Methods and compositions for prevention or treatment of inflammatory-related diseases and disorders
Introduction Leukocyte adhesion and migration plays a key role in response to inflammation and infection. This process is a well-orchestrated series of adhesion, de-adhesion, signaling and cytoskeletal changes that is tightly regulated. Upon activation, i.e., by cytokines or chemokines, leukocytes rapidly modulate changes in integrin conformation and/or clustering to alter integrin affinity and/or avidity that permit targeted integrin-mediated adhesion to the vascular endothelial cells and subsequent transmigration. However, an inappropriate or overexuberant leukocyte response may cause significant tissue damage. The elucidation of the intricacy of protein kinase pathways and the complexity of the relationship and interaction among and between the various protein kinases and kinase pathways highlights the importance of developing pharmaceutical agents capable of acting as protein modulators, regulators or inhibitors that have beneficial activity thereby modulating various disease states. A need exists to develop new therapeutic treatments that are useful in treating various conditions associated with protein kinase activation conditions associated with inappropriate leukocyte accumulation. For many of these conditions the currently available treatment options are inadequate. Technology description Dr Schnapp and her collaborators have developed a method for preventing or treating inflammatory-related diseases and related disorders comprising administering one or more modulators of cyclin dependent kinase 4 (Cdk4) activity to reduce or eliminate the inflammatory-related disease or disorder or prevent its occurrence or recurrence. The modulator can be an inhibitor, which can be a small chemical compound, peptide or peptide derivatives, siRNA, ribozyme, antisense, or antibody. Business Opportunity Chronic and acute inflammatory diseases, such as rheumatoid arthritis (RA), and septic shock, respectively, pose a substantial economic burden. Inflammatory diseases affect more than 500 million patients in the major pharmaceutical markets. The market for anti-inflammatory drugs to treat these patients was approximately $31.1 billion in 2005 and is projected to increase to$47.8 billion in 2010. Intellectual Property Position Published Patent Application: 20070270362 “Methods and compositions for prevention or treatment of inflammatory-related diseases and disorders"
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