Microemulsions as a Transdermal Drug Delivery Vehicle

The Challenge A key challenge in developing an effective transdermal delivery system for hydrophobic compounds, involves the creation of formulations that balance high permeability of the stratum corneum barrier with minimal skin irritation. Because of their small droplet size, high oil solubili...
...

Rapid Protection from Neuronal Failure following Heat-stroke and Hyperthermia

The Technology We have identified that the down-regulation and reduced activity of certain protein kinase signaling molecules by pharmacological intervention allows the central nervous system to both function at much higher temperatures and recover RAPIDLY following heat-induced neural trauma...
...

Rim 3F4 Hybridoma Cell Line

The University of British Columbia have developed a cell line for the Rim 3F4 antibody and have isolated and characterized the epitope sequence in the Rim 3F4 protein. The epitope sequence is amenable to recombinant protein expression and the binding characteristics of the Rim 3F4 antibody are ideal...
...

Rho 1D4 Antibody

Dr. Robert Molday and coworkers at The University of British Columbia, have developed a cell line for the Rho 1D4 antibody and have isolated and characterized the epitope sequence in Rho 1D4 (9 amino acids). The antibody can be covalently bound to affinity gels directly using cyanogen bromide or ind...
...

The Ocean Surface Wave Identification and Tracking System (WITS)

APL-WAVES is a set of integrated software tools for the analysis and display of ocean surface directional wave data and related information. Custom wave partitioning and tracking tools provide comprehensive analyses and display of evolving wind sea and swell systems. APL-WAVES can be applied to dire...
...

Advantages of Insulin Delivered as an Aerosol Through the Lungs

A method of delivering a protein, in particular insulin, to the lungs. The method is characterized in that an aerosolized mist of small particles is produced in an associated medicament delivery chamber, the distance from the chamber to the patient's mouth is set to slow the speed of aerosol particl...
...

A New Potent Irreversible Inhibitor of y-Aminobutyric Acid Aminotransferase (21058/23058)

A promising new candidate inhibitor of the enzyme gamma-aminobutyric acid aminotransferase, critical to central nervous system disorders, has been prepared. Therapeutic potential in the treatment of epilepsy, drug addiction, pain control and neurological disorders is indicated. ADVANTAGES: In vit...
...

Inhibitors of B-Lactamases and Uses Therefor (22090, et al)

Over 100 novel inhibitors to b-lactamase, an enzyme that hydrolyzes the lactam ring of the b-lactam containing antibiotics to render the antibiotic inactive, have been identified and developed at Northwestern. These novel inhibitors have affinity for class C b-lactamases as low as 1 nM. As bacterial...
...

Protein Kinase Targeted Therapeutics (26087)

A validated novel compound and medicinal chemistry refinement for bioavailable small molecule inhibitors of protein kinases or protein kinase-mediated cellular stress response pathways. ADVANTAGES: A small molecule p38α MAPK inhibitor presents significant therapy potential for neurodegenerative ...
...

Clock Gene and Gene Product

Pharmaceutical control of circadian rhythms, whether directly through CLOCK or through other components of the pathway, has a wide range of applications. U. S. Patent Nos. 5,874,241 ,6,057,125, 6,291,429...
...

Formulation of Toll-like Receptor Ligand with Whole Cell Tumor Vaccine to Enhance Anti-tumor Responses

Established reports in literature have shown that the innate immune system can modulate immune responses against cancer. Lipopolysaccharide (LPS), a Toll-like receptor ligand 4 (TLR4), was absorbed onto whole cell tumor vaccine using a liposome formulation. The liposome reagent was titrated with LPS...
...

Use of High-dose Oxazaphosphorine Drugs in Combination with Monoclonal Antibodies for Treating Immune Disorders

(Set) Autoimmune diseases afflict more than 8 million people in the U.S alone. Autoimmunity usually occurs when lymphocytes, which are designed to defend the body against infections and foreign agents, start attacking one or more of the body's tissues or organs. The conventional treatment for many ...
...

Use of High Dose Cyclophosphamide in Combination with Immune Therapeutics in Anti-Cancer Therapy

Cyclophosphamide and especially high-dose cyclophosphamide has been used for the treatment of certain autoimmune diseases such as severe aplastic anemia. Low to intermediate doses of cyclophosphamide have also been used in combination chemotherapy for treating certain cancers and appears to work eit...
...

Emission Ratiometric Kinase Activity Reports in High Throughput Drug Screening and Analysis

Protein phosphorylation is one of the major regulatory mechanisms controlling cellular functions and aberrant kinase activities are found to form the molecular basis for many disease phenotyes. As a result, protein kinases are well recognized as important drug targets and are a focus of small molecu...
...

PS-341 Rescues Cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded, damaged, or mutant proteins with abnormal conformation from the cell. The most common disease-causing protein folding mutation is deletion of phenylalanine at position 508 of the cystic fibrosis transmembrane regu...
...

Valosin Containing Protein (VCP)/p97 Gene Inhibition Rescues cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded, damaged, or mutant proteins with abnormal conformation from the cell. The most common disease-causing protein folding mutation is deletion of phenylalanine at position 508 of the cystic fibrosis transmembrane regu...
...

Nrf2 as a Target for Intervening Pulmonary and Systemic Inflammation

Sustained inflammation is critical in the development of several pathophysiological diseases such as Chronic Obstructive Pulmonary Disease (COPD), asthma, sepsis, acute lung injury, cardiovascular disease, in addition to cancer. Research suggests that controlling inflammation is an effective mechan...
...

Inhibiting Binding of Inducible Nitric Oxide Synthase to Cyclooxygenase-2 to Treat Inflammation

Cyclooxygenase (C0X2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to C0X2 and S-nitrosylates it, enhancing C0X2 catalytic activity. Selectively disrupting iN0S-C0X2 binding prevents NO-mediated activation of C0X2. The synergistic ...
...

Selectively Targeted Histone Deacetylase Inhibitors

Inhibitors of histone deacetylases (HDAC) are regarded as an important approach to cancer chemotherapy, since they disrupt the aberrant cellular metabolism that occurs in many tumor types. The HDAC inhibitors currently in clinical trials and typified by compounds such as trichostatin (TSA) and MS-27...
...

Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants

Vaccines for diverse viruses will be most effective when they direct the recipient?s response to recognize the most virulent form of the organism. Scientists at JHU have found that circulating strains of hepatitis C virus (HCV) contain substitutions that render the virus less fit. Therefore, the use...
...

Method for Targeting Motor Neurons

Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy are disorders of motor neurons for which there is presently no effective treatment. As understanding of the mechanisms of these conditions increases, the possibility for therapy involving delivery of genes to the motor nerve cell bodies is be...
...

Immune Modulation Through Targeting of the MINOR Gene

this gene will induce apoptosis in dendritic cells, thereby limiting immune responses. Inhibition of the gene will prevent dendritic cell death, thereby enhancing immune responses. Dendritic cells are critical to the initiation of the immune response, thus this will provide a central tool to manipul...
...

Molecular Switches and Methods for Making and Using the Same Involving the Circular Permutation of DNA

The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellula...
...

Suppression of HIV Replication and Prevention/Treatment of HIV-Associated Dementia by Minocycline

This invention describes the addition of a tetracycline derviative to existing combinations of antiretroviral drugs for treatment of HIV-infected individuals. JHU researchers have determined that the tetracycline derivative, which is a potent anti-inflammatory and neuroprotective drug, also inhibits...
...

Antitumor Effects Generated by pNGVL4a-Sig/E7 (detox)/HSP70 DNA Vaccine Administered Through Gene Gun, Biojector and Syringe

DNA vaccines have emerged as an attractive approach for antigen-specific cancer immunotherapy. We have previously linked Mycobacterium tuberculosis heat shock protein 70 (HSP70) to human papillomavirus type 16 (HPV-16) E7 in the context of a DNA vaccine. Vaccination with DNA encoding E7/HSP70 has ge...
...

Use of Hedgehog Pathway Inhibitors in Small Cell Lung Cancer

We have shown that small cell lung cancer (SCLC), a highly aggressive and frequently lethal tumor, uses an embryonic signaling pathway to promote its growth. This signaling pathway is known as the Hedgehog pathway, and its normal function is to regulate organ formation and regulate progenitor cells ...
...

Method for producing diverse libraries of encoded polymers

With our reagents, libraries of drug-like molecules are rendered in a format where they can be subjected to evolution. This enables processing of libraries that are about 10 orders of magnitude more diverse than those typically used in high-throughput screens. Such diversity makes it probable that ...
...

Inhibitors of N-ethylmaleimide Sensitive Factor

JHU researchers have discovered that a previously described protein N-ethylmaleimide Sensitive Factor (NSF) regulates thrombosis. Inhibition of NSF, by certain cell permeable peptides, has been discovered as a novel method of anticoagulation. It has also discovered that these cell permeable NSF pep...
...

Comparison of HPV DNA Vaccines Employing Intracellular Targeting Strategies

Human papillomavirus (HPV) E6 and E7 are consistently expressed and are responsible for the malignant transformation of HPV-associated lesions. Thus, E6 and E7 represent ideal targets for therapeutic HPV vaccine development. Scientists at JHU previously used a gene gun approach to test several intr...
...

A Molecular Mechanism for Action of Immunophilins and a Method to Identify Novel Pharmaceuticals

The immunophilins are a family of proteins that are functionally related by their rotamase activity (ie they are peptidylprolyl isomerases, PPIase) and their ability to bind immunosuppressive drugs such as FK-506, rapamycin, and cyclosporin A. Immunophilin ligands also hold great promise for the tre...
...

Enhancement of Adenoviral Oncolytic Activity by Modification of the E1A Gene Product

The present invention relates to compositions and methods for enhancing the oncolytic activity of replication-competent, target cell-specific adenovirus vectors by modification of the E1A gene product. The target cell-specific replication-competent adenovirus vectors comprise a chimera of an adenovi...
...

inhibition of Tumor Growth Through Reduction of Peroxiredoxin 3 levels

The primary transforming activity of MYC is thought to arise through transcriptional regulation of numerous target genes. Scientists at Johns Hopkins have demonstrated that PRDX3, which encodes a mitochondrial protein of the peroxiredoxin gene family, is a direct target of MYC and is required for MY...
...

3-BROMOPYRUVIC ACID As a Potent Anticancer Agent Delivered Intraarterially

Liver cancer is one of the most common fatal cancers in the world and may reach epidemic levels in the future due to increased viral hepatitis. Current treatment options are rarely successful indicating a real need for alternative therapies. We have developed a new approach based on delivering the c...
...

Use of Proaerolysin Toxins Modified to Contain Tissue Specific Protease Activation Sequences as Targeted Therapy for Cancer

Proaerolysin is a bacterial toxin that is normally activated by furin protease to produce the pore forming toxin aerolysin which is toxic to prostate cancer cells at picomolar concentrations. We have removed the furin activation site and replaced it with a site that is recognized by the serine prote...
...

Modulation of systemic Immune Responses by Transplantation of Hemotopoietic Stem Cells Transduced with Genes Encoding Antigens and Antigen Presenting Cell Regulatory Molecules

The initiation of T cell-dependent immune responses depends on presentation of antigens by bone marrow-derived antigen-presenting cells such as dendritic cells. Tolerance induction depends on expression of antigens by tolerizing antigen presenting cells. Immunotherapy approaches are aimed at introdu...
...

Oncogenic Osteomalacia-Related Gene 1: MEPE

This invention provides isolated polynucleotides encoding an oncogenic osteomalacia-related factor and polypeptides encoded by this polynucleotide. Expression systems, including gene delivery vehicles such as liposomes and vectors, and host cells containing the polynucleotides are further provided b...
...

Phosphatonin-Related Gene: FRP - 4

This invention provides methods for modulating phosphate homeostasis and renal phosphate transport by delivering agents that alter the expression of the FRP-4 gene or alter the activity of the FRP-4 protein. The methods of the invention are useful for modulating bone mineralization, renal phosphate ...
...

Enhancement of Suicidal DNA Vaccine Potency by Linkage Mycobacterium Tuberculosis Heat Shock Protein 70 to an Antigen

Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. There are particular concerns, however, such as potential integration into the host genome, cell transformation, and limited potency. The usage of DNA-b...
...

A Method for Generating Constitutively Active Transmembrane Proteins

The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels....
...

Enhancement of Nucleic Acid Vaccine Potency by Intercellular Spreading and Enhancement of MHC Class I Presentation of Antigen Linked to Herpesvirus VP22 Protein

The potency of naked DNA vaccines is limited by their inability to amplify and spread in vivo. VP22, a herpes simplex virus type 1 (HSV-1) protein, has demonstrated the remarkable property of intercellular transport and may thus provide a unique approach for enhancing vaccine potency. We therefore ...
...

Gene Responsible for Stargardt-like Dominant Macular Dystrophy

The gene responsible for Stargardt-like macular dystrophy has been identified, along with its normal allelic form. The mutant gene encodes a mutant protein containing a frameshift mutation, resulting in abnormal fatty acid synthesis and transport in the retina. Also disclosed are assays for Stargard...
...

Oral Gene Delivery for Hemophilia

This invention is a non-viral trans gene delivery system developed for the long-term treatment of genetic disease. A recombinant plasmid construct with a cDNA of the gene implicated in hemophilia B was used to form nanospheres. Complex coacervation of the recombinant constrct with chitosan, a bioplo...
...

The Analgesic and Anesthetic Effects of Inhibiting the Interaction of the NMDA Receptor Subunits 2A/2B with Neuronal Nitric Oxide via PDZ Domain of PSD95/SAP90

PSD-95/SAP90 is a molecular scaffold protein that, through interactions involving its PDZ domains, couples the NMDA receptor to cellular signaling pathways at neuronal synapses. PSD-95/SAP90?s mRNA and protein are enriched in the spinal cord and selectively distributed in the superficial dorsal horn...
...

Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Mycobacterium Tuberculosis Heat Shock Protein 70 Gene to an Antigen Gene

Self-replicating RNA vaccines (RNA replicons) have emerged as an effective strategy for nucleic acid vaccine development. Unlike naked DNA vaccines, RNA replicons eventually cause lysis of transfected cells and therefore do not raise the concern of integration into the host genome. We evaluated the ...
...

Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to the Extracellular Domain of FLT3-Ligand Gene

professional antigen presenting cells (APCs), particularly dendritic cells (DCs). A recombinant chimera of the extracellular domain of Flt3-ligand (FL) linked to a model antigen may potentially target the antigen to DCs and their precursor cells. Using HPV-16 E7 as a model antigen, we evaluated the ...
...

Fusion of Calreticulun (CRT) to Antigens Enhances the Potency of DNA Vaccines

Antigen-specific cancer immunotherapy and anti-angiogenesis have emerged as two attractive strategies for cancer treatment. An innovative approach that combines both mechanisms will likely generate the most potent anti-tumor effect. In this study, we tested this notion using calreticulin (CRT) since...
...

Genetic Engineering of Autologous Vein Grafts with thrombomodulin-Expressing Vectors to Resist thrombosis, Neointimal Hyperplasia and Atherosclerosis

Autologous vein grafts are the most widely used conduits for coronary and peripheral arterial bypass surgery. Compared to arterial grafts, vein grafts suffer significantly higher failure rates that limit their clinical efficacy. The pathophysiology of graft occlusion varies with graft age, with acut...
...

Human BARX2 Gene

Surprisingly, it has been found that the Barx2 gene is mutated in ovarian cancer. The invention provides methods of diagnosis, prognosis and treatment of cancer related to the Barx2 gene. Description (Set) Proposed Use (Set) This technology could be commercialized as diagnostic and prognostic k...
...

Biodegradable and Biocompatible Lactide-Phosphate Copolymers, Compositions, Articles and Methods for Making the Same

The growing need for new polymer-based drug delivery materials continues to stimulate polymer research. Although several classes of synthetic polymers have been studied for controlled drug delivery and tissue engineering, polylactide (PLA) and poly (lactide-co-glycolide) (PLGA) still remain the most...
...

Phenylalkenoic Acid-Mediated Corection of Aberant Protein Trafficking

This discovery encompasses the compound 4-phenyl-delta3-transbutenoic acid, which restores normal biosynthetic trafficking to the CFTR mutation deltaF508 The mechanism centers on butyrate-mediated down-regulation of the chaperone protein Hsc70. The compound 4-phenyl-delta3-transbutenoic acid is rela...
...

Biosynthetic Engineering of Cell Surface Sialic Acids

Surrounding every cell is a halo of glycoproteins, glycolipids and proteoglycans termed the glycocalyx. On these structures, the most common terminus is the sugar sialic acid which is unique in its 9-carbon structure and tissue specific derivatization. Because of its location and potential for diver...
...

A New Human p53 Homologue (p46)

Since its identification as a tumor suppressor gene, p53 has become one of the most studied genes in human cancer. Inactivation of p53 is though to represent the most common genetic event in all neoplasms and may contribute to the development of 50% of all human cancers. Because of p53?s role in DNA...
...

Cloning of a Novel Telomerase Associated Protein from Human Cells

Telomerase activity is associated with human cancer and is often associated with the selection of cells that grow well after immortalization. Since cancer cells have high levels of telomerase, some tumors may require telomerase for growth. However, cells grown from a telomerase knockout mouse form t...
...

Human Smad3 and Smad4 are Sequence-Specific Transcription Activators

Mounting evidence suggests that Smad proteins are required for TGFbeta signaling, but the way(s) in which Smad proteins propagate this signal is unclear. It was found that two human Smad proteins (Smad3 and Smad4) could specifically recognize an identical 9 bp palindromic sequence (GTCTAGAC). Tandem...
...

SynGAP

The PSD-95/SAP90 family of proteins have recently been implicated in the organization of synaptic structure. Here we describe the isolation of a novel ras-GTPase activating protein, GAPSYN, that specifically interacts with the PDZ domains of PSD-95 and SAP102 in vitro and in vivo. GAPSYN is selectiv...
...

Oral Delivery of Nucleic Acid Vaccines by Particulate Complexes

Nanoparticle coacervates of nucleic acids and polycations serve as effective vaccines when administered orally. They can induce immunity to a variety of disease causing agents and raise a protective response to allergens. This invention is related to the field of immunology and allergic diseases. In...
...

A Simplified System for Generating Recombinant Adenoviruses

Recombinant adenoviruses provide a versatile system for gene expression studies and therapeutic applications. A strategy, which simplifies the generation and production of such viruses is reported here. A recombinant adenoviral plasmid is generated with a minimum of enzymatic manipulation, employing...
...

Therapeutic Nanospheres

4-Phenylbutyrate exerts many beneficial biological effects. It appears to induce the transcription of certain promoters, as well as having a remedial effect on proteins which are aberrantly localized within the cell. In addition, it appears to cause cells to developmentally differentiate. The presen...
...

Semaphorins

The semaphorin gene family consists of a large family of conserved proteins several members of which have been shown to function in inhibitory and repulsive axon guidance. In addition, semaphorins may influence neural regeneration in vertebrates. It is herein reported that neuropilin a type 1 transm...
...

Arachadonic Acid/Ceramide-Based Screens for Colorectal Cancer Chemopreventive Agents

Nonsteroidal antiinflammatory drugs (NSAIDS) can inhibit colorectal tumorigenesis and are one of the few agents known to be useful for the chemoprevention of neoplasia. It is shown that NSAID treatment of colon tumor cells induces apoptosis and a dramatic increase in ceramide, a known mediator of ap...
...

Autologous GVHD

Portions of the MHC class II invariant chain peptide, termed CLIP, exhibit immunomodulatory properties and can skew the cytokine response. In particular, the flanking regions of CLIP interact with receptors on the T lymphocyte surface. Polypeptides engineered to comprise different sub-sequences of t...
...

Isolation of GRIP

The invention concerns the discovery of a novel family of proteins named as glutamate receptor interacting proteins (GRIPs). GRIPs interact with non-NMDA glutamate receptors and, in particular, interact selectively with the C-termini of AMPA glutamate receptors. A novel gene that encodes GRIP has be...
...

Reversal of Loss of Imprinting in Tumor Cells by 5-aza-2"-deoycytidine

In order to determine whether loss of imprinting (LOI) in cancer might be reversed by altering DNA methylation, tumor cells were treated with 5-aza-2?deoxycytidine, a specific inhibitor of cytosine DNA methyltransferase. Treated cells showed several significant and reproducible changes: equal expres...
...

Therapeutic use of Ligands for CD46 for treatment of patients with disorders associate patheogenetically w/inappropriate or excess production of IL-12.

The present invention provides a method of treating a variety of disorders in a mammal characterized by dysregulated, physiologically abnormal, aberrant IL-12 production and/or overproduction of IL-12. The mammal is preferably a human. As discussed herein, IL-12 is critical for the generation of cel...
...

Use of Recombinant Bacteriophages to Monitor Ion Channel Receptor Expression im Mammalian Cells

The present invention concerns a novel method for detecting cell surface proteins utilizing a modified virus. This method combines peptide display technology and traditional immuno-amplification strategy to provide an economical detection system. In contrast to traditional approaches, both specifici...
...

Discovery of Human Mad-related Genes

Resistance to the growth inhibitory effects of TGF-beta is common in human cancers. However the mechanism(s) by which tumour cells become restistant to TGF-beta are generally unknown. We have identified five novel human genes related to a Drosophila gene called Mad which is thought to transduce sign...
...

Generation of Soluble Divalent Heterodimeric Analogs of Proteins involved in Immune Responses

This invention is directed to compositions comprising soluble divalent and multivalent heterodimeric analogs of proteins that are involved in immune regulation and methods of making and using the same. The high affinity that these complexes have for their cognate ligands enables them to be effective...
...

Interferon Gamma-Gene-Based Therapy in Allergic Diseases

In vivo delivery of an interferon-y gene to mucosal cells of the lung is an effective means to treat and prevent the development of allergen-induced diseases Description (Set) Proposed Use (Set) Therapeutic for treatment and prevention of allergic diseases Patent (Set) 6,121,247...
...

Gdf -14

The present invention provides a growth and differentiation factor, GDF-14, and a polynucleotide sequence encoding GDF-14. GDF-14 is expressed at highest levels in muscle, brain, uterus, spleen, and thymus and at lower levels in other tissues. In one embodiment, the invention provides a method for d...
...

4.0 Demethyl Perclomedine

Substantially pure 3,5-dichloro-2-nethoxy-4-hydroxy-6-(trichloromethyl)pyridine or 4-demethylpenclomedine (formula I), acid addition salts thereof, pharmaceutical compositions containing the aforesaid compound, and a method of using the compound in the treatment of cancer in a mammal are disclosed....
...

Enhancing Nerve Regeneration

Compounds have been identified which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG). Specifically, complex carbohydrates have been identified which will bind to MAG, thereby inhibiting the MAG-mediated inhibiting mechanism so that...
...

cDNA Cloning and Sequencing of Peptidyl-Glycine Alpha-Amidating Monooxygenasse

The sequence of bovine PAM is taught as well as new forms of PAM not known before. One new form is membrane bound and provides the basis and methods for alpha-amidating inactive precursors of peptide hormones. Patent (Set) 6,255,067;...
...

Therapeutic Suppression of Specific Immune Responses by Administration of Oligomeric Forms of Antigen of Controlled Chemistry

The method and construct used to reduce undesired antibody response in a mammal by administering a non-immunogenic construct of which contains at least two copies of a B cell membrane immunoglobulin receptor epitope bound to a pharmaceutically acceptable non-immunogenic carrier. This directly binds ...
...

Methods and Compositions for Creating Biopolymers with Modulatable or Novel Functionalities by Insertional Mutagenesis

The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellula...
...

O2-Benzyl-substituted Dizeniumdiolates that Release Nitric Oxide at Controlled Rates Upon Photolysis

Nitric oxide (NO) is a critically important bioregulator, involved in a wide range of processes including neurotransmission, blood clotting, and blood pressure control. In addition, macrophages have been shown to kill cancerous tumor cells and intercellular parasites by releasing large amounts of NO...
...

Inhibitors of Plasmepsin II, an Anti-Malarial target

Compounds and methods for the inhibition of anti-malarial target aspartyl protease plasmepsins (e.g. Plasmepsin I, Plasmepsin II, Plasmepsin IV and HAP) are provided. The compounds are based on allophenylnorstatine substituted at positions R1-R4, such that R1 is isoquinoline, carboxyl, naphtalene, p...
...

Modulation of Cell Survival Using E1B and Aven

The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of a cell-related product by ...
...

Structural Prediction of Allosterism

During the course of biological function, proteins interact with other proteins, ligands, substrates, inhibitors, etc. These interactions occur at precisely defined locations with the protein but their effects are sometimes propagated to distal regions triggering highly specific responses. These eff...
...

Antiproliferative Vitamin D3 Hybrids

The present invention is based on the unexpected finding that certain modifications to the A-ring portion of vitamin D.sub.3 analogues produce compounds of superior biological activity. In its broadest aspects, the invention provides vitamin D.sub.3 analogues which include a 1-hydroxyalkyl group or ...
...

Formation of Oligonucleotide Triplexes with Selectively Modified Cytosines

The present invention is based on the finding that it is possible to use the bisulfite-catalyzed transamination reaction to selectively introduce aminoalkyl or carboxyalkyl linker arms at a specific deoxycytidine site within oligonucleotides or analogs thereof which also contain one or more 5-methyl...
...

1, 2, 4 - Trioxanes Having Antimalarial Activity

Because of the widespread incidence of malaria in certain parts of the world and because of the increasing parasite resistance to standard anti-malarial drugs, there is an urgent need for new and effective anti-malarial drugs. A wide variety of anti-malarial compounds have been proposed for use. One...
...

Vitamin D3 Analogues

The present invention is based on the unexpected finding that the A-ring portion of vitamin D.sub.3 analogues can be modified without negatively affecting the biological activity of the resulting compounds. In its broadest aspects, the invention provides vitamin D.sub.3 analogues which include at le...
...

Identification of a new Type II Heat-labile Enterotoxin

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants and antigen delivery systems that promote the desired kinds of immune responses. In addition, many of the new subunit vaccine candidates lack sufficient immunog...
...

Calcium Sulfate (sulphate)-Based Nanoparticles: Synthesis and Modification Methods and Application in Bone Regenerative Therapy

Bone regeneration within critical size defects, both in the oral cavity and throughout the rest of the body, occurs very slowly in the absence of bone stabilizing agents to act as scaffolds. Though autogenous and allogenic bone grafts have been used to address this limitation, each faces its own set...
...

Methods for Preparing Multivalent RNA-Targeting Ligands with Specific Application Towards Targeting the (CUG)n Oligomers that Cause Myotonic Dystrophy

Trinucleotide repeat disorders are genetic disorders caused by extended stretches of DNA encoded with the same trinucleotide sequence repeated many times. Some of the most notable trinucleotide repeat disorders include Myotonic Dystrophy, Fragile X, Huntington’s, and Friedreich’s ataxia. Myotoni...
...

Using Selection to Define Rules for Small Molecule Targeting of RNA

Information needed to design nucleic acid-based compounds which target RNA can be as limited as knowing the Watson-Crick base pairing “code”. However, to date, the clinical success of such compounds (e.g. antisense and RNAi) has been elusive. Unlike nucleic acid-based drug candidates, delivery and s...
...

Inhibition of Mechanical Ion Channels by Peptide Enantiomers

Stretch-activated cation channels (SAC) are wide-spread in the body and trigger cellular responses to mechanical stresses. They mediate the senses of touch and hearing and help to regulate organ functions. GsMTx4, a tarantula venom peptide, and its enantiomer selectively block SAC channels. By block...
...

Transgenic mouse model for neurodegenerative diseases

The study of neurodegenerative diseases such as Parkinson’s Disease (PD) and the subsequent development of therapeutic agents to combat these diseases rely upon accurate non-human models that mimic the pathogenesis of their human counterparts. As th e current PD models fail to simulate all of the pa...
...

Composition of Liposomal GM-CSF

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customiz...
...

Method for Inhibiting Proteases in the Oral Cavity

Sensitive teeth, a condition which affects more than 45 million Americans each year, likely results from exposed dentinal tubules. A number of products have been developed that either occlude the exposed dentinal tubules or desensitize the nerves r esponsible for transmitting signals that the brain ...
...

Composition and method of preparation of liposomal microparticulate IL-12 for immunotherapy

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customiz...
...

Composition of the reconstitution medium for protein and peptide formulations

Pharmaceutical scientists at the University at Buffalo have developed a rational strategy to design compositions for the reconstitution of freeze-dried protein/peptide formulations. These compositions confer stability to otherwise unstable protein p roducts such as replacement therapies (i.e. factor...
...

Gene silencing of human c-myc oncogene by poly-DNP-RNA

Overexpression of the c-myc proto-oncogene has been implicated in the onset and progression of a wide range of cancers; in restenosis following arterial injury or intervention; and in the loss and dysfunction of insulin-producing ??cells in diabetes. UB researchers have synthesized a new compound, D...
...

Novel Human Gene with Immunoregulatory and Antiproliferative Properties

Abnormal or unregulated control of the body’s immune system can contribute to a variety of disorders, including but not limited to autoimmune disease and cancer. Standard treatments for autoimmune disease involve administration of non-steroidal anti- inflammatory drugs, corticosteroids, and disease ...
...

Poly-DNP-RNA-21

The RIa/PKA gene is often overexpressed in cancers of the breast, lung, colon, prostate and ovary. UB researchers have synthesized a new compound, DNP-ssRNA-21, that triggers cleavage of the mRNA of RIa/PKA, thereby leading to growth inhibition and apoptosis of these cancer cells but with no effect ...
...

Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the accessibility of donor sites. A definite need exists for an alternative, easily accessible stem cell sourc...
...

Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood cells. The cells isolated via this method have shown utility in at least one tissue engineering applic...
...

Biological Vaccine Delivery System

This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displayed a heterologous or homologous peptide sequence having biological activity. The protrusion of loo...
...

Use of RNA inhibitors based on IL-14 and antibodies to IL-14 for the treatment of autoimmune diseases and lymphomas

Autoimmune disorders and B cell derived lymphomas cause life-long suffering or premature death. Often the treatment for these diseases is symptomatic at best with severe side effects. An effective new treatment would be life saving for those patie nts. The cytokine interleukin-14 (IL-14) also known ...
...

Monoclonal antibody 3F5-5E5 and P107 diagnostic markers and putative vaccine antigen for Moraxella catarrhalis and supplemental Mab 4G5

This invention includes monoclonal antibodies, proteins, nucleic acid seqeunces and lipoologosaccharides (LOS) which are specific to Moraxella catarrhalis. These materials are useful for designing a much-needed diagnostic test. The ability to diagn osis this form of otitis media would be very valuab...
...

HIV antisense ORF(s) and putative protein(s)

The current invention is a gene comprising an open reading frame on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is related to, and has a structural motif resembling t hat of chemokine proteins. Depending upon the ribo...
...

Outer Membrane Protein B1 of Moraxella Catarrhalis

The present invention includes a method for the isolation and purification of outer membrane protein B1 as well as B1 peptides from Moraxella catarrhalis, and the resulting compositions. The method involves growing the bacteria in iron-depleted medi um to enhance the expression of the B1 protein, ha...
...

Novel 4-Substituted Indole compounds and methods for making same

The basic indole structure has been a structure of great interest to synthetic and medicinal chemists because of its presence in a large number of biologically active agents. For the most part, the current methods for producing substituted indole mo lecules rely upon cyclization of a suitably substi...
...

Erogorgiaene derivatives and method for making

Marine-derived bioactive compounds hold great promise as therapeutics in the treatment of human disease. One particular family of marine-derived diterpene compounds has demonstrated anti-cancer, anti-tubercular and anti-inflammatory activities. How ever, the complete evaluation of such compounds and...
...

Novel Chalcogenoxanthylium Dyes for Purging Blood Pathogens

Researchers at the University at Buffalo and the American Red Cross have developed a suite of chemical compounds to be used to purge pathogens found in the blood supply. There is a dire need to increase the blood supply. At current rates of donat ion, there is barely a three-day supply in many a...
...

21,23-Core-Modified Porphyrins as Sensitizers for Photodynamic Therapy

Photodynamic Therapy (PDT) is a unique approach to the treatment of cancer and other diseases. Able to differentiate cancerous and normal tissue while minimizing or eliminating many of the side effects associated with conventional chemotherapy and r adiation, PDT offers an appealing and cost-effecti...
...

Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the accessibility of donor sites. A definite need exists for an alternative, easily accessible stem cell sourc...
...

Composition and Method of preparation of Lipidic particles containing VEGF for lymphadema

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customiz...
...

Identification of a new Type II Heat-labile Enterotoxin

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants and antigen delivery systems that promote the desired kinds of immune responses. In addition, many of the new subunit vaccine candidates lack sufficient immunog...
...

Method of treating bacterial infection in humans using antimicrobial nanoparticles applied in vivo and ex vivo

Method of treating bacterial infection in humans using antimicrobial nanoparticles applied in vivo and ex vivo Categories: Environment, Therapeutic and Vaccines...
...

Composition of Liposomal GM-CSF

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customiz...
...

Methods for Preparing Multivalent RNA-Targeting Ligands with Specific Application Towards Targeting the (CUG)n Oligomers that Cause Myotonic Dystrophy

Trinucleotide repeat disorders are genetic disorders caused by extended stretches of DNA encoded with the same trinucleotide sequence repeated many times. Some of the most notable trinucleotide repeat disorders include Myotonic Dystrophy, Fragile X, Huntington’s, and Friedreich’s ataxia. Myotoni...
...

Anti-tumor compounds

Members of the inhibitor of apoptosis protein (IAP) protein family are often expressed at high levels in cancer cells. It is thought that high expression of IAP proteins leads to a disruption in the apoptotic pathway (programmed cell death). This d isruption allows for continuation of the cell cycle...
...

Method and Composition of Less Immunogenic, Long Circulating EPO

Over one million patients in the U.S. are prescribed a therapeutic erythropoietin to treat anemia caused by kidney failure or cancer chemotherapy. It is estimated that over 80% of cancer patients and 87% of patients with severe kidney disease devel op this condition. Treatment is critical considerin...
...

Using Selection to Define Rules for Small Molecule Targeting of RNA

Information needed to design nucleic acid-based compounds which target RNA can be as limited as knowing the Watson-Crick base pairing “code”. However, to date, the clinical success of such compounds (e.g. antisense and RNAi) has been elusive. Unlike nucleic acid-based drug candidates, delivery and s...
...

Calcium Sulfate (sulphate)-Based Nanoparticles: Synthesis and Modification Methods and Application in Bone Regenerative Therapy

Bone regeneration within critical size defects, both in the oral cavity and throughout the rest of the body, occurs very slowly in the absence of bone stabilizing agents to act as scaffolds. Though autogenous and allogenic bone grafts have been used to address this limitation, each faces its own set...
...

Method for Delivering Hydrophobic Drugs Via Nanocrystal Formulations

This technology explains the formulation of a nanosized drug delivery carrier and the method of delivering photodynamic drugs, which are free from the external agents. From the results obtained for significant photosensitizing efficacy in vitro and in vivo conditions, it is believed that upon admin...
...

Organically Modified Silica Nanoparticles Coencapsulating Photosensitizing Drug and Two-Photon Absorber for Two-photon Activated Photodynamic Therapy

Photodynamic therapy (PDT), following health agency approvals throughout the world for various cancers and other diseases, is slowly being accepted as a standard treatment for the treatment of obstructive esophageal and lung cancers as well as e arly stage lung cancer, and actinic keratoses. However...
...

Method for Inhibiting Proteases in the Oral Cavity

Sensitive teeth, a condition which affects more than 45 million Americans each year, likely results from exposed dentinal tubules. A number of products have been developed that either occlude the exposed dentinal tubules or desensitize the nerves r esponsible for transmitting signals that the brain ...
...

Chimeric TBP-Toxin Proteins as Mucosal Antigens for Vaccination against Neisseriae

Neisseria gonorrhoeae, the causative agent of the sexually transmitted disease gonorrhea, has been a burden to mankind from antiquity. Central to this bacteria's prolific nature, is its antigenic avariability of surface structures, as well as abilit y to avoid initiating host immune responses. Its c...
...

Method and Composition of Less Immunogenic, Long- Circulating Protein- Lipid Complexes

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant or full-length Factor VIII) associated with LIPRO-FORM (see R-6031 as well) exhibited markedly improved pharmacokinetic profiles and higher e fficacies in animal models. With characteristics su...
...

Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood cells. The cells isolated via this method have shown utility in at least one tissue engineering applic...
...

Method and composition of Pegylated protein (FVIII)-Phosphoserine complex

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant Factor VIII) associated with LIPRO-FORM exhibited improved pharmacokinetic profiles and higher efficacies in animal models. With characterist ics such as lowered immunogenicity and increased ci...
...

Composition and method of preparation of liposomal microparticulate IL-12 for immunotherapy

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF and VEGF-C. Depending on the preferred method of a dministration, these formulations can be customiz...
...

Novel 4-Substituted Indole compounds and methods for making same

The basic indole structure has been a structure of great interest to synthetic and medicinal chemists because of its presence in a large number of biologically active agents. For the most part, the current methods for producing substituted indole mo lecules rely upon cyclization of a suitably substi...
...

Erogorgiaene derivatives and method for making

Marine-derived bioactive compounds hold great promise as therapeutics in the treatment of human disease. One particular family of marine-derived diterpene compounds has demonstrated anti-cancer, anti-tubercular and anti-inflammatory activities. How ever, the complete evaluation of such compounds and...
...

TLR2-mediated adjuvant activities of LT-II B subunits

The present invention deals with heat-labile enterotoxins (LT-IIs) in which the toxic A-subunits are absent, leaving only the nontoxic B pentamers. Researchers found that despite the absence of toxic A-subunits, the B-subunits alone are immunostimula tory and that their ability to activate NF-?B and...
...

Gene silencing of human c-myc oncogene by poly-DNP-RNA

Overexpression of the c-myc proto-oncogene has been implicated in the onset and progression of a wide range of cancers; in restenosis following arterial injury or intervention; and in the loss and dysfunction of insulin-producing ??cells in diabetes. UB researchers have synthesized a new compound, D...
...

Inhibition of Mechanical Ion Channels by Peptide Enantiomers

Stretch-activated cation channels (SAC) are wide-spread in the body and trigger cellular responses to mechanical stresses. They mediate the senses of touch and hearing and help to regulate organ functions. GsMTx4, a tarantula venom peptide, and its enantiomer selectively block SAC channels. By block...
...

Use of anti-T antibody to block metastasis of T antigen bearing tumors

Many cancer cells contain a carbohydrate structure on their surface known as the Thomsen-Friedenreich Antigen (TF-Ag). This antigen, which is not detectable on normal cells, plays a pivotal role in metastasis. An antibody which binds strongly to TF -Ag would be extremely useful in imaging cancer in ...
...

Monoclonal antibody 3F5-5E5 and P107 diagnostic markers and putative vaccine antigen for Moraxella catarrhalis and supplemental Mab 4G5

This invention includes monoclonal antibodies, proteins, nucleic acid seqeunces and lipoologosaccharides (LOS) which are specific to Moraxella catarrhalis. These materials are useful for designing a much-needed diagnostic test. The ability to diagn osis this form of otitis media would be very valuab...
...

MUC7 12-mer-D isomer: novel and promising antimicrobial agent

This invention encompasses isomeric peptide derivatives of a naturally occurring protein found within the human body. These isomeric derivatives have been shown to possess potent antifungal activity comparable to that of currently used antifungal ag ents but with far less toxicity. The microbes used...
...

Novel Chalcogenoxanthylium Dyes for Purging Blood Pathogens

Researchers at the University at Buffalo and the American Red Cross have developed a suite of chemical compounds to be used to purge pathogens found in the blood supply. There is a dire need to increase the blood supply. At current rates of donat ion, there is barely a three-day supply in many a...
...

Adjuvant activities of a mutant LT-IIb enterotoxin lacking binding to ganglioside GD1a

UB microbiologists have developed a mutant heat-labile enterotoxin (LT-IIb) that demonstrates promising adjuvant activity and appears to overcome the limitations and concerns related to various mucosal adjuvants currently under investigation. The abi lity of the mutant LT-IIb to stimulate mucosal an...
...

Novel Human Gene with Immunoregulatory and Antiproliferative Properties

Abnormal or unregulated control of the body’s immune system can contribute to a variety of disorders, including but not limited to autoimmune disease and cancer. Standard treatments for autoimmune disease involve administration of non-steroidal anti- inflammatory drugs, corticosteroids, and disease ...
...

Composition of the reconstitution medium for protein and peptide formulations

Pharmaceutical scientists at the University at Buffalo have developed a rational strategy to design compositions for the reconstitution of freeze-dried protein/peptide formulations. These compositions confer stability to otherwise unstable protein p roducts such as replacement therapies (i.e. factor...
...

A vaccine to prevent infection by nontypeable Haemophilus influenzae infection

Currently, there is no effective vaccine to prevent infection by non-typeable Haemophilus influenzae (NTHi), a leading cause of otitis media as well as a number of other upper respiratory tract infections that affect both pediatric and adult populati ons. The most common treatment for OM is antibiot...
...

Poly-DNP-RNA-21

The RIa/PKA gene is often overexpressed in cancers of the breast, lung, colon, prostate and ovary. UB researchers have synthesized a new compound, DNP-ssRNA-21, that triggers cleavage of the mRNA of RIa/PKA, thereby leading to growth inhibition and apoptosis of these cancer cells but with no effect ...
...

Method for preparing less-immunogenic protein-lipid complexes

A novel method has been developed for preparing less immunogenic protein formulations. One composition derived from this method has demonstrated promising results in the delivery and efficacy of protein therapeutics (Factor VIII) involved in hemophi lia. By shielding the most immunogenic portion of ...
...

Organic Mixtures for the Encapsulation of Proteins in Dispersed Systems

Liposome technologies were developed to circumvent the problems associated with delivering therapeutic proteins into the human body. By encapsulating the protein of interest, the liposome allows the protein to remain in the circulation long enough t o have a pharmacological effect. While liposomes c...
...

Novel Antihemophilic (AHF) Formulations: Surface Coated Dispersion Systems as a Delivery Vehicle for AHF and its Fragments

Liposome technologies were developed to circumvent the problems associated with delivering therapeutic proteins into the human body. By encapsulating the protein of interest, the liposome allows the protein to remain in the circulation long enough t o have a pharmacological effect. While liposomes c...
...

Chimeric LT-II toxins as adjuvant-carrier molecules

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants, or delivery systems that promote the desired kinds of immune responses. The present invention provides m ethods of inducing immune responses by recombinant...
...

Protein Components of Streptococcus Pneumonae That Bind to Mucin Glycoproteins of Human Nasal and Middle Ear Secretions

Currently, there is no effective vaccine to prevent infections by Streptococcus pneumoniae, a leading cause of otitis media (OM) as well as a number of other upper respiratory tract infections that affect both pediatric and adult populations. A prer equisite for infection is bacterial colonization o...
...

Outer Membrane Protein B1 as a Vaccine for Branhamella Catarrhalis

The present invention encompasses nucleotide sequences derived from Moraxella catarrhalis which encode one or more epitopes of its outer membrane protein B1. Recombinant B1 protein or B1 peptides may be produced from genetically engineered host cells that contain and express these nucleotide sequenc...
...

HIV antisense ORF(s) and putative protein(s)

The current invention is a gene comprising an open reading frame on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is related to, and has a structural motif resembling t hat of chemokine proteins. Depending upon the ribo...
...

Stabilization of Taxane Formulations

The clinical development of taxanes has been hampered by poor aqueous solubility, which necessitates administration of the drug in a vehicle such as Cremophor EL mixed with ethanol. Unfortunately, the formulation vehicle causes a variety of adverse r eactions, including anaphylactic hypersensitivity...
...

Biological Vaccine Delivery System

This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displayed a heterologous or homologous peptide sequence having biological activity. The protrusion of loo...
...

Specific glycan-modified HIV envelope proteins as vaccine immunogens against

Introduction A major obstacle in current AIDS/HIV vaccine development is the failure to induce broadly neutralizing antibodies against primary isolates of human immunodeficiency virus. Standard vaccination approaches prime the adaptive immune system to recognize viral envelope proteins. However, the...
...

BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediates the efflux transport of a broad spectrum of substrates, including many drugs routinely administere...
...

Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")

Summary Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrices (see Harvard Case No. 1438). The present invention extends the polony technology to provided minia...
...

Synthesis of Compounds with Peptide Characteristics

Summary Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflexibility. Over ...
...

High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a particular target ligand or structural features designed to mimic a particular aspect of a class of nat...
...

Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease

Summary The development of more selective immunosuppressive agents to mitigate transplant rejection and autoimmune diseases requires effective strategies of blocking signaling pathways in T cells. Current immunosuppressive strategies use cyclosporin A (CsA) or FK506 to inhibit calcineurin, which dep...
...

Toxin-Phage Bacteriocide Antibiotic and Uses Thereof

Summary The rise of antibiotic resistant bacterial strains will necessitate the development of new strategies for treating bacterial infections. One potential alternative to conventional antibiotics is phage therapy - the use of bacteriophage viruses to specifically target and destroy disease-causin...
...

Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain

Summary Background: Although peptides have shown some promise in clinical trials as therapeutic agents, their success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflex...
...

Liposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells.

Summary Liposomes are man-made spheres, or vesicles, with an aqueous interior enclosed by one or more phospholipid bilayers. Liposomes can enhance the pharmacokinetics and efficacy of therapeutics by allowing slow diffusion of a drug through the liposomal membrane, so that the concentration of the d...
...

Antisense Inhibition of Angiogenin Expression in Cancer

Summary Antisense oligonucleotides targeted to anigogenin and designed based on the known sequence of the ANG gene have been synthesized. Angiogenin is a potent positive mediator of neovascularization, a process required for both primary tumor growth and metastasis. Initial immoassay studies showed ...
...

Methods and Reagents for Modulating TGF-beta Superfamily Signalling

Summary Harvard Medical School researchers have developed compositions and methods for modulating TGF-b signalling. TGF-b superfamily members regulate a wide range of normal and pathological biological processes, and have been implicated in a variety of developmental and immunological disorders, as ...
...

Novel Chemistry and Method to make Compounds Active Against Picornaviruses

Summary Picornaviruses are a large family of viruses responsible for many serious human and animal diseases, including hepatitis A, meningitis, diarrhea, summer flu, the common cold and polio. Several candidate antivirals have been shown to bind and inactivate picornaviruses. Current drugs active ag...
...

Synthesis of Compounds with Peptide Characteristics

Summary Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflexibility. Over ...
...

Compositions and Methods for Treating Papillomavirus-Infected Cells

Summary Human papillomaviruses have been linked to widespread, serious human diseases, especially cervical carcinoma. Researchers estimate that over 90% of the 500,000 cases of cervical cancer that arise worldwide each year may be linked to HPV. In addition to cervical cancer, papillomaviruses...
...

High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a particular target ligand or structural features designed to mimic a particular aspect of a class of nat...
...

Small Molecule Arrays: a New Forefront in Drug Discovery

Summary Scientists from the laboratory of Professor Stuart Schreiber at Harvard University have developed a novel method of printing small molecule libraries on glass microscope slides. This method represents a next-generation platform for drug discovery. Small Molecule Printing is simple and ef...
...

Drug candidate for neurological stroke and septic shock

Summary Apoptosis is a genetically regulated cellular suicide mechanism that plays an important role in regulating normal development and tissue homeostasis as well as pathogenesis of diseases. This process is mediated by one of at least 14 members of the Ced-3/ICE (caspase) family of cysteine prote...
...

Next Generation Diagnostics for Breast Cancer, Prostate Cancer, and Melanoma

Summary From the labs of Professor Alun Jones (inventor of CardioliteTM) and Professor Ashfaq Mahmood, comes a series of small molecule imaging probes, capable of conjugation to both SPECT-based and PET-based imaging agents. Lead candidates include sigma-1 and selective sigma-2 receptor probes in th...
...

Techniques for high yield synthesis of macrocyclic compounds

Summary Many useful pharmaceuticals, including natural products, have a macrocyclic structure that can be a challenge when exploring synthesis methods. The Walsh Laboratory has discovered a new process using of a solid-phase resin to synthesize macrocycle compounds, including polyketide synthase (PK...
...

Method of Creating Self-Assembled, Selectively-Permeable Colloidosome Structures

Summary Colloidosomes are spherical shells of micron-sized particles made by the simple technique of self-assembly onto emulsion droplets. These hollow, elastic capsules are ideal for efficiently encapsulating active agents for selective and timed release because they are highly controllable in stre...
...

Aminoglycosides Scaffolding Targeting Antibiotic-Resistant Bacteria

Summary This invention encompasses key modifications to the chemistry of aminoglycosides to overcome bacterial resistance. The novel chemistry leverages: (a) the weak stereospecificity of aminoglycoside binding to rRNA, and (b) the stereospecific binding of extrinsic enzymes shown to inactivate amin...
...

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host’s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel of this immune response pathway are the so-called Major Histocompatibility Complex (MHC) molecu...
...

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary Inhibition of bacterial septation machinery represents a promising approach for countering antibiotic-resistant bacteria. One such approach targets FtsZ, an essential protein and key mediator of bacterial cell division, which is highly conserved in prokaryotes, yet absent in the mitochondria...
...

Ephrins as Novel Targets in Neuronal Regeneration

Summary Chemokines play an intrinsic role in immunity and neural trafficking through their interactions with GPCRs. A reverse signaling mechanism of Ephrin B/EphB receptor has been discovered to inhibit GPCR sensitivity to chemokine binding. Reduced GPCR sensitivity is mediated by a novel cytoplasmi...
...

TreeDock protein docking software

Summary Predicting protein-protein and protein-ligand docking remains one of the challenging topics of structural biology. The main problems are (i) to reliably estimate the binding free energies of docked states, (ii) to enumerate possible docking orientations at a high resolution, and (iii) to con...
...

Techniques for high yield synthesis of macrocyclic compounds

Summary Many useful pharmaceuticals, including natural products, have a macrocyclic structure that can be a challenge when exploring synthesis methods. The Walsh Laboratory has discovered a new process using of a solid-phase resin to synthesize macrocycle compounds, including polyketide synthase (PK...
...

Toxin-Phage Bacteriocide Antibiotic and Uses Thereof

Summary The rise of antibiotic resistant bacterial strains will necessitate the development of new strategies for treating bacterial infections. One potential alternative to conventional antibiotics is phage therapy - the use of bacteriophage viruses to specifically target and destroy disease-causin...
...

Treatment of alcoholism and substance abuse using selective inhibition of alpha 2 adrenergic receptors and dopamine D2 receptors

Summary To date, most alcohol and substance-abuse drugs have been plagued by moderate efficacy and a lack of specific target mechanisms. A new approach is proposed involving weighted inhibition of the brain’s alpha 2 noradrenergic receptors (A2) and dopamine D2 receptors (D2). Lowered dependency o...
...

Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain

Summary Background: Although peptides have shown some promise in clinical trials as therapeutic agents, their success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflex...
...

In Vivo Evolution of an RNA-Based Transcriptional Activator

Summary This invention claims a method of evolving potent RNA transcriptional regulators using a combination of directed evolution and site directed mutagenesis. Also described are specifically evolved RNA aptamers and their structures. The potency of the evolved RNA based transcriptional activators...
...

Manipulating Stem Cells for Repair and Drug Delivery at Various Anatomic Sites

Summary Cellular and gene therapy for chronic drug delivery and tissue repair have been explored in a range of anatomic sites including the heart, brain, bone marrow, and skeletal muscle. Mashimo and colleagues present a new approach using modified embryonic stem (ES) cells to deliver drugs to the g...
...

Novel Avrainvillamide-like Compounds with Anti-proliferative Properties

Summary Avrainvillamide and stephacidin B, (a dimer of avrainvillamide) have been identified in culture media from various strains of the fungus Aspergillus. Both compounds demonstrate anti-proliferative activity, and avrainvillamide is reported to exhibit antimicrobial activity against multidrug-re...
...

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary The emergence of bacterial strains resistant to current drugs has prompted a renewed effort to discover new methods for fighting infectious disease. A promising new target is FtsZ, a key mediator of bacterial cell division that is highly conserved among bacteria. Because FtsZ, much like its ...
...

Novel Urazole Epoxyquinol Inhibitors of Hepatitis C Virus Replication

Summary Background: Hepatitis C virus (HCV) infects about 200 million people worldwide and frequently leads to cirrhosis, liver failure, and hepatocellular carcinoma. Currently, the best therapy for the treatment of chronic hepatitis C is a combination of pegylated interferon (PEG-IFN) and ribavirin...
...

Clinical Stage HIV Vaccine Candidate and Other Vaccine Vectors

Summary Replication-defective viruses integrate the safety advantages of a killed virus vaccine and the immunogenicity of a live virus vaccine. Professor David Knipe and his research team present a novel replication-defective HSV-1 virus for the delivery of heterologous immunogens and nucleic acids ...
...

Hydroxapatite -Antigen Conjugates AMPERSAND Methods for Generating a Poly-IG Immune Resp

Summary Issued patents 5,443,832: SUMMARY OF THE INVENTION We have discovered that hydroxylated calcium phosphate (HCP) particulate is a particularly useful carrier for antigens to be applied to mucosal surfaces. The antigen-HCP conjugate is transported across epithelium where it raises a poly...
...

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Summary Since its initial discovery and characterization over 40 years ago by Vallee and colleagues, metallothionein has attracted a remarkable level of scientific attention due to its unique structural characteristics, its ubiquitous expression in eukaryotes, and its impressive metal binding and re...
...

Genetically Attenuated Microbial Vaccines

Summary The invention, covered by U.S. Patent No. 6,254,874, provides vaccines that comprise attenuated pathogens. It also encompasses methods for the creation of attenuated microorganisms useful in such vaccines. As claimed, attenuation of the organism against which the vaccine is to be directed in...
...

Novel Surfactants for Stabilizing Emulsions of Water or Hydrocarbon Oil-Based Droplets in a Fluorocarbon Oil Continuous Phase

Summary Emulsions—dispersions of two immiscible fluids—have many applications in industry and everyday life. These range from paints, to crop protection, chemical synthesis, and production of latices. They are also increasingly attractive for analytical applications. Traditional emulsions consis...
...

High-throughput hydrogels for cell culture in realistic tissue stiffness environments

Summary Markets/ Needs Addressed: The physical environment surrounding a living cell influences its ability to proliferate, metabolize, differentiate and survive. In particular, the stiffness of the underlying matrix greatly affects cell fate and behavior. For example, cultured stem cells undergo n...
...

Targeting MEF-2 for the Treatment of Neurodegenerative Disease

Summary Post-synaptic differentiation of dendrites is an essential step in synapse formation and is intrinsic to neural reprogramming following CNS trauma or neurodegenerative disease. Investigators from Harvard Medical School have discovered an important molecular switch of the transcription factor...
...

Genetic Test for Periodontal Disease

Summary Peridontitis is a serious oral disease characterized by highly painful loss of tissue between the tooth and the gingival tissue. In the US, it is estimated that dentists perform upwards of 28.5 million periodontal procedures each year, accounting for a multibillion dollar treatment market. ...
...

Brainbow Mice: a Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have faced when attempting to map the neural circuitry of the brain has been their inability to clearly ...
...

Array of Micro Differential Scanning Calorimeters for Combinatorial Studies

Summary Differential scanning calorimetry (DSC) is a primary technique for measuring the thermal properties of materials. A typical DSC system requires relatively large amounts of test material, making thermal measurements on nano-scale samples difficult if not impossible. Thus, while traditional DS...
...

Brainbow Mice: a Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have faced when attempting to map the neural circuitry of the brain has been their inability to clearly ...
...

AlignAce motif searching software

Summary Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at high resolution for motifs that occur with non-random frequency. This algorithm is built into a multi-level sequence analysis program that highlights gen...
...

Time and concentration warping software for RNA and protein expression data

Summary The predominant strategies for drug discovery today employ high-throughput screens and microarray-based methods that generate large data sets. Increasingly, these techniques are being used to study biological processes as a function of time and/or chemical concentration. Functionally-related...
...

TreeDock protein docking software

Summary Predicting protein-protein and protein-ligand docking remains one of the challenging topics of structural biology. The main problems are (i) to reliably estimate the binding free energies of docked states, (ii) to enumerate possible docking orientations at a high resolution, and (iii) to con...
...

Algorithm for Haplotype Construction of Single Nucleotide Polymorphism

Summary The Haplotyper software program utilizes a novel algorithm called Partition-Ligation to reconstruct individual haplotype phase information from unphased genoptype data. The Partition-Ligation method uses an ingenious Markov chain Monte Carlo approach both to construct the partial haplotypes ...
...

GoFish gene annotation and database query software

Summary GoFish, a genomics software tool developed at Harvard Medical School, provides methods for improved gene annotation and query of gene annotation databases. The software enables efficient analysis of large genomics data sets by allowing the user to search for genes that possess investigator-d...
...

Phenotype Drug Screening Platform ; Based on Quantitative Morphometric Analysis of Cells

Summary A new platform has been developed for rapid phenotypic drug screening and cytological profiling. Recent studies demonstrate the platform’s efficacy for rapidly discovering and characterizing novel pharmaceutical compounds using morphometric analysis. This is achieved using a proprietary im...
...

Method and Apparatus for Fluid Dispersion

Summary The invention is a microfluidic device for focusing and/or breaking fluid sections and drops. The subject fluid flows in the device's central channel as the dispersing fluid flows in the two outer channels. The outer fluid exerts pressure and viscous stresses that focus the inner fluid into ...
...

Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease

Summary The development of more selective immunosuppressive agents to mitigate transplant rejection and autoimmune diseases requires effective strategies of blocking signaling pathways in T cells. Current immunosuppressive strategies use cyclosporin A (CsA) or FK506 to inhibit calcineurin, which dep...
...

Methods to Regulate the Duration of Th2 Activation

Summary TID1 encodes two human mitochondrial matrix localized splice variants. Expression of each of two splice variants has opposing effects on the cell's ability to respond to exogenous apoptotic stimuli. TNF and mitomycin c both trigger apoptosis via hTID1(L) expression. Both forms affect cytochr...
...

A Novel Class of Phospholipase A2 Preferentially Expressed in Th2 Cells

Summary This invention describes the identification of a novel, low molecular weight class of Phospholipase A2 enzyme, PLA2 Group XII, that is involved in Type 2 T helper (Th2) cell differentiation and activity. This enzyme provides a potential target for therapeutic modification of Th2 activity, in...
...

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host’s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel of this immune response pathway are the so-called Major Histocompatibility Complex (MHC) molecu...
...

Ephrins as Novel Targets in Neuronal Regeneration

Summary Chemokines play an intrinsic role in immunity and neural trafficking through their interactions with GPCRs. A reverse signaling mechanism of Ephrin B/EphB receptor has been discovered to inhibit GPCR sensitivity to chemokine binding. Reduced GPCR sensitivity is mediated by a novel cytoplasmi...
...

A Sensitive Assay to Identify Inhibitors of HSV DNA Polymerase

Summary Investigators from Harvard Medical School have developed a novel in vitro screening assay for small molecule inhibitors of viral DNA polymerase subunits. A number of hit have been identified with this assay that show antiviral effect in the low micromolar range, and the activity profiles of ...
...

Anti-Mitotic Eg5 Inhibitors for Treatment of Cancer and Inflammatory Disease

Summary Background: Molecules targeting mitosis and microtubule stability are important for the treatment of cancer. Unfortunately, the mechanism of action of these agents can cause undesirable toxicities For example, antimitotic agents such as taxol, epothilone, and vinca alkaloids produce toxicity...
...

Saframycin Assay

Summary Background: Chemotherapeutic DNA-binding compounds exert their effects, in part, by preventing DNA synthesis and initiating events that leads to apoptotic death. Despite the excellent antiproliferative activity of these compounds, though, elucidating their particular modes of action (i.e. th...
...

Small Molecule Approaches to the Management of Macular Degeneration by Short-Circuiting the Visual Cycle

Summary Age related macular degeneration (AMD) affects millions of persons worldwide and is a leading cause of vision loss and blindness in ageing populations. In this disease, daytime vision (cone dominated vision) degrades with time because cone photoreceptors, which are concentrated in the foveal...
...

Novel Avrainvillamide-like Compounds with Anti-proliferative Properties

Summary Avrainvillamide and stephacidin B, (a dimer of avrainvillamide) have been identified in culture media from various strains of the fungus Aspergillus. Both compounds demonstrate anti-proliferative activity, and avrainvillamide is reported to exhibit antimicrobial activity against multidrug-re...
...

Brainbow Mice: a Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have faced when attempting to map the neural circuitry of the brain has been their inability to clearly ...
...

Method of Creating Self-Assembled, Selectively-Permeable Colloidosome Structures

Summary Colloidosomes are spherical shells of micron-sized particles made by the simple technique of self-assembly onto emulsion droplets. These hollow, elastic capsules are ideal for efficiently encapsulating active agents for selective and timed release because they are highly controllable in stre...
...

Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)

Summary This invention comprises methods for non-homologous random recombination (NRR) of nucleic acids, and their use to develop and select nucleic acids or polypeptides with novel structure and function. This technology is distinct from previous DNA shuffling methods in that it provides more compr...
...

Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)

Summary This invention comprises methods for non-homologous random recombination (NRR) of nucleic acids, and their use to develop and select nucleic acids or polypeptides with novel structure and function. This technology is distinct from previous DNA shuffling methods in that it provides more compr...
...

Novel Surfactants for Stabilizing Emulsions of Water or Hydrocarbon Oil-Based Droplets in a Fluorocarbon Oil Continuous Phase

Summary Emulsions—dispersions of two immiscible fluids—have many applications in industry and everyday life. These range from paints, to crop protection, chemical synthesis, and production of latices. They are also increasingly attractive for analytical applications. Traditional emulsions consis...
...

Animal Model for Benign Prostate Hyperplasia

Summary The invention provides transgenic mouse models of benign prostate hyperplasia. These animals are useful in toxicity screens, as well as in assays aimed at the development of drugs to prevent prostate hyperplasia in mammals, including humans. References: Muller et al., 1990, "The int-2...
...

Targeting MEF-2 for the Treatment of Neurodegenerative Disease

Summary Post-synaptic differentiation of dendrites is an essential step in synapse formation and is intrinsic to neural reprogramming following CNS trauma or neurodegenerative disease. Investigators from Harvard Medical School have discovered an important molecular switch of the transcription factor...
...

Purification of a Smooth Muscle Cell Mitogen from Beta Tumor Cell Conditioned Me

Summary This invention describes a novel human growth factor, sometimes referred to as "BTC-GF". BTC-GF is a mitogen for smooth muscle cells, 3T3 fibroblasts, and retinal pigment epithelial cells, but has no such effect on endothelial cells. Applications -smooth muscle replication in hypertension...
...

A New p53 Cell-Based Assay

Summary Harvard researchers developed a reliable, high-throughput screening assay to identify activators and inhibitors of p53. This cell-based luminescence assay measures the level of a reporter gene product under the control of a promoter containing a p53-binding site. P53 is a transcription fa...
...

Dominant negative inhibitor of anthrax toxin

Summary The invention enables prevention and emergency treatment of anthrax. It provides a dominant negative inhibitor (DNI) of an essential infectivity factor of B. anthracis, a potentially lethal pathogen. Animal testing has been performed, and an IND has been filed for human therapeutic use. T...
...

ras Oncogene Inhibitors

Summary Activated ras genes have been associated with a number of human cancers. An activated ras gene, H-ras-1, was the first non-viral oncogene discovered. Several other human ras proto-onco genes have subsequently been identified including H-ras-2, K-ras-1, K-ras-2, and N-ras. Activated K-ras gen...
...

Deglycosylating gp120

Summary This invention describes a method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis. Removal of multiple carbohydrate residues by mutation of their consensus N-linkage sites exposes gp160/gp120 protein domains to the host immune system and ...
...

Methods for Treating Arteriosclerosis

Summary Scientists at Harvard Medical School have identified imidazoles that inhibit endothelial cell, vascular smooth muscle cell and fibroblast proliferation. These imidazoles can be used to beneficially treat a variety of arteriosclerotic conditions. U.S. Patent No. 5,358,959 protects the use of ...
...

Mediators of Chronic Allograft Rejection and DNA Molecules Encoding Them

Summary This invention provides methods of detecting and treating arterial inflammatory disease, including chronic allograft rejection subsequent to organ transplantation or chronic vascular Chlamydia pnuemonii infection, that results in atherosclerosis or restenosis. A major limiting factor for ...
...

NF-X1: Novel Target for Inhibition of MHC Class II Transcription and Autoimmune Disease

Summary The class II MHC molecules function in the presentation of processed peptides to helper T cells during an immune response. Dysregulated expression of class II major histocompatibility complex (MHC) molecules is hypothesized to contribute to the pathogenesis of a severe combined immunodeficie...
...

EPH Receptor Ligands, and Uses Related Thereto

Summary The EPH kinases constitute the largest family of receptor tyrosine kinases. EPH receptors and their ligands (ephrins) play a central role in embryonic development and increasing evidence also implicates EPH and ephrins in cancer progression and metastasis. Harvard's researchers have iden...
...

Novel Synthetic Mechanism to b-Lactone and Analogs: Lead Compounds for the Treatment of Proteasome-Related Diseases

Summary Background: Proteasome inhibition offers considerable promise in the therapy of a number of types of diseases, such as cancer and neurodegenerative diseases. One such proteasome inhibtor, Velcade, is currently marketed for treatment of multiple myeloma by Millennium Pharmaceuticals. Despite ...
...

Liposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells.

Summary Liposomes are man-made spheres, or vesicles, with an aqueous interior enclosed by one or more phospholipid bilayers. Liposomes can enhance the pharmacokinetics and efficacy of therapeutics by allowing slow diffusion of a drug through the liposomal membrane, so that the concentration of the d...
...

Improved Method of Expression Cloning

Summary The human genome will soon be completely sequenced, presenting a vast new array of targets against which pharmaceutical agents can potentially be designed. However, to capitalize on this new information, the cellular function and medical significance of each of these genes will need to be de...
...

Assay and Reagents for Detecting Inhibitors of Ubiquitin-dependent Degredation o

Summary Issued US patent 5,726,025 : SUMMARY OF THE INVENTION The present invention provides a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein in cells from vertebrate organism, espec...
...

In Vitro Differentiation of CD34+ Progenitor Cells into T-Lymphocytes (formerly

Summary Harvard Medical School researchers have developed a method for the production of large quantities of T lymphocytes in vitro. A monolayer of non-human primate thymic stromal cells is cocultured in vitro with human hematopoietic T cell progenitor cells, resulting in the differentiation and gro...
...

High Lead Expression of Soluble CMV UL97 and Development of an Assay to Screen Inhibitors

Summary The Coen Lab has expressed UL97 and UL97 fusion proteins and developed an assay to identify agents that inhibit or activate UL97 to be used in the treatment of human cytomegalovirus (HCMV) infection. HCMV is a beta herpes virus that causes significant pathology in individuals who are imm...
...

A Novel Tumor Suppressor Protein and Gene

Summary A novel tumor suppressor gene, doc-1, has been discovered which is structurally altered during oral carcinogenesis and which is expressed by normal and not transformed human tissues, and not by oral carcinoma. The expression of this gene as a tumor suppressor protein is inducible in cells wi...
...

Herpesvirus Antiviral Drug Screen

Summary Herpesviruses continue to be a significant medical problem, causing painful chronic genital infections as well as devastating neonatal infections. To address these problems, Harvard Medical School faculty member Dr. David Knipe has looked at factors that control the replication of HSV. ICP-4...
...

Smooth Muscle Cell Lim Protein

Summary Summary Issued patents claim DNA encoding the SmLIM polypeptide and/or promoter sequence, and the SmLIM polypeptide. Background and Significance Cardiovascular disease is the leading cause of death in the United States and other Western countries, responsible for twice as many deaths p...
...

Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases

Summary Background: One promising target of recent cancer therapy research involves a family of proteins primarily involved in gene regulation known as histone deacetylases or HDACs. Currently there are over 15 separate clinical trials ongoing with HDAC inhibitors. A major drawback with the use of p...
...

Antisense Inhibition of Angiogenin Expression in Cancer

Summary Antisense oligonucleotides targeted to anigogenin and designed based on the known sequence of the ANG gene have been synthesized. Angiogenin is a potent positive mediator of neovascularization, a process required for both primary tumor growth and metastasis. Initial immoassay studies showed ...
...

Methods and Reagents for Modulating TGF-beta Superfamily Signalling

Summary Harvard Medical School researchers have developed compositions and methods for modulating TGF-b signalling. TGF-b superfamily members regulate a wide range of normal and pathological biological processes, and have been implicated in a variety of developmental and immunological disorders, as ...
...

Cell Based Assay for Discovery of Glycogen Synthase Kinase Inhibitors

Summary Background: Lithium exhibits numerous physiological effects in animals. For example, lithium mimics insulin action by stimulating glycogen synthesis and is remarkably effective for the treatment of mania in many human patients. Research over the years has demonstrated that lithium administer...
...

Method for Cloning Secreted Proteins

Summary Many biologically important molecules, including many used therapeutically, are secreted proteins, such as interferons, erythropoietin and insulin. Secreted proteins have a hydrophobic signal peptide at the amino terminus of the protein. This hydrophobic signal sequence is typically about 16...
...

Novel Chemistry and Method to make Compounds Active Against Picornaviruses

Summary Picornaviruses are a large family of viruses responsible for many serious human and animal diseases, including hepatitis A, meningitis, diarrhea, summer flu, the common cold and polio. Several candidate antivirals have been shown to bind and inactivate picornaviruses. Current drugs active ag...
...

Surface-Bound, Bimolecular, Double-Stranded DNA Arrays

Summary The invention, developed at Harvard Medical School, achieves high array feature density and accurate feature production through enzymatic second-strand synthesis of immobilized single-stranded DNA on one or more solid- or semi-solid support structures. Efficient, high-fidelity production of ...
...

A Rapid and Inducible Method for Repressing Gene Function

Summary The Struhl lab has developed a rapid and effective mean to inactivate a target gene, including genes involved in essential pathways. This invention allows the inducible degradation of the polypeptide product in addition to the repression of a targeted gene. In combination, this double shut-o...
...

Production and uses of polymerase colony ("polony") arrays

Summary The invention provides methods for rapid fabrication and use of replicable, high-density nucleic acid arrays. Array features are produced through amplification on a support matrix of nucleic acid templates of interest. A significant advance over conventional DNA array technologies, the so-ca...
...

Surface-Bound Double-Stranded DNA Protein Arrays

Summary Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular analyses enabled by this technology are advan...
...

AlignAce motif searching software

Summary Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at high resolution for motifs that occur with non-random frequency. This algorithm is built into a multi-level sequence analysis program that highlights gen...
...

Cellular Basis of Vascular-Graft Stenosis

Summary The invention features a mouse model of vascular graft stenosis in which the stenosis develops rapidly and closely mimics the development of vascular graft stenosis in humans. Methods of surgically modifying a mouse artery to obtain the desired model are detailed. About 400,000 patients u...
...

Synthesis of Compounds with Peptide Characteristics

Summary Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflexibility. Over ...
...

Systematic, condition-independent identification of essential genes of microorganisms

Summary Traditional antibiotics have been aimed at a small subset of cellular processes (such as cell wall synthesis, protein synthesis and mRNA synthesis) and targets (including DNA gyrase and the cell membrane). Linkage of additional genes, proteins and pathways with functions essential to microbi...
...

Compositions and Methods for Treating Papillomavirus-Infected Cells

Summary Human papillomaviruses have been linked to widespread, serious human diseases, especially cervical carcinoma. Researchers estimate that over 90% of the 500,000 cases of cervical cancer that arise worldwide each year may be linked to HPV. In addition to cervical cancer, papillomaviruses...
...

Monoclonal Antibody 2F12, Anti-ITK

Summary Monoclonal antibody to the T cell signaling protein ITK (Tyrosine kinase), developed by Heather Wilcox in Dr. Leslie Berg's lab, in the department of Molecular and Cell Biology, Harvard. These monoclonal antibodies were raised against a GST fusion protein comprising the first 26 amino acids ...
...

Geminin: a Biomarker with Significant Prognostic Potential in Cancer and Neuronal Differentiation

Summary A nuclear protein known as geminin is proposed as a broadly applicable cancer biomarker. The geminin protein was initially discovered by Kirchner et al. as an inhibitor of DNA synthesis and as a key regulator of genetic stability during chromosomal replication. Recent studies have pointed ou...
...

Polo-Like Kinase Polo Box: Lead Target for Cancer Therapeutics

Summary Elevated expression of mammalian polo-like kinase (Plk) 1 occurs in many different types of cancers, such as head and neck, squamous cell carcinomas, oropharyngeal carcinomas, non-small cell lung cancer, melanomas, and ovarian and endometrial carcinomas. Plk1 has also been proposed as a nove...
...

Methods and Compositions Relating to Modulation of Cartilage Growth by Modulatio

Summary Dr. Laurie Glimcher at Harvard University has recently discovered that the transcription factor NFATp plays a critical role in regulating the formation of cartilage. Mice that lack NFATp display uncontrolled proliferation of cartilage over time as well as the capacity to regenerate cartilage...
...

The Cytoblot: a Miniaturized High-Throughput Immunodetection Screening Assay Kit

Summary Background: A major goal of drug discovery efforts is to develop successful high throughput assays. Current assays either detect specific protein-ligand interactions using recombinant proteins or study the effects of small molecules on cell proliferation. The detection of cell proliferation ...
...

A Tool for the Linkage and Presentation of Multiple Protein Functional Domains

Summary Recent molecular biology research is moving beyond genetics to look at protein - protein interactions and how cells interact or communicate. These exciting areas are in need of improved tools that allow these interactions to be identified and studied. Harvard Medical School researchers h...
...

A Method to Target the Degradation of Specific Cellular Proteins

Summary In order to study the role of specific proteins in cellular processes, researchers use a variety of techniques, including gene knockout, antisense, and RNA interference technologies. These technologies are limited in their all or nothing nature - they do not permit a low level of expression....
...

On Bead Tagging and Decoding for Combinatorial Synthesis

Summary Pharmaceutical drug discovery has been greatly impacted by the development of novel approaches to the rapid synthesis of novel compounds, including combinatorial synthesis approaches. A common problem in combinatorial synthesis is that the compounds are frequently produced as mixed pools att...
...

Drug screening tool for herpes antivirals

Summary Harvard Medical School researchers have developed a genetically modified herpes simplex virus that has utility as a drug screening tool. To develop this tool, Harvard researchers engineered a replication competent herpes virus that contains green fluorescent protein (GFP) fused to a viral re...
...

Small Molecule Therapeutic and Screening Assays for Drugs Active Against Chronic Neural Degenerative Diseases.

Summary Huntington's disease, as well as other ataxias, are caused by the abnormal expansion of nucleic acid CAG repeats that code a glutamine stretch. These repeats are found within several otherwise non related proteins. The abnormally long polyglutamine tracts are believed to trigger programmed c...
...

Direct and Practical Synthetic Route to Pseudopterosins: Important Anti-Inflammatory, Anti-Pain, and Anti-Irritant Compounds

Summary Background: The pseudopterosins are a group of diterpene glycosides isolated from the Caribbean sea whip, Pseudopterogorgia elisabethae. The pseudopterosins represent an important structural class of anti-inflammatory and analgesic metabolites, and exhibit superior analgesic activity compare...
...

Bilins as anticancer agents

Summary A remarkable discovery at Harvard Medical School has led to the recognition that a naturally-occurring small molecule and analogs thereof possess potent anticancer properties through their ability to control cell differentiation. According to the invention, bilins are administered to induce ...
...

Inhibitors of Protein-Processivity Factor

Summary Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal interaction between known Pol family members and other cellular factors. Unlike most protein-protein interactions, the target site is uniquely suited to small m...
...

Drug candidate for neurological stroke and septic shock

Summary Apoptosis is a genetically regulated cellular suicide mechanism that plays an important role in regulating normal development and tissue homeostasis as well as pathogenesis of diseases. This process is mediated by one of at least 14 members of the Ced-3/ICE (caspase) family of cysteine prote...
...

Small Molecule Arrays: a New Forefront in Drug Discovery

Summary Scientists from the laboratory of Professor Stuart Schreiber at Harvard University have developed a novel method of printing small molecule libraries on glass microscope slides. This method represents a next-generation platform for drug discovery. Small Molecule Printing is simple and ef...
...

Method of Detecting Compounds Utilizing Genetically Modified Lambdoid Bacterioph

Summary This invention describes a method to detet a molecule of interest in a given solution, and a method of selecting or screening for cell lines that can continuously produce desired compounds. This method uses a genetically and chemically modified lambdoid bacteriophage that has a target molecu...
...

Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases

Summary Background: One promising target of recent cancer therapy research involves a family of proteins primarily involved in gene regulation known as histone deacetylases or HDACs. Currently there are over 15 separate clinical trials ongoing with HDAC inhibitors. A major drawback with the use of p...
...

Reaction Microarrays: Ultra Fast Method for Chiral Catalyst Discovery

Summary Background: While combinatorial chemistry has been successfully applied to the problem of chiral catalyst discovery, its utility is severely hampered by the lack of rapid, high-throughput screens for enantiomeric purity. Current methods require weeks to screen the products of 10,000 reaction...
...

Dominant negative inhibitor of anthrax toxin

Summary The invention enables prevention and emergency treatment of anthrax. It provides a dominant negative inhibitor (DNI) of an essential infectivity factor of B. anthracis, a potentially lethal pathogen. Animal testing has been performed, and an IND has been filed for human therapeutic use. T...
...

"Teabag" Processing: an Automated, High Throughput Method for Affinity Purification

Summary A high throughput system for protein purification has been developed, whereby a “tea-bag” structure is used to house microspheres for targeted protein binding and elution. The microspheres are compatible with any solid-phase protein purification, which includes coupling of Ni++/Histidine...
...

Methods to Regulate the Duration of Th2 Activation

Summary TID1 encodes two human mitochondrial matrix localized splice variants. Expression of each of two splice variants has opposing effects on the cell's ability to respond to exogenous apoptotic stimuli. TNF and mitomycin c both trigger apoptosis via hTID1(L) expression. Both forms affect cytochr...
...

Aminoglycosides Scaffolding Targeting Antibiotic-Resistant Bacteria

Summary This invention encompasses key modifications to the chemistry of aminoglycosides to overcome bacterial resistance. The novel chemistry leverages: (a) the weak stereospecificity of aminoglycoside binding to rRNA, and (b) the stereospecific binding of extrinsic enzymes shown to inactivate amin...
...

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary Inhibition of bacterial septation machinery represents a promising approach for countering antibiotic-resistant bacteria. One such approach targets FtsZ, an essential protein and key mediator of bacterial cell division, which is highly conserved in prokaryotes, yet absent in the mitochondria...
...

A Drug Discovery Platform Using Novel Labeled Uridine Analogs: Unique moieties contribute to molecular biology research

Summary Background: Uracil is a nucleic acid base that, when bound to ribose or deoxyribose, forms uridine or deoxyuridine, respectively. Certain analogs of uridine and deoxyuridine have been synthesized and used in a variety of applications. For example, deoxyribouridine analogs containing a 5-amin...
...

A Versatile Method for Accelerated Chromosome Walking and DNA Fingerprinting

Summary Background: A variety of DNA amplification methods deal with sequence analysis of an uncharacterized region adjacent to a known element. These methods include inverse PCR (iPCR), panhandle PCR, cassette ligation-anchored, and Thermal Asymmetric Interlaced PCR. Despite various degrees of succ...
...

Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)

Summary This invention comprises methods for non-homologous random recombination (NRR) of nucleic acids, and their use to develop and select nucleic acids or polypeptides with novel structure and function. This technology is distinct from previous DNA shuffling methods in that it provides more compr...
...

HDAC Inhibitors

HDAC Inhibitors Laura Brass Email: laura_brass@harvard.edu Telephone: (617) 495-3067...
...

Absolute Quantification of Proteins (AQUA)

Summary This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from cell lysates. In particular, the invention provides peptide internal standards for use in high performance liquid chromatography (HPLC) with online detec...
...

Tome-1, a novel cell-cycle gene required for mitotic entry

Summary This invention, out of Marc Kirschner's research group, concerns the discovery of a novel protein required for mititic entry. Harvard researchers have isolated and identified the protein and the gene encoding the protein. Further work has shown Tome-1's key role in the activation of cdk1/Cyc...
...

Saframycin Assay

Summary Background: Chemotherapeutic DNA-binding compounds exert their effects, in part, by preventing DNA synthesis and initiating events that leads to apoptotic death. Despite the excellent antiproliferative activity of these compounds, though, elucidating their particular modes of action (i.e. th...
...

Susceptibility to Tuberculosis 1 (sst1): Novel Target for Diagnosis and Treatment of Mycobacterium tuberculosis

Summary Background: Tuberculosis is the seventh most important cause of global premature mortality and disability. Currently there are 8 million new cases and 3 million deaths annually from tuberculosis, and it is projected that a total of 225 million new cases and 79 million deaths will occur betwe...
...

Monoclonal IgE anti-ovalbumin antibody

Summary A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of asthma. Currently there is no commercial IgE...
...

Transgenic GFP-Rhodopsin Zebrafish Model System for Study of Retinal Disease

Summary Background: Rhodopsin is a G-protein coupled receptor that initiates the light response upon absorption of a photon in the outer segment of the retina (ROS). Rhodopsin constitutes at least 90% of the total protein in the outer segment and as a consequence the efficient transport of this mole...
...

Method and Apparatus for Fluid Dispersion

Summary The invention is a microfluidic device for focusing and/or breaking fluid sections and drops. The subject fluid flows in the device's central channel as the dispersing fluid flows in the two outer channels. The outer fluid exerts pressure and viscous stresses that focus the inner fluid into ...
...

A Novel Class of Proteosome Inhibitors

Summary Harvard Medical School investigators has discovered a number of anticancer small molecules, termed ubistatins, that inhibit cell cycle machinery through interference with the ubiquitin-proteasome system. Lead ubistatins were able to arrest cyclin B proteolysis in Xenopus extract assays, and ...
...

Small Molecule Approaches to the Management of Macular Degeneration by Short-Circuiting the Visual Cycle

Summary Age related macular degeneration (AMD) affects millions of persons worldwide and is a leading cause of vision loss and blindness in ageing populations. In this disease, daytime vision (cone dominated vision) degrades with time because cone photoreceptors, which are concentrated in the foveal...
...

Novel Candidates for Tuberculosis Therapy

Summary There is a need for new antibiotics that are useful against tuberculosis. Proteasomes of Mycobacterium tuberculosium are essential in enabling these bacteria to evade killing by macrophages of the infected host. Proteasome inhibitors, an emerging class of drugs, enhance the ability of host m...
...

Fully-integrated 2D microelectromagnet coil arrays in silicon for magnetic manipulation and RF imaging of cells and magnetic particles

Summary The invention comprises a novel method and an apparatus to manipulate, segregate, detect and analyze biological samples on a microfluidic CMOS chip. This technique offers sub-micrometer precision and fast processing speeds for a cheap, easily accessible lab-on-a-chip system. The technology i...
...

Genetic Test for Periodontal Disease

Summary Peridontitis is a serious oral disease characterized by highly painful loss of tissue between the tooth and the gingival tissue. In the US, it is estimated that dentists perform upwards of 28.5 million periodontal procedures each year, accounting for a multibillion dollar treatment market. ...
...

Deteremination of intracellular protein-protein interactions by colocalization with cytoplasmic inclusions

Summary Viral inclusion bodies are formed in transfected mammalian cells to enable an endogenous assay for protein-protein or nucleic acid-protein interactions. Inclusion bodies are generated by transfecting a cell with a vector encoding a protein fused with a modified reovirus protein/GFP hybrid. A...
...

Simultaneous Study of Multiple Genetic Interactions Using Multi-mutant Yeast

Summary While the Saccharomyces Genome Deletion Project succeeded in deleting many open reading frames in the S. cerevisiae genome, the possibility of multiple deletions in the same strain still represents an unmet challenge. A method has been discovered to precisely delete large numbers of genes in...
...

Novel Cancer Target Following HDAC Track: First Histone Demethylase offers opportunity in treating resistant cancers

Summary The invention encompasses a novel target representing a potential new avenue in the treatment of cancer and other diseases, based on interference with gene regulation. The target, LSD1 (lysine-sepcific demethylase 1), the first example of histone demethylase, is responsible for trimming meth...
...

A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates

Summary Background: Molecular studies of the genomic organization of HIV-1 show that it encodes a number of genes common to all retroviruses, such as the gag, pol, and env genes. The env gene of HIV-1 produces a cleaved envelope glycoprotein (gp120) that is expressed on the exterior viral envelope s...
...

Correlated Mutation Analysis-assisted Chimeric-Engineering/Directed-Evolution of Novel Portein/Enzyme Function

Summary Chimeric protein engineering and directed-evolution are increasingly popular methods to obtain enzymes with desired activities and substrate specificities. Chimeric-engineering goes about this by grafting select components of two homologous enzymes together (preserving activity while combina...
...

Novel Avrainvillamide-like Compounds with Anti-proliferative Properties

Summary Avrainvillamide and stephacidin B, (a dimer of avrainvillamide) have been identified in culture media from various strains of the fungus Aspergillus. Both compounds demonstrate anti-proliferative activity, and avrainvillamide is reported to exhibit antimicrobial activity against multidrug-re...
...

Targeting the Par-4 Protein as a Novel Approach in Depression Treatment

Summary Harvard researchers have discovered methods for identifying agents that modulate the interaction between Par-4 and the dopamine D2 receptor (D2DR). The ability to screen for this interaction may provide researchers with the ability to identify specific small molecule inhibitors of this inter...
...

Proteasome-Mediated Degradation of RISC: Lead Target for Treatment of Long-Term Memory Disorders

Summary Background: Breakthrough research by Professor Sam Kunes and colleagues at Harvard University demonstrates that degradative control of the miRNA RISC pathway underlies the synaptic pattern of protein synthesis associated with the establishment of a stable long-memory. Manipulation of this pa...
...

Single Cell mAB Discovery: ; Discovering Therapeutic Antibodies Invisible to Current Screening Platforms

Summary Monoclonal antibodies, including the epitope specific antibodies, represent a rapidly growing pharmaceutical segment, driven by the need for targeted therapeutics and growing knowledge of disease pathways. However, despite the high value of therapeutic mABs, discovery techniques have not adv...
...

Wnt1-Cre transgenic mouse model

Summary Background: The ability to generate specific genetic modifications in mice provides a powerful approach to assess gene function. As such systems allowing conditional genetic modification have been developed; for example, inducible forms of the Cre recombinase from P1 phage have been generate...
...

Attenuated RNA Viruses for Vacine and Drug Delivery

Summary Research in the lab of Prof. Sean Whelan has revealed new compositions to attenuate non-segmented negative-sense RNA (nsNS) viruses. Successful attenuation was demonstrated on vesicular stomatitis virus (VSV) and involved specific residue modifications that impair methylation capping in new ...
...

Brainbow Mice: a Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have faced when attempting to map the neural circuitry of the brain has been their inability to clearly ...
...

Transgenic Mice with Fluorescently Tagged Neuronal Mitochondria as a New Tool to Study Axonal Transport

Summary Background: Axonal transport supplies organelles to axons and synapses but little is known about how organelles are distributed among the branches of an axon to insure adequate supply of resources. This problem applies to axonal mitochondria, which play the central role in the energy metabol...
...

Targeting MEF-2 for the Treatment of Neurodegenerative Disease

Summary Post-synaptic differentiation of dendrites is an essential step in synapse formation and is intrinsic to neural reprogramming following CNS trauma or neurodegenerative disease. Investigators from Harvard Medical School have discovered an important molecular switch of the transcription factor...
...

Smaller and faster biocalorimeter for ultra-sensitive temperature sensing that helps reduce drug-development cost and risk

Summary Innovation and Advantages: We have developed a novel calorimetry device for ultra-sensitive temperature sensing associated with a chemical reaction using surface plasmon-enhanced radiation. Radiation is directed at a thin electrically conductive film having one or more small apertures. The i...
...

Small Molecule Microarrays: a New Forefront in Drug Discovery

Summary Scientists from the laboratory of Professor Stuart Schreiber at Harvard University have developed a novel method of printing small molecule libraries on glass microscope slides. This method represents a next-generation platform for drug discovery. Small molecule arrays can be utilized in all...
...

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Summary Since its initial discovery and characterization over 40 years ago by Vallee and colleagues, metallothionein has attracted a remarkable level of scientific attention due to its unique structural characteristics, its ubiquitous expression in eukaryotes, and its impressive metal binding and re...
...

HEK293T cells stably expressing Divalent Metal Transporter-1 (DMT1-1): Model System to Screen for Inhibitors of Iron Uptake

Summary A HEK293T cell line that stably expresses Divalent Metal Transporter-1 (DMT-1). DMT1 functions in transport of ferrous iron across the plasma membrane and/or out of the endosomal compartment. Thus, the cell line is an ideal tool to screen for potential iron transport inhibitors. In one examp...
...

Generating transgenic models via in-vitro selection of embryonic stem clones:; an accelerated route to in-vivo disease models and target validation

Summary Techniques to customize and predict transgenic animal phenotype through in-vitro pre-screening would be highly advantageous. Research from the lab of Professor David Sinclair presents a new platform for generating transgenic animals using a series of in-vitro screening techniques and a libra...
...

High-throughput hydrogels for cell culture in realistic tissue stiffness environments

Summary Markets/ Needs Addressed: The physical environment surrounding a living cell influences its ability to proliferate, metabolize, differentiate and survive. In particular, the stiffness of the underlying matrix greatly affects cell fate and behavior. For example, cultured stem cells undergo n...
...

Magnetic Resonance Force Microscope

Introduction Magnetic resonance force microscopy (MRFM) is a variant of scanning probe microscopy that combines the sensitivity and spatial resolution of atomic force microscopy with the threedimensional and nondestructive imaging capabilities of magnetic resonance imaging. Technology description Mo...
...

Preparative-Scale Microfabricated Capillary Electrophoresis

Introduction The demand for precise, high throughput protein separation is increasing due to both the growing number of protein based therapeutics being developed and the emphasis on proteomic analysis in research and drug discovery applications. The established technologies are electrophoresis and ...
...

Droplet Compartmentalization for Chemical Separations and On-Line Sampling

Introduction The ability to separate complex mixtures of chemicals and biomolecules is an important component of any chemical synthesis or biological processing. To date, there is no technology available to combine the high resolution of analytical separations with monodisperse droplet generation. I...
...

BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediates the efflux transport of a broad spectrum of substrates, including many drugs routinely administere...
...

In Vivo Drug Discovery Assay for Otoprotective Compounds

Introduction A number of commonly used drugs are known to kill hair cells in the mammalian inner ear and cause dose-dependent sensorineural hearing loss. Most notably, aminoglycoside antibiotics and platinum-based chemotherapeutic agents are known to cause irreversible hearing damage. While these dr...
...

Fabrication of Gold Nanocages and Cubic Nanoframes for Biomedical Treatment through Etching Nanoboxes

Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive research because of their unique and tunable surface plasmon resonance (SPR) properties. Because of...
...

The Multiple Drug Resistance Gene, Polymorphisms, and uses Thereof

Introduction Multiple drug resistance is a well-documented phenomenon and critical problem in the treatment of various diseases including cancer and HIV. While there are many mechanisms leading to multiple drug resistance, one area of focus is the MDR1 gene and its protein product P-glycoprotein (Pg...
...

A Yeast Ligand Sensor

Introduction The yeast ligand sensor is a novel approach for the detection and quantification of ligandbinding, an issue of great interest in drug discovery and other areas. The approach is a protein-derived biosensor in which the readout is a change in growth of temperaturesensitive yeast. The yeas...
...

Delivery of PEGylated Drugs from Bioadhesive Formulations

Introduction While significant advances have been made in the field of PEGylated drug delivery, there is still a need for novel and improved PEGylated drug delivery formulations, particularly those that are useful in the area of sustained drug delivery. Technology description Researchers at the Univ...
...

Use of Adhesion Molecules as Shear-Induced Nanoscale Binding Switches

Introduction Methods, compositions, and devices for using shear-dependent binding switches in a variety of applications would be extremely useful in biomedical and other fields. Applications for this technology include the following: 1) as a non-invasive probe for force fields; 2) to control the agg...
...

Solubility Enhancing Fusion Proteins

Introduction Recombinant proteins having therapeutic, diagnostic or any other commercial or research applications are produced by expression in a host cell. However these proteins of interest are often misfolded and form insoluble aggregates known as inclusion bodies. Inclusion bodies are difficult ...
...

Novel Synthesis of Iduronate a Heparan Sulphate Subunit

BACKGROUND Heparan sulphate and heparin play a central role in a large number of processes including anti-coagulation, angiogenesis, cell growth and migration. A new class of medicinal drugs can be envisaged that would either promote or inhibit the function of heparan sulfate/heparin by mimicking or...
...

A Functional Food with Indications for Peptic Ulcers

BACKGROUND 1 in 10 people are affected by peptic ulcers over the course of their lifetime. Incidence of the condition is set to increase as the population ages. Current treatment relies on combination antibiotic therapy. However, a 20% failure rate and increasing antibiotic resistance highlight the ...
...

Novel Antimicrobial Peptides

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY ...
...

A novel antibiotic for the control of biofilm formation

Invention TA is a broad spectrum antibiotic differing from known antibiotics by virtue of its adhesiveness to synthetic materials and to biological tissues, whilst retaining its bactericidal activity in the bound form. TA may be topically administered to the implanted device or infected zone withou...
...

Identification and Isolation of Osteogenic Progenitor Cells

Invention A novel gene, termed chromatin remodeling protein (ChroM1), from osteoblast progenitor cells has been cloned and sequenced. ChroM1 functions as a transcriptional regulator of genes involved in osteoblast differentiation and is differentially expressed on osteogenic progenitor cells. It c...
...

Modulation of sperm activity in fertility and contraception

Invention Prof. Naor’s team has recently discovered that two Mitogen-Activated Protein Kinases (MAPKs) play a role in human sperm functions. The team discovered that human sperm progressive and hyperactivated motility is maintained by the ratio of these kinases, by either stimulating or inhibiting...
...

Novel Anti Bacterial Drug

The Invention Two non-toxic short peptides were conjugated to form a novel drug candidate. One of the peptides is a polymyxin-B or polymyxin-E analog (PMBN or PMEN, respectively) while the other is an immune cell chemotactic peptide (fMLF). The resultant new drug candidates (PMBN-fMLF or PMEN-fML...
...

Topical Therapy for Fungal Nail Infections (Onychomycosis)

Invention The invention comprises a two-step topical treatment for fungal nail infections combining (a) enzymatic digestion of dermatophyte hyphae by lysing enzymes to expose the growing tips and (b) application of a new highly effective fungicide (a derivative of the non-specific protease inhibito...
...

Improved Calcitonin-based Therapeutics

Invention The aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin manipul...
...

An inhibitor to the ß-secretase pathway of Aß generation in Alzheimer´s Disease

Invention Antibodies have been raised against the β-secretase cleavage site in Amyloid β precursor protein (AβPP). These antibodies can prevent the processing of AβPP and the subsequent formation of amyloid deposits, a central event in the pathogenesis of Alzheimer’s Disease. This approach will not...
...

Collagomers - Widely Applicable Drug Delivery Technology

Invention Collagomers are bioadhesive micro and macro particles generated by linking a phospholipid to collagen. Collagomers entrap a wide range of molecules and release them slowly over long periods of time. They bind with high affinity to cells providing an efficient, widely applicable drug deli...
...

Single-Trigger Molecular Amplifiers

Invention Dendrimers were synthesized, whereby a single specific cleavage event releases all the functional groups at the tips of the dendrimer, via spontaneous fragmentation of the dendrimer to its building blocks. These dendrimers, with the capacity to self destruct, have been termed Self-Immol...
...

Targeted Nanoparticles for Drug Delivery

Invention Novel particulate drug delivery technology comprises of lipidated Glycosaminoglycan, that form micro or nano particles in a controlled manner. The particles (neither a liposome nor a microsphere/nanosphere) can encapsulate DNA, proteins and small molecules with high efficiency and perform...
...

GSK-3 inhibitors for the Treatment of Insulin Resistance-Related Diseases

Invention Novel inhibitors of GSK-3 were identified. These inhibitors represent substrate competitors that interact specifically with the GSK-3 substrate binding site. GSK-3 modulates insulin action by controlling the activity of two other proteins in the insulin-signaling pathway, and its activit...
...

Inhibitors of Amyloid Fibril Formation for the Treatment of Type II Diabetes

Invention Novel inhibitors directed against a newly identified sequence, aimed to prevent amyloid plaque formation and beta cell death are currently being developed. These inhibitors present a novel approach to the treatment of Type II Diabetes and prevention of disease progression. They are based...
...

Immunotherapy for the prevention and treatment of osseous metastasis

Invention A gene encoding a novel cell adhesion protein whose expression is associated with bone metastases has been identified. The gene is termed SEL-OB and codes for a selectin type protein. SEL-OB is expressed in human breast cancer cell lines and invasive pleomorphic lobular carcinoma. The SEL...
...

Novel Peptides for Therapeutic Angiogenesis and lschemic Cardiovascular Diseases

Invention Novel peptides were identified that bind endothelial cells and induce angiogenesis. The peptides were demonstrated to induce proliferation, migration and vascularization of endothelial cells under hypoxic conditions and completely restored blood perfusion in ischemic tissues in an ischemi...
...

Novel anti-cancer drugs with improved potency and acitivity against drug resistant cells

Invention Antimetabolites and antineoplastic agents have been chemically modified to render them active against resistant as well as sensitive cancer cells The Need The major reason for chemotherapy failure in cancer treatment is the emergence of cells that are resistant to therapeutic agents Po...
...

New Application for Vitamin D

Invention A new application / Use for Calcitriol - It was demonstrated, in vitro, that calcitriol and some of its synthetic analogs have the potential to reduce the damage inflicted to normal tissue by accepted anti-cancer therapy. Vitamin D offers protection from programmed cell death to cells in...
...

Genetic Screen for Hepatitis C virus (HCV) Protease Inhibitors

Invention A novel in vivo genetic screen for Hepatitis C virus (HCV) Protease Inhibitors has been developed based on the concerted co-expression of a reporter gene, recombinant Hepatitis C virus (HCV) non-structural 3 (NS3) protease and a potential inhibitor within a bacterial host. Potential inhi...
...

Cell Replacement Therapy for Diabetes

Invention A novel source of surrogate insulin producing beta cells has been developed. Genetic and epigenetic manipulations are employed to induce differentiation of a number of human progenitor cell types into mature, functional beta cells for treatment of diabetes. The Need Type 1 (insulin-d...
...

Cell THerapy for Diabetes: Expansion and re-differentiation of adult human pancreatic islet cells for transplantation

Invention Conditions have been discovered for efficient expansion of adult human islet cells expressing normal beta-cell function (beta-cell gene expression and insulin content) The Need Type 1 (insulin-dependent) diabetes mellitus, which results from the autoimmune destruction of the insulin-pro...
...

Adamantyl-OEG-fullerene Hybrids as potential therapeutic agents

The Invention A series of novel soluble adamantyl-oligoethyleneglycol-fullerene hybrids was prepared via Bingel-Hirsch functionalization of C60 fullerene with various adamantyl-oligoethyleneglycol malonates. As NMDA-targeted antioxidants, these compounds have potential as therapeutic agents for the...
...

Macrolid Induced Correction of Premature Stop Codons: a novel Treatment for Colorectal Cancer

The Invention An antibiotic of the Macrolid family was demonstrated as a new treatment for colorectal cancer and other genetic human diseases that arise from pre-mature stop codons in important coding sequences. The Need Around one third of all genetic disorders as well as most cases of sporadi...
...

TAR-1: a human single chain antibody for the treatment of cancer related to mutations in p53

The Invention TAR-1, a human single chain antibody, which recognizes the common epitope exposed in mutant p53, but not in wild type p53, has been isolated. Binding of TAR-1 to the mutant p53 common epitope restores both the wt conformation and function of p53, and thus restores its ability to bind ...
...

Novel psychotropic agents for the treatment of both negative and positive symptoms of Schizophrenia

The Invention New Chemical Entities (NCE's) psychotropic agents have been developed, possessing anti-dopaminergic activity, along with positive modulatory glutamate NMDA receptor activity. These agents are aimed at the treatment of schizophrenia and bipolar disorder affecting positive symptoms as w...
...

Serotonin Reuptake Inhibitors as Novel Anti-Platelet Drugs

The Invention Serotonin-selective reuptake inhibitors (SSRIs) were chemically modified to produce novel quaternary nitrogen derivatives having a peripheral-restricted serotonin reuptake inhibitory activity. The lead compound GR-101 was demonstrated as a novel anti-platelet drug (for reducing plat...
...

ASSNAC: a novel treatment of oxidative stress induced by reactive oxygen

The Invention ASSNAC, S-allymercapto-N-acetylcysteine, is a small bi-functional molecule that up-regulates cellular glutathione levels, the major cellular anti-oxidant. ASSNAC dissociates in peripheral tissues, slowly releasing s-allylmercaptan and NAC. s-allylmercaptan, the thiol-active component ...
...

Novel Hapatatis C Virus NS3 serine protease inhibitor

The Invention Novel single chain and single domain antibodies and peptide aptamers which inhibit NS3 protease, have been isolated The Need Hepatitis C virus (HCV) infection is a major world-wide health problem, causing chronic hepatitis, liver cirrhosis and primary liver cancer (HCC). Currently...
...

Gagomers - Novel drug delivery system for the delivery of proteins to the brain

The Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked via phospholipids. Gagomers could be generated either as micro or nano particles. The research team at Tel Aviv University has demonstrated the ability ...
...

Novel oral formulation of Insulin

The Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micro or nano particles. The research team at Tel Aviv University has demonstrated that: (1) Gagomers ef...
...

Targeting Cancer and Bone Metastases with Novel Anti Angiogenic Polymer Therapeutics

The Invention A new strategy for cancer and bone metastases therapy was developed using combined targeted polymeric drug delivery system with angiogenesis inhibitors. The novel compounds are composed of three elements: 1. Water soluble synthetic copolymer (HPMA) as specific carrier enabling the m...
...

Cell Permeable Peptides for the Treatment of Allergy, Asthma and Inflammatory Related Diseases

The Invention Novel cell permeable peptides that fuse a membrane permeation sequence to a functional sequence were developed. These cell-permeable peptides are capable of blocking signal transduction pathways in mast cells, preventing mediator release and the subsequent inflammatory reactions. The ...
...

Silencing of Mortalin with siRNA as Adjuvant for Cancer Immunotherapy

The Invention We suggest a novel mode of treatment by inhibition of mortalin or mortalin synthesis as an adjuvant to antibody-based immunotherapy. Novel siRNA was designed as blocker of Mortalin expression. The anti-mortalin siRNA binds specifically to mortalin mRNA and leads to its destruction. Up...
...

HDACIvir´s- Novel anticancer agents

The Invention The research teams at Tel Aviv and Bar Ilan Universities have developed novel compounds derived from known histone deacetylase inhibitory (HDACI) molecules linked to acyclovir and its analogs. The new compounds (HDACIvir's) demonstrated potent anticancer activity both in vitro and in ...
...

Production of Novel Human Collagens

BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the University of Manchester. The collagens most closely mimic human collagen structure, giving a far superio...
...

Advanced 3d Flexible Fibre Material for Wound Management, Orthopaedic, Sports & Personal Protective Equipment Applications

BACKGROUND Spacer structures find applications is many areas. These include automotive, sports wear, medical, mattresses and protective clothing such as gloves and body armour. Spacer structures could provide a replacement for foam. These structures can be specifically tailored to meet the needs of ...
...

Collaboration/Licence Opportunity PAEDIATRIC ANAESTHESIA RE-BREATHING APPARATUS

BACKGROUND In the normal Jackson-Rees system that is used to provide anaesthetic gas to a patient, one part of the apparatus connects to an open tailed reservoir bag. This bag expands and contracts in unison with the patients breathing and allows the anaesthetist to ventilate the patient by partial ...
...

Novel Antimicrobial Peptides

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY ...
...

Corticosteroids with Reduced Side Effects

BACKGROUND Glucocorticoids (GCs) have been used therapeutically for many years to treat a range of inflammatory conditions as immunosuppressants and in the treatment of certain cancers. These compounds are the most potent and effective anti-inflammatory agents known. Their use has been limited howev...
...

Opticin a Treatment for Cancer and Angiogenesis

BACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic AND anti-angiogenic (blood vessel formation) effects on a range of cell lines from different cancers...
...

Novel Synthesis of Iduronate a Heparan Sulphate Subunit

BACKGROUND Heparan sulphate and heparin play a central role in a large number of processes including anti-coagulation, angiogenesis, cell growth and migration. A new class of medicinal drugs can be envisaged that would either promote or inhibit the function of heparan sulfate/heparin by mimicking or...
...

A Functional Food with Indications for Peptic Ulcers

BACKGROUND 1 in 10 people are affected by peptic ulcers over the course of their lifetime. Incidence of the condition is set to increase as the population ages. Current treatment relies on combination antibiotic therapy. However, a 20% failure rate and increasing antibiotic resistance highlight the ...
...

Tumour Vascular Targeting Agents

A new pharmacophore for selective targeting of tumour blood-supply BACKGROUND Cancer is a huge killer, responsible for more than 500,000 deaths in the US and 150,000 in the UK each year, thus making new anti-cancer drugs a key driver in the pharmaceutical industry. Most cancer treatments are poorly ...
...

Opticin a Treatment for Cancer and Angiogenesis

BACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic AND anti-angiogenic (blood vessel formation) effects on a range of cell lines from different cancers...
...

Novel Drugs for the Treatment & Prevention of Allergy

BACKGROUND There is a high and increasing incidence of allergic disorders such as asthma and hay fever. It is expected that some 300m people in the western world will suffer from allergic diseases by 2010. Upwards of 60% of asthma cases are triggered by allergic responses and up to 1 in 4 urban chil...
...

Zebra Fish Models for Drug Discovery

THE TECHNOLOGY Transgenic zebrafish are becoming increasing important as models for human disease. This organism offers the drug discovery industry a number of advantages including rapid reproductive cycle and large numbers of offspring, ethical preference over other animal models, cost effectivenes...
...

Mitochondrial DNA Variants Associated with Metabolic Syndrome

Background: Over the past 25 years, the Wallace's laboratory discovered that the variation in the maternally-inherited human mtDNA forms a single mtDNA tree in which the branches of the tree are region specific. The mtDNAs in each major branch of the tree are thus a group of related haplotypes, cal...
...

Energy-Saving Technological Method for Long-Term Storage of Bio-Degradable Tissue

Background: Currently the critical storage of bio-degradable tissue for long periods of time is done at -70" C. This temperature does provide nearly unlimited storage time. Storage at -70' C is substantially more expensive as compared with that at -40" C Technology: The crucial part of this prop...
...

Compound to Aid in Smoking Cessation

Background: Clinical studies have illustrated that tobacco is highly addictive. Paradoxically, nicotine, the psychoactive component in tobacco, is weakly reinforcing in animals. This phenomenon has led researchers to hypothesize that nicotine may interact with other constituents in tobacco smoke to...
...

A Chemical Compound with Possible p53 Cancer Mutant Rescue Activity

Background: Mutants of the tumor suppressor protein are frequently found in human cancers. About three quarters of them have a single amino acid change in the core domain of p53 that is needed to bind to p53 DNA binding cites. There is great interest for identifying chemical compounds that can rest...
...

Mouse Model of Cardiac and Muscle Disease and Cancer Caused by a Mitochondrial DNA Point Mutation

Background: It is becoming increasingly clear that mitochondrial DNA (mtDNA) base substitution mutations are a common cause of age-related degenerative diseases as well as cancer. However, no mouse model has been generated in which a mtDNA base substitution has been stably introduced into the mouse...
...

CPET Laboratory

Technology: UCI clinic developed a novel algorithm to analyze the results of stress tests done in patients having a new pulmonary valve implant. Application: Analysis of exercise stress tests...
...

Chronic Sequential Sensorimotor Neural Probe Array

Background: The Chronic Sequential Neural Probe Array is designed for patients with an axonal injury in the peripheral nerves or spinal cord who require chronic intervention where stimulation of and/or recording from the axonal bundles is desired. There are two major categories of potential patient...
...

Novel Inhibitors of N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA)

Background: Ethanoloamides of long-chain fatty acids, termed N-acylethanolamines (NAEs) have been reported to have a variety of biological activities. NAEs are a substrate of N-acylethanolamine-hydrolyzing acid amidase (NAAA) that catalytically hydrolyze NAEs to ethanolamine and the corresponding f...
...

Antigens for Borrelia Infection Diagnosis and Prevention

Background: Lvme disease is the most frequently reported arthropod-borne disease in the United States and Europe. Serological assays are the most common laboratory tests used to confirm or support a diagnosis based on clinical features and epidemiological circumstances. Direct detection of the orga...
...

Prokineticin 2 and Prokineticin Receptor 2 as a Target to Treat Epilepsy and Seizures

Background: PK2 belongs to a family of secreted peptides that regulate diverse biological functions including serving as a regulatory molecule for circadian rhythms. The signaling of PK2 is mediated through two cognate G-protein coupled receptors Prokineticin Receptor 1 and Prokineticin Receptor 2 ...
...

Method for Making and Using Vascularized Tumor Spheroid to Predict Response to Antiangiogenesis Agents

Background: Angiogenesis drugs act to inhibit survival of newly formed blood vessels required for tumor growth and progression. These drugs have recently shown good activity in the clinic for breast, lung, colon and kidney cancer. However, these drugs can be toxic and even cause death. Only about h...
...

A New Mouse Model of Sjogren's Syndrome

Background: Sjogren's Syndrome is a grave autoimmune disease in which destruction of the exocrine glands leads to severe dryness of the eyes and mouth, with additional systemic complications. The pathogenesis of Sjogren's Syndrome is unclear, and treatment options are limited. Development of good a...
...

A Novel 7 Base Deletion in the Gene on Chromosome 21 for Diagnostic of Keratoconus

Background: Keratoconus is a noninflammatory progressive corneal thinning disorder leading to mixed myopic and irregular astigmatism and is implicated as a major cause of cornea transplants in the Western world. Genetic factors have been suggested as a cause of keratoconus. The stromal thinning of ...
...

Hybrid Binding Proteins Against Pathological Protein Aggregates in the Central

Background: The pathological protein aggregates such as beta-amyloids, alpha-synuclein and prion protein deposits in the CNS can be removed by vaccination, i.e., immunization using specific antibodies andlor synthesized antigens. Studies have demonstrated that clearance of these pathological protei...
...

Methods and Reagents for Screening New Drugs and Treating Ion Pump Associated Disorders

Background: Sodium/potassium ATPases (Na+/K+-ATPases), a family of multi-subunit ion pumps, are the most important active transporters in animal cells. They are required for maintaining the electrochemical gradient responsible for resting membrane potentials in neuronal cells and for the function o...
...

Biomarker-Guided Prediction of Patient Adherence to Medications

Background: Adherence is one of the pivotal determinants of treatment outcomes for many medical disorders. It is estimated that 50% or more of patients with chronic conditions are noncompliant with medications at some time during their illness. Although there have been numerous attempts to develop ...
...

Treatment of Retinal Disorders by Transforming Growth Factor-Beta (TFG-beta ) Superfamily Proteins and their Antagonists

Background: Retinal disorders often turn into debilitating diseases, and in most cases only few treatment options are available. With available treatment options, vision is usually not restored and treatments are often limited to delaying disease progression. Recent developments using implanted dev...
...

Rapid Multiplex Gene and mRNA Detection in Picoliter Droplets by Molecular Beacons

Background: Breast cancer is a world wide public health concern and the estimated death toll in the U.S. in 2001 was 20,000 and it also ranked first as the cause of cancer death for women between the ages of 20 to 59. People carrying a mutation in the BRCA1and BRCA2 genes are prone to breast cancer...
...

New Therapy to Inhibit Plasma Cells in Autoimmune Diseases

Background: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodies that specifically binds to axons in early stage of acute lesions in multiple sclerosis (MS) brain...
...

A New PET Radiotracer for Serotonin 5HT1A Receptors

Background: Serotonin 5-HT1A receptors are implicated in Alzheimers disease, dementia, anxiety, schizophrenia, and depression, and significant efforts have been undertaken to develop various compounds that bind to these receptors for potential use in diagnosis and therapy of disorders associated wi...
...

Methods of Improving Memory and Cognition

Technology: University of California, Irvine researchers have discovered a new method of improving memory by selectively modulating nuclear receptor cell signaling. The technology has been validated in several animal models of memory in both rats and mice. Application: This technology provides a...
...

Methods and Compostions for the Treatment of Immune Disorders and Regulation of Cytokine and Growth Factor Signaling

Categories: Pharmaceuticals: Central Nervous System Disorders, Immune and Inflammatory Disorders Biotechnology: Assays, Diagnostics, Model Systems Background: Mgat5 is an enzyme that glycosylates T-cell receptors to modulate T-cell activation and autoimmune response. Mgat5 Null PL/J Mice were...
...

Phage-displayed Peptide Library with Affinity for Bacterial Elongation Factor Tu

Background: The highly abundant GTP binding protein elongation factor Tu (EF-Tu) fulfills multiple roles in bacterial protein biosynthesis. EF-Tu also binds other ligands, including four structurally distinct families of antibiotics. The lack of sequence homology among the identified EF-Tu ligands ...
...

Selective Inhibitors of Monoacylglycerol Lipase as a Treatment for Neurological Disorders

Background: Acute stress elicits the rapid formation of two endocanabinoid ligands, 2-arachidonoylglycerol (2-AG) and anandamide (AEA). These endogenous lipids bind to the CB1 cannabinoid receptor and inhibit pain sensation by acting as non-opioid stress-induced analgesics. AEA and 2-AG are metabol...
...

New Polymeric Biomaterials

Technology: The invention is on new polymeric biomaterials. The new biomaterials were created by chemical synthesis with carbohydrates and amino acids as building blocks. The biopolymers have a specific alternating structure between carbohydrate and peptide units. Application: The new biomateria...
...

Somatic Mitochondrial DNA (mtDNA) Control Region (CR) Mutations Associated with Alzheimer's Disease: the Cause and Diagnosis

Background: Sporadic Alzheimer's Disease (AD) has been associated with defects in mitochondrial oxidative phosphorylation (OXPHOS) as well as inherited and somatic mitochondrial DNA (mtDNA) mutations. To determine if mtDNA mutations contribute more generally to the etiology of AD, we have investiga...
...

Antibodies that Bind and Detect Acute Lesions in MS Brains

Background: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodies that specifically binds to axons in early stage of acute lesions in multiple sclerosis (MS) brain...
...

Using Female Endocrine Hormones to Improve Psoriasis

Background: The most commonly prescribed medications for severe psoriasis are methotrexate and cyclosporine. Both these medications have serious side effects. The next line of treatment includes phototherapy but this is limited by the availability of light boxes in the dermatologist's office. Biolo...
...

Neuropeptide S (NPS) as a Treatment for Anxiety, Sleep Disorders, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, and Asthma

Background: Patent "WO02/31145" discloses a newly deorphanized GPCR system, Neuropeptide S (NPS), the endogenous ligand, and its cognate GPCR. However this patent does not detail the pharmacological or physiological function of NPS and its GPCR. University of California, Irvine researchers have cha...
...

Melanin Concentrating Hormone Receptor Small Molecule Antagonists for the Treatment of Obesity and Related Metabolic Disorders

In mammals, Melanin Concentrating Hormone (MCH), a GPCR, has been shown to regulate food consumption and energy metabolism. Central administration of MCH has been shown to promote feeding while mRNA levels of the MCH Receptor 1 (MCHR1) rise as a result of starvation and leptin deficiency. MCH also s...
...

Design and Synthesis of PET Radioligands for alpha 4 beta 2 Nicotinic Acetylcholine Receptors

Background: Nicotinic acetylcholine receptors (nAChRs) belong to the superfamily of ligand-gated ion channels and are distributed widely in the human and nonhuman brain. Several nAChRs have been identified and characterized pharmacologically and have distinct patterns of distribution in the brain. ...
...

Treatment of Bladder and Urinary Tract Cancers Using Chalcone and Flavone Derivatives

Background: About 56,000 new cases of bladder cancer are diagnosed in the United States each year and approximately 12,000 Americans will die of the disease. Drawbacks of older cisplatin based therapies, such as MVAC, include toxicity and poor patient tolerance. Newer therapies such as paclitaxel d...
...

R6G9 Treatment Improves Viral-Induced Neurological Disease

Background: Multiple Sclerosis (MS) is a devastating neurological disease. MS patients often experience neurologic dysfunction believed to be the result of infiltration of immune cells, inflammation of the central nervous system and eventual nerve damage. Technology: Researchers at the Universit...
...

An Antibody-based Method for Reducing Ocular Inflammation which Can Aid in Corneal Transplantation

HSV keratinitis is characterized, in part, by scarring of the eye as a result of HSV reactivation. To date, corneal transplantation is the standard treatment method. A significant obstacle preventing successful corneal transplantation is inflammation that occurs within the eye (ocular inflammation)....
...

A Reduction in Sumoylation of Cellular Proteins Reduces Polyglutamine Toxicity in Vivo in a Drosophila Fruit Fly Model of Huntington's Disease

Background: Huntington's disease (HD) is a fatal, autosomal dominant, progressive neurodegenerative disorder. Clinical symptoms are progressive and include chorea, impaired voluntary movement, behavioral changes and dementia. Present therapies are limited to alleviating these symptoms without any i...
...

Triple Transgenic Mouse Model of Alzheimer's Disease

University of California, Irvine researchers have developed a novel transgenic mouse model that contains the three major genes that contribute to the hallmark pathological features of Alzheimer's disease. These mice are exceedingly valuable for therapeutic investigations and for basic research aimed...
...

Screening and Therapeutic Methods for Promoting Wakefulness and Sleep

Background: Current drugs used to modulate sleep and wakefulness cause a number of undesirable side-effects such as anxiety, addiction, and continued sedation. AMPA and PrRP receptors are found in the reticular thalamic nuclear (RTN) region of the brain that has been implicated in sleep rhythms, at...
...

Novel Retinoblastoma Binding Protein-Related Gene and Potential Use As Cancer Vaccine

Background: The central objective in the development of an effective immunotherapy is the identification of tumor antigens that can elicit antibody and cellular immune responses in humans. Human autologous or allogeneic antibodies from cancer patients are an alternative to the use of monoclonal ant...
...

DRD4, ADHD

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD individuals may have abnormal release of dopamine resulting in a "dopamine deficit" that leads to cognitive as well as beha...
...

Her2/neu Vaccine Protects Against Tumor Growth

Background: Her2/neu is over-expressed in various types of tumor cells, including 20-30% of breast cancers, adenocarcinomas of the ovary, salivary gland, stomach and kidney, colon cancer, and non-small cell lung cancer. Passive immunotherapeutics like Herceptin control and prevent further tumor cel...
...

Platelet Aggregation Inhibitors

Thrombin is an enzyme in the blood that plays a key role in platelet formation during injury. While blood coagulation is essential for a surface wound, platelet activation underlies various pathological situations such as unstable angina pectoris, myocardial infarction and stroke. Thrombin is mediat...
...

ADP Glucose Receptor as a Target for Disorders Involving Platelet Aggregation

Background: Recently, activation of the P2Y12 G-protein coupled receptor (GPCRs) has been shown to be central to platelet aggregation. Drugs preventing platelet aggregation are being tested, but one that would be specific to the P2Y12 receptor would capture a large market share. Developing drugs fo...
...

Treatment for Prostate Cancer

Background: Polyamines are naturally synthesized by the body and are involved in many biochemical processes, including cellular proliferation, cell cycle regulation, and protein synthesis. The prostate epithelium synthesizes plyamines at a high rate making the prostate gland having one of the highe...
...

A Novel Treatment for Upper Respiratory Tract Irritation and Cough

Background: Traditional cough suppression therapy has included palliatives in the form of herbal remedies, narcotics such as codeine, and local anesthetics such as benzonatate. The anesthetic compounds have limited efficacy, while the narcotics cause severe side effects because they work through th...
...

A New Process of Adding Alkyl Groups to Organic Substrates Using TmI2(MeOCH2CH2OMe)3

Background: In the pharmaceutical industry, synthetic chemists often alkylate starting compounds to generate compounds that have more desirable properties. However, the current reagents used in this modification process can be expensive or harmful to the chemist. Technology: Researchers at the U...
...

Donor Organ Preservation for Transplantation Using a Hemoglobin Based Solution

During heart transplantation, the heart must be preserved while it is transported from donor to recipient. Standard techniques call for the heart to be immersed and cooled in cardioplegia or saline solution. Unfortunately, this method does not deliver necessary oxygen, nutrients, and electrolytes to...
...

Use of Perillyl Alcohol in Organ Transplantation

Background: Current state of the art in the field of organ transplantation employs various immunosuppressive agents to prevent post-surgical allograft rejection by the host. However, these pharmacological agents often result in many adverse side effects due to the quantities of medication that are...
...

Treatment for Circadian Performance Deficits By Upmodulation of Central Glutamate Receptors

Background: Alertness and general physical and mental performance are impaired during normal sleep periods compared to those during normal waking periods. Unlike stimulants such as caffeine or methamphetamine, certain glutamatergic enhancer compounds have been shown to improve memory and performace...
...

Novel and Selective Inhibitors of HIV-1 Integrase

In the ongoing battle against the human immunodeficiency virus (HIV), researchers at the University of California, Irvine, have synthesized novel compounds that inhibit the protein HIV Integrase and prevent the virus from replicating, thus providing an alternative to currently available AIDS therapy...
...

Diagnostic Marker and Novel Therapeutic Target for Neurodegenerative Disorders

Scientists at the University of California, Irvine, have isolated a candidate gene that may be responsible for increasing the risk of schizophrenia and bipolar disorder. This elusive gene encodes for a potassium ion channel that acts like an "off switch" by dampening electrical activity in neurons. ...
...

Drugs to Improve Synaptic Transmission

About 5% of the general population over the age of 65 suffers from Alzheimer's disease for which there is no known treatment. Synaptic connections in the hippocampus, a brain region known to be important for learning and memory are especially vulnerable to Alzheimer's disease. This presumably reflec...
...

Silica Nanoboxes

Microporous crystalline materials (e.g. zeolites, aluminophosphates), also called molecular sieves, are widely used as catalysts, adsorbents, and membranes. Two factors largely determine the utility of such materials: their regular nanoscaled size of pores and cavities, and their structural rigidity...
...

A library containing more than 3000 new enzymes produced by 14 Fungi

Solution / invention summary : 14 fungi have been grown in various harsh conditions in order to produce a variety of enzymes. A high throughput platform is then used to isolate some 3000 new enzymes. A few of them are being tested by industrial partners. Advantages / benefits : The isolated enz...
...

Novel Targets for Preterm Labour

New Market Opportunity Over 4 million births occur annually in the US, between 0.5-1 million women are treated annually with tocolytic drugs to halt early preterm labour contractions, while annual tocolytic drug sales of in the USA are estimated at up to $500 million. With over 8 million births in...
...

Live-Cell based assay for DNA Damage Response

New Market Opportunity Cell-based assays play a decisive role in the current drug screening process, yielding safer drugs in a cost effective manner. Such assays offer the potential to screen out compound failure earlier in the discovery and development lifecycle, delivering increased productivity...
...

Novel Sirtuin Activating Compounds

An improved method of synthesizing stilbene analogs, specifically resveratrol, that can activate sirtuins with increased efficiency, activity, and stability. General Information Sirtuins are NAD+ - dependent deacetylases that regulate many cellular processes that promote cell survival in respons...
...

Use of Equol for Treating Skin, Hair, Brain and Prostate Health and Obesity/Weight Control

General Information Dihydrotestosterone (DHT) is a metabolite of the principal male hormone testosterone. However, it is more powerful than testosterone because of its increased affinity for the androgen receptor. DHT’s function is to promote male secondary sex characteristics, such as growth of ...
...