Type I Adenylyl Cyclase Knockout Mouse

Introduction The type I adenylyl cyclase (I-AC) is neurospecific and expressed in areas of the brain that show long-term potentiation. This enzyme is thought to play an important role in the development of the central nervous system, circadian rhythm, and memory formation. Technology description Dr. Daniel R. Storm’s laboratory has generated I-AC knockout mice. A gene-targeting vector encoding the disrupted N-terminal of I-AC was constructed and used for homologous recombination in AB1 embryonic stem cells. A clone with the disrupted I-AC gene was injected into C57BL/6 blastocysts to generate chimeric mice. Male chimeric mice were bred with C57BL/6 females to produce heterozygotes that were subsequently inbred to produce homozygous mutant mice. Mutant mice have normal growth, motor coordination, and longevity. I-AC knockout mice are important tools to isolate drugs that can affect various aspects of central nervous system function, including learning and memory. Related Publication(s)
PNAS 92(1):220-224, 1995.

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