Biocompatible Non-fouling Materials with Active Functional Groups
Introduction As combination medical device/pharmaceutical products become more widespread, one big challenge is to find materials that are both biocompatible and chemically active. For example, it is desirable that drug delivery carriers, tissue scaffolds, and biosensor surfaces all have functional groups for the attachment of drugs, cell-binding proteins, and biospecific binding elements while remaining immune to nonspecific binding of proteins and cells. Technology description Researchers at University of Washington have developed a biocompatible material that can be covalently functionalized with bioactive proteins while retaining its very low fouling properties. This biomimetic material is derived from poly-(carboxybetaine methacrylate) (polyCBMA), a zwitterionic compound shown to exhibit low protein and platelet adhesion. PolyCBMA grafted surfaces and hydrogels show remarkable protein and cell adhesion resistance both before and after ligand immobilization. Business opportunity This technology should be of interest for drug delivery applications, diagnostic devices, and tissue engineering applications. Intellectual property position The UW has pending patents on this technology.
Type of Offer: Licensing
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