Col 2A promoter Cre transgenic mice

Summary Description: Modulating gene activity on chondrocytes

Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in chondrocytes. The strain initiates Cre-mediated recombination predominantly in immature chondrocytes and the inner layer of perichondrial cells within the developing endochondral skeleton . However, there is also significant Cre-activity in other regions of the embryo reflecting the widespread expression of Col2a1.

Applications Research tool and animal model for the study of chondrocytes and arthritis. For Further Information Please Contact the Director of Business Development Laura Brass Email: [email protected] Telephone: (617) 495-3067

Inventor(s): McMahon, Andrew P.

Type of Offer: Licensing



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