Medical Devices Patents for Sale or License

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Orthopaedic Device for the Correction of Hallux Valgus

Orthopaedic Device for the Correction of Hallux Valgus

I offer to sell or license all the IP rights connected to my invention - the corrective device for bunions. Product is a swift orthosis, which can be put on patient's foot to distance the big toe from the other toes. Product has two hinges of rotation to suit the biomechanics of the 1st MTP joint an...
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Orthopaedic Walker

A unique, patented Orthopaedic Walker for the treatment of broken metatarsals....
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Assays and Methods for Detecting Mycobacterial Infections

Human tuberculosis (TB), caused by bacterial pathogen Mycobacterium tuberculosis (Mtb) has been the leading cause of death by infectious diseases worldwide. TB is also the leading cause of death among people who are co-infected with HIV. It is important to accurately diagnose patients with TB infect...
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Mobility Assistive Device for Crutches and Canes

Mobility Assistive Device for Crutches and Canes

The SandPad™ LandPad is the only patented crutch and cane tip product that allows users to walk on sand, grass, mud, gravel and snow. Its shape and design allows parallel daily usage providing maximum stability on paved and flat surfaces as well. The SandPad™ is easy to attach to any conventional c...
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Sleep Apnea Oral Device

A hybrid device employing 2 previously FDA approved devices working in concert to address obstructive sleep apnea and snoring. A fully adjustable oral device employing a palate lifter and tongue retainer to maintain an airway during sleep for those afflicted with obstructive sleep apnea. The pala...
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Tee Shirt

The shirt is designed to snap closed on the shoulder and down the side for easier ability to dress after shoulder surgery. The shirt is versatile and can be used for patients who had surgery on either shoulder. It can be used by men, women and children also who may have a disability. ...
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Cane Leg Support

WORLDS FIRST KIND OF THIS PRODUCT..... OF INTEREST TO MEDICAL EQUIPMENT DISTRIBUTORS Development of the Cane Leg Support began in 2003, and U.S. patent 8,215,325 B2 was awarded on July 10, 2012 The Cane Leg Support continues to be successfully marketed on the Internet, and purchased by persons ...
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Omni-directional Remote-controlled Mobility Apparatus

An omnidirectional mobility apparatus. The current invention is an omni-directional, remote-controlled mobility apparatus, similar to a wheelchair, which allows the transport of an individual or object(s). The device includes a cubic-shaped base with wheel wells on each vertical side of said base. W...
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Endoscope System with Disposable Sheath

Listing Purpose We already have the product manufactured. Now we are seeking partners to license our product. Background Current conventional digestive endoscopy carries risk of deadly cross infections, and the reprocessing procedure is time consuming. To solve the problem, we developed an ant...
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Holistic Breast Patch: Device for Postpartum Women to Aid in the Relief from Breast Engorgement Pain and Suppresses Breast Milk Production

Lactation Suppression: “The Forgotten Aspect of Women Postpartum Care.” Currently, there is no drug approved by the Food Drug Administration (FDA), to safely provide relief from breast engorgement pain and/or breast milk suppression. According to data from the National Vital ...
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Skin patch instrument for treating pain

A therapeutic patch for treating pain capable of compressing a tender area up to a boundary thereof and/or an entire induration with metallic grains or crushed stones by a treatment method in accordance with a classification determined after clarifying a site of pain by pressing a skin with a pressi...
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MC2 Folding Rescue Stretcher

The present invention provides a foldable rescue stretcher having an open position for transporting a patient and a storing position for storing the foldable rescue stretcher. The foldable rescue stretcher includes a rigid supporting frame having a plurality of sections, a protective barrier, and an...
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Methods for resection of a luminal structure

Provided is a method of resecting a luminal structure, such as a colon. A first luminal structure and a second luminal structure are defined by severing the original luminal structure. The second luminal structure is secured to the distal end of an elongate body disposed within the second luminal st...
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Asymmetric Disc Distracting Cage

An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement with less risk of nerve injury, as well as with likely decreased risk of destruction of the end plate ...
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Tractal Erectile Device

Male Erectile Dysfunction (ED) is a condition that affects many men and can have a negative physical and psychological impact on their lives. Stimulation of the penis may be difficult for men suffering from ED, and although attempts have been made to treat ED, those attempts have failed to provide a...
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Digital Video & Music Belt Buckle-WEARABLE TECHNOLOGY

I think the timing for my patent to be leveraged is NOW, sans the industry up-tick in this paradigm of the white-out WEARABLE TECHNOLOGY DEVICE space. Below is patent, and these recent articles discussing the space and providing the hard DD for the model. I think a proper deal would be to license an...
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Shoe sole sanitizing device and associated method for eradicating microorganisms from an exterior surface of a shoe sole

A shoe sole sanitizing device preferably includes a portable platform including a pair of shoe sole-receiving sections including open bottom surfaces respectively. Each of the shoe sole-receiving sections may be adapted to receive the exterior sole of the shoe thereon. The portable platform may furt...
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MagnaStone, sinusoidal magnetic field therapy, alternative medicine.

MagnaStone US patents 7648454, 7803104, 8202192, 7915846, 8050059, 8257242, 8469872 is a instrument designed to generate a sinusoidal magnetic field that has been proven to have therapeutic value. This therapy has been effective in the field of orthopedics and depression. This is believed to stimula...
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Vaginal cream applicator.

The new Gentle-Comfort vaginal cream applicator is easier to use, more comfortable to use, safer to use and more hygienic for women to use than the standard syringe type applicator is. Details of this device may be viewed at http://www.gentlecomfort.com US D457,627S, a United States Design Pa...
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Disposable speculum with included light and mechanisms for examination and gynecological surgery

The disposable speculum with included light and complementary mechanisms for examination and gynecological surgery is a device used for medical and surgical procedures in the vagina, neck level and the uterus. It has two separate sheets joined in their own handles; the upper sheet has three cuts to ...
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Joint Heat

An electric heating device that is constructed in a unique fashion that allows it to be drapeable so that its three-dimensional, `scoop-like` shape fits the curvature of a relaxed shoulder, a crooked knee, crooked elbow, fetal-positioned hip or ankle and is held in place by an adjustable strap whose...
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Quick-E Emergency ECG Electrode Chest Pad

A disposable ECG electrode chest pad that has pre-wired electrodes in the proper positions which can be applied in one step and easily connected to nearly any ECG machine with pre-existing adapters. It can be used in any setting an ECG would be used, in addition to being used to monitor patients in ...
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Fluid Delivery Micropump

Fluid Delivery Micropump

Infu-Disk™ , developed and manufactured by Med-e-Cell, is a commercially available fluid administration pump currently used in a variety of applications particularly veterinary medicine, toxicology/pharmacokinetic studies, and preclinical research, with the exception of human use. Infu-Disk™ flu...
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Biodegradable Self-Expanding Drug-Eluting Prosthesis

Implantable radially expandable medical prostheses for treatment of vascular diseases through percutaneous deployment. ...
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Device for stopping abnormal electric activity in the brain causing epilepsy

Epilepsy is a condition in which there are repeated attacks of seizures resulting from epileptogenic focus in the brain. This focus once activated from time to time causes abnormal electric activity leading to hyperexcitation of cerebral centers precipitating seizures. There are several means of a...
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Polyp Screen

US Patent # 7,488,312 Polyp Screen - this is a multiple product patent for screens that insert into existing mucous traps by Medline, Busse, etc. We have one actual product that has been manufactured for Medline Mucous Traps, so we have a mold and inventory. The polyp screens fits into the trap an...
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Composition in the Form of Liquid for Maintenance of Contact Lenses and Medical Materials

The invention relates to a composition, particularly in the form of liquid to be used externally as a rinsing contact lenses, containing nanocrystalline photocatalyst active in visible light, and optionally hydrogen peroxide. Titanium dioxide based materials are commonly known as photocatalysts ...
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“Deep” needle holder

Introduction: A number of open urological procedures demand deep and narrow surgical fields. This fact in correlation with special circumstances (like hemorrhage) makes many times the manipulation of a curved needle with a conventional needle holder very difficult, even for an experienced surgeon. ...
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Nasal Cleaning Insert

January 14, 2013 Nasal Cleaning Insert Patent -USA 5,895,408 A device is used as a daily nasal cleaning insert. Use to clean remotes areas in nasal cavities. Is intended to use a daily hygiene to dialog Nasal cavities from mucus substances and germs as the same time reaching farther areas that...
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Special Bed for Self Induced Traction / Decompression

Please go to ebpocorp.com and read the article on Reverse Exercise which explains fully the lead up to this invention. The author believes that regular Traction in low doses is needed from early stages of one's growth years for healthy joints all through life. The invention describes a bed on which...
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Special Bed for prevention of Bedsores

It is a BED for the totally INVALID person prone to BED SORES. The paraphrased abstract reads as follows: A specialized bed will prevent bedsores, heal existing bedsores, with no repositioning of person required. The bed is provided with a series of BANDS that can be made to be TAUT and horizon...
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Lined Balloon Mounted Stent

A stent that is implanted by catheter to narrow or occlude the lumen of any vessel in a graded reversible pattern as needed. May be used to perform patent ductus arteriosus closure in neonates, pulmonary artery banding, reverisble control or occlusion of bleeding aneurysms..etc in all age groups. ...
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Lockable Specimen Transporter

Patent Number: US6354104 Portable Medical Device: Suited for the collection of Urine and Blood Specimens both inner office and in field. Industry: Health/Medical fulfilling World Health Organization, Center for Disease Control and Health and Human Services guidelines specific to Chain of Custo...
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Ultrasound for Locating Anatomy or Probe Guidance

A hand-held apparatus can be used to assist in guiding a probe or locating a particular anatomical target in a subject. The apparatus can include an ultrasonic transducer located on or within a housing and configured to generate ultrasonic energy directed into tissue of a subject and configured to r...
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Non-invasive Systems and Methods for In-situ Photobiomodulation

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extra...
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Hip joint orthosis for e.g. supporting musculature of patient after hip joint implantation, has electro stimulation device for generating electro stimulation, where beginning and ending of stimulation

The orthosis has a hip belt including three parts in the form of shell elements (1), which are movably arranged and fixed on a flexible anti-rotation cable. An orthosis joint (5) includes an adjustable, progressive resistance, which works against movement of a patient at an extreme position. An elec...
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Bite guard splint i.e. lower jaw bite guard splint, for keeping open of respiratory tract at asleep of patient, has fastening elements provided for connection element to piercing-like implant at regio

The splint (13) has fastening elements (14) e.g. hooks (15), for a connection element (17) e.g. fastening lug, to a piercing-like implant at a region of a tongue body of a patient. The fastening elements are arranged at the lower jaw bite guard splint, and are provided at interior sides of the lower...
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Magnetically Mounted Artificial Joint

The invention relates to a prosthesis for replacing a joint compound in the same magnetic fields of joint head 10, socket 12 and pivot collar 14 can be superimposed so that the repulsive forces produce a state of suspension of the joint head 10 in the bearing and the damping effect is maximal.The in...
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Repositioning Device for the Handling of Distal Radius Fractures By Means of a T-shaped Osteosynthesis Plate

The invention relates to a repositioning device for the handling of distal radius fractures by means of a T-shaped osteosynthesis plate, comprising a long leg and a short leg, disposed in a T-shaped and angular manner in relation to said long leg, wherein the short, distal leg has a face that comes ...
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Device for ventilating the middle ear, has stent having hollow cylinder which has funnel-shaped expansion at two ends, where inner diameter of hollow cylinder lies in certain range

The device has a stent (10) having a hollow cylinder (12) which has a funnel-shaped expansion (18) at two ends (14,16). The inner diameter of the hollow cylinder lies in the range of 0.5 millimeter to 10 millimeter. The stent has a length in the range of 1 centimeter to 5 centimeter along the longit...
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Device for in Situ Milling of Joint Surfaces

The invention relates to a device for in situ milling of joint surfaces, comprising a milling device (20 24) and a joint clamping device (10). The invention further relates to a use of a corresponding device and to a method for in situ milling of joint surfaces. The joint clamp device (10) of the de...
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Method for Determining the Clamping Force on a Mechanical Joint Connection Connecting At Least Two Components

The invention relates to a method for determining the clamping force on a mechanical joint connection connecting at least two components by coupling sound waves into the joint connection. The invention is characterized by the combination of the following method steps: exciting the mechanical joint c...
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Device for testing endurance limit of medical device, has two fixing devices at end cross sections of medical device, and two actuators which are coupled with fixing devices

The device (1) has two fixing devices (3,4) at the end cross sections of a medical device, and two actuators which are coupled with the fixing devices. The device has a guiding element (10) at which the medical device is formed or shaped. A deformation kinematic of the medical device is recreated at...
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Medical implant i.e. flexible hollow implant, for ventilation of middle ear in head of human, has flexible peristalsis elements assigned to implant and causing pressure balance between openings on imp

The implant i.e. flexible hollow implant (5), has peristalsis elements flexible over entire length and assigned to the flexible hollow implant and causing pressure balance between distal and proximal openings on the flexible hollow implant by peristalsis movements. The peristalsis elements are desig...
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Medical Implant for Treating Arthritis in Joints of the Human Or Animal Body

The invention relates to a medical implant for treating arthritis in joints of the human or animal body, in particular in the knee joint of a patient. In order to prevent extensive means for inserting stable plates in the gap of the knee joint, the invention provides two magnet bodies (9, 10; 20) th...
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Device and Method for Measuring Tibial Translation

The invention relates to a device and a method for measuring tibial translation in mammals under loading. The device has at least a first and a second splint, which can be fastened laterally to the upper and lower leg and have an overlapping region in the area of the knee joint. The displacement of ...
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Suture Anchor System

The invention relates to a suture anchor system for fixing sutures to bone, having a screw, an adjacent anchor, a cannulation in the anchor, and a thread, wherein the anchor comprises two opposite indentations at which the cannulation terminates at each end. In order to provide a suture anchor syste...
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Organization and Security System for Functional Connections

The invention relates to a device for separating functional connections, in particular in the medical field, for example infusion and perfusion lines, but also to cable connections from and to medical devices and/or surgical instruments, for example endoscopes or heart catheters. The invention is ch...
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Cell Coated Implantable Device

The present invention relates, in general, to a cell-coated implantable medical device and, in particular, to an implantable medical device the blood-contacting surfaces of which are coated with endothelial progenitor cells (EPCs). In a preferred embodiment, the medical device is a titanium or titan...
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Apparatus for Occipito-cervical Fixation Enabling Supplemental Occipital Bone Fixation

An apparatus for stabilization of a patient's head relative to the patient's neck joint includes an occi-cervical base member having a "C '-shaped central part and first and second attachment rods respectively connected to and extending transversely from free ends of the central part. An occiput att...
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Translational Manipulation Polyaxial Screw Head

A novel surgical screw is presented as a polyaxial, multiaxial, or monoaxial screw. The polyaxial screw allows versatile angulation between a bone anchor section and a screw body and allows the surgeon to attach a rod to the invention in a top-loading manner and manipulate the rod to accommodate a p...
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Intracranial Catheter and Methods of Use

A catheter assembly for intracranial treatment of a subject that includes an outer tube that may be connected to an infusion or osmotic pump and delivered through a bendable catheter to the target brain site of the subject. The assembly facilitates regular accurate placement of drug or compound deli...
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Bladder Drainage Aid

Provided is a bladder drainage aid which attaches to the end of Foley Catheter and removes the need for a catheter bag. In a preferred embodiment, the device is a spring-loaded valve with an inflow tube and an outflow tube. The inflow tube connects to the external end of a catheter. The outflow tube...
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Apparatus for Osteotomy and Graft Preparation

Surgical tools that increase surgical accuracy for orthopedic procedures involving long bone osteotomy with or without supplementation with allograft or autograft. Two clamps on the operative side are rigidly interconnected to one another with an adjustable rod that is locked into place, preserving ...
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Trans-endoscopic Hydraulic Balloon Apparatus

A trans-endoscopic hydraulic balloon dilation apparatus includes a fluid reservoir containing a hydraulic fluid. A shaft has a lumen in fluid communication with a leading end of the fluid reservoir. A balloon is mounted on the shaft and an opening in the shaft enables hydraulic fluid to flow through...
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Endoscopic Overtube

An over-tube was developed for receiving and guiding endoscopic instruments into a patient's anus, through the colon, and into the peritoneum. The over-tube has a flexible sheath adapted for insertion into the anus through the colon and out the peritoneum of a patient. A stiffened region is used to ...
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Cervical plate system

An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked spong...
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Embolectomy Stroke Device

Devices and methods for removing an obstruction from a blood vessel are described. The devices are deployed in a collapsed condition and are then expanded within the body. The devices are then manipulated to engage and remove the obstruction. A system for removing an obstruction from a blood vessel ...
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Predetermined Presentation of Patient Data At Bedside

Techniques for presenting patient data at the patient's bedside include receiving predetermined presentation style data that indicates a subset of fewer than all parameters available from an electronic medical records (EMR) system and a first arrangement on a display device of related parameters in ...
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Holding Device, Bite Element and System for Intraoral Radiography

The invention relates to a bite element, a holding device, a method, a computer program product and a system for creating and/or processing intraoral shadow images, in particular X-ray images. To this end, a holding device comprises a device base which is designed to define a determined or determina...
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Devices and Methods for Percutaneous Access, Hemostasis, and Closure

The present invention provides methods and devices for obtaining percutaneous access, maintaining hemostasis, and providing closure of openings in tissues of the body. In particular, the present invention provides methods and devices for maintaining hemostasis and providing closure surgical incision...
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Fluid Containment Apparatus

The invention relates to the treatment of wounds. In particular, the invention relates to systems, devices, and methods enabling pulse lavage irrigation of wounds in a non-controlled setting while providing containment of contaminated irrigation fluid, thereby preventing exposure of individuals and ...
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Ablation Devices and Related Methods Thereof

The present invention relates generally to devices for performing targeted tissue ablation in a subject. In particular, the present invention provides devices configured to deliver energy to a targeted tissue region without causing damage to untargeted tissue....
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Devices for Material Delivery, Electroporation, and Monitoring Electrophysiological Activity

The invention relates generally to devices for material delivery, electroporation and monitoring electrophysiological activity. In particular, the present invention provides devices and systems configured to deliver therapeutic compositions, to provide electroporation to increase therapeutic efficie...
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Apparatus and Method for Airway Patency and Head Immobilization

A jaw-thrust device includes a base with an extension arm disposed on each side of a patient's head mounted on the base. A mandible rest is mounted on each extension arm such that the mandible rest may be deployed proximate to a patient's mandible. A chin pad and at least one connector connects the ...
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Methods and Devices for Arytenoid Repositioning

Methods and devices for repositioning the arytenoid cartilage of a human subject are disclosed....
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Agr-mediated Inhibition and Dispersal of Biofilms

The present invention involves the use of activators of bacterial agr quoroum-sensing systems to block, inhibit or reverse biofilm formation. The biofilm may be located on an industrial or medical surface, or may be located in a subject, such as in a wound or infected organ, or on an in-dwelling med...
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Fastener Deployment System and Method

This document discloses, among other things, a long reach, side ejecting fastener placement apparatus suitable for use in nasal septal surgery. A first linear member carries a fastener body and a second linear member delivers a fastener retainer or provides support for placement of the fastener body...
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Tissue and Object Retrieval Device and System

The invention described herein provides a device for tissue and/or object retrieval constructed for use with minimally invasive medical procedures. By virtue of its construction and operation, the device of the invention can obtain a relatively large amount of tissue (or object) while reducing or mi...
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Treatment and Placement Device for Sinusitis Applications

Devices, methods and kits which, when installed or used, access, aspire, dilate, insufflate, drain or deliver fluid medicaments to, or place a patency device within a sinus area, such as a maxillary sinus or a maxillary sinus ostium. The device can include a hollow catheter and probe, and can be con...
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Implantable Devices for Treatment of Sinusitis

Devices, methods and kits which, when installed or used, urge or maintain patency of sinus ostia, such as the ostium between a nasal passageway and a maxillary sinus, while maintaining some function of cilia extending within or near the ostium. In various examples, the devices comprise a first porti...
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Spinal Probe with Tactile Force Feedback and Pedicle Breach Prediction

A spinal probe (10) comprises a handle (18), a shaft (20) coupled to the handle and a force sensor (14) to detect forces applied to a tip of the shaft. A controller that executes a predictive algorithm to predict whether or not the tip of the shaft is going to breach a cortex of a pedicle based on t...
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Catheter Insertion Sterilization

A device includes a sheath having a lumen defined by a wall. The wall has an outer surface that is configured to emit ultraviolet light in a direction substantially normal to the wall. The lumen has a distal end configured for percutaneous placement. The lumen has a proximal end configured to receiv...
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Bioactive Peptide for Cell Adhesion

Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a...
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Intelligent Powered Mobility for Infants and Special Needs Children

A powered mobility device for advancing cognitive, perceptual and motor abilities of a child lacking natural mobility is disclosed. The device includes a seat sized for the child to be secured therein and a motorized drive assembly coupled to the seat. A local operating instrument is operably couple...
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Dynamic Vibrational Method and Device for Vocal Fold Tissue Growth

Dynamic vibrational methods and devices for inducing differentiation of stem cells into vocal fold fibroblast-like cells or for generating vocal fold-like tissue from cultured cells. Also provided are matrices providing sustained release of growth factors, and bioreactors generating and delivering a...
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Delivery System for Heparin-Binding Growth Factors

A device comprising a scaffold coated with a protein having at least 83% identity to the amino acid sequence of the core protein of domain I of a mammalian perlecan, wherein at least one glycosaminoglycan is attached to the protein is described. The device may be used in vitro or in vivo to induce r...
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Image-based Control Systems

Image-based control systems and methods automate the adjustment of medical devices. An image based-control system for an endoscope can include, in addition to the endoscope, a processing system and an actuator. The processing system can receive an image from an image capture device of the endoscope....
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Targeting Therapeutic Agents

Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration of peri-urethral bulking agents....
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Devices and Methods for Modulating Brain Activity

Devices and methods for brain modulation are provided herein. A device may comprise a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat ...
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Neurostimulator

Methods and devices of stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry (12), an acoustic transducer (14) and a pair of electrodes (28)....
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Rotating Needle Driver and Apparatuses and Methods Related Thereto

Featured is a medical instrument driver, a robotic apparatus embodying such a medical instrument driver and methods related thereto for inserting a medical instrument into tissue of a mammal (e.g., human). Such medical instruments include medical needles, biopsy needles, trocars, cutters and introdu...
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Cylindrical Illumination Confocal Spectroscopy System

A cylindrical illumination confocal spectroscopy system has a fluidic device having a fluid channel defined therein, an objective lens unit arranged proximate the fluidic device, an illumination system in optical communication with the objective lens unit to provide light to illuminate a sample thro...
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Articulated Device with Visualization System

An articulated device may include a first steerable multi-linked mechanism and a second steerable multi-linked mechanism. The second steerable multi-linked mechanism may include a first link, a plurality of intermediate links and a second link movably coupled to a second one of the intermediate link...
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Insertable Surgical Imaging Device

A body-insertable imaging device includes a first camera that comprises a first image sensor and a first lens to pass incident light onto the first image sensor, a control interface to receive a remotely generated control signal, and an actuator communicatively coupled to the control interface and c...
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Systems and Methods for Inserting Steerable Arrays Into Anatomical Structures

Systems and Methods are provided for inserting a steerable array into an anatomical structure of the body. The system includes an insertion module for holding a proximal end of the steerable array and a force sensor configured to detect force on the steerable array and to produce force information. ...
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Inhibiting Staphylococcus Epidermidis Infections

The invention relates to Staphylococcus epidermidis peptides, antibodies and nucleic acids that can inhibit Staphylococcus epidermidis infection of a mammalian subject and colonization of a medical device in the mammal....
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Medical implant and method of its manufacture

The implant has an outer mantle layer consisting of a set of coils (10) movably arranged to each other in a longitudinal direction. A hollow space is provided between the coils, which exhibit conicity and differ in rotational directions. The spirals differ in its starting point and/or direction of t...
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Medical Implants, Prostheses, Prosthesis Parts, Medical Instruments, Devices and Auxiliary Contrivances Made of a Halogenide-modified Magnesium Substance

The use of a magnesium substance, whose corrosiveness is altered as a result of modification with halogenides, enables medical implants, prostheses or prosthesis parts and medical instruments, devices and auxiliary contrivances, especially surgical instruments or tools, for use in and on the human o...
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Fixation Device and Method for Soft Tissue Grafts

An expandable medical device for surgical implantation that secures the ends of a soft tissue graft in a tunnel made in bone, such as in ligament replacements. The graft material is positioned between the bone and the flexible portion of the fork component with intimate contact with the bone surface...
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Arrayed Detector System for Measurement of Anti-viral Immune Response

A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of ...
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Device and method for disinfecting stethoscope heads

A device for disinfecting a head of a stethoscope has a receiver adapted to hold a supply of disinfecting agent. A dispenser that is mounted to reciprocate relative to the receiver has a receptacle for receiving the head of the stethoscope. The dispenser can communicate with the supply of disinfecti...
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Dna Microarray Having Hairpin Probes Tethered to Nanostructured Metal Surface

A sensor chip and detection device are disclosed. The sensor chip includes a substrate, at least a portion of which is covered by a metal nanoparticle film; a first nucleic acid molecule that is characterized by being able to (i) self-anneal into a hairpin conformation and (ii) hybridize specificall...
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Intraocular Pressure Regulating Device

Systems and methods are described for implanting a device in a mammalian eye to raise intraocular pressure. In some embodiments, the device (54) includes an arcuate body that, when implanted, obstructs aqueous humor outflow from the anterior chamber (38) of the eye....
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Arrayed Detector System for Measurement of Influenza Immune Response

A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. ...
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Cmos Image Sensor on Stacked Semiconductor-on-insulator Substrate and Process for Making Same

Methods and apparatus for producing a CMOS image sensor result in a plurality of photo sensitive layers (A,B,C ); each layer including: a glass or glass ceramic substrate (102A, 102B, 102C) having first (102A-1, 102B-1, 102C-19 and second (102A-2, 102B-2, 102C-2) spaced-apart surfaces; a semiconduct...
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Simultaneous Ambulatory Pulse Oximetry and Ph Monitoring for the Diagnosis of Gerd-related Respiratory Disease

Respiratory diseases related to gastroesophageal reflux disease in a patient are diagnosed by detecting esophageal or pharyngeal impedance and pH in the patient, detecting oxygen saturation in the patient, and diagnosing the respiratory diseases from the esophageal or pharyngeal impedance, the pH, a...
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Needle Shield for Injections

A needle shield for hiding a needle from a patient during an injection is disclosed. The needle shield comprises an attaching portion for attaching the needle shield to a syringe and an opaque collapsible element extending from the attaching portion, the collapsible element having an orifice extendi...
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Transcutaneous Magnetic Energy Transfer Device

Transcutaneous magnetic energy transfer to drive a VAD or other implanted medical device can be supplied through two spinning (or otherwise moving) permanent magnets, or a moving permanent magnet and a moving ferric material, or a moving permanent magnet and a coil or an array of coils, One part is ...
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Gas Syringe Device

PROBLEM TO BE SOLVED: To provide a unit dose, gas-filled syringe which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. ; SOLUTION: The syringe (12) is filled with a selected g...
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A System and Method for Patient Self-assessment Or Treatment Compliance

A system and method for transmission of alphanumeric messaging between mobile subscribers and an external system to send messages directly to the mobile subscriber's existing mobile phone to query them, for example, on the psychometric scale of interest. The resulting daily assessments may then be s...
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Vertebral Body Reduction Instrument and Methods Related Thereto

Featured is a reduction instrument being configured and arranged to allow correction of vertebral translation and applying distraction across a segment in an independent fashion. Such a reduction instrument embodies one or more identical modules that are configured as needed for correcting the defor...
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Nasal Airway Management Device with Inflatable Supraglottic Laryngeal Cuff

An airway management device such as, for example, an nasal airway management device with inflatable supraglottic laryngeal cuff is provided. The airway management device includes an airway tube, an inflatable cuff, and an inflation passage. The airway tube defines a lumen extending between a proxima...
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Method of Making 3-dimensional Neural Probes Having Electrical and Chemical Interfaces

A method of fabricating a three-dimensional neural probe includes the steps of: growing thermal oxide layer; depositing a layer of Au/Cr on the thermal oxide layer; patterning the layer of Au/Cr; depositing a layer of parylene C; etching the thermal oxide layer to release a plurality of islands; and...
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Device for Collection and Preservation of Tissue Or Stool Samples

An arrangement for collecting a tissue or stool sample has a sample vial and a source of preservative fluid. A fluid valve controls a flow of the preservative fluid from the source of preservative fluid to the sample vial. An air equalization vent tube is coupled to the source of preservative fluid ...
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Device and Method for Transfecting Cells for Therapeutic Use

This invention generally relates to devices and methods for transfection of living cells using electroporation, in particular high throughput microtluidic electroporation, and to therapeutic uses of the transfected cells....
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Intrinsic Hand Strength Measurement Device

A device for measuring intrinsic hand muscle strength comprising an adjustable restraint adapted to restrain at least a portion of a hand, a force transfer member adapted to fit on or around one or more digits of the hand, a force sensor connected to the force transfer member, and a processing unit ...
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Electrocardiogram Reconstruction from Implanted Device Electrograms

A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an arbitrary fashion and reconstruction technique is obtained through physical measurement of the orientatio...
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Implantable Device, System Including Same, and Method Utilizing Same

An implantable device. The implantable device includes a computing device, a microelectromechanical system (MEMS) pH sensor connected to the computing device, and a communication system connected to the computing device....
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Electrode Systems, Devices and Methods

An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q' ratio (A) of at least 5 as defined by the equation wherein WG is the dry weight of the hydrophilic polymer and WW is weight ...
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Powered Vehicle Convoying Systems and Methods of Convoying Powered Vehicles

A vehicle convoy system for use in connection with a vehicle (for example a self-propelled wheelchair), wherein the vehicle includes at least one drive mechanism to impart drive to the vehicle, includes a first processor to effect control of the drive mechanism based upon data of the position of a l...
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An Echo-specific K-space Reordering Approach to Compatible Dual-echo Arteriovenography

A dual-echo sequence technique provided herein empowers simultaneous acquisition of both TOF MRA and BOLD MRV in a single MR acquisition. By this approach, an echo- specific K-space ordering scheme permits the adjustment of the scan parameters that are compatible for each of the MRA and MRV. The ima...
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Automated Assessment of Optic Nerve Head with Spectral Domain Optical Coherence Tomograph

A fully automated optic nerve head assessment system, based on spectral domain optical coherence tomography, provides essential disc parameters for clinical analysis, early detection, and monitoring of progression....
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Intracorporeal Gas Exchange Devices, Systems and Methods

A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adap...
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Coils for Magnetic Resonance Spectroscopy and Imaging of Human Breast

System(s) and method(s) for magnetic resonance imaging and spectroscopy, and magnetic resonance spectroscopic imaging (MRSI) are provided. A unified heteronuclear coil system includes a volume coil tuned to detect a first nuclei and a butterfly coil tuned to detect a second nuclei for simultaneous d...
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System for At-home Eye Movement Monitoring

An apparatus for monitoring eye movement in a patient, includes a frame structured to be worn on the head of the patient. An infrared illumination device structured to illuminate an eye of the patient is supported by the frame. A camera structured to capture images of the eye when illuminated by the...
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Articulating Laryngoscope

Articulating laryngoscope to aid in the intubation of patients by providing illumination of the oral cavity and trachea during the process having, for example, 'fingers' with fiber optic lights at the ends and at joints of the fingers, fingers spread open or 'flower' when the device is deployed, gen...
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Joint Bioscaffolds

Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilaginous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can pro...
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Cortical Control of a Prosthetic Device

A methodology for using cortical signals to control a multi jointed prosthetic device for direct real-time interaction with the physical environment, including improved methods for calibration and training....
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Magnetic Device for Guiding Catheter and Method of Use Therefor

One or more external magnets that are suitable for placement on the back or front of a patient's neck and methods for using the external magnet(s) to guide a feeding tube containing one or more internal magnets through the esophagus are described herein. The external magnet is applied to the back or...
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Paracorporeal respiratory assist lung

A paracorporeal respiratory assist lung (900), comprising a housing (920) having an outer body including an upper portion and a lower portion; an upper gas port (945) located on the upper portion; a lower gas port (940) located on the lower portion; an upper blood inlet (930) located on the upper po...
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Detection and Quantification of Biomarkers Via a Piezoelectric Cantilever Sensor

Quantification of a target analyte is performed using a single sample to which amounts of the target analyte are added. Calibration is performed as part of quantification on the same sample. The target analyte is detectable and quantifiable using label free reagents and requiring no sample preparati...
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Two-piece Lightweight Litter System

This invention is directed to a durable, compact, two-piece, light weight, load sustaining litter system for the transport of humans, animals or objects. The litter system comprises a litter frame, a fabric disposed between the structure of the frame, at least one hinge and at least one coupling mec...
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Methods and Devices For

The 'Smart Tool' includes a 'Smart Tool Probe' and two processing modules. The Smart Tool Probe is a hand held, wired or wireless, device that a surgeon utilizes for interrogating and identifying a tissue site, such as the entrance to a pedicle. The processing units, an Electro-Optical Control (EOC)...
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Apparatus for Atmospheric Pressure Pin-to-hole Spark Discharge and Uses Thereof

Disclosed herein are atmospheric pressure pin-to-hole pulsed spark discharge devices and methods for creating plasma. The devices include a conduit for fluidically communicating a gas, a plasma, or both, therethrough, portion of the conduit capable of being connected to a gas supply, and a second po...
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Apparatus and Methods for Detecting Inflammation Using Quantum Dots

Apparatus and methods for detecting an a biomarker indicative of an inflammatory condition, including a capillary tube adapted for one or more biomarkers to adhere to an interior surface thereof, a light source for energizing quantum dots conjugated with the biomarkers within the capillary tube, and...
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Intracranial Pressure Sensor

An intracranial pressure device for measuring CSF pressure in a skull includes a housing located between the scalp and the skull containing pressure device circuitry and a conduit extending downwardly from the housing to the vicinity of the CSF. A pressure sensor is coupled to the conduit and locate...
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Cervical Spine Protection Apparatus and Methods of Use

The invention is directed to a cervical spine protection apparatus one or more composite bands attached to provide restraint of one or more motions of the cervical spine of a wearer. The apparatus is designed to protect a wearer from incurring cervical spinal injuries, and/or to reduce the severity ...
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All Electric Piezoelectric Finger Sensor (pefs) for Soft Material Stiffness Measurement

A PEFS (Piezoelectric Finger Sensor) acts as an "electronic finger" capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus var...
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Balloon-assisted Annulus Repair

The present invention is directed to an inflatable annulus repair device (10) for sealing an annulus defect located in an annulus fibrosis of an intervertebral disc space. In use, the inflatable device is introduced, in a first non-expanded state, preferably via a cannula (100) into the annulus defe...
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Devices and Methods for Detecting and Monitoring Hiv and Other Infections and Diseases

Disclosed herein are bio-nanosensor devices and methods suitable for blood assays. The bio-nanosensors are based on thickness shear mode transducer capable of transmitting a shear wave into a biofluid adjacent to a bio-functionalized sensing interface of a piezoelectric crystal. The bio-functionaliz...
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Stabilized Ultrasound Contrast Agent

Provided is a particle-stabilized ultrasound contrast agentn (UCA) and methods of preparing same. Also provided is a method for preparing a lyoprotected UCA, a freeze-dried lyoprotected UCA, and a reconstituted freeze-dried lyoprotected UCA....
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Multimodal Laser Speckle Imaging

A system for multimodal laser speckle imaging may include a first light source positioned to emit laser light toward a target, a second light source positioned to emit light toward the target, a camera positioned to receive light scattered from the target, and a processor. The processor may be progr...
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Wrist Mounted CPR Chest Compression Monitor

A chest compression monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression ...
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Optimized Mri Strip Array Detectors and Apparatus, Systems and Methods Related Thereto

Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer>=1 at least one of the N reactive components is electri...
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Devices and Methods for Treatment of Gastrointestinal Disorders

An implantation device for releasably holding implantable microstimulators can be used to guide one or more microstimulators to any site within the gastrointestinal tract for implantation. The device can further releasably hold one or more ligation clips for securing the one or more microstimulators...
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Systems and Methods for Testing Vestibular and Oculomotor Function

The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a ...
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Automated Surface-based Anatomical Analysis Based on Atlas-based Segmentation of Medical Imaging

A non-invasive imaging system, including: a non-invasive imaging scanner; a signal processing unit in communication with the imaging scanner to receive an imaging signal from a subject under observation; and a data storage unit in communication with the signal processing unit, wherein the data stora...
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Visual Tracking and Annotation of Clinically Important Anatomical Landmarks for Surgical Interventions

A visual tracking and annotation system for surgical intervention includes an image acquisition and display system arranged to obtain image streams of a surgical region of interest and of a surgical instrument proximate the surgical region of interest and to display acquired images to a user; a trac...
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Systems and Methods to Reduce Power Deposition in Tissue Exposed to Radio -frequency Electromagnetic Fields

An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between th...
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Surgical Instrument and Systems with Integrated Optical Sensor

A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end...
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Low-cost Image-guided Navigation and Intervention Systems Using Cooperative Sets of Local Sensors

An augmentation device for an imaging system has a bracket structured to be attachable to an imaging component, and a projector attached to the bracket. The projector is arranged and configured to project an image onto a surface in conjunction with imaging by the imaging system. A system for image-g...
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Adiabatic Multi-band Rf Pulses for Selective Signal Suppression in Magnetic Resonance Imaging

A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner comprising: a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation; and a radio frequency (RF) coil configured to irradiate a radio frequency (RF) pulse into a ...
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Iodinated Polymers

The invention provides medical devices that comprise an iodinated polymer and that can be viewed using X-Ray imaging techniques. The invention also provides novel iodinated polymers that can be incorporated into or coated on medical devices....
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Method for Determining the Quality of Heparin

The invention relates to a method for determining contamination of heparin with other sulfated glycans, comprising the steps: incubating a predetermined amount of heparin together with a predetermined amount of an enzyme that specifically digests heparin for a predetermined duration, wherein the amo...
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Image-based Risk Score-a Prognostic Predictor of Survival and Outcome from Digital Histopathology

The present invention relates to an image-based computer-aided prognosis (CAP) system and method that seeks to replicate the prognostic power of molecular assays in histopathology and pathological processes, including but not limited to cancer. Using only a tissue slide samples, a mechanism for digi...
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Radiopaque Polymeric Stents

The present invention relates to polymeric medical devices such as stents. More particularly the polymeric compositions disclosed herein comprise halogen-containing, tyrosine-derived diphenols, optionally in conjunction with other groups, such as dicarboxylic acids and/or poly(alkylene oxides), such...
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Biocompatible Polymers for Medial Devices

The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device application...
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Compliant Biocompatible Polymer Compositions for Medical Uses

Phase-separated elastomeric biocompatible polymer compositions are disclosed that are bioresorbable and/or biodegradable, and are useful in a variety of medical applications in which a low modulus polymer is desired, such as in the fabrication of medical devices....
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Biocompatible Polymers for Medical Devices

The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio- opacity and are useful for medical device applicati...
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Multi-user Smartglove for Virtual Environment-based Rehabilitation

A low-cost, virtual environment, rehabilitation system and a glove input device for patients suffering from stroke or other neurological impairments for independent, in-home use, to improve upper extremity motor function, including hand and finger control. The system includes a low-cost input device...
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Variable Resistance Hand Rehabilitation Device with Linear Smart Fluid Damper and Dynometer Capabilities

A variable resistance hand rehabilitation device and corresponding system. Improvements over the prior art include: a new damping system or damper design, to reduce friction and increase maximum force output; a dynometer feature that enables converting the dynamic device to a static grip force measu...
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Patient Specific Ankle-foot Orthotic Device

The unique advantages of computer-controlled fabrication of a patient-specific orthotic device using an automated fabrication machine capable of following computer instructions to create 3D surface contours and new developments in non-invasive three-dimensional (3D) scanning have made it possible to...
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Apparatus and Method for Modulating Neurochemical Levels in the Brain

A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neur...
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System and Method for Calibration for Image-guided Surgery

A method of calibrating a transformation of ultrasound data in an imaging system from a first coordinate system into a second coordinate system, the method comprising applying a transformation having parameters. The parameters are calibrated by imaging a planar object, extracting points correspondin...
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Electrical Impedance Sensing Biopsy Sampling Device and Method

A biopsy sampling device has an inner trocar having a sharpened tip and a sampling opening. The trocar is slideably engaged in a central cavity of an outer needle with its sharpened tip and sampling opening protruding from an end of the outer needle. Impedance measuring apparatus measures impedance ...
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Systems and Methods for Combined Ultrasound and Electrical Impedance Imaging

A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical impedance imaging overlay 330 is adapted to be positioned on a transducer window 304 of an ultrasound probe 32...
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Electroencephalography Monitoring Device Having a Self-adaptive Analog-to-digital Converter

An EEG monitoring device, contains at least one electrode, a non-linear analog signal processor, a variable resolution analog-to-digital converter, a storage, and a power source. The non-linear analog signal processor receives a signal from the at least one electrode and determines whether the signa...
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Biological Particle Collector, and Methods of Use Thereof

One aspect of the invention relates to the devices and methods for the collection of bioaerosols (such as viruses, bacteria, and proteins) from the exhaled breath of humans and/or animals, for the purpose of determining, for example, particle size, generation rate, diseases and interventions for par...
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Organometallic-Polyisomonoolefin Block Copolymers

The present invention provides copolymers which include a plurality of constitutional units that correspond to at least one cationically polymerizable isomonoolefin species and a plurality of constitutional units that correspond to at least one anionically polymerizable monomer species selected from...
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Ceramic/structural Protein Composites and Method of Preparation Thereof

Ceramic/structural protein composites and methods of preparation are disclosed, including coatings and films. Ceramic/structural protein coatings can be fabricated on the surface of substrates, including the surface of implantable medical devices....
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Shape Memory Main-chain Smectic-c Elastomers

Shape memory main-chain smectic-C elastomers are described, as are methods for their preparation and monomers used in such methods. The elastomers are prepared by hydrosilylation of a reaction mixture including a liquid crystalline diene, a crosslinking agent, and a bis(silyl hydride) compound. The ...
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Implantable Medical Devices

A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diamet...
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Blends of Amorphous and Semicrystalline Polymers Having Shape Memory Properties

Blends of amorphous and semicrystalline polymers having shape memory properties were prepared by blending a crystalline polymer such as poly(vinylidene fluoride), polylactide, poly(hydroxxybutyrate), poly(ethylene glycol) polyethylene, polyethylene-co-vinyl acetate, poly(vinyl chloride), poly(vinyli...
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Methods and System for Confocal Light Scattering Spectroscopic Imaging

The present invention is generally directed to imaging methods and apparatus that employ angular and/or wavelength distribution of light backscattered from multiple portions of a sample in response to illumination by electromagnetic radiation to generate one, two or three dimensional images of the s...
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Apparatus and Method of Analyzing Arterial Plaque

A method of identifying arterial plaque analyzes arterial plaque using one or more non-invasive tests to determine if the plaque has any of a plurality of hallmarks that are predictive of disruption. The one or more tests do, in fact, test the plaque for the plurality of the hallmarks. The method th...
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Labeled Skin Lesion Biopsy Punch and Uses Thereof

The present invention relates to a biopsy device, methods, kits and systems for marking the location of a biopsy site in order to later identify the location of a biopsy or surgery in a subject, where the marker is a dye or tattoo which is not visible to the naked eye under normal (white) light, but...
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Biological Circuit Chemotactic Converters

Described herein are novel biological circuit chemotactic converter that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for detecting and converting external inputs, such as chemoattractants, into outputs that allow for autonomous chemotaxis ...
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Biological Analog-to-digital and Digital-to-analog Converter Switches

Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs to digital outputs, and digital inputs to analog outputs, in cells and cellular systems. Flexibility in ...
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Fully automated control system for type 1 diabetes

An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and...
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Low Cost Disposable Medical Forceps to Enable a Hollow Central Channel for Various Functionalities

The present invention relates to an endoscopic biopsy forceps (10) with an open central channel. The forceps include a sheath (20) having a proximal end and a distal end, a housing (50) connected with the distal end of the outer sheath, an open channel actuator control means (30) having a proximal e...
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Dermal punch device

A dermal punch for extracting skin or tissue samples. The dermal punch has a blade having a pair of walls. Each wall is convex and opens towards each other. The walls are connected to each other at a pair of mating edges. Each wall has a cutting edge. In a preferred embodiment, the ratio of the mino...
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Bone Fixture Assembly

An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non not locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate...
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Modular Therapeutic Pressure Application Devices

The invention relates in some aspects to therapeutic pressure application devices and methods of manufacturing and using the same. In some aspects, the devices comprise a support structure shaped to conform to a portion of a body of an individual; a bladder having a port for the passage of a fluid, ...
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Spectroscopic Sensors

Disclosed herein are sensors that include: (a) a circuit board that includes an electronic processor; (b) a plurality of radiation sources, each source being attached to the circuit board; and (c) a spectral detector attached to the circuit board, the spectral detector being configured to analyze ra...
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Suspension/retraction Device for Surgical Manipulation

A device that can be delivered into a body cavity to manipulate tissue intracorporeally while being controlled extracorporeally and a method of using the device to perform a single-port laparoscopic or natural orifice surgery. The device is being capable of being passed through an interior diameter ...
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Intrauterine Fallopian Tube Occlusion Device

An intrauterine device for occluding orifices of fallopian tubes includes a resilient body having an elongated member with a first end and a second end. The elongated member further includes a first leg ending with the first end of the elongated member, a second leg ending with the second end of the...
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Parallel Magnetic Resonance Imaging Using Nonlinear Gradient Encoding

In MRI by excitation of nuclear spins and measurement of RF signals induced by these spins in the presence of spatially-varying encoding magnetic fields, signal localization is performed through recombination of measurements obtained in parallel by each coil in an encircling array of RF receiver coi...
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Volume Status Monitor: Peripheral Venous Pressure, Hypervolemia and Coherence Analysis

Systems and methods are provided for monitoring changes in blood volume using waveforms in the peripheral vasculature. In particular, the systems and methods relate to detecting ventilation-induced variation (VIV) of waveforms in the peripheral vasculature. Advantageously, the systems and methods ma...
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Dynamic spine stabilizer

A dynamic spine stabilization device is provided that includes at least one force imparting member, e.g., a spring. The force imparting member is adapted to deliver a force of between about 150 lb/inch and 450 lbs/inch, and restrict the relative travel distance between said first and second pedicles...
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Method of Assessing Blood Volume Using Photoelectric Plethysmography

A method and system for assessing blood volume within a subject includes generating a cardiovascular waveform representing physiological characteristics of a subject and determining blood volume of the subject by analyzing the cardiovascular waveform. The step of analyzing includes generating a firs...
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Bone Implant Device and Methods of Using Same

A bone implant device comprising a plurality of interconnected plate members, at least one plate member defining a plurality of apertures therein adapted for permitting bone growth there through from an interior portion of the bone in which the device is implanted for aiding in securing the device w...
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Access Device

A device may include a hollow needle, a dilator mounted coaxially on the needle, and a sheath mounted coaxially on the dilator. The dilator may be slideably displaceable relative to the sheath....
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Method for Implanting Intraocular Pressure Sensor

Methods of implanting an intraocular pressure sensor and systems tbr sensing intraocular pressure are disclosed. An intraocular pressure sensor, including, a top surface, may be placed through the sclera of an eye of a patient. The intraocular pressure sensor may be caused to be inserted into the sc...
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Uveoscleral Drainage Device

An ophthalmic shunt implantable in an eye having an elongate body (10) and a branched conduit (40) for conducting aqueous humor from an anterior chamber of the eye to the suprachoroidal space of the eye and the subconjunctival space, and a plate extending from an upper surface of the elongate body....
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Device for Measuring and Analysing the Colour of the Outer Ear and Ear Canal

The present invention concerns a device for measurement and analysis of the middle ear and ear channel colour. This device allows thus automatic patient middle ear colour measurement and intends to be auxiliary equipment for health professionals in the diagnosis of ear infections. The device is comp...
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Suprapubic Instrument Used Specifically in Endoscopic Prostate Surgery

The invention relates to a single tool that complements the technique performed by a resectoscope (4), which combines puncturing and subsequently extracting the irrigation liquid and remains of the extracted tissues, optimising said processes and increasing the intervention time, being suitable for ...
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Magnetic Hyperthermia Application Device

Magnetic hyperthermia application device (1) to apply magnetic hyperthermia treatment to a sample, characterized as such because it includes: an LC resonant tank (3), consisting of a first coil (5) and a first condenser (6), connected to an alternating voltage power supply (2) of variable frequency ...
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Device for Clamping Samples in Mechanical Tests on Soft Tissue

The invention relates to a jaw-type device that can be used to clamp soft tissue samples, such as biological tissue, in order for traction tests to be performed on said tissues. The device can also be used to perform tests on these types of samples in submerged environments....
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Micro-stereoscopic Retinal Photography Method

The invention relates to a micro-stereoscopic retinal photography method, characterised in that said method uses a combination of two axes, X and Y, manipulating the moving parts of a retinal scanner and positioning the lens thereof at the axial focal length on the retina in a primary position, foll...
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Device for Applying a Contact Anaesthetic

Device for applying a contact anaesthetic, such as those used mainly in superficial ophthalmological surgery for application of a local anaesthetic, characterized in that it consists of a porous strip of gelatine sponge which is flexible and preferably rectangular in shape with a small thickness, wh...
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Forensic Identification System Using Craniofacial Superimposition Based on Soft Computing

The invention relates to a method and an automatic system for assisting a forensic anthropologist in the task of identification by means of craniofacial superimposition. First, the system automatically builds a three-dimensional model from a device providing partial views of the skull. Said model is...
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Portable Device for Self-viewing Blood Cells in the Retina

The invention relates to a compact, portable instrument that is easy to use, enabling the patient to evaluate him/herself in a few seconds whether the blood circulation in his/her retina is correct, and to therefore self-detect pathologies such as vascular retinopathies, arteriosclerosis or diabetic...
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Device for Thoracostomy

The invention relates to a device (1) for thoracostomy, in particular for relief of a (tension) pneumothorax, comprising a cannula (2) and a needle (3) slidingly sheathed m the cannula (2). A spring (13) resiliently couples the needle (3) to the cannula (2), at least during insertion of the device (...
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Microneedle Injecting Apparatus

A method of delivering a microneedle array to a substrate including the steps of propelling the microneedle array towards the substrate utilising a microneedle applicator device which propels the microneedle array towards the substrate at a speed of 0.5 m/s to 5 m/s, the device subsequently withdraw...
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Tools for Use in Treatment of Male Urinary Incontinence.

A transobturator technique was developed for treating male urinary incontinence. This approach helped to design specific instruments to pass around the ischio-pubic branches of the male pelvis from inside to outside (i.e from the suburethral space to the thigh fold). The inside-out transobturator sl...
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Devices for Surgical Treatment of Female Urinary Incontinence

A variety of specifically designed surgical instruments to perform a new, quick, simple, efficient, safe, and reproductible surgical technique for the treatment of female urinary incontinence, in which the posterior urethra is suspended using a tape passed through the obturator orifices from inside ...
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A method and device for processing and presenting medical images

The present invention relates to a method for processing and presenting at least a first image and a second image, these images being digital medical images. A first step in the method is performing image registration between the first image and the second image to generate a pixel-level mapping bet...
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Methods and Systems for Analysing Resuscitation

A system (100) for analysing resuscitation is described. The system comprises an input means (120) for obtaining a plurality of pressure values over time. It also comprises a tracheal pressure value processing means (140), and a clinical parameter determination means (150) for determining at least o...
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GDF15 As Molecular Tool to Monitor and Enhance Phenotypic Stability of Articular Chondrocytes.

The present invention relates to GDF15 as a molecular marker in in vitro assays determining phenotypic stability of articular chondrocytes and predicting the outcome of chondrocyte transplantation....
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Implantable Sensor

A sensor is described for sensing a substance such as for example glucose. The sensor is implantable in the body of a living creature. The sensor comprises a photonic integrated circuit, e.g. silicon-photonics, based radiation processor for spectrally processing radiation interacting with the sample...
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Cochlear Implant Apparatus

The invention relates to cochlear implants and to improved methods of operating such implants. We describe cochlear implant apparatus comprising an audio signal processing unit with a wired or wireless coupling to an implantable cochlear stimulation device, wherein said audio signal processing unit ...
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Active Interface Device

An active interface device including a transducer or sensor array having a plurality of transducers or sensors arranged to transform a cell activity into an electrical signal, at least one detection unit for detecting the electrical signal(s), at least one recording unit for recording the electrical...
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Large Time Constant Steering Circuit and Instrumentation Amplifier Implementing Same

The present invention relates to a large time constant steering circuit for slowly changing a voltage on a node between at least two discrete voltage levels. The present invention further relates to a slow steering current DAC comprising said large time constant steering circuit. The present inventi...
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Flexible Endoscope Device with Visual Control and Process for Stabilization of Such a Device

A flexible endoscope device includes an elongated flexible body having an end segment bearing or defining the endoscope head, and provided with an optical system that can be curved or bent in at least two mutually perpendicular directions, the elongated body being functionally connected at the other...
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Adjustable Catheter Or Endoscope Structure

The structure e.g. catheter (27), has a resiliently deformable longitudinal body (28) including a memory shaped actuator e.g. yarn (38), integrated longitudinal to the body that is in the form of an elongated cross-sectional blade. A heating unit longitudinally contracts the actuator by Joule effect...
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Surgical Instrument

The invention relates to a surgical instrument (1) comprising: an elongated arm (11; 307) according to a longitudinal axis and having a distal end (2; 305) mounted with a pivot joint on the elongated arm according to an axis substantially orthogonal to the longitudinal axis; a drive shaft (3) substa...
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Device for Measuring the Activity of the Spinal Cord of a Vertebra

The invention relates to a device for measuring the activity of the spinal cord of a vertebra, characterized in that the device comprises at least one main probe (1) shaped so as to be attached to a spinous process (2) of a vertebra (3) and to maintain in position, on either side of the vertebra, at...
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Assay device and method for chemical or biological screening

An assay device (1) comprises a base (2) and glass plate lid (3). The base (2) has an array of shallow microwells (4), each having a flat rim (9), all rims being co-planar. When the lid (3) is placed on the base (2) a thin capillary gap (10) is formed on each rim, acting as a liquid seal for a micro...
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A device for treating tissue

An apparatus for use in carrying out a prophylactic or treatment procedure on tissue comprises a head piece 1 having a receiver 2 for receiving an instrument such as an endoscope 10 and a chamber 3 into which is drawn by vacuum. There are two electrodes 11 within the chamber 2 and two electrodes 25 ...
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A stent delivery system

A stent delivery balloon 1 is used to deploy a plurality of mini-stents 5 into a bodily lumen at a controlled spacing. The balloon 1 has formations 3 for retaining the stents in a designed position. The formations may comprise ridges 3, or retractable bridging elements, on the surface of the balloon...
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Endoscopy System with Motion Sensors

An endoscopy system (1) comprises an endoscope (2) with a camera (3) at its tip. The endoscope extends through an endoscope guide (4) for guiding movement of the endoscope and for measurement of its movement as it enters the body. The guide (4) comprises a generally conical body (5) having a through...
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Intravasculature Devices and Balloons for Use Therewith

An inflatable device (1) for use within the vasculature of a body and having an expandable annular body (Ia) which is expandable by inflation of a series of inflation lumen (2) defined therein, the device having inflated (b) and non-inflated (a) states and inner (3) and outer (4) annular walls, the ...
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Method and apparatus for imaging tissue topography

The present invention related to an optical device for imaging and measuring characteristics of an objects surface shape, surface spectral reflectance and structure of sub-surface layers. In particular, the invention related to imaging of topography of human skin and skin sub-surface layers and dete...
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Method and System for Monitoring Sleep

A method of monitoring sleep comprises simultaneously recording a person's electrocardiogram (ECG) and photoplethysmogram (PPG), deriving a plurality of parameters from the recorded data, and providing an output indicative of a sleep characteristic based upon an analysis of the parameters. The ECG a...
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A Lateral Flow Assay Device for Coagulation Monitoring and Method Thereof

The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device compri...
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Vessel Support Device and Methods for Supporting a Vessel

The present invention is directed to a vessel support member having opposing ends adapted to move in a circumferential plane, the support member configured for deployment in a substantially radial direction to support a substantial portion of the circumference of a vessel, the support member adapted...
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Orthopaedic Device for the Treatment of Spinal Disc Degeneration Disease

An orthopaedic device is provided for the treatment of spinal disc degeneration disease (DDD). The device comprises a vertebral body spacer capable of being placed between a first vertebral body and a second vertebral body of a human or vertebrate animal subject such that said vertebral body spacer ...
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Method, System and Apparatus for Ventilation

The invention relates to a ventilator for delivering fluid pressure to the lungs of a subject, the ventilator having; a pump in operative connection with a first pressure vessel for control of the peak inspiratory pressure (PIP) of the subject, wherein the volume of the first pressure vessel is subs...
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Respiratory Aid Device

A system is described for stimulating the chest wall of a subject to reduce breathlessness. The system includes a respiration sensor (3) operable to generate an output signal dependent on respiration of the subject; a stimulation device (7) operable to stimulate the chest wall of the subject; and a ...
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A Wireless Code Game Enuresis Alarm for the Treatment of Enuresis

A system (10) and method for use by a subject with a sleep disorder, such as nocturnal enuresis. The system (10) comprises at least one sensor (11) that detects at least one attribute of the sleep disorder, for example urine, and outputs at least a first signal on or after detection of that attribut...
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Pressure sensor for measuring intraocular pressure that can be worn on the eye.

A pressure sensor that can be worn on the eye of the user for measuring the intraocular pressure of the user. The pressure sensor may take the form of a strain gauge 24 which has a resistance element. The pressure measuring device may also be incorporated into a corneal contact lens, the contact len...
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Phase Lock Evoked Response Audiometer

An evoked response audiometer method and apparatus in which a patient receives an auditory stimulus signal comprising a carrier frequency which is periodically amplitude modulated and frequency modulated whereby the stimulus is at least substantially frequency specific, the brain potential signals o...
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Method and Apparatus for Sensory Field Assessment

A method for assessing the function of at least one sensory field of a subject, and apparatus and systems for carrying out the method, the method comprising: using a display, presenting stimuli to selected locations of the sensory field, the selected locations being centred at points on a sampling g...
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Neural Circuits and Stereotactic Apparatus

Herein are disclosed: - solid or semi-solid implantable neural circuits conduit comprising an elongate polymer sheath and one or a plurality of neurons in the lumen of the sheath or embedded in the scaffold; - methods of manufacturing said implantable neural circuits; - a stereotactic syringe appara...
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DEVICES AND METHODS FOR DETECTING ss-HAEMATIN AND HAEMOZOIN

In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the application of a magnetic field. Figure 1 shows apparatus, shown generally at (10), for performing magneto-op...
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Microfluidic Apparatus and Method for Dna Extraction, Amplification and Analysis

An integrated gel based microfluidic sample processing device An integrated gel based microfluidic sample processing device, suitable for forensic investigations at the scene of a crime,comprising a substrate having a plurality of micro-channels to form at least a DNA extraction chamber in fluidic c...
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Speech valve

The valve 10 comprises a generally cylindrical body 12, 14, 16 and a closure member 62 which is slidably movable within the body between a closed position and an open position. The valve body and the closure member 62 are formed of a rigid, smooth material which is resistant to the growth of biofilm...
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A Speech Valve, a Tool for Facilitating Insertion of a Speech Valve and a Tool for Holding a Speech Valve

A tool (106) for facilitating insertion of a speech valve (10) with a flexible retention flange (56) into a fistula between the trachea and the oesophagus of a human patient, having a wall (108) curved to define a passage (116) having opposed open first and second passage ends and an axis extending ...
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Transpedicular Access to the Intervertebral Disc Space for Discectomy, End Plate Preparation, and Interbody Fusion

An insertion device is configured to access a disc positioned between adjacent vertebrae. The insertion device includes a cannula having a passage formed therein. The cannula has an exit aperture. An obturator is substantially positioned within the passage formed in the cannula. One end of the obtur...
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Insertion Assembly for Minimally Invasive Spinal Surgery

A telescopic insertion assembly is configured to insert a pedicle screw into a vertebral body. The insertion assembly includes an attachment fixture having one end configured to mate with the pedicle screw and another end having a ridged portion. A center tube is provided having one end slidably att...
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Pedicle Screw Assembly Having a Retractable Screw Tip for Facilitating the Securement of the Pedicle Screw Assembly to a Spinal Vertebra

A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank ...
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Fixation Assembly Having an Expandable Insert

A fixation assembly having one or more insertions member that include one or more expandable and retractable anchoring inserts positioned along at least a portion of the insertion member and methods of use thereof are disclosed....
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Directional Soft Tissue Dilator and Docking Pin with Integrated Light Source for Optimization of Retractor Placement in Minimally Invasive Spine Surgery

A soft tissue dilator for use in a surgical procedure includes a first dilator member that defines a first axis and a second dilator member that defines a second axis. The second dilator member is supported on the first dilator member such that relative rotational movement of the first and second di...
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Pedicle Screw Assembly Having a Retractable Screw Tip for Facilitating the Securement of the Pedicle Screw Assembly to a Spinal Vertebra

A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank ...
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Needle for Directional Control of the Injection of Bone Cement Into a Vertebral Compression Fracture

A needle for use in a surgical procedure includes an outer cannula including a shaft portion having a side wall and an end wall. A first aperture extends through the side wall of the outer cannula, and a second aperture extending through the end of the outer cannula. The needle also includes an inne...
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Sterilization of Medical Devices Using Expanded Organic Acids

The present invention concerns a process for sterilizing biomedical devices using organic acids expanded by compressed gases to form an "expanded liquid". The term "expanded liquid" means, in the technical literature, an organic solvent that is liquid at room temperature and pressure, modified by di...
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Air Cushion Sensor for Tactile Sensing During Minimally Invasive Surgery

A sensor is described for detecting the force applied to or by soft material, and that is thus able to measure the stiffness of a soft material. The sensor comprises a sensor body into which is supplied a fluid under pressure. At least one sensor members are provided that are arranged to project fro...
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Apparatus and Method for Measuring Blood Pressure

The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject's pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determin...
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CMyBP-C and MLC2 As Diagnostic Markers of Cardiac Injury

The invention relates to markers for acute myocardial infarction (AMI), particularly markers that may be used in the rapid and accurate diagnosis of AMI or reinfarction. A method of diagnosing cardiac injury comprising identifying an elevated concentration of cardiac myosin binding protein C (cMyBP-...
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Reversibly Gelling Polyurethane Composition for Surgical Repair and Augmentation

A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear a...
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Bioactive Material Delivery Systems Comprising Sol-gel Compositions

Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed....
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Medical Tubing Securement Assembly and Methods of Use

A medical tubing securement assembly includes a base having a disc, and a retaining adapter removably and rotatably attached to the disc. The retaining adapter includes a longitudinal passage for receiving a locking adapter. The locking adapter includes a longitudinal passage for receiving a medical...
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Universal Catheter Securement Device

A universal securing device for holding catheters of various shapes and sizes and the like in place includes a base and cover. The cover may be connected to the base by a hinge which allows the cover to be lifted open or pushed down into a closed position, over a catheter fitting. The base may have ...
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A Device for Delivering Medical Treatment

he present invention provides a medical device for the delivery of treatment fluid to body vessels, having a distal (21) and a proximal (20) end, comprising a self-expanding, hollow tubular member (9) and a delivery catheter (10) suitable for deploying a self-expanding, tubular member (9), wherein t...
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Methods and Devices for Continuous Suture Passing

Described herein are suture passers for suturing tissue in a continuous manner by passing a suture attached to a suture shuttle through. A suture passer may include a first jaw, a second jaw, and a tissue penetrator that is retractable and extendable from the first jaw. The tissue penetrator may hav...
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Ambulatory Aid with a Power Unit

A device comprising an ambulatory aid, the device comprising a distal end, a load, a first portion positioned at, or close to the distal end and adapted to allow the device to move along a surface, a second portion spaced apart from the first portion and the distal end and adapted to allow a user to...
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Target Acquisition System

A targeting system and method for remotely controlling the zoom and pan features of a device for display in an operating room is provided. The invention generally relates to a system and method for allowing a controller in an operating room to control the zoom and pan features of one or more remo...
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Stent Delivery Devices, Systems & Methods

The present invention relates to devices, systems and methods to maintain self- expanding stents in a compressed form during delivery and positioning at a treatment site. Such a device may comprise a cylindrically-shaped material with a plurality of slots which are spaced on said material to accept ...
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Implantable and Lumen-supporting Stents and Related Methods of Manufacture and Use

An implantable stent includes multiple circumferential segments that surround a bore and are connected in series along a length to form a tubular wall. Multiple adjacent alternating opposite facing crowns arranged along each segment's circumference are bridged by struts. The struts include a series ...
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Suture Passing Instrument and Method

A continuous suture passer device (10) may include a first jaw (20) and a second jaw (21 ); an actuator (15) including a jaw control which may manipulate at least one jaw; a tissue penetrator (50) which may be configured to form a pathway through a tissue which may be positioned between the first an...
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Surgical Antenna

A surgical instrument (100) (e.g. scalpel) is disclosed which has an antenna arranged to emit a substantially uniform microwave radiation field (e.g. having a frequency of 5-100 GHz) at an edge of a cutting element (110) (e.g. blade). The emitted radiation can cauterise tissue e.g. broken blood vess...
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Needle Structure and Method of Performing Needle Biopsies

A biopsy needle (80) having a longitudinal channel (84) formed within an inner conductor (86) of a coaxial antenna is disclosed. The coaxial antenna terminates in a rigid insertion tip (82) e.g. a ceramic cone that is insertable into biological tissue. Microwave energy (e.g. having a frequency of 1 ...
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Medical Devices, Apparatuses, Systems, and Methods

Apparatuses and systems for enabling electrical communication with a device positionable within a body cavity of a patient. Apparatuses and systems for magnetically positioning a device within a body cavity of a patient. Medical devices. Methods of use....
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Therapeutic Methods Using Controlled Delivery Devices Having Zero Order Kinetics

An injectable or implantable medical device having orifice(s) on the surface that release an active agent with zero-order release kinetics is described herein. The device is a hollow matrix of any size or shape, which can be made from both metal and non-metal surfaces. The device comprises of a rese...
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Photokinetic Ocular Drug Delivery Methods and Apparatus

The present invention relates generally to transscleral and transocular delivery of biologically active substances through the tissues, blood vessels and cellular membranes of the eyes of patients without causing damage to the cellular surface, tissue or membrane. The invention provides compositions...
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Apparatus for Treating Tissue with Microwave Radiation and Antenna Calibration System and Method

A calibration method and apparatus for surgical antennas which are arranged to deliver microwave radiation (e.g. having a treatment frequency of 500 MHz to 100 GHz) into biological tissue is disclosed. An emitting region of the antenna is exposed to a plurality of calibration standards each having a...
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Oesophageal Treatment Apparatus

A probe and associated apparatus for treating oesophageal tissue with microwave radiation (e.g. radiation having a frequency of 5-60 GHz) are disclosed. The probe comprises a flexible substrate that expands and retracts between an access configuration, e.g. suitable for insertion through an endoscop...
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Electrical Wound Healing System and Method

A wound healing system comprising an array of electrodes incorporated in a device for applying an electrical signal to a wound. The electrodes are configurable to form at least one composite electrode and the electrical signal is applied to the wound via the composite electrode(s). The system prefer...
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Skin Marker

A skin marker for providing a reference point for a plurality of different medical imaging procedures, said marker incorporating one or more substances having one or more of radiance and/or hydration and/or radiopaque and/or radio luminescent and/or radioactive properties for detection by X-ray and/...
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An Infant Incubator with Radiant Heater

An infant incubator comprises a radiant means (30) with an infrared heater (12). A infant bed (16) is provided under the radiant means (30) and includes a humidifier (7) and a second temperature controller (18). A transparent sphere cover (6) is mounted around the bed (16), and a cover board (28) fo...
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Hard Tissue Regeneration Device

PROBLEM TO BE SOLVED: To provide a new hard tissue regeneration device using osteoblast. ; SOLUTION: The hard tissue regeneration device is a complex of an osteoblast and a honeycomb porous body having through-holes with 1 [mu]m-14 [mu]m pore diameter comprising calcium phosphate produced by the ost...
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Urine Collection Device

A pad assembly for use with a urine collection device comprises an external layer (2), which is preferably an impermeable conformable material. The external layer (2) partially surrounds a filling material (3), which preferably comprises a single layer of open low-density material that does not appr...
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Device for supporting at least one arm of an operating person during a surgical or medical operation

A device for supporting at least one arm of an operating person during a surgical or medical operation comprises at least one supporting element for supporting the at least one arm of the operating person, the supporting element being arranged at a carrying structure for carrying the at least one su...
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Heating system

A body part heating system (10) comprises a temperature sensor (28) adapted to measure the temperature of a body part, and a heater (34a, 34b) in communication with the temperature sensor (28). The heater (34a, 34b) is adapted to be activated to heat the body part in response to the temperature sens...
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Magnetic Resonance Imaging of Labelled Cells

A method and apparatus for obtaining a magnetic resonance image of a sample by applying a radio frequency signal to a sample containing magnetically labelled cells or tissues in order to heat the magnetically labelled cells or tissues and applying a sequence of radio frequency pulses to the sample t...
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Pressure Measurement Device

A non-invasive device adapted to measure intraocular pressure (IOP) comprising: a pressure sensor mounted on a soft contact lens to be worn on the eye of a subject, wherein the device is adapted such that, when worn on the eye, the pressure sensor is located at or near the transitional region of the...
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Apparatus and Method for the Manipulation of Objects Using Ultrasound

A method and apparatus for manipulating particles. The apparatus comprising an ultrasound source for providing a variable ultrasound signal within a region of interest, and a controller connected to the ultrasound source such that it provides a control signal to the ultrasound source. The variable u...
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Apparatus and Method for Mineralising Biological Materials

An apparatus and method for mineralising demineralised and hypo-mineralised biological material such as tooth or bone. The apparatus has a probe electrode for receiving a mineralisation agent and a counter electrode. It is also provided with means for controlling the electrical signal provided to th...
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Methods for Reducing False Hypoglycemia Alarm Occurrence

A system and method for reducing the number of hypoglycemic alarms presented to a user is presented. The system and methods include use of model based state estimation and variable-delayed threshold values to balance the risk of not presenting an alarm caused by an actual hypoglycemic state with the...
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Valve disc and combination filling device using the valve disc, and tube, pipe jointing device, connection port manufacturing device, and pipe jointing system

A tube (51,30) including a flow path (51) in the inside, at least a part of which is constituted by a flexible material, the tube (51,30) is provided with at least one inner slit along an axis of the tube in a closed state or an opened state that reaches an internal peripheral surface (72,302) there...
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Automatic sample collector

This invention relates to an automatic sample collector for liquids which are discharged from a chromatographic column, a dialysis apparatus, or a reaction container, for example, and are consecutively collected at a give volume division, a method for collecting samples of a liquid in a predefined c...
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Microdialysis Chamber System with Included Colloidal Materials and Method for the Manufacture Thereof

The invention relates to a microdialysis chamber system comprising a base member (1) made of a solid material that does not swell in water, at least one cavity (4) functioning as a dialysis chamber, containing water soluble colloidal materials (5) and at least one asymmetrical composite membrane (3)...
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Method and System for the Integral and Diagnostic Assessment of Listening Speech Quality

A method for determining a speech quality measure of an output speech signal with respect to an input speech signal, wherein the input signal passes through a signal path of a data transmission system resulting in the output signal, includes the steps of pre-processing the output signal; determining...
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Hand-held tattooing device for bringing e.g. medical active ingredient into e.g. human skin, has drives that are coupled to cutting blade for shifting blade in multiple cutting positions along cutting

The device (1) has a cutting blade (3) that is shiftable between multiple basic positions that are assigned to respective cutting depth. A liquid supplying device supplies liquid to be brought for entry in a cutting channel produced by the cutting blade. Two drives (4, 5) are coupled to the cutting ...
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Anastomosis Ring and Anastomosis Ring Assembly

The invention relates to an anastomosis ring and to an anastomosis ring assembly for connecting hollow organs made from human or animal tissue. The anastomosis ring includes a first support ring and a second support ring, which can be coupled with the first support ring for fixating the tissue, so t...
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Polymerstent

The invention relates to a polymer stent with open ends at the longitudinal support structure which includes an interior that allows the passage flow of body fluid (eg blood) from an open longitudinal end to another longitudinal end open. According to the invention has the the interior surface facin...
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Ultrasonic Diagnostic Apparatus

PROBLEM TO BE SOLVED: To provide an improved ultrasonic diagnostic apparatus to be used for diagnosing a bone including a healthy region and a diseased region. ; SOLUTION: An ultrasonic beam 40 for echo tracking is formed for a healthy region 52a of the bone 50 including healthy regions 52a and 52b ...
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Bone Examination System

PROBLEM TO BE SOLVED: To easily position lower limbs in a bone examination system for executing an examination based on the deformation of bones by adding loads to the bones of the lower limbs. ; SOLUTION: A lower limb L of a subject P is mounted on a proximal supporting block 26 disposed on a rotar...
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Ultrasonic Probe Supporting Device

PROBLEM TO BE SOLVED: To move an ultrasonic probe along a kneecap to obtain ultrasonic echo information for the cartilage of a knee joint. ; SOLUTION: An attaching unit 16 is positioned by an attaching unit frame 58 to abut to the thigh with the knee in the bending state and a knee abutting part 62 ...
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Knee Acoustic Matching Box for Ultrasonic Probe

PROBLEM TO BE SOLVED: To achieve acoustic matching between the kneecap and an ultrasonic probe when the ultrasonic probe is moved along the kneecap for obtaining ultrasonic echo information for the cartilage of a knee joint. ; SOLUTION: The acoustic matching box includes a water bag 64 filled with w...
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Blood-pressure Sensor System

There is provided a blood-pressure sensor system wherein a blood-pressure sensor including a plurality of structures which induces surface plasmon resonance on a light-receiving plane of a photoelectric conversion element is attached to an outer wall of a blood vessel, in which if the blood-pressure...
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System for Transporting Drugs and Medical Materials in Hospital

Provided is a system for transporting drugs and medical materials in a hospital wherein drugs and medical materials required in each ward can be mounted previously on a tray which is a unit of transportation or use, and a plurality of trays can be set in a tray cart and kept in a transportation stan...
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Automated Vitrification System

Market Opportunity Cryopreservation of biological materials by vitrification has made significant inroads in displacing the more conventional slow-freeze process. However, technicians must conduct a laboriously manual and technique-driven process to vitrify biological materials. Manual vitrificat...
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Device for High Efficiency Cell Encapsulation using Novel On-Demand Droplet Generation and Impedance-Based Detection

Tech ID: 21236 Brief Description Researchers have developed a novel microfluidic device that is capable of encapsulating cells at a very high efficiency. The device integrates impedance measurement with a novel on-demand droplet generation process to enable the selective generation of droplets t...
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Colloidal Self-Assembly of Droplets for High Density Microfluidic Micro-Reactor Arrays with High Throughput Functionality

Tech ID: 21274 Brief Description Researchers have developed a simple method for the rapid self-assembly of predictable high density droplet-reactor arrays for high throughput microfluidic applications in biology and chemistry. By controlling the ratio of the chamber height to droplet diameter, t...
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Microfluidic Device using Dielectrophoresis Separation of Heterogeneous Cell Populations

Tech ID: 21272 / UC Case 2011-181-0 Brief Description Researchers have developed an automated microfluidic device that traps different cell populations in different chambers based on the cells’ dielectric properties. The device consists of one main channel with individual sets of electrodes in t...
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TIO2 Nanotubes - a New Cold Cathode for X-Ray Generation

Tech ID: 20909 Brief Description Researchers have shown that titanium dioxide (TiO2) nanotubes (NT) may be used as a cold cathode X-ray source. Full Description Researchers have shown that titanium dioxide (TiO2) nanotubes (NT) may be used as a cold cathode X-ray source. In contrast to CNTs,...
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A Removal Esophageal Stent

Tech ID: 20908 Brief Description Physicians have developed a new esophageal stent that can be easily removed. Suggested uses This stent may be used to prevent or treat gastrointestinal leaks. Advantages Currently to remove an esophageal stent, endoscopy is performed to grasp the suture ...
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Hydrostatic Pressure Pump and its use in Valving for Centrifugal Microfluidics

BRIEF DESCRIPTION Researchers have developed a hydrostatic pressure pump for centrifugal microfluidic applications. FULL DESCRIPTION In centrifugal microfluidics, the hydrostatic pressure pump is generated natively during rotation. In the design, when fluid from a main reservoir is propelled ...
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Portable Ultrasound Bladder Monitor

“Proactive Bladder Health” through a wearable, non-invasive device for wireless monitoring of bladder volume. • Non-invasive operation ideal for systematic use, e.g. every night or all day • No wires between the patient and base station making it safe to use while sleeping • Motor and mechanic...
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Portable, Foldable Mirror

The present invention relates generally to mirrors and, more specifically, to a portable mirror having a plurality of foldable mirror panels, each hingedly attached to a main mirror panel. A light fixture is provided and sits at the top of the device, flush with the folding panels when in the closed...
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Digital Staining for Histopathology

Background 99.9 % of cancer cases are diagnosed and monitored by histopathological assessment of a biopsy sample. The presence, concentration and distribution of biological molecules (such as nucleic acid, protein or lipids for example) can be determined by selecting a specific combination of chem...
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Confocal Microscope with 2-D Array of LEDs

Background Confocal microscopes can provide 3-dimensional (3D) images with superior contrast and depth resolution compared to conventional wide-field microscopy because they reject the out-of-focus light. This makes them the tool of choice for advanced laboratory imaging, e.g. for life sciences or...
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C-Pap Face Protector

A comfortable, moisture absorbant barrier between the face and the plastic of the c-pap mask. Helps to eliminate discomfort of sweating around the nose & mouth as well as helping to control skin problems due to that sweating....
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Magnetic apparatus for the treatment of cataracts and other eye conditions

Cataract is the leading cause of blindness in the world today. More than 160 million people have visual impairment, with three quarters of the cases related to cataracts. Sixty per cent of world blindness occurs in China, India and Sub-Saharan-Africa; blindness numbers are estimated to be increasi...
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Portable Imperial College Surgical Assessment Device (pICSAD)

Background Dexterity is a crucial aspect of surgical competence. Technical ability to perform a procedure is considered to be crucial for a safe and effective outcome and is also an important aspect of surgical training. However, a lack of haptic feedback particularly in laparascopic surgery t...
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Sutureless Chest Drain Dressing

Background Air or blood in the pleural cavity is a serious condition which can become life threatening. World-wide, it is estimated that 5 million chest drains are inserted annually. Currently, chest drains are secured in place using an arrangement of stitches, dressing pads and self-adhesive ta...
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Improved Tunneling Catheter

Annually, approximately 100,000 US patients suffer end stage renal disease and commence renal dialysis (1). All of these patients require an AV access. Over 70% of patients initiating chronic haemodialysis in the US have a tunnelled central venous catheter (CVC) as their first blood access device an...
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Post-Stroke Neuro-Rehabilitation Device

Stroke is one of the leading causes of adult disability in the world, with more than 15 million cases every year. Most stroke survivors suffer from hemiparesis, a paralysis of one side of the body, resulting in a severe decrease in their ability to perform typical activities of daily living. Rehabi...
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Improved Endoscope

Current endoscopes fall into the categories of rigid optical endoscopes, flexible video endoscopes and flexible optical endoscopes. Rigid endoscopes are typically used in orthopaedic surgery or surgery in the large body cavities, and for imaging in rodent brains. They are not usually suitable for ...
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Oblique Selected Plane Microscopy for Optically Sectioned Imaging

Conventional optical microscopy provides high resolution images and has a huge range of applications. In many cases, it is desirable to obtain so-called ‘optically sectioned’ images, i.e. an image of only a thin axial slice through the sample. The conventional method for obtaining high quality opti...
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Novel Doppler Method

Recent advances have demonstrated the feasibility of molecular imaging using targeted microbubbles and ultrasound. However, one technical challenge is to selectively detect targeted bubbles from those freely flowing bubbles and surrounding tissue. Pulse Inversion Doppler (PID) is a known imaging te...
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A Novel Attenuation Correction Technique for Ultrasound Contrast Agent Imaging

Quantification of tissue perfusion using ultrasound and contrast agents has great potential for various clinical conditions which involve changes of blood flow in tissue, e.g. tumours or myocardial infarction. However, the application of these techniques is limited by a lack of an effective correcti...
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Active Mobilization Shoulder Brace

Many types of shoulder injuries can be treated by positioning the arm in abduction (elevated sideways) and external rotation (twisting the arm outwards). This results in an extremely uncomfortable position for the patient and it is difficult for this position to be maintained. Furthermore, the inwar...
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Modular Partial Knee Replacements

There is growing demand for surgical procedures to remedy pain caused by early stage arthritis in the knee, but due to physical wear and osteolysis, implants are not expected to last a patient’s life time. Younger, active individuals wanting to maintain their lifestyle or overweight people, who wea...
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Hip Resurfacing Implants

In 2008, there were 378,865 hip replacement procedures in the US alone and the number of procedures is predicted to increase with a CAGR of 5.1 % from 2008 to 20151. All hip replacements currently are based upon the ball and socket principle. The acetabular socket component is a part sphere, typic...
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Low Level Laser battery operated medical devise

Medical Device: A low level hand held battery operated medical laser device has been developed and clinically tried with proven good results on almost all medical conditions encountered in a medical office including diabetes, strokes uncontrolled pain obesity and many others. Easy to learn techni...
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Device to Monitor Cardiac Tissue Viability

DESCRIPTION: The last decade of cardiac surgery has witnessed significant strides towards better understanding and management of previously lethal cardiac pathologies. It is now recognized that conditions of myocardial stunning and hibernation exist, in which the injured myocardium is only temporari...
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Platform for Chemical and Biological Sensing by Surface Enhanced Raman Spectroscopy

BACKGROUND: Surface-Enhanced Raman Spectroscopy (SERS) is an optical analysis technique that can provide molecular identification and quantification by recording a spectrum that displays characteristic vibrational fingerprints of molecules or parts of molecules. SERS is potentially among the most s...
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Epidermal Marking Pen for use in Surgical Marking and Cosmetics

The current use of surgical marking pens in the operating theater is quite common. However, these pens suffer from many drawbacks. These pens smear and despite the thinness of their tip, the ink spreads so that an initial thin line becomes wide as the skin absorbs the ink. Additionally, if the ski...
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Novel Microneedle and Micro-Blade Fabrication Technique for Biomedical Applications

This invention presents a novel needle fabrication technique for creating a sharp, beveled metallic microneedle. Using a SU-8 mold structure, needle tip geometry with beveled dimensions can be controlled in 3D. The same fabrication method can be adopted to create a micro-blade with controlled blade ...
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Releasable Safety Mechanism for Prosthetic Implants

Prosthetic implants for amputees contain a metal post surgically implanted into the bone that protrudes through the skin. Any torsional or bending force applied to the prosthetic may fracture the bone/implant interface. This technology describes a novel safety device to prevent damage to the bone-...
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Antimicrobial Contaminant Cap for Prosthetic Implants

This novel technology describes an antimicrobial contaminant cap for preventing infection at the implant-tissue interface for prosthetic implants. The cap is designed to slide along the pin, tube, post or any protruding material and would capture and contain antibacterial substances at the interfac...
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Occipital-Cervical Plate for Spinal Fixation

Fixation of the skull to the cervical spine may be used to treat trauma to the neck, degenerative diseases such as rheumatoid arthritis, and congenital instability. Many current implantable devices designed to immobilize the skull with respect to the upper cervical spine are assemblies of several c...
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Disposable Fluid Sensor

This technology is useful for determining the level of fluid in a container. An indicator such as a flashing light or an audible alarm is used to indicate when the fluid level in a container drops below a desired predetermined level. The sensor detects the change in fluid level by sending and recei...
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Physiologically Motivated Control for Blood Pumps

Heart failure is one of the leading causes of death in America. Currently 4.7 million Americans suffer from congestive heart failure in different stages, with 954,000 people dying every year from some form of heart or vascular disease. While a heart transplant is still the preferred treatment plan...
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Surgical Electric Blade Coated with Quasicrystalline Twin Films

Medical surgery is performed in all countries of the world ranging from very simple procedures involving flesh and bones in hands to very complex procedures on the brain. It is desirable to use surgical tools that are of high quality that do not cause unnecessary damage to the organ or tissue. Elect...
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Catheter Tracking with Phase Information

Background Currently invasive cardiovascular procedures rely on x-ray angiography to navigate a cardiac catheter to a location of interest. Interventional cardiology would benefit from using MR guidance by exploiting MRI’s excellent soft tissue contrast. For example, MRI is able to distinguish be...
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The TeleWatch Patient Monitoring System

The Johns Hopkins Medical Institutions, Division of Cardiology and The Johns Hopkins Applied Physics Laboratory have developed medical procedures and associated telehealth system capabilities for the home monitoring and disease management of high risk outpatients suffering from congestive heart fail...
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An Unclad Fiber Optic Sensor for Measuring Chromophoric Compounds in Human Blood and Amniotic Fluid

Yellow or brown tinged skin and eyes are the hallmarks of jaundice – seen most often in infants. The yellowing is a result of elevated levels of a substance called bilirubin in the blood (hyperbilirubinemia). Hyperbilirubinemia is commonly seen in 50-70 percent of newborn babies and is the most comm...
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Combined Chemical/Biological Agent Detection by Mass Spectrometry

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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Remote Monitoring and Relaying for Wrist Watch Alarm

Hearing loss can be a problem for many segments of the population. As the population gets older and the ability to hear high pitch sounds decreases, it may not always be possible to hear a watch alarm or cell phone ringing. It is common to see people use watch alarms to remind them to take medicatio...
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Helmet System Including at Least Three Accelerometers and Mass Memory and Method for Recording in Real-Time Orthogonal Acceleration Data of a Head

Conventional devices which measure acceleration in a single direction, or from a single event, or only above a predetermined threshold, or in a way which does not permit use during performance of the actual sport do not provide the dynamics necessary to correlate exposure to forces to the injury cau...
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Instrumented Model of the Human Torso for Ballistic Impact

Effective body armor minimizes injury by transferring the kinetic energy of a projectile over an extended time-scale or surface area. Body armor that accomplishes such energy transfer using lightweight materials that are comfortable to wear involves sophisticated technology and engineering. To bette...
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Time-of-Flight Mass Spectrometer Array (TOF Spectrarray)

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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Method and System for Detecting Small Structures in Images

The potential difficulties and pitfalls of many automated detection techniques can be summarized as follows: a. Too little enhancement may preclude the detection of minor microcalcification peaks while too much enhancement may increase significantly the amplitude of small background structures (nois...
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Auscultation Diagnostic Support Device

Current medical training techniques rely on significant patient contact, resulting in high training costs and often not the expected outcomes. In a 1997 study published in The Journal of American Medical Association, researchers found that on average, internal medicine and family practice residents ...
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Core Body Temperature Pill Technology

A multichannel circuit for telemetry signals representing physiological values from a point in a human body to a receiver (24) outside of the body. The two signals (S1, S2) other than the temperature signal (27') are used to provide two frequency modulated signals (14, 16) summed by an amplifier (18...
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Non-invasive Fetal Heart Signature Monitor

Regardless of the monitoring technique, critical difficulties frequently arise when there is an emergent need to transfer the monitored patient from the labor area to the operating room. The monitors are usually detached during this critical interval with the mother and her fetus unmonitored during ...
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Portable pH Data Collector

The present invention provides an apparatus for continuously recording physiological data. The invention includes a unique data mapping and compression technique, which allows relatively long-term data acquisition without compromising the data sampling rate. The present physiological data recorder h...
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Noninvasive Transcervical Tubal Occlusion (Sterilization) in Women

In 1985, Platia and Krudy reported the first successful transcervical catheterization of one obstructed fallopian tube in a woman with bilateral tubal obstruction. Since then a number of reports have documented successful retrograde tubal cannulation. From this preliminary work, the concept of a s...
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Systems and Methods for Combined Ultrasound and Electrical Impedance Imaging

Ultrasound imaging provides good spatial resolution and can identify the borders of tissues, and possibly tumors, but the technique is unable to discriminate between benign versus malignant tissue. Electrical impedance imaging ("EII"), on the other hand, is a medical imaging technique that provides...
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Thermal Treatment Systems with Acoustic Monitoring and Associated Methods

Thermal treatment systems are used, for example, to ablate liver metastatic tumors, treat benign prostatic hyperplasia, ablate cardiac tissue for the prevention of arrhythmia, heat corneal tissue to correct myopia, treat urinary incontinence, treat sleep apnea and snoring, tighten ligaments within t...
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The Dartmouth Acoustic Plethysmograph: a Novel Method for Measuring Breathing in Very Small Animals

As genetic modification of brain respiratory control processes becomes more advanced, there is great interest in measuring breathing and the development of respiratory control in neonatal mice and rats to evaluate the roles of the affected processes. Traditional methods for measuring breathing in an...
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Improved Aneurysm Clips and Improved Aneurysm Clip Applicators

Cerebral Aneurysm Clips Prior art aneurysm clips are fabricated of metal (usually a cobalt metal alloy of steel or titanium). These metallic clips limit the usefulness of non-invasive imaging, i.e. Magnetic Resonance Imaging (MRI) and Computed Tomography Angiography (CTA) for patients that have ...
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Magnetic Proximity Sensor System and Associated Methods of Sensing a Magnetic Field

Magnetic Resonance Imaging (MRI) provides an unparalleled window into the human body and is highly regarded as a safe and effective medical technique. There is however a potential for interaction between the magnetic field generated by the MRI instrument and ferrous metal objects, either internal o...
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SYSTEMS AND METHODS FOR tomographic IMAGE RECONSTRUCTION

Diffuse Optical Tomography (DOT) is a relatively new optical imaging modality that uses visible and near infrared radiation for the detection and diagnosis of surface and near-surface anomalies. Measuring and modeling of the attenuation and scattering of light in tissue allows for a determination o...
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Novel Method for Early Detection of Hypovolemia

Early detection of hypovolemia is clinically important because severe hypovolemia, blood loss of more than 1 liter, can lead to rapid decline and cardiovascular collapse. By the time the tachycardia or low blood pressure associated with severe hypovolemia is finally detected, the patient will alread...
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Method and Device for the Non-invasive Detection of Pre-neoplasia in Vivo

Dartmouth has developed a system capable of measuring tissue optical properties in vivo. The fluorescence lifetime spectrometer (FLS) is a clinically compatible, portable, fiber based instrument capable of simultaneously measuring native tissue fluorescence and the corresponding emission lifetime i...
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METHOD AND DEVICE FOR THE MEASUREMENT OF THE PARTIAL PRESSURE OF OXYGEN (pO2) IN VIVO, INCLUDING FOR ROUTINE USE IN CLINICAL SETTINGS INVASIVELY AND NON-INVASIVELY

We have developed a new system which, for the first time, makes it feasible to measure pO2 in the clinical setting with the accuracy, sensitivity, and repeatability needed for effective clinical use. The method measures at defined sites in the region(s) of interest and measurements can be made simu...
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Crutch Foot Rester (Foot Rester on Crutch)

I am an inventor with a new product that I invented “TITLED” CRUTCH FOOT RESTER(FOOT RESTER ON CRUTCH). I invented this product, which goes on the tip of a crutch, so that it will offer people who have cast on their leg due to an ankle or foot injure an opportunity to have a place to rest the injur...
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Implantable Biotelemetry System for Preterm Labor and Fetal Monitoring (ARC-14280)

Abstract: In 1993, The FTC established a relationship with Sensors2000! (S2K!) to adapt NASA's implantable biotelemetry devices to their monitoring needs of the human fetus and its uterine environment. One of their major goals was to measure intra-uterine pressure changes in order to monitor and tr...
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Insulin Receptor Knockout Mice

Description: The Insulin/IGF family of ligands and receptors controls mammalian growth, metabolism and reproduction, and insulin signaling at the insulin receptor is implicated in important signal transduction pathways. Interactions at this receptor can either amplify, diversify or terminate i...
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Methods and Compositions for Inducing Brown Adipogenesis

Description: The most common fat cells are white adipose tissue (WAT) cells, which have a thin ring of cytoplasm surrounding a lipid or fat droplet. WAT is found underneath the skin and provides heat insulation, cushioning against shock and jarring, and energy reserves. An average lean person ...
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Exemer Ablation Within Bowman

Abstract (Set) Method and apparatus for laser ablation of the cornea to correct strabismus. The laser beam is controlled by a system of limiting shutters to cut prism lenses into the cornea. The ablation is to remain substantially within the Bowman's layer, keeping scarring to a minimum. ...
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Corrections for Image Artifacts in MRI

A method for removing image artifacts in MRI created when data acquisition is synchronized to a physiological and therefore uneven intervals. The method simultaneously records both image data from the MRI scanner as well as the exact interval between each data acquisition. The image data is then mod...
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New Inhibitor of Rotavirus

An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, the milk mucin complex, the 46 Kd apparent MW glycoprotein, a polypeptide having the rotavirus-binding specificity of the 46 Kd apparent M...
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New Surgical Instruments for Vocal Cord Repair

A device and method to lateralize, or alternatively medialize, the vocal cord is described that is adjustable so that the final position of the vocal cord can be adjusted to enhance the quality of the patient's voice following the procedure. The multi-component device preferably includes, in the cas...
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Use of Botulinum Toxin for Treatment of Smooth Muscle Disorder

Direct injection of sphincteric botulinum toxin is disclosed as an effective, safe and simple method of treatment for disorders of gastrointestinal muscle or smooth muscles elsewhere in the body, with results that appear to be sustained for several months. Muscle disorders which are suitable for suc...
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Endoscopic Cryospray Device

A cryoprobe instrument for endoscopic use has been provided that permits the delivery of liquid or gaseous cryogens in the form of a spray. In an embodiment, the cryoprobe instrument includes an elongated, flexible tube having a fluid passage defined therethrough; a proximal connector portion provid...
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Dosing Model

A drug dosage modeling system that simulates the effect of therapeutic agents in humans to allow accurate evaluation not possible using conventional methods. Description (Set) Proposed Use (Set) The pre-clinical drug development process could utilize this invention to more accurately evaluate ...
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Bipolar Cautery Catheter

A bipolar electrocautery valvulotome in the form of an elongated catheter having a longitudinal axis, a proximal end for being held and manipulated by a user, and a distal end. The device is used to remove the valves in veins for peripheral by-pass surgery. ...
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A Mouse Model of Hemophilia A

A transgenic mouse deficient in blood factor VIII has been developed. This mouse serves as a model of human hemophilia. ...
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Adaptive and Reconfigurable Chip for DC Motor Control

Abstract (Set) An integrated chip for control of position/velocity and torque of DC motor is provided. The technique uses armature current feedback and on-chip position/velocity estimate from an incremental optical encoder to implement a closed loop mechanism that controls the motor. The chip is re...
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Surface-Immobilized Antimicrobial Peptoids (28138)

Northwestern researchers have developed peptoid mimics of antimicrobial peptides that can be immobilized onto surfaces, rendering these surfaces capable of compromising the membranes of attached bacteria. ADVANTAGES: Peptoids afford promising alternatives to conventional antimicrobials because o...
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Device and Method for Measuring Spinal Reposition Sense (20013)

Proprioception is used by the body to communicate position sense and appreciation of movement of body parts. Receptors located in muscles, ligaments, tendons, capsules, menisci and the skin provide proprioceptive input about the body's static and dynamic position sense in space. A growing body of re...
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Sandwich Holder

INVENTION: The Sandwich Holder enables patients with limited use of their hands to independently feed themselves. In contrast to currently available sandwich holders, the Sandwich Holder delivers the following: Secure grip Sleek and discrete design Minimal readjustments during a meal Ease of ...
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List-mode Image Reconstruction Software for Positron Emission Tomography (PET) Imaging

Abstract (Set) The technology is software capable of performing accurate and efficient reconstruction of a high resolution PET scanner, namely the high resolution research tomography (HRRT). The software also includes state-of-the-art compensation capability. Description (Set) Proposed Use (Set...
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Novel Calcitriol Analogs

Abstract (Set) Five to eight million people in the US and 125 million people worldwide have psoriasis. Current treatment of Psoriasis includes Maxacalcitol, an oxa analog of calcitriol which is a necessary regulatory steroid hormone. Scientists at JHU have rationally designed and easily synthesized...
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Automate White Matter Parcellation Based on Diffusion Tensor Imaging

Brain white matter looks homogeneous in conventional MR. This makes it difficult to identify specific white matter regions (similar to locate a place in desert). DTI provides contrasts based on axonal fiber orientations, with which locations of specific white matter tracts can be visualized. This in...
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Biodegradable Polyphosphates for Controlled Release of Bioactive Substances

The present invention includes a series of polycationic biodegradable polymers, the process for making the polymers, and the process for making compositions contain polymers and bioactive ligands. The biodegradable polymers are capable of forming a complex with biological active substances which inc...
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Biofunctional Fibers

The present invention describes a method to functionalize polymeric fibrous scaffolds. Surface biofunctionalization is achieved by linking bio-functional ligands and growth factors onto polymeric biocompatible fibers. These biofunctional ligands are crucial for cell attachment, proliferation, and fu...
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PECAM-1 Related Compositions and Associated Methods of Use

PECAM-l (CD 31), a member of the IG superfamily, is expressed strongly at endothelial cell junctions, leukocytes and platelets. PECAM-l has been suggested to play a role in angiogenesis, vasculogenesis and is critical in mediating the transendothelial migration of monocytes. This is an important fir...
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Improved Fitting Calculation for Diffusion Tensor Imaging

Diffusion tensor imging is a new MRI modality, which is becomig a very important technque to assess various tyes of brain diseases. However, this technque has one weakness; its extreme sensitivity to patient motions. The image is often corrpted by patient motions as small as cardiac pulsation of the...
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Transplantable Membrane Systems for Use in Ocular Tissue Repair

The present invention is a novel non-immunogenic collagen vitrigel membrane for use in ocular tissue repair. The unique properties of the collagen vitrigel permit it to be transplanted alone or as a supporting film for corneal epithelial, stromal, endothelial, or other ocular surface tissue. The mem...
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Mutant DISC1 Inducible Transgenic Mouse Model of Schizophrenia

Description (Set) Transgenic mice with inducible expression of mutant human DISC1 (hDISC1) limited to forebrain regions were generated. Proposed Use (Set) The mouse model could be used to study of aspects of the pathogenesis and preclinical experimental therapeutics of schizophrenia. ...
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EmboGel / EmboClear Therapeutic Solution � Dissolvable radio-opaque alginate-based biomaterial for endovascular delivery and controlled therapeutic agent release

Johns Hopkins University is seeking licensees for EmboCaps and Emboclear. EmboCaps are an alginate matrix with controllable porosity that provides diffusion-controlled release of therapeutic agents. EmboClear is an alginate dissolving solution with minimal toxicity in vivo and enables erosion-contro...
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Pull-Out Resistant Pedicle Screw for Osteoporotic Patients

This novel device is a pullout resistant pedicle screw that will provide enhanced stability and fixation in osteoporotic spine surgery patients. The use of the new pedicle screw may also be indicated in patients necessitating revision surgery due to the fact that it increases osseous fixation and pu...
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A System and Method for Image Based MR Interventional Device Tracking and Scan Plane Guidance

The present invention is a method of using projection images for interventional device tracking. Specifically, the new tracking method involves acquisition, device detection on 2D projection images, reconstruction of the 3D device from its 2D projection, and selecting the plane of the device without...
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Platform for High-Quality 3D Elasticity Ultrasound

The Johns Hopkins University seeks a partner to commercialize a new platform for generating high-quality elasticity ultrasound images. The system uses a novel set of algorithms that integrate with traditional ultrasound machines to produce highly accurate and stable segmentation of areas with high o...
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Optimized MRI Strip Detectors

Strip MRI detectors offer the advantages over conventional detectors of minimal coupling and high-frequency operation as phased arrays. This invention is a method to optimize the SNR for MRI strip detector designs. The rules were determined by numerical electromagnetic Method of Moment (Mom) analysi...
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A Novel Method for Programmed Release of Biomolecules

Johns Hopkins University seeks a partner to commercialize a novel method for programmed release of biomolecules and nanoparticles. This is a useful tool for the controlled delivery of drugs, DNA, proteins, viruses, and nanoparticles. This invention provides a method to release small quantities of th...
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Multi-Imager Compatible Robot for Image-Guided Interventions and Fully Automated Brachytherapy Seed Injector

The present technology is a robot designed for image based percutaneous needle intervention of the prostate gland. The robot is constructed of nonmagnetic and dielectric materials for complete MR compatibility. The system utilizes a pneumatic stepper motor (PneuStep) providing the precision required...
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A Method for the Efficient Functional Examination of Mammalian Noncoding Sequences in Transgenic Zebrafish

sequence conservation is recognized as a reliable indicator of both coding and non-coding functional sequences. Consistent with this hypothesis, coding sequences may be readily identified based on evolutionary conservation. However, of the 5% of the human genome that is predicted to be functional ba...
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Microfluidic Device for High-throughput Cellular Gradient and Dose Response Studies

This invention is a microfluidic device made of a silicone elastomer (PDMS) that can be used for dose response, gradient detection, and chemostatic growth studies of most cell types, particularly non-adherent cells. The gradient is generated by the diffusion of molecules between two reservoirs of c...
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Device for High-throughput Stimulation, Immunostaining, and Visualization of Single Cells

This invention exploits the high efficiency and exquisite control afforded by microfluidic devices by allowing a group of cells to be stimulated in a precise and dynamically regulated fashion and stained in parallel. The device is composed of a series of chambers in which cells are seeded and susta...
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Pneumatic Stepper Motor

The present technology is a new pneumatic motor, a pneumatic stepper motor that can be easily controlled for precise motion. Directional rotary motion of discrete displacement is achieved by sequentially pressurizing three ports of the motor. This is the first pneumatic stepper motor. The motor asse...
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Image Guided Device for Rodent Brains

Stereotaxic device for rodent brains is widely used for various types of brain surgeries, injections, and other types of manipulations. The device is essential for many research labs in Universities and Chemical and Pharaceutical companies. For stereotaxic operations, precision is the key element. ...
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Dual Vector Information via Audible Pulse Oximeter Signals

This invention allows anesthesia providers to audibly detect both a patient�s oxygen saturation and blood pressure. Currently, the pulse oximeter signal carries information about oxygen saturation (via frequency) and heart rate (via time between pules). Modifying the timbre of the audible signal pro...
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Modified Pipette Tips for Plasma Collection

Description (Set) Blood collection is a common technique used in a variety of capacities ranging from human to mouse. In all cases, blood coagulation during and after collection can be fairly problematic. Scientists at Johns Hopkins University have invented a modified pipette tip designed to inhibi...
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A New Method for Co-registering PET and CT Images Acquired in Separate Dedicated Small Animal Scanners

Abstract (Set) Background - Positron Emission Tomography in dedicated small animal scanners is a very attractive imaging modality for many research applications due to the high sensitivity and potential for absolute quantification. However, PET images, although revealing valuable functional informa...
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Transcaval Mesenteric Venous Anastomosis and Access System

This device is used to create a percutaneous anastomosis between the Inferior Vena Cava (IVC) and the mesenteric/portal system. The subsequent anastomosis can be used to divert blood flow for the reduction of portal hypertension; and provide access into the mesenteric, portal, and splenic system for...
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IB3-1

Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?F508 /W1282X. Cells were immortalized with adeno12SV0. Description (Set) Proposed Use (Set) This cell line will be useful for the identification of drugs that treat cystic fibrosis. ...
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A Method of Assessing Vascular Reactivity Using Magnetic Resonance Imaging

precision, using magnetic resonance imaging. The most commonly used noninvasive technique for assessing arterial endothelial function employs ultrasound. There are several improvements using this invention. One problem with the ultrasound-based method is that shear rate during hypermia, the stimulus...
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A "Wireless" Scleral Search Coil for the Measurement of Eye Movements

The present invention improves upon the existing scleral search coil system by introducing a new ?wireless? contact lens. The new system uses a similar scleral contact lens on the eye but without the connecting wire leading to the amplifier system. Additionally, the transmitter/receiver coils are pr...
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Medical Device for Treatment of Ulnar Neuropathy

UlnarGuardTM is a non-invasive medical device used for treating pain and disability due to ulnar neuropathy. It is designed to worn under clothing so that patients can undergo treatment day and night. Background Ulnar nerve abnormalities are found in as many as 40% of adult Americans. Often due to e...
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Point-of-care Mass Spectrometer

The invention is an apparatus for clinical diagnostics using a point-of-care approach to mass spectrometry technology to provide a single broad-based assessment of viral infection, HIV, and/or cancer. The approach records a survey mass spectrum that can be compared with patients' baseline data to de...
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Disposable Sleep and Breathing Monitor

The apparatus consists of two parts, 1.) a calibrated flowmeter for measuring breathing and 2.) electrical sensors attached to the mask for measuring biomedical signals such as, but not limted to, oxygen saturation, head position as well as bioelectrical signals. The flow meter unit delivers a stabl...
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Hypothermia Induction Device

JHU researchers have developed a device that cools the heart and brain from normal temperature to mild hypothermia (35-32?C) within a few minutes. The device cools blood extracorporealy. It requires only venous access and thus suitable for uses in an out-of-hospital environment. The device is not de...
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Modified 0.8 mm-tipped Laparoscopic Dissecting Clamps used to Aid in Cavernous Nerve Preservation During Nerve-Sparing Laparoscopic Radical Prostatectomy

Laparoscopic radical prostatectomy has recently been proposed as a less invasive technique as compared to conventional open radical prostatectomy for the surgical management of prostate cancer. Preservation of the cavernous nerves during radical prostatectomy is a delicate surgical technique that is...
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The Cysteine Noose of the Attachment Protein of Respiratory Syncytial Virus Inhibits the Effects of the Endotoxin and the Innate Immune Response

Both endotoxin and RSV protein F stimulate CD14/TLR4 receptor in monocyte/macrophages resulting in a strong inflammatory response. In the case of endotoxin, this response has a direct pathogenic role in septic shock, autoimmune diseases, HIV, and asthma. And, it is the first response of the immune s...
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Interventional Devices for Chronic Total Occlusion Recanalization Under MRI Guidance

Recanalization of chronic total occlusion (CTO) is a chanllenging clinical procedure traditionally conducted under x-ray guidance to improve blood flow to patients with symptomatic ischemia. X-ray guidance generally does not provide satisfactory imaging nor geometric information about the artrtial c...
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A System for Macro-micro Distal Dexterity Enhancement in Microsurgery of the eye

The system is a system for providing dexterity inside the eye for micro-surgical procedures. The system includes a remote center of motion unit (RCM) and a Macro-Micro Distal Dexterity (MMDD) unit. the MMDD unit is of several unique design variants that provide dexterity, deliver a micro robot close...
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A Highly Accurate Ultrasound-Guided Interstitial Intervention

The Johns Hopkins University seeks a partner to commercialize a new approach to dramatically increase the accuracy of image-guided intervention systems, with the use of interstitial ultrasound. Click here for high-quality marketing materials. Description (Set) • Interstitial ultrasound (ISUS) ...
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A New Ultrasound Imaging Method for Prostate Visualization

The Johns Hopkins University seeks a partner to commercialize a new method of ultrasound strain imaging for prostate therapies. Click here to view high-quality marketing materials. Description (Set) • A major problem in prostatic interventions and therapies is localizing and tracking of the pr...
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A Novel, Robust Method for Ultrasound Probe Calibration

Abstract (Set) The Johns Hopkins University seeks a partner to commercialize a novel, robust method for calibration of an ultrasound probe. The technique relies on a unique closed-form solution that provides real-time quality assurance for two-dimensional and three-dimensional ultrasound data. By u...
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A Synthetic Torso for Training and Evaluation of Laparoscopic Skills

We report the development a new synthetic torso for urologic laparoscopy training allowing the placement of animal organs in situs. The trainer, Lapman, has the exact shape of a human torso, presenting abdominal and thoracic cavities. Animal and/or synthetic models of the abdominal organs can be rea...
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Method of Three-dimensional Video-oculography

JHU researchers describe a novel, inexpensive, method and apparatus for real time measurement of binocular three-dimensional rotational eye position and velocity. The method employs consumer grade digital video cameras to track an array of three fluorescent non-collinear markers affixed to each eye....
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A Novel Robotic Five-Dimensional Ultrasound System

The Johns Hopkins University seeks a partner to commercialize a novel robotic five-dimensional ultrasound system that incorporates four-dimensional ultrasound imaging (three spatial dimensions and time) with strain data in a unique volume-rendering pipeline to provide highly accurate ultrasound imag...
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A Radiometric Approach to Temperature Monitoring in the MR Scanner

The present invention offers a novel method of using the Magnetic Resonance (MR) scanner as a radiometer for measuring body temperature. This methodology utilized the radiated thermal noise to estimate the absolute body temperature by non invasive means. The methodology can be further extended to cr...
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Using Wireless Electromyographic Data to Infer Hand Applied Forces

In an effort to quantify hand-applied forces without instrumentation of the object, we have developed a force measuring system that can wirelessly transmit force-related information to a data acquisition(DAQ) unit. This system includes using electromyography (EMG) measurements of forearm and other s...
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Genetically Engineered "Down Syndrome" Mice

We used chromosome engineering to create mice that have the extra genes in a ?critical region? proposed to cause Down syndrome. These mice can be assessed for mental retardation as well as problems that occur in the heart, gut, muscle, immune, and skeletal systems that occur in Down syndrome Descr...
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MRI Flex Circuit Catheter Imaging Coil

The invention is a long, narrow, thin flexible piece of printed wiring board that can fit into an 8 French cardiac catheter that acts as a shielded coil useful for picking up magnetic lines of flux in a noisy electric field environment. The coil is deployed as a flat piece of flexible wiring through...
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MRI Compatible Positioning Arm

Scientists at Johns Hopkins have developed a family of passive positioning arms designed to carry a robot, instrument, or other tool at its distal end. The prototype has full six degrees of freedom (3 translation and 3 rotation) when unlocked, and the rigidity when locked to hold 100N at its fully e...
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Process of Fiber Fabrication by Intrefacial Polyelectrolyte Complexation and the Encapsulation of Biological Materials Within Said Fibers

This invention includes a method of producing drug-loaded fibers using interfacial polyelectrolyte complexation for tissue engineering. Fibers are produced by pulling from the interface between two polyelectrolyte solutions at room temperature. Drugs, proteins, cells, genetic materials and bioactiv...
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Electroporation System for Enhancing Wound Healing Using Plasmid DNA Expression Vectors

We have invented a gene therapy protocol (system, kit) that enhances wound healing. Our approach is to combine the application of plasmids expressing growth factors and the technique of electroporation to enhance transfection efficiency of the plasmid transfection. The combination of these two appro...
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A Chitosan-DNA Mucosal Vaccine for Respiratory Syncytial Virus Infection

A gene expression vaccine (GXV) comprising of a cocktail of pDNAs encoding nine immunogenic antigens was developed in the form of chitosan-DNA nanospheres. This GXV was tested in a BALB/c model of RSV infection. Results demonstrate that an intranasal GXV is safe and effective against RSV and signifi...
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Miniaturized Sample Scanning Mass Analyzer

This mass spectrometer is being developed as a compact analytical instrument capable of handling large sample arrays, such as the 96 and 384 microtiter sample formats. It is aimed at both research and high throughput screening applications. Description (Set) Proposed Use (Set) Protein research...
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Device, Method, and System for Needle Insertion Inside a Medical Imager, from Within Body Cavity

The Invention is a device, computerized system, and methods for entering a needle into the body inside a medical imager such as a MRI scanner, CT, X-ray fluoroscopy, and ultrasound imaging, from within a body cavity (such as the rectum, vagina, or laparoscopically accessed cavity). A three degree-of...
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Adjustable Remote Center of Motion Robotic Module

The invention is a robotic module that can be used to orient an end-effector about two axes intersecting at a fixed geometric point located distal to the mechanism materializing a pivot point or a Remote Center of Motion (RCM). A robotic tool (or end-effector) mounted on an RCM module will rotate ab...
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Noninvasive System for Assessing Cardiac Filling Pressure

Abstract (Set) The invention is a system for assessing cardiac filling pressure noninvasively. It consists of a device and method that can be used at the bedside, in clinic, in the emergency department, an intensive care unit, or at home. It can be used repeatedly and conveniently, and is inexpensi...
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Combination device and solution for efficient removal of insect from the ear canal

Abstract (Set) Johns Hopkins University is seeking a licensee for a combination solution and device for efficient removal of insects from the ear canal. A JHU Emergency department study showed that insects were found in 85% of adults with ear foreign bodies. The hard outer shell and legs of an inse...
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Ambulatory Raynaud's Monitor

Monitoring a person?s response to cold by recording their skin temperature is a key physiological response parameter for identifying Raynaud?s. This device would provide the means for physicians to definitively diagnose the disease without having to rely solely on a patient?s subjective feedback. Ac...
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System for Refibrillation of the Heart for Treatment of Post Countershock Pulseless Electrical Activity and Asystole

A method and/or system for inducing ventricular fibrillation (VF) of the heart for treatment of post-countershock pulseless electrical activity (PEA) or asystole. In certain example embodiments, it has been found that reinduction of ventricular fibrillation, followed by restoration of blood flow wit...
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A Multiple-projection DXA Scanner for Improved Accuracy and Precision in the Measurement of Bone Cross-sectional Geometry and Body Composition

Osteoporosis and a number of other diseases and conditions alter the mechanical strength of the skeleton such that bones fracture easily. A number of treatments exist that can mitigate the loss of bone strength, hence accurate diagnosis and assessment of the effects of treatment are critical. Bone-w...
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Laser-based CT and MR Registration

A simple method for robot and precise instrument registration in computer tomography and magnetic resonance imaging systems. The method uses the laser markers readily available on any CT or MR scanner. It does not require imaging thus eliminating radiation exposure in the CT case. Its accuracy is in...
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Design and Fabrication of High Performance AFM Cantilivers

High performance cantilevers with optimal combinations of high resonant frequency and low force constant are provided. AFM cantilevers with spring constants in the range 1-10-6 N/m with fundamental resonant frequencies in aqueous solutions of 0.1-100 MHz are provided. The high performance cantilever...
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Accessing the Scala Media of the Inner Ear with Robot Assistance

Accessing the scala media of the cochlea would permit the delivery of drugs, growth factors, gene therapy vectors and cells in order to treat hearing loss of cochlear origin. Many forms of hearing loss begin with trauma to the acoustic hair cell receptors, which in turn, initiates a downstream casca...
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Clinician's Portable, Digital, Intelligent Assistant (Pain Informatics Program)

The input devices are mobile pen-based computers and palm pad systems that will emulate and expand the clinician's present paper patient system. The system will provide for semi-automation of the collection, archiving, and retrieval of patient information. The Pain Informatics system provides medica...
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The Cardiac Ausculatory Recording Database (CARD): an Internet-based software Program and Digital Heart Sound Recording Database for Teaching and Study of Cardiac Auscultation

The Cardiac Auscultatory Recording Database (CARD) was also developed. Developed using the Microsoft Access relational database program, CARD is available online through the World Wide Web. CARD contains digitized heart sound recordings collected from patients at the Pediatric Cardiology Echocardiog...
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Analysis of Cardiac MR Relaxation Time Images with Application to Quantifying Myocardial Perfusion Indexes

The present invention is a method and apparatus for semi-automatically registering low signal to noise ratio relaxation-time images, with particular application to tracking motion in moving organs and quantifying myocardial perfusion reserve. For each image acquired in a time series, a corresponding...
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Controllable Motorized Device for Accurate Percutaneous Needle Placement in Soft Tissue Target

The invention is a motorized controllable needle driver for percutaneous delivery of needles and devices of circular cross section profile to soft tissue targets inside the body. The device can be used with flouroscopy, X-ray or CT (CAT-scan, or computed tomography) guidance in image guided surgery,...
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Auscultation Diagnostic Support Device

This invention is a screening tool for heart and lung aliments. Advanced signal processing techniques have been applied to heart and lungs sounds as an aid to diagnoses. A database containing patient demographics, relevant health information, physical exam results, ECG traces, echocardiograph diagno...
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Near-field Radio Frequency Planar Strip Array Antenna for NMR Imaging

A device for detecting electromagnetic signals, more specifically, the magnetic resonance signals from excited nuclei as well as related apparatuses, systems and methods is provided. This detection device includes a planar strip array antenna including a plurality, and in more particular embodiments...
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Transgenic Mice Expressing a Truncated Mutant of Rat Cardiac Troponin

Stunned myocardium is a reversible contractile failure secondary to coronary artery disease. It has been found that selected proteolysis of the protein troponin is associated with stunned myocardium and this effect has been modeled using transgenic mice expressing the major degradation product of tr...
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Circumferential Pulmonary Vein Ablation using a Laser and Fiberoptic Balloon Catheter

The purpose of this invention is to deliver near-infrared laser radiation radially from a diffusing optical fiber through an optically transparent distendable balloon to create complete circumferential thermal lesions at the pulmonary vein ostia or orifice. Electrical isolation of the pulmonary vein...
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Gastric Reduction Endoscopy

Methods and devices for partitioning or plicating a region of a hollow body organ are described herein. These methods and devices relate generally to medical apparatus and methods and more particularly to devices and methods for affecting a change in the function of a hollow body organ, particularly...
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Transgastric Peritoneoscopy

A novel approach to diagnostic and therapeutic interventions in the peritoneal cavity is described. More specifically, a technique for accessing the peritoneal cavity via the wall of the digestive tract is provided so that examination of and/or a surgical procedure in the peritoneal cavity can be co...
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A Flexible Retinal Vessel Cannulation Device

A microcatheter system that allows for vascular infusion into retinal veins for extended periods of time. The microcatheter system includes a flexible cannula that is inserted into the retinal vein lumen and that remains stably within the retinal vein lumen without being held by a robot, micromanipu...
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Method for Parallel Spatial Encoded Magnetic resonance Imaging

In a MR imaging system spins in a selected slice of the object are excited by RF excitation pulse and the signal is then received by an array of RF detectors. The phases of signals from multiple channels are uncorrelated and a Fourier-Hilbert Transform method analytically restores the phase coherenc...
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Intraoperative Microsurgical Ultrasound Device

Featured is a device that provides a mechanism for imaging structure and/or tissue of a surgical site during and after performing a microsurgical procedure such as ophthalmic surgical procedures. Also featured are methods and systems related thereto. In the imaging method of the present invention u...
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Surgical Device for Enhanced Perception

Featured are surgical devices that provide enhanced perceptual feedback to a medical practitioner in the form of e.g. tactile sensations or auditory feedback, and methods of use of the devices. The devices and methods of the present invention are particularly suitable for microsurgery applications i...
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Cardiac Sock Electrode and Implantable Defibrillator System

An object of this invention is to provide an implantable cardioverter defibrillator (ICD) system and/or method that is less painful to a patient than one or more conventional ICD systems/methods. Another object of this invention is to provide a flexible array including a plurality of electrodes for ...
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Non-traumatic Infusion Cannula

In preferred aspects, the present invention features a non-traumatic cannula for use in connection with eye surgery, such as retinal tear and/or detachment surgery. The non-traumatic cannula of the present invention is particularly configured so as to minimize or avoid the potential for damage to th...
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Injectable Bag Intraocular Lens System

Featured is an injectable intraocular lens system including an insertion and injection device and an injectable intraocular lens. In its broadest aspects, the injectable intraocular lens is a deflated flexible bag that is disposed within the insertion and injection device prior to insertion into the...
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MR Safe Coaxial Cables

This invention is a novel coaxial cable design that will reduce the induced currents and hence the risk of excessive heating or burns in MR scanner. Compact resonance circuits/structures are placed along the length of a coaxial cable with short intervals in a way that an external field could not ind...
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A Surgical Needle Probe for Electrical Impedance Measurements

An electrical impedance probe constructed within a surgical needle. The probe consists of a two-part trocar needle designed to acquire impedance measurements at its point. Since the impedance of cells varies by cell type, the new probe may be used to confirm needle position in a desired anatomical t...
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Brain Stimulation as a Treatment for Seizures

The present invention includes adaptive technologies to detect and treat brain seizures. Neural networks or other mathematical methods which model seizure patterns are used to detect the seizures. A number of methods for simulation are suggested which include increasing the output of inhibitory stru...
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Tympanic Membrane Prosthesis with Mechanical Fixation

Perforations of the tympanic membrane result from many different processes such as infections of the middle ear, direct trauma to the eardrum, or poor post-operative healing. They usually do not present an immediate danger to the patient?s hearing apparatus, but they can lead to symptoms of decrease...
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Passive Intraocular Pressure Sensors & Patient-Worn Monitorying Recorder

A device for passively measuring intraocular pressure of a patient including an in vivo sensor and an instrument external to the patient for remotely energizing the sensor, thereby permitting the instrument to determine the intraocular pressure. The device directly and continuously measures the intr...
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Eye Fixation Monitor and Tracker

The eye fixation monitor can non-invasively and remotely detect when a human eye looks directly at it. The apparatus illuminates the eye with infrared light energy, uses a photodetection system to analyze polarization-related changes in the light reflected by the fundus of the eye, and identifies th...
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Friction Transmission with Axial Loading

As a common characteristic of friction rotational-translational transmissions, the force generating the friction was oriented radial with respect to the rotational shaft of the transmission. Our approach differs in this orientation of the friction loading. To the best of our knowledge, such an appro...
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Method to Objectively Quantify the Level and Density of a Neural Blockade

Electromyogram (EMG), temperature, and heart rate measurements, which correlate to the dermatomal level and density of neural blockade, are obtained in a passive manner, i.e., the patient is not stimulated or exposed to any sensor that requires an active conduction in order to make a measurement and...
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Device forTranstracheal Insufflation in Treating Obstructive Sleep Apnea

A novel ventilatory support system which controls the flow of breathing gas to a patient based upon the physiological need of the patient is disclosed. Gas pressure in the trachea of the patient is monitored to control breathing gas delivery to the patient. The breathing gas flow rate (Vin) to the p...
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Method for Assessing Cardiac Contractility and Cardiovascular Interaction that may be Applied to Non-Invasive Clinical Practice

It has been found that E.sub.N (t.sub.N) curves are surprisingly similar among hearts, particularly during early contraction. Based on this observation, the present invention provides an arrangement (method and apparatus) for determining a good approximation of ESPVR using pressure, volume and timin...
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A Method for Designing Non-Linear Field Reflectrons

This is an approach to the design of reflectron time-of-flight mass analyzers that utilizes a cylindrical geometry to achieve nearly-quadratic retarding and reflecting fields without employing a set of resistively-coupled lenses. The mass analyzer consists of a simple grounded cylinder capped with a...
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Transcatheter, Non-surgical Left Ventricular Assist Device

The invention comprises a method and device for draining blood from the left atrium of the heart by utilizing a cannula and catheter in which a guide wire and a needle assembly are positioned axially. The guide wire and the needle assembly can be extended alternately through the distal catheter orif...
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Cryo Filter Exchanger

This device maintains parallelism between diffracting crystals while allowing the crystals to continuously travel through high to low take-off angles. A central shaft that rotates by one half of the value of the take-off angle drives the device. The central shaft allows for variable collimation to t...
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Virtual Instrument & Permeability System

This camera-based system provides improved water permeability measurement over prior LED methods. Rather than tracking air bubbles by sensing light transmisson, this system uses a camera and virtual instrument to capture the bubble images. The software uses a pattern recognition algoriithm to identi...
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Copper-Based Probes for Determining Nucleic Acid Structure in Vitro and in Vivo

The present invention is related to a novel method for splitting nucleic acids at specific points on a complementary nucleic acid segment using a trinuclear copper-based compound of formula (I). Additionally, the present invention is related to a novel treatment of cancer, tumors, and cancer cells u...
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Multi-Band Image Analysis

Computation of contrast, which includes computation of gradient and zero-crossings, has been used in computer vision as one of the primary methods for extracting grayscale and color features. It seems plausible, therefore, that the correct way to compare versions of the same image in terms of featur...
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Miniature Immuno-Optical Rapid Analyte Sensor Platform

A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereb...
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Apparatus and Method for Exercising and Measuring Strength of a Patient's Limb

An apparatus for measuring the strength of and for performing physical therapy exercises to strengthen a patient's limb. The device includes a pair of pivot clamps each having a end for connecting the pivot clamps to a solid object such as a physical therapy table or hospital bed. A second end of ea...
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Polarization Lens

The present invention pertains to a polarization viewer. The polarization viewer comprises a mechanism or means for forming a broadview image having a spectral width preferably greater than 2 angstroms and 0.50.degree. based on polarization information of a scene, although it can be used in that ran...
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Skills Trainer for Robotic Surgery

Robotic surgery is becoming increasingly popular with the advent of robotic technology in medicine. With this, there arises a need to extensively train the surgeons to effectively use these devices. Surgeons using these robotic systems need to be tra ined for a large number of procedures before bein...
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CPAP titration using artificial neural network

For 18 million Americans suffering from Obstructive Sleep Apnea (OSA) this is as frustrating as a dog chasing its tail. Lack of proper sleep can lead to severe health problems and increased risk of accidental death. Continuous Positive Airway Press ure (CPAP) provides effective treatment. However, d...
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Intestinal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments invo...
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Esophageal Coupling Rings

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments invo...
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Esophageal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments invo...
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Catheter for endovascular intervention

A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device...
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Non-Invasive Screening Device for Upper Aerodigestive Tract Neoplasia

Diagnostic medical equipments are probably one of the most important paraphernalias of the medical field. This is because of the fact that in all the medical procedures, diagnosis is the first step towards combating diseases. It assumes critical impo rtance when the diseases are of the nature that r...
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Methodology for the Synthesis of fluoride (NaYF4) nanophosphors co-doped with Gd3+ and other rare-earth ions and its applications in security printing and bimodal (optical and MRI) imaging

Methodology for the Synthesis of fluoride (NaYF4) nanophosphors co-doped with Gd3+ and other rare-earth ions and its applications in security printing and bimodal (optical and MRI) imaging Categories: Materials & Chemicals, Imaging: Medical Imaging ...
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Skills Trainer for Robotic Surgery

Robotic surgery is becoming increasingly popular with the advent of robotic technology in medicine. With this, there arises a need to extensively train the surgeons to effectively use these devices. Surgeons using these robotic systems need to be tra ined for a large number of procedures before bein...
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Catheter for endovascular intervention

A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device...
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CPAP titration using artificial neural network

For 18 million Americans suffering from Obstructive Sleep Apnea (OSA) this is as frustrating as a dog chasing its tail. Lack of proper sleep can lead to severe health problems and increased risk of accidental death. Continuous Positive Airway Press ure (CPAP) provides effective treatment. However, d...
...

Non-Invasive Screening Device for Upper Aerodigestive Tract Neoplasia

Diagnostic medical equipments are probably one of the most important paraphernalias of the medical field. This is because of the fact that in all the medical procedures, diagnosis is the first step towards combating diseases. It assumes critical impo rtance when the diseases are of the nature that r...
...

Intestinal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments invo...
...

Esophageal Coupling Rings

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments invo...
...

Esophageal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments invo...
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Stent Vascular Intervention Device and Method Modification

A team of University at Buffalo researchers has developed novel stent vascular devices for the treatment of cerebral aneurysms. The new stents can be deployed by a conventional balloon-catheter and a single stent could replace the use of multiple emb olic coils resulting in reduced procedure duratio...
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Stent Vascular Intervention Device and Method Modification

A team of University at Buffalo researchers has developed novel stent vascular devices for the treatment of cerebral aneurysms. The new stents can be deployed by a conventional balloon-catheter and a single stent could replace the use of multiple emb olic coils resulting in reduced procedure duratio...
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Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— either inherent to the structure or appended to it. Unfortunately, not every important substrate has a con...
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"MoleProbe": a Real-Time Molecular Diagnostic Device

Summary A novel engineering method for generation of freestanding 2-D and 3-D tissue structures. Biopolymers (proteins, carbohydrates, lipids, nucleic acids or combinations thereof) are deposited onto a transitional polymer surface with a patterning technique that allows for nanometer-to-millimeter-...
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Enhanced Nanoparticle-Based Molecular Imaging via MRI

Summary Enhanced Nanoparticle-Based Molecular Imaging via MRI Elevator pitch: For biotech and pharmaceutical companies who need to track drug effectiveness in the drug discovery and for MRI facilities, hospitals and physicians who seek to diagnose and treat specific diseases through molecular im...
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Compounds and Methods for Tumor-Specific Targeting

Summary A novel strategy for developing cancer-homing drugs has been developed by Dr. Amin Kassis that combines Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) with radionuclides (see figure below). This powerful method achieves a multimodal effect, since it can be exploited for therapeutic effic...
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Biological Computers: in Vivo Autonomous Doctors that Diagnose and Treat Disease

Summary Background: The promise of computers made from biological molecules lies in their potential to operate within the biochemical environment of a living organism and to interact with that environment through inputs and outputs with other biological molecules. For example, a biomolecular compute...
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Slowing Down Light for Enhanced Detection of Biomolecules

Summary Allows for optical sensing and chemical and biological detection using extremely small and highly-sensitive devices. Also allows for fabrication of exceptionally small lasers for applications in displays and telecommunications, quantum optical devices, and barcoding. Applications The phot...
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Robust and inexpensive actuator to generate motion in small-scale devices

Summary Innovation and Advantages: The invention is a novel design and fabrication of a millimeter scale SMA actuator used to generate motion. In addition, the researchers have developed a novel system for annealing shape memory alloys (SMA). This system allows for the creation of a spring that has ...
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New Nitrate Measurement Method

Summary By employing novel filtration methods, this semi-continuous ambient particulate nitrate monitor measures the concentration of particulate ammonium nitrate (NH4NO3) contained in PM2.5. The device consists mainly of an inlet, filter, heater and detector. In 10-minute cycles, nitrates are c...
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An Ultra Low Power System Architecture for Sensor Network Applications

Summary Ultra-low-power chip for sensor network applications Application and Benefits: Wireless sensor networks (WSNs) are used in a wide variety of applications including environmental monitoring, vehicle tracking, health-care, and business supply-chain management. Often such networks must prov...
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Smart Balloon Catheters for Diagnosis and Therapy of Narrowing Lumen

Summary Modern techniques for the diagnosis and treatment of narrowing of lumen can use dilating balloon catheters. A common risk with such procedures -- for instance, in the case of peptic and non-peptic strictures, or the sweeping of ducts -- is the improper dilation of the balloon catheter. In th...
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A Novel Color Filter Array Design

Summary Background In digital imaging applications, data are typically obtained via a spatial subsampling procedure implemented as a color filter array (CFA). CFA assigns a separate primary color to each pixel by placing a filter of that color over the pixel. The most well known CFA is the Bayer ...
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Device and Method for Restoration of Sight through Patterned Thalamic Microstimulation.

Summary This technology aims to restore sight in people who are blind due to disease or injury by placing an electrode implant in a part of the vision system known as the lateral geniculate nucleus (LGN). Unlike other visual prostheses in development, this new approach could make it possible to trea...
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Target-locking Confocal Microscope System

Summary Eliminating tumors via a non-invasive target-locking technology Markets/Needs Addressed: Many tumors occur in parts of the body that are difficult to locate and image dynamically (e.g., colon, stomach or lung tumors) because a patient’s breathing can causes the entire area to move sev...
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Biological Computers: in Vivo Autonomous Doctors that Diagnose and Treat Disease

Summary Background: The promise of computers made from biological molecules lies in their potential to operate within the biochemical environment of a living organism and to interact with that environment through inputs and outputs with other biological molecules. For example, a biomolecular compute...
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Novel way of brain mapping to be used in pre-surgical planning

Summary Innovation and Advantages: Harvard researchers have developed a method for mapping the organization of a patient’s brain for pre-surgical planning by using functional MRI, but without requiring performance of specific task. With this system, a patient would lie in an MRI scanner, at rest w...
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Slowing Down Light for Enhanced Detection of Biomolecules

Summary Allows for optical sensing and chemical and biological detection using extremely small and highly-sensitive devices. Also allows for fabrication of exceptionally small lasers for applications in displays and telecommunications, quantum optical devices, and barcoding. Applications The phot...
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Robust and inexpensive actuator to generate motion in small-scale devices

Summary Innovation and Advantages: The invention is a novel design and fabrication of a millimeter scale SMA actuator used to generate motion. In addition, the researchers have developed a novel system for annealing shape memory alloys (SMA). This system allows for the creation of a spring that has ...
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New Delivery Device for Protein Therapeutics and Vaccines

Summary Harvard's researchers have developed a new device for protein and gene delivery. It makes use of the unique ability of unicellular organism protozoa to infect a host, evade their immune defense, and target specific tissues. Protozoa are single-celled, independently living eukaryotic organism...
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Animal Model of Diabetes and Obesity: Cross-bred JNK1 KO/JNK 2 KO Mice

Summary Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity. Nature: Vol 420, Nov 21, 2002, pp 333-336 ...
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Elucidating Novel Protein Interactions Using MALDI-MS and a Self-Assembled Monolayer Chip

Summary The ability for real-time identification of protein binding from whole cell lysates is a challenge for protein microarrays. This invention uses MALDI-MS to analyze complex biological mixtures using a protein or small molecule microarray, which is characterized by a self-assembled monolayer o...
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Enhanced Nanoparticle-Based Molecular Imaging via MRI

Summary Enhanced Nanoparticle-Based Molecular Imaging via MRI Elevator pitch: For biotech and pharmaceutical companies who need to track drug effectiveness in the drug discovery and for MRI facilities, hospitals and physicians who seek to diagnose and treat specific diseases through molecular im...
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Crosslinkable Hole Transporting Materials for Organic Lightemitting Diodes

Introduction High-performance organic or polymer light-emitting diodes comprise multilayer configurations having hole-transporting, emissive and electron-transporting layers to balance the injection and transport of both holes and electrons. In general, holetransporting material is the first applied...
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Non-toxic protocol to establish paraoxonase 1 (PON1) status

Introduction Paraoxonase 1 (PON1) is a member of a three-gene family localized on human chromosome 7. Due to its role in the metabolism of both lipids and organophosphorus (OP) compounds, genetic variability in PON1 has been examined by many research groups as a risk factor for vascular and other d...
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Use of Adhesion Molecules as Shear-Induced Nanoscale Binding Switches

Introduction Methods, compositions, and devices for using shear-dependent binding switches in a variety of applications would be extremely useful in biomedical and other fields. Applications for this technology include the following: 1) as a non-invasive probe for force fields; 2) to control the agg...
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Optical Coherence Tomography: High-Resolution Balloon Catheter Imaging, Dispersion Management, and Lateral-Priority Real-TimeImaging and Focus Tracking

Introduction Optical coherence tomography (OCT) is an imaging technique that uses light to acquire three-dimensional images of biological tissue. This non-invasive technique generates highquality images in real time and easily integrates with existing endoscope technologies. It is commonly used to i...
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A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys...
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Localization Wire for Surgical Excision of Breast Lesions

Introduction With the introduction of screening mammography, the median tumor size has decreased considerably, and approximately half of breast cancers in surgical practice are non palpable and amenable to breast conserving surgery. Traditionally, non palpable lesions are excised with a wire or wire...
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Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTPA complexes approved for clinical use are cleared within a few minutes and do not provide sufficient...
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Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p...
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Tissue-Engineered Urinary Bladder Using Autologous Cells

Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladders tend to suffer from critical complications, such as inadequate performance, infection, and adverse h...
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Advanced Biomimetic Surfaces for Surface-Enhanced Raman Spectroscopy (SERS)

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subj...
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Networked Surgical Robot Control System

Introduction The individual soldier remains the most valuable asset of the military and in spite of the current emphasis on the threat of weapons of mass destruction, and biological warfare, attending to the soldier's needs when they become a casualty remains a top priority. There is a significant o...
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A Staged Balloon-Tipped Overtube for Endoscopic Peritoneal Access

Technology description Researchers at the UW have developed a staged balloon-tipped overtube for improved peritoneal access, particularly applicable to trans-gastric endoscopic surgery. The field of minimally invasive surgery has recently focused on the use of natural body lumens as a point of entry...
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Evanescent Wave Coupling Sensor for Shear/Pressure Measurement

Introduction Lower limb complications associated with diabetes include the development of plantar ulcers that can lead to infection and subsequent amputation. Several authors have postulated that shear stress is an important component of ulcer development. While it is known from force plate analyses...
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Novel Spherical Mechanism for Minimally

Introduction Minimally invasive surgical instruments coupled with robotics are being used in a vast array of modern surgeries to minimize patient trauma and reduce recovery time. As these instruments progress in their capabilities, the need for smaller and more robust mechanical joints becomes incre...
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A Method and Design for Performing Rapid Parallel Microfluidic Molecular Affinity

Introduction Point-of-care diagnostic testing, or testing performed at the patient bedside, allows physicians to diagnose patients more rapidly than traditional laboratory-based testing. Rapid results can enable better patient management decisions, improved patient outcomes, and a reduction in the o...
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A Prosthetic Liner incorporating Shear & Pressure Sensors

Introduction Fitting prosthetic limbs for amputees is a time-consuming, tedious process that is more art than science, often requiring ten or more visits by the patient before the proper fit is achieved. Changes in the size and shape of the limb over time need to be monitored and adjustments made to...
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Periarticular Plates

Introduction A bone plate is typically used to maintain different parts of a fractured bone substantially stationary relative to each other during and/or after the healing process in which the bone mends together. A bone plate which attaches to both a head and the shaft of the bone includes an elong...
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Signal Amplification Method for SPR-based Chemical Detection

Introduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versatile platform for the observation and quantitation of chemical reactions and intermolecular binding at...
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Interactive 3D Registration of Ultrasound and Magnetic Resonance Images based on a Magnetic Position Sensor

Introduction Accurate guidance and localization of the surgical tool within the brain is essential for the success of various neurosurgical procedures, such as biopsy or tumor resection. Stereotactic systems provide guidance to the surgeon based on preoperative tomographic images, such as CT and MRI...
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Microfabricated multiplexed devices for sample application and sample delivery to a microelectrospray-mass spectrometer

Introduction The most conclusive and reliable protein identification method is based on correlating collision-induced dissociation (CID) mass spectra of peptides with sequence databases. CID spectra of peptides are most frequently generated by electrospray ionization tandem mass spectrometry (ESI-MS...
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Wearable Low Vision Aids Using Retinal Light Scanning Technologies

Introduction Severe visual impairment (those persons classified as legally blind) affects over 1 million Americans currently. With the aging of the U.S. population, this visually impaired segment is expected to rise at 10 times the rate of general population growth. Technology description Researcher...
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Endoscopic Imaging Devices Using Micromotor Scanners

Introduction Endoscopes are increasingly involved in performing common surgical procedures and in diagnosing cancer and other medical conditions. New technologies can demonstrate significant cost savings by moving these procedures from an inpatient to an outpatient setting. Technology description Re...
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Programmable Logic Controller Safety System for Surgical Robot

Introduction Surgical robotics is revolutionizing the way in which clinicians deliver health care. As the field of surgical robotics continues to evolve, it is important to keep patient safety in mind. A surgical robot presents a complex software and hardware system with strong requirements for safe...
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Mobile Antiseptic Spraying Tube (MAST)

Introduction Pneumatic tube systems are integrated within the walls and ceilings of many biomedical facilities and allow for the rapid transport of important materials, such as lab specimens and blood and tissue samples. In such a system, contamination due to biohazards must always be a concern, and...
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Grasper Pad Sensing

Introduction Minimally invasive surgery is now being used routinely as one of the most preferred choices for various types of operations. Despite its many advantages, such as reduction of trauma, less pain, smaller injuries, faster recovery time, and reduction of postoperation complications, MIS dec...
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Microfluidic Platform for Assessment of Blood Coagulation

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p...
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Active Contact Lens

Introduction The interstitial fluid in the eye over the cornea is in indirect contact with blood serum via capillaries in the eye and is a good target for biomarkers that signal certain health conditions. If sensors and data transmitters could be implanted in a contact lens, the health of the user c...
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Programmable Ultrasound Back-End System Using Multi-Core Processor

Introduction Ultrasonography is a noninvasive medical imaging technique, which utilizes ultrasonic waves to visualize soft tissue within the body, and advances in this technology have led to various therapies, including those that utilize high-intensity focused ultrasound (HIFU) capable of rapidly ...
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Micro-Fabricated Thermal Conductivity Sensor for Biomaterials

Introduction Advances in microscale technology are constantly opening doors to new and exciting applications. Of special interest, novel microscale biosensors and other diagnostic devices promise to revolutionize patient care and biomedical research with point-of-care devices, personalized medicine,...
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Design of Bio-Actuator for Medical Treatment Based on Ferromagnetic Shape Memory Alloy Helical Spring

Introduction FSMA (ferromagnetic shape memory alloy) materials provide fast speed of actuation using magnetic fields and large strain and stress capability. Technology description Researchers at the University of Washington have developed applications for FSMA devices in stents encapsulated with mic...
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Polymer Solar Cells using Self-Assembled Monolayer modified Zinc Oxide/Metal as Cathodes

Introduction Conjugated polymer-based organic solar cells are considered an essential source of inexpensive renewable energy due to their advantages of being fabricated by low-cost and large-area printing and coating techniques on light-weight flexible substrates. Bulk heterojunction (BHJ) solar cel...
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Safe last step

Introduction A common cause of injury among orchard workers in Washington state occurs when the user dismounts the ladder. The user often cannot accurately gauge the last step of the ladder because the line of sight is obscured by the apple bag when descending the ladder, with their back facing the ...
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Fast Calibration for 3D Ultrasound Imaging and Multimodality Image Registration

Introduction Three-dimensional (3D) localization of two-dimensional (2D) ultrasound (US) images involves the determination of the position and orientation of a set of acquired 2D US images with respect to a given coordinate system. Accurate image localization is critical when US is used for the mea...
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Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventional techniques have significant drawbacks: for instance, electrochemical techniques have low sensiti...
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Episodic Monitor

Introduction Epilepsy affects over three million Americans and is characterized by recurring seizures, which typically involve problems with motor, sensory, and/or cognitive functions. These seizures may occur with or without loss of consciousness. One of the hazards of having a seizure, especially ...
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Feiter a New Method of Brain Scanning

BACKGROUND A number of techniques are available for brain scanning and imaging including CT scanners, MRI, fMRI and PET. All require large expensive fixed installations and cannot be made available in all hospitals. Their imaging speed does not allow measuring brain activity or functional responses ...
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An Innovative Implant for Treating Glaucoma

The Invention The Glaucoma Implant is a new shunt that eliminates the complications created by devices currently in use and it may eliminate the need for repeat surgeries. It is small in size, easy to implant and thus causes less discomfort for the patient and results in faster recovery time. For h...
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DQF-MRI Strain Maps of Blood Vessel Walls

The Invention Two images that display a 2D map of a bovine coronary artery, unstressed (Left) and 55% elongated (Right). Strain maps of blood vessels walls, tissue composition and strain distribution are now possible through the use of DQF-MRI (Double Quantum Filtered-MRI). This innovative m...
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Slice-Selective DQF-MRI of Connective Tissues

The Invention Reduced signal loss and the achievement of optimal contrast for imaging tendons and ligaments are made possible through the innovation of Slice-Selective Double Quantum Filter MRI (DQF-MRI). This new DQF-MRI is performed on a time scale shorter than any previous imaging sequence, ma...
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MRI Sequence for Macromolecule Characterization of Brain Tissue

The Invention Brain macromolecules can now be detected and identified according to contrasting macromolecular characteristics of the tissues, using this new MRI sequence. The dynamics and rigidity of a host of macromolecules can be identified, including proteins and lipid membranes. In the brain ...
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Real-time Diagnosis of Ovarian Malignancy

The Invention Automatic, non-invasive and immediate diagnosis of ovarian malignancy with an accuracy rate of over 90% is made possible through this innovative Real-time Diagnostic ultrasound package. The package includes two components, which together increase the likelihood of a highly accurate...
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Improving Speech Intelligibility for the Hearing Impaired

The Invention An improved method for processing audio inputs to hearing impaired, allowing them to better understand speech in a noisy environment The Need Most common speech enhancement techniques were designed and developed on the basis of cochlear psychoacoustical and physiological research. I...
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Drug-Eluting Bioresorbable Composite Fibers for Medical Applications

The Invention A novel class of bioresorbable, composite (core/shell) fibers loaded with bioactive agents (hydrophobic or hydrophilic) has been developed. These fibers have: excellent tensile mechanical properties (high strength and flexibility) desired controlled release profile. controllabl...
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Contrast Improvement in CT images

The Invention An improved algorithm for handling CT scan information which enables the display of all relevant anatomical features in a single image. The Need An important clinical problem in radiology is the inability to see abnormalities in tissues with marked differences between their X-ray...
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Passive accurate detection of elderly patient falling events

The Invention A very accurate method utilizing a combination of non-intrusive installed vibration detectors and microphones to detect the fall of humans in the domicile. The Need The elderly desire to remain independent as much as possible. This translates to living alone without constant superv...
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Production of Novel Human Collagens

BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the University of Manchester. The collagens most closely mimic human collagen structure, giving a far superio...
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Feiter a New Method of Brain Scanning

BACKGROUND A number of techniques are available for brain scanning and imaging including CT scanners, MRI, fMRI and PET. All require large expensive fixed installations and cannot be made available in all hospitals. Their imaging speed does not allow measuring brain activity or functional responses ...
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A Device for Treating Swallowing Problems (dysphagia) After Stroke

Swallowing problems after stroke are common, with over 40,000 patients annually in the UK suffering from dysphagia and its attendant consequences of aspiration pneumonia and malnutrition. This leads to longer hospital stays, increased demands on feeding resources, higher admissions to nursing homes ...
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Novel Antimicrobial Peptides

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY ...
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Methods of Identifying Lung Homing Molecules Using Membrane Dipeptidase

Methods of Identifying Lung Homing Molecules Using Membrane Dipeptidase 6,174,687; 6,232,287; 6,933,281; 6,784,153; 6,610,651;...
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Thryroid Hormone Receptor

Thryroid Hormone Receptor...
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Molecules that Home to a Selected Organ or Tissue in Vivo and Methods of Identifying Same

Molecules that Home to a Selected Organ or Tissue In Vivo and Methods of Identifying Same...
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Hybrid Automated/ Curated/ Peer-Reviewed Publication System

Hybrid Automated/ Curated/ Peer-Reviewed Publication System...
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High Affinity EPHB Receptor Binding Compounds and Methods of Use Thereof

High Affinity EPHB Receptor Binding Compounds and Methods of Use Thereof...
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Nucleic Acid Encoding Proteins Involved in Protein Degradation, Products and Methods Related Thereto

Nucleic Acid Encoding Proteins Involved in Protein Degradation, Products and Methods Related Thereto...
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PAAD Domain-Containing Polypeptides, Encoding Nucleic Acids, and Methods of Use

PAAD Domain-Containing Polypeptides, Encoding Nucleic Acids, and Methods of Use...
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Producing Energetic, Tunable, Coherent X-rays with Long Wavelength Light

A coherent X-ray source based on low power laser has been developed to replace traditional synchrotron as a radiation source. It is much cheaper to build and operate than a synchrotron and it is has also a much compact set up. This is achieved through the generation of high harmonic radiation with l...
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Quantitative Quantum Yield Measurements Using Flourescents Modulated Imaging

Background: Modulated imaging (MI) is a non-contact imaging modality that employs broadband, spatially modulated illumination capable of wide-field imaging, depth sectioning of turbid media, and the simultaneous extraction of the optical absorption (µa) and reduced scattering (µs') properties. The ...
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High Sensitivity Optical Coherence Tomography

Background: Optical coherence tomography (OCT) is a non-invasive sub-surface optical imaging modality with high axial resolution and high signal to noise ratio compared to other imaging modalities such as ultrasound and MRI. Depending on the tissue's scattering and absorption, usually the imaging d...
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Flexible Endoscopic Tube

Background: In performing, through an anatomical channel inside the body, a diagnostic or surgical procedure, the surgeon or operator may need to rotate with precision the distal end inside the body, from the proximal end outside the body. Precise transfer of angular rotation from the proximal to t...
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Intragastric Balloon for Treatment of Obesity

Background: The BioEnterics Intragastric Balloon System™ is a non-surgical, non-pharmaceutical alternative for the treatment of obesity. The balloon system is designed to provide loss therapy to reduce health risks related to obesity or risks prior to vital supervised weight loss program. Endoscopi...
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Fabrication of Renewable RNA Microarrays and Methods

Background: Numerous methods and devices are available to detect and/or quantify target DNA in a test sample. In almost all of these methods, detection and/or quantification are performed utilizing a detectable label such as radiolabels, fluorescent and luminescent labels. Methodologies employing l...
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Use of Optical Coherence Tomography (OCT) for Use of Comprehensive Intra-oral Diagnosis

Background: In dentistry there exists a pressing need for novel diagnostic modalities. A strong consensus for reducing patient exposure to ionizing radiation is countered by the absence of other non-invasive diagnostic and monitoring tools. Diagnostic options for soft tissue pathologies are also li...
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Formulation of Monodisperse Contrast Agents in Microfluidic Systems for Ultrasonic Imaging

Background: Ultrasound imaging may be used to produce a 2D image of the body's internal structures. However, since blood is much less (1000x less) echogenic than tissue, small vessels, blood pool volume and blood flow all are difficult, if not impossible, to image using traditional ultrasound techn...
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Total Ankle Arthroplasty

Background: Total ankle arthroplasty (TAA) is the process of replacing a diseased ankle with a prosthetic ankle. Over the years there have been several efforts to provide a total ankle replacement solution. However, all such current solutions have significant drawbacks, including complications relat...
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Fluoro-Free Guidewire for Improved Colonscope

Background: Endoscopes with a soft insertion unit can be inserted into the lumen of a body cavity to diagnose problems located in a deep region in the body cavity without the necessity of incision and can also be used to guide treatment appliances to a desired location within the body cavity. In th...
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A Diffusive Probe for Quantification of Optical Properties of Superficial Layers

Background: Diffuse optical spectroscopy (DOS) has been successfully employed for quantitative determination of in vivo optical properties and chromophore concentrations of deep tissues such as breast and brain. This invention is a method and probe design for obtaining quantitative optical properti...
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Robotic Hip Swinger

Background: Over 700,000 people in the U.S alone suffer strokes each year often resulting in an impairment of walking ability. A popular approach to locomotion rehabilitation called body weight supported (BWS) training shows promise in improving locomotion after strokes. However the technique invol...
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Corneal Transplantation

Background: Corneal damage due to accident or disease results in varying degrees of blindness in millions of individuals throughout the planet. In some cases it is possible to restore vision by a corneal transplant. A full-thickness transplant (penetrating keratoplasty, PK) runs a high risk of graf...
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Humidity and Temperature Sensor Device for the Determination of Oxygen Consumption in Medical Applications

Background: The determination of oxygen consumption is an important monitor of normal cardiopulmonary and tissue function in anesthesia and critical care medicine. This requires accurate measurement of inhaled and exhaled volumes. Traditionally, it has been very difficult to measure the extra volum...
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A Method and Apparatus for Use in Antifibrotic Therapy of Ophthalmic Filtration Surgery

A Method And Apparatus For Use In Antifibrotic Therapy Of Ophthalmic Filtration Surgery ...
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Tissue Viability Monitor

Background: The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernatio...
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Novel Device for Determining the Viability of Human Myocardium Or Other Animal Tissues

Background: The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernatio...
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New Multimodal Probes Compatible with Flourescence and MRI

APPLICATIONS OF TECHNOLOGY: - Effective as multimodal probes for: - Imaging - Targeting specific cells or tissue - Therapeutics delivery and imaging in vivo or in vitro - Detects locality and size of diseased cells by MRI, PET, ESR, or deep tissue NIR with greater sensitivity than possible with ex...
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Nanotube Radio for Communications and Medical Applications

APPLICATIONS OF TECHNOLOGY: - All-in-one radio receiver for cell phones/wireless networks/GPS and other electronic devices - Radio controlled devices that can exist inside the body, e.g. used as drug release triggers, diagnostic instrumentation, interfacing with muscle or brain function - Ultra sma...
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Co-registration of PET and Transrectal Ultrasounds (TRUS) Images for Improved Prostate Imaging and Biopsy

IB-2420 Dual PET-TRUS imaging co-registers positron emission tomography and transrectal ultrasound images taken during the same patient exam. The simulated “merged PET-TRUS image” (central image), helping to pinpoint any cancer present, will be used to guide diagnosis and potential treatments, as...
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Co-registration of PET and Transrectal Ultrasounds (TRUS) Images for Improved Prostate Imaging and Biopsy

APPLICATIONS OF TECHNOLOGY: Detects prostate cancer using accurately co-registered positron emission tomography (PET) and transrectal ultrasound (TRUS) images Guides prostate biopsy sampling Monitors response to treatment and detects local recurrence ADVANTAGES: Provides high-resolution...
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Power Tester

Abstract The present invention relates to a power tester for testing reaction time and muscular power. More specifically, the present invention relates to a portable power tester which can be used to determine muscular power. The ability to exert muscle power is important in the effective performa...
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Potent Tyrosine Phosphatase Inhibitors

TECH FIELD(S) Medical Therapeutic FEATURES Protein tyrosine phosphates (PTPs) are becoming the next hot target area of drug development. The targets are believed involved in cancer, diabetes, obesity, autoimmune diseases, and infectious diseases. However, a potent drugable PTP inhibitor is y...
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Percutaneous Thrombolytic Reinfusion Device

FEATURES Blood clots, such as thrombi (localized clots) and emboli (clots which have moved through the bloodstream), can pose serious health risks, including stroke, breathing difficulty, other attendant health concerns and death. As such, a safe and effective method of removing such clots is high...
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Percutaneous Stent-Graft and Method for Delivery

FEATURES Over 130,000 patients undergo chronic hemodialysis in the United States each year. The procedure requires access to the patient’s vascular system, but such access may eventually fail due to the formation of scar tissue inside the vessel or due to vessel occlusion. Failure of hemodialysi...
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Novel Monomer-Free Light-Cured Glass-Ionomer System for Improved Dental Restoratives

FEATURES Glass-ionomer cements are one of the most promising restoratives in dentistry. Since their invention, these cements have been successfully applied in dentistry for more than 25 years. The success of these cements is attributed to the facts that they are known for their unique properties s...
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Improved Intravenous Catheter and Delivery System

FEATURES A common problem faced by practitioners introducing intravenous (IV) catheters is the uncertainty as to whether the catheter is properly positioned within the vein. A major reason for this uncertainty is that the practitioner bases his judgment of proper insertion upon the observation of...
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Disposable Two-Way Valve Filter for Use in Re-infusion After Blood Clot Removal

FEATURES Several of the current treatments for thrombotic conditions such as arterial emboli and thrombosis, deep vein thrombosis and pulmonary thromboembolytic disease, require mechanical fragmentation of clots followed by aspiration of clot fragments. During removal, moderate to large amounts o...
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Device for Digital Retinal Imaging

FEATURES A digital camera with simplified optics for imaging the retina and anterior structures. BENEFITS * The device can be produced at lower cost that current products. In addition, it will be easier to operate which will facilitate use in lesser developed regions of the world. Moreover, ...
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Carrier for Medical Equipment for Motor Vehicle Transport

FEATURES The inventor’s observational surveys of children with special health care needs have shown that families transport their needed equipment unrestrained. In the event of a motor vehicle crash these objects become projectiles. This invention is a light weight carrier designed to safely tran...
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Brachytherapy Catheter Positioning Guide

FEATURES Stenosis of arteries or veins by the formation of atherosclerotic plaque is a well known and frequent medical problem. The most common procedure to treat such blockages is a technique commonly referred to as a "balloon angioplasty." In many patients the newly opened vessel undergoes reste...
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Automatic Retractable Floor System for 360 Degree Rotating Gantry

FEATURES A commercial360 degree rotating gantry has a hazardous cavity for radiation technologists and nurses working in the area. Horizontal, pneumatically actuated, retractable floor plates aligned with the treatment room permanent floor are designed to cover this cavity and automatically retra...
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Adventitial Delivery of Agents for the Treatment and Prevention of Restenosis

FEATURES Balloon angioplasty is one of the most widely used treatments for heart and vascular disease with an estimate of nearly two million procedures performed each year. However, roughly 25% of patients treated with balloon angioplasty experience renewed narrowing of the treated arteries, or rest...
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Steerable Epicardial Lead to be Placed via the Subxiphoid

Congestive Heart Failure (CHF) is a significant and growing healthcare problem with almost five million patients suffering from this condition in the U.S. alone. The resulting hospitalization costs for treating these patients are $15B. While there have been numerous advances in treating CHF, few pat...
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Method and Means for Intracranial Implantation of Carmustine Anti-Tumoral Agents

Biodegradable wafers containing the anti-tumoral agent carmustine (BCNU) are often inserted into the surgical void in the brain following the debulking of a glioma. The timed-release of the drug and subsequent diffusion of it into the peri-tumoral region allow for an effective, although relatively s...
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Manometrically-Monitored Introducer Needle and Method of Use

Congestive Heart Failure (CHF) affects over 5,000,000 people in the U.S. alone and its incidence is growing. As the number of CHF cases grows, so will the rate of Ventricular Tachycardia (VT). Implantable Cardioverter Defibrillators (ICDs) can prevent sudden death from VT and drug therapies are ofte...
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Epicardial-Cathode Catheter for Ablation Procedures

Two million Americans suffer from atrial fibrillation, which can cause palpitations, syncope, strokes and is associated with death. Cardiac ablations are becoming a standard method of treatment utilizing radiofrequency energy to render tissue, which is electrically faulty, inactive. However, AF abla...
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Epicardial Ablation Catheter and Access Sheath and Methods of Use

Today most electrophysiologic ablations are done from the endocardium because many superventricular tachycardias originate there. However, two of the fastest growing areas of ablation atrial fibrillation ablation and ventricular tachycardia (VT) ablation have significant contributors in the epicardi...
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Closure Device for Skull Plates

An estimated 18,000+ people will develop brain tumors this year in the US, and over 30,000 people will develop subarachnoid hemorrhages caused by brain aneurysms. Aneurysms and brain tumors are only two of the several conditions that require neurosurgical procedures for treatment. Neurosurgical proc...
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Innovative catheters - for dilating difficult lesions and delivering therapeutics to the Diseased Artery Wall

New Market Opportunity: Therapeutic delivery Advances in local drug delivery have proven extremely effective in the coronary arena. Drug-eluting stents have made a significant breakthrough in the prevention of instent restenosis. However, there are a number of areas where drugeluting stents cannot ...
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Glass Matrix to Preserve Proteins and Biopolymers

This glass-like matrix preserves proteins without refrigeration or freezing. Appropriately plasticizing carbohydrate or polymeric glasses yields a biopreservation matrix that can provide stability enhancement for encapsulated biological agent of as much as 100-fold over current best-practice formula...
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