cDNA clone Encoding a β1-subunit of a Brain Sodium Channel

Introduction The voltage-gated sodium channels that are responsible for action potential generation in central neurons are important targets for the actions of antiepileptic drugs. These channels consist of a complex of three glycoprotein subunits: a pore-forming α subunit associated noncovalently with a β1 subunit and disulfide-linked to a β2 subunit. Sodium channel β subunits are multifunctional. They modulate channel gating and regulate the level of channel expression at the plasma membrane. More recently, they have been shown to function as cell adhesion molecules in terms of interaction with extracellular matrix, regulation of cell migration, cellular aggregation, and interaction with the cytoskeleton. Technology description Researchers at the University of Washington have cloned the β1-subunit of brain sodium channels in rats. Using this cDNA clone, our scientists have shown that the β1 subunit is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the rat brain sodium channel. Related Publication(s)
Science. 1992 May 8;256(5058):839-42.

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