MAGI-CCR5 Cells

Introduction Chemokines are a large family of chemotactic proteins, which regulate leukocyte activation and recruitment to sites of inflammation. Human chemokine receptor CCR-5 was shown to serve as a major human immunodeficiency virus type 1 (HIV-1) coreceptor for T- and M-tropic HIV-1 isolates, respectively. The chemokines MIP-1a, MIP-1b, and RANTES specifically block infection by M-tropic HIV-1 strains because they are ligands for the CCR-5 coreceptor. Technology description Dr Julie Overbaugh’s laboratory has developed a cell line to allow the visualization of HIV infection of the cells via lacZ assay. The MAGI cell line (HeLa cells expressing an integrated copy of human CD4 and the HIV-1 long terminal repeat [LTR] fused to the β-galactosidase reporter gene) was engineered to express CCR-5. This cell line can be used to screen for anti-HIV drugs. Related Publication(s)
J Virol 1997 May;71(5):3932-9.

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