Instrumentation and Optical Design for a High-Performance SPR Imager

Introduction Surface Plasmon Resonance (SPR) microscopy is a method to detect an analyze particles. SPR sensors work by shining a polarized light beam at an internally reflecting surface within a piece of glass which is coated with a metal on the outside, typically gold is used. This creates two optical paths: one created by the total internal reflection process and the second propagating on the metal surface. At the correct angle the interaction between these two paths, neither of which is directly detectable, creates a drop in the light reflected from the surface, and using this method allows for the detection of immunoassays. Technology description Our researchers have developed a new SPR device that increased the sensitivity of SPR imaging by allowing for the easy manipulation of some of the key variables in SPR microscopy to fine tune the image and detection properties. Business opportunity This technology will be important to SPR microscope manufacturers to allow them to build a highly sensitive and easily variable SPR microscope. Stage of Development Our researchers have successfully manufactured this device and have a working prototype and preliminary data. Intellectual property position The UW has a US patent application pending for this technology.

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