Use of Adhesion Molecules as Shear-Induced Nanoscale Binding Switches

Introduction Methods, compositions, and devices for using shear-dependent binding switches in a variety of applications would be extremely useful in biomedical and other fields. Applications for this technology include the following: 1) as a non-invasive probe for force fields; 2) to control the aggregation of ionic and molecular scavengers; 3) to fabricate devices for particle and cell sorting; 4) to allow for the assembly of molecules, particles, and micro- or nanosystems into novel materials and devices;
and 5) for drug delivery or as part of carriers for cardiovascular, urinary tract, and other medical applications. Technology description Researchers at the University of Washington have discovered that they can modulate the binding strength of an adhesion molecule using shear forces in order to develop new systems, devices, compounds, and drug delivery methods. Business opportunity Novel systems, devices, and drug delivery methods are just a few of the business opportunities for this technology. Stage of development Initial data and working prototypes exist for this technology. Intellectual property position The UW currently has US and PCT patent applications on file. For more information on this technology contact:
Kelly FitzGerald, PhD Technology Manager, Invention Licensing [email protected] 206-543-3970

Type of Offer: Licensing

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