On Bead Tagging and Decoding for Combinatorial Synthesis
Summary Pharmaceutical drug discovery has been greatly impacted by the development of novel approaches to the rapid synthesis of novel compounds, including combinatorial synthesis approaches. A common problem in combinatorial synthesis is that the compounds are frequently produced as mixed pools attached to solid state supports. From these, it is necessary to identify the specific compound of interest by deconvoluting or using encoding techniques during synthesis.
Harvard Medical School researchers have developed a novel approach for encoding the reaction history in the synthesis of novel combinatorial libraries. Tags, based on bi-aryl amides with an amino hexanoyl spacer for attachment to the matrix, are added throughout the synthesis of the library on the outside of the beads. Decoding of the synthesis history is achieved using a binding partner (for example an antibody) that specifically recognizes a tag. The decoding step does not require preliminary cleavage of the tag and can be directly performed on the beads.
Applications - Combinatorial library synthesis - Solid phase encoding For Further Information Please Contact the Director of Business Development Michal Preminger Email: firstname.lastname@example.org Telephone: (617) 432-0920
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