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Process for making reinforcing elastomer-clay nanocomposites

A process for producing a natural rubber nanocomposite containing exfoliated organically modified montmorillonite and maleic anhydride grafted elastomer in a dispersion of natural rubber and reinforcing filler/inert filler wherein the cured nanocomposite has improved mechanical properties compared t...
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Method for Obtaining Oxide Catalysts on the Base of Exfoliated Layered Aluminosilicates

The subject of the offer is a novel, affordable and environmentally friendly method of synthesis of oxide catalysts with high surface area dispersed on aluminosilicate supports. The method may be applied in the production of catalysts for many processes, such as dehydrogenation and oxidation of hydr...
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Method of synthesis of CMK-3 carbon replica

The subject of the offer is an innovative, environmentally friendly method for obtaining of CMK-3 carbon replica, which may be a material useful in various catalytic and sorption processes as well as electrochemical applications. The method has a high potential for industrial application, and its us...
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Sun Care Patent

Sunscreen Protectant – Dermal Science UV ProtectantTM protects you and your clothing from harmful UV radiation. Available in tablet form, this protectant is added to a normal load of laundry and provides long lasting UPF protection to cotton clothes. Laundry care is an $8B category in the US and s...
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Hydroxy Ceramides and analogs thereof and their use for Preventing or Treating Cancer

Disclosed are compounds, compositions, methods of treatment and synthetic methods for making compounds related to stereoisomers of 2-hydroxy-ceramides and the use of 2-hydroxy-ceramides and their analogs....
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Antibacterial, Self-Cleaning Photocatalytic Material

The subjects of the offer are new materials obtained by the modification of nanocrystalline titanium oxide(IV) and the photocatalytic coatings of TiO2 deposited on polymer surfaces widely used for the manufacture of disposable medical equipment. Materials can be applied for an efficient photocatalyt...
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On Site Carbon Dioxide Generation

Commercial use of carbon dioxide (CO2) depends largely on compressed CO2 or “dry ice”, both inconvenient sources for small users, since dry ice sublimates uncontrollably and compressed CO2 requires heavy, thick-walled containers, in addition to valves and regulators. A more convenient, on-site, sour...
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Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents

Radiotherapy is the treatment of cancer and other diseases with ionizing radiation. Radiotherapy is used in curative therapy, palliative therapy, adjuvant therapy after or before surgery, simultaneous radio-chemotherapy, etc. Radiotherapy is successful because ionizing radiation kills dividing cells...
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Compositions and Methods for Inhibiting Sphingosine Kinase

Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells....
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Bicyclic Sphingosine 1-Phosphate Analogs

Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors....
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Alkynes and Methods of Reacting Alkynes with 1,3-Dipole-Functional Compounds

1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functiona...
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Synthetic Lipid a Derivative

The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative....
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Synthesis and Stabilization of Neutral Compounds with Homonuclear Bonds

The present invention is directed to the synthesis and stabilization of neutral molecules containing homonuclear single or multiple bonds, methods of preparation, and uses thereof....
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Phosphorescent Compositions, Methods of Making the Compositions, and Methods of Using the Compositions

Compositions, methods of making compositions, materials including compositions, crayons including compositions, paint including compositions, ink including compositions, waxes including compositions, polymers including compositions, vesicles including the compositions, methods of making each, and th...
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Microbial production of alanine

Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wildtype cells. Acetate and glucose are supplied as a carbon sources....
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Preparation of Alkenes By Mild Thermolysis of Sulfoxides

Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively bloc...
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Heparan Sulfate Synthesis

The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesis, are combined in numerous ways to produce a range of oligosac...
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Microbial Production of Pyruvate and Pyruvate Derivatives

Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources....
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Near Infrared Doped Phosphors Having a Zinc, Germanium, Gallate Matrix

Phosphors based on transition metal-activated gallates, particularly Cr3+- and Ni2+-activated zinc germanium gallates, are disclosed herein. In some embodiments such phosphors can exhibit persistent infrared phosphorescence for as long as 400 hours. Such phosphors can be used, for example, as compon...
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Near Infrared Doped Phosphors Having an Alkaline Gallate Matrix

Phosphors based on doping of an activator (an emitter) into a host matrix are disclosed herein. Such phosphors include alkaline gallate phosphors doped with Cr3+ or Ni2+ ions, which in some embodiments can exhibit persistent infrared phosphorescence for as long as 200 hours. Such phosphors can be us...
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Fluorescent Prochelators for Cellular Iron Detection

Fluorescent probe compound of Formula Ia or Formula Ib: are described, along with methods of using the same to detect iron, copper, and hydrogen peroxide....
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Methods and Compositions for Predicting Success in Addictive Substance Cessation and for Predicting a Risk of Addiction

The present invention relates to genetic polymorphisms that are associated with dependence on an addictive substance. In particular, the present invention relates to a method for predicting success in addictive substance cessation in a subject, such as predicting success in nicotine cessation. In so...
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Methods and Compositions for Identifying Individuals At Reduced Risk of Sepsis

The present invention provides a method of identifying a subject having a reduced risk of developing sepsis, comprising detecting at least one APOE3 allele in nucleic acid from the subject....
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Nicotinic Acid Receptor Ligands

The present invention relates, in general, to nicotinic acid receptor ligands and, in particular, to ligands that have a relative efficacy for activating a G- protein-coupled receptor function (e.g., signaling) that is greater than their relative efficacy for stimulating ss-arrestin function (e.g., ...
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Asymmetric Alpha Functionalization and Alpha, Alpha Bisfunctionalization of Aldehydes and Ketones

The present invention relates, generally, to asymmetric a-functionalization and to asymmetric a,a-bisfunctionalization of ketones and aldehydes and, in particular, to chiral auxiliaries suitable for use in effecting such functionalizations and to methods of using same....
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Method for Distinguishing Follicular Thyroid Adenoma (FTA) from Follicular Thyroid Carcinoma (FTC)

Follicular thyroid adenoma (FTA) is distinguished from follicular thyroid carcinoma (FTC) by comparing amount of an expression product of at least one gene selected from the group consisting of DDIT3, ARG2, ITM1, C1orf24, TARSH, and ACO1 in a test follicular thyroid specimen to a normal control thyr...
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Droplet-Based Surface Modification and Washing

The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one o...
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METHODS AND COMPOSITIONS FOR IDENTIFYING INHIBITORS OF MUTS-alpha OR MUTS-beta INTERACTION WITH MUTL-alpha

Disclosed are methods and kits for screening potential inhibitors of MutS[beta] by screening agents for the ability to selectively inhibit interaction between MutS[beta] and MutL[alpha]. Also disclosed are kits for performing the methods of the invention....
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Reacting chemical compound by biotransformation, preferably whole cell biotransformation, useful for degrading environmental pollutant and producing chiral intermediate, comprises adding alginite as r

Reacting chemical compounds by biotransformation, preferably whole cell biotransformation, comprises adding alginite as reaction additive to the reaction medium....
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Cleavage of esters, amides or thioesters of formic acid, comprises converting ester, amide or thioester of formic acid to carbon dioxide and corresponding alcohol, amine or thiol by a formate dehydrog

Cleavage of esters, amides or thioesters of formic acid, comprises converting ester, amide or thioester of formic acid to carbon dioxide and corresponding alcohol, amine or thiol by a formate dehydrogenase. An independent claim is also included for a kit for the cleavage of formyl protecting groups,...
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Distillation of ionic liquids

Process for the distillation of mixtures containing salts with a melting point below 200 ° C at 1 bar (ionic liquids) contained, characterized in that - contains the cation of ionic liquid, a heterocyclic ring system with at least one nitrogen atom and all nitrogen atoms of the heterocyclic ring sys...
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Procedures and preparation of ionic liquids by anion

Process for the preparation of salts of formula I, (B +) nxAy-where B is a cation which contains at least one nitrogen atom, A is an anion and n is an integer from 1 to 3, x and y are whole numbers are 1 to 3 and the product of x and y equal to n, by reaction of salts of the formula II, (B +) nxCy, ...
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Method for Producing Cellulose Acetals

The present invention describes a method for producing acetals of poly-, oligo-or disaccharides by dissolving them in at least one ionic liquid and then reacting them with a vinylether. The resulting acetalized poly-or oligosaccharides can be cross-linked by treatment with acid. The present inventio...
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Process for Silylating Cellulose

The present invention describes a process for silylating polysaccharides, oligosaccharides or disaccharides or derivatives thereof by dissolving these in an ionic liquid and reacting them with a silylating agent....
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Acid Ceramidase Polymorphisms and Methods of Predicting Traits Using the Acid Ceramidase Polymorphisms

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the ...
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Methods and apparatus for manipulating droplets by electrowetting- based techniques

An apparatus is provided for manipulating droplets. The apparatus is a single-sided electrode design in which all conductive elements are contained on one surface on which droplets are manipulated. An additional surface can be provided parallel with the first surface for the purpose of containing th...
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Droplet-Based Pyrosequencing

The present invention relates to droplet-based pyrosequencing including a method of identifying a base at a target position in a sample nucleic acid. The method includes: (a) providing a droplet microactuator including a first droplet including a sample nucleic acid immobilized on a bead; and (b) on...
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C16 Unsaturated FP-selective Prostaglandin Analogue

PROBLEM TO BE SOLVED: To provide a new PGF (prostaglandin F) analogue useful in treating various diseases and symptoms including bone disorders. ; SOLUTION: A compound having a structure in accordance with formula (I) is provided. Besides, optical isomers, diastereomers and enantiomers of formula (I...
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Droplet-based Biochemistry

The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs load...
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Cobalt-catalyzed Asymmetric Cyclopropanation with Diazosulfones

Asymmetric cyclopropanation of olefins with diazosulfones....
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Acylsulfonamides and Processes for Producing the Same

The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide....
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Triazoles and Processes for Producing the Same

The present disclosure relates to triazoles and processes for their preparation. The processes involve a target-guided synthesis approach, whereby an alkyne and an azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the triazole....
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Enantioselective Ring-opening of Aziridines

A process for the preparation of a nucleophilic addition product of an aziridine and a nucleophile, the process comprising treating the arizidine with the nucleophile in the presence of a biaryl phosphoric acid catalyst....
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Cobalt-catalyzed Asymmetric Cyclopropanation of Electron-deficient Olefins

Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins....
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Supramolecular Assemblies and Building Blocks

The present invention generally relates to supramolecular assemblies and their modes of synthesis. The supramolecular assemblies include a 1:8 ratio of a supermolecular polyhedral building block and a triangular molecular building block, the supermolecular polyhedral building block having points of ...
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Proteasome Inhibitors Having Chymotrypsin-like Activity

Disclosed herein is the use of HLM-008182, as well as its analogues formed via in-house synthesis, as a potent proteasome inhibitors. A new method was developed for HLM-008182 through a four-step protocol and the method was further optimized to a two step protocol. The synthesis in both protocols wa...
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Alkene Aziridination

A process for the asymmetric aziridination of an alkene comprising treating the alkene with a sulfonyl azide, preferably trichloroethoxysulfonyl azide, in the presence of a cobalt(II) porphyrin....
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Asymmetric Cyclopropanation with Succinimidyl Diazoacetate

Cobalt(ll) complexes of the D 2-symmetric chiral porphyrins are effective catalysts for asymmetric cyclopropanation reactions with succinimidyl diazoacetate. The Co-catalyzed reaction is suitable for various olefins, providing the corresponding cyclopropane succinimidyl esters in high yields and exc...
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Cobalt-Catalyzed Asymmetric Cyclopropanation of Alkenes with alpha-Nitrodiazoacetates

A process for the cyclopropanation of olefins with a metal porphyrin catalyst and an acceptor/acceptor substituted diazo reagent....
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Asymmetric Cyclopropanation of Electron-deficient Olefins with Diazo Reagents

Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins....
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Ionic Liquid Mediated Sol-gel Sorbents

Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises from high viscosity of ILs significantly slowing down sol-gel reactions. A method was developed which p...
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Metal Porphyrin Catalyzed Olefin Aziridination with Sulfonyl Azides

Cobalt(II) complex of P1 [Co(P1)], a new porphyrin that was designed on the basis of potential hydrogen bonding interactions in the metal-nitrene intermediate, is a highly active catalyst for olefin aziridination with azides. The [Co(P1)]-based system can be effectively employed for different combin...
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Heterosubstituted N-thiolated Beta-lactam Compounds and Methods of Use

The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of bacteria. In one embodiment, the compounds have the structure shown in formula (A) or formula (B) or ...
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Silica-based Material for Detection and Isolation of Chitin and Chitin-containing Microorganisms

The subject invention provides silica-based material that has high affinity to chitin, chitin derivatives and chitin-containing microorganisms at an acidic pH. In an embodiment, the silica-based material surface comprises glass. Also provided are methods for preparing the subject silica-based chitin...
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Eggshell Catalyst and Method of Its Preparation

An eggshell catalyst useful for a Fischer-Tropsch (FT) synthesis or other reactions comprises a homogeneously dispersed transition metal and a promoter situated in an active phase in a precisely selected outer region of a catalyst pellet. The active phase region is controlled to a specific depth, wh...
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Light Curing Compositions

The present invention relates to light curing compositions, comprising radically polymerizable vinyl compounds and daylight sensitive radical initiators of the formula (I) and/or (II), and optionally containing further additives, such as fillers, pigments, solvents, and to the use thereof as a coati...
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Device for the Continuous Annular Electrochromatography

An annular gap apparatus (110) for performing a capillary electrochromatography is disclosed. The annular gap apparatus (110) has at least one separator (112) with at least one fixed annular gap (114), wherein the annular gap (114) is at least partially filled with at least one stationary phase (204...
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Catalyst systems comprising an alkaline earth metal chloride and their application for metathesis reactions

Catalyst system (I) comprising a metathesis catalyst containing a complex catalyst on basis of a 6th or 8th group metals and exhibits at least one carbene group at the metal bonded ligands, and an alkaline earth metal chloride, preferably calcium chloride or magnesium chloride, is new. An independen...
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New ruthenium- and osmium-carbene-complex catalysts, which are bonded with chiral carbon atoms or over double bonds at a catalyst base skeleton, useful e.g. in metathesis-reactions, preferably in ring

Ruthenium- and osmium-carbene-complex catalysts (I), which are bonded with chiral carbon atoms or over one or more double bonds at a catalyst base skeleton, are new. Ruthenium- and osmium-carbene-complex catalysts of formula (I), which are bonded with chiral carbon atoms or over one or more double b...
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Chelating Agent

A compound of the formula: wherein R is selected from H, methyl, ethyl, carboxyl protecting groups and hydrophilic moieties, R and R are independently selected from H, methyl, ethyl and carboxyl protecting groups, R is selected from H, methyl, ethyl, hydrophilic moieties and carboxyl protecting grou...
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Polycrystalline silicon thin layers produced by titanium-supported metal-induced layer exchange

The method involves applying a layer sequence on a substrate, where the layer sequence has an oxidation layer arranged between an output layer and an activator layer. The layer sequence is treated with heat for forming a polycrystalline end layer, and the stable oxidation layer is produced by oxidat...
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Multilayer Silk Protein Films

The present invention is directed to a method of forming multilayer silk protein films and a multilayer film obtained therefrom. The invention is further directed to various materials, products and compositions containing said multilayer film and to the use of Said multilayer film in several applica...
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Use of Prokaryotic Tir-domain Containing Proteins As Therapeutic and Diagnostic Agents

The present invention relates inter alia to nucleic acid molecules encoding prokaryotic TIR-domain containing polypeptides as well as fragments and functional homologues thereof for diagnostic and therapeutic purposes....
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Muteins of hNGAL and Related Proteins with Affinity for a Given Target

The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. Th...
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Polymeric Delivery Systems for Active Agents

A composition, comprising: (a) at least one copolymer comprising repeating units of formula (I) wherein RA is a hydrocarbon group, optionally substituted with -OH, -SH, -COOH, NR'2, -COOR', -CONR', -CHO, with R' representing H or C1-3 alkyl, and with RA being selected such that the repeating unit of...
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Mutated Abl kinase domains

The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, ...
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NMP-containing Extract, a Method of Its Production and Uses Thereof

The present invention relates to a N-methylpyridinium cation (NMP)-containing extract, a method for its production, uses of said NMP-containing extract as a dietary supplement and for the prevention or reduction of oxidative stress, and to foodstuff containing said extract....
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Compounds for Non-invasive Measurement of Aggregates of Amyloid Peptides

The invention relates to the provision of compounds, methods for producing them, and their use for imaging and quantification of aggregates of ss-amyloid peptides in vivo. In a preferred aspect of the invention, a tracer is administered to humans and displays enrichment in body parts that are contai...
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Deuterium Isobaric Tag Reagents for Quantitative Analysis

Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more 2H in each reagent. Generally, the reagents are described by the formula: reporter group - balancer group - reactive group, wherein the reporter gr...
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CYCLOPENTADIENYLPHOSPHAZENE COMPLEXES (CpPN COMPLEXES) OF METALS OF THE THIRD AND FOURTH GROUP AND OF THE LANTHANOIDS

The present invention relates Cyclopentadienylphosphazen complexes (CPPN complexes) of Group III. and group IV and the lanthanides with the exception of lutetium. The novel complexes are too isolobal and isoelectronic [(CpSiN) TiR2] complexes. In the novel there is exactly one complex CPPN unit. In ...
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Non-viral Transfection Agent

The invention relates to a non-viral transfection agent comprising polymer/nucleic acid complexes and nanofibers, wherein the polymer/nucleic acid complexes are composed of at least one nucleic acid and at least one cationic polymer. The nanofibers carry the polymer/nucleic acid complexes, wherein t...
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Process for Preparation of Polyolefins Via Living Coordinative Chain Transfer Polymerization

Disclosed is a method of producing a polyolefin composition comprising contacting a metallocene pre-catalyst, co-catalyst, and a stoichiometric excess of a metal alkyl; adding a first olefin monomer; and polymerizing the first monomer for a time sufficient to form the polyolefin. The method allows f...
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Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions

The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) "paddlewheel complexes, and in particular, dirhodium carboximat...
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Aminde Detection Method and Materials

Compounds linked to a solid support through a divalent linker moiety are disclosed. In particular, compounds such as 1-hydroxybenzotriazole-6-carboxylic acid are directly linked to the support under mild conditions (i.e., in aqueous or organic solvents at neutral pH and at room temperature). The pol...
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Synthesis Methods of Histone Deacetylase Inhibitors (HDACIS)

Simple and efficient procedures for the synthesis of histone deacetylase inhibitors. The procedure may provide MS-275 in 72% overall yields....
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Processes for Plant Polysaccharide Conversion

The present invention provides a novel process for ethanol fermentation....
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Method and Device for Isolating a Chemically and Radiochemically Cleaned 68Ga-radio Nuclide and for Marking a Marking Precursor with the 68Ga-radio Nuclide

The invention relates to initial Ge/Ga-generator elute which is guided directly to a cation exchanger, whereon Ga is quantitatively absorbed and is cleaned simultaneously in a chemical and radio chemical manner. Subsequently, the Ga-radio nuclide is combined with a radio pharmaceutical substance by ...
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Antioxidant and Paramagnetic Heparin-nitroxide Derivatives

The present invention relates to novel heparin-nitroxide derivatives comprising heparin and at least two and more nitroxides/polynitroxide radicals that are covalently coupled to heparin by derivatisation of glycosaminoglycan carboxyl or amino groups. The heparin-nitroxide derivatives are useful as ...
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Methods and Compositions for Diagnosis and Treatment of Cancer

The invention relates to an isolated regulatory nucleic acid, comprising a nucleic acid sequence according to SEQ ID NO 2 or a biologically active fragment thereof that can be specifically amplified and detected by a polymerase chain reaction (PCR), to the use thereof as a tumor marker and for sampl...
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Use of 3-(indolyl)- Or 3-(azaindolyl)-4-arylmaleimide Derivatives in Leukenia Management

The present invention relates to the use of a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy groups and R3 is indolyl or azaindolyl which may carry one or two substituents independently selected f...
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3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma

The present invention relates to the use of a compound of formula (I) wherein R 1 , and R 3 are as defined in the description and R 2 is a phenyl group which is substituted with 2 or 3 C 1 -G 6 alkoxy groups, or a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) o...
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Universal Phosphoramidite for Preparation of Modified Biomolecules and Surfaces

Reagents useful for attaching biomolecules (e.g., proteins, oligonucleotides, and other biomolecules) to a surface, processes of attaching molecules to a surface to form modified surfaces using these reagents, and methods of detecting a target compound using these modified surfaces are disclosed....
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Conjugated Monomers and Polymers and Preparation and Use Thereof

Disclosed are new conjugated compounds (e.g., monomers and polymers) that include ladder-type moieties which can be used for preparing semiconducting materials. Such conjugated compounds can exhibit high n-type carrier mobility and/or good current modulation characteristics. Compounds of the present...
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Chalcogenide Compounds with a Clay-like Cation-exchange Capacity and Methods of Use

Chalcogenide compounds with cation exchange capability and methods of using the compounds are described. Compounds of the general formula A2xMxSn3-XS6 are described wherein x is 0.1-0.95, A is Li+, Na+, K+ or Rb+ and M is Mn2+, Mg2+, Zn2+, Fe2+, Co2+ or Ni2+. Compounds of the general formula H2xMxSn...
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Enhancing the Physical Properties of Semi-crystalline Polymers Via Solid-state Shear Pulverization

Solid-state shear pulverization of semi-crystalline polymers and copolymers thereof and related methods for enhanced crystallization kinetics and physical/mechanical properties....
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Modified Acrylic Block Copolymers for Hydrogels and Pressure Sensitive Wet Adhesives

A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate)....
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Catalytic Enantioselective Synthesis of Flavanones and Chromanes

Various chromanone, flavanone and abyssinone compounds as can be prepares enantioselectively using a chiral thiourea catalyst....
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Networks for Organic Reactions and Compounds

A method for analyzing a collection of organic chemical reactions and compounds reported in the literature in the form of a complex network in either a normal, one-mode graph or a bipartite graph is disclosed. Also disclosed are methods, algorithms, computer-readable storage mediums and other applic...
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Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition

Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition....
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Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protec...
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Systems and Methods for Selective Alcohol Production

The present invention relates to metabolic engineering issues related to flux determinism in core primary-metabolism pathways. In particular, the present invention relates to alcohol (e.g., butanol) production and selectivity, and related methods thereof....
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Tetratopic Phenyl Compounds, Related Metal-organic Framework Materials and Post-assembly Elaboration

Disclosed are tetratopic carboxylic acid phenyl for use in metal-organic framework compounds. These compounds are useful in catalysis, gas storage, sensing, biological imaging, drug delivery and gas adsorption separation....
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Click Chemistry, Molecular Transport Junctions, and Colorimetric Detection of Copper

Click chemistry is used to construct molecular transport junctions (MTJs) through assembly of a molecular wire across a nanogap formed between two electrodes. Also disclosed are methods of using click chemistry and oligonucleotide-modified nanoparticles to detect the presence of copper in a sample....
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Antifouling Hydrogels, Coatings, and Methods of Synthesis and Use Thereof

The invention provides an antifouling hydrogel comprising an effective amount of antifouling polymer modified with a compound containing catechol functional groups to yield a modified antifouling polymer comprising at least one catechol functional end group; and an effective amount of at least one o...
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Chiral Pyrrolidine Core Compounds En Route to Inhibitors of Nitric Oxide Synthase

Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors....
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Short Duplex Probes for Enhanced Target Hybridization

The present disclosure is directed to compositions and methods for detecting or associating with a target polynucleotide....
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Methods for Total Nitrogen Removal from Waste Streams

A method and related apparatus for oxidation and reduction of a reduced aqueous nitrogen contaminant....
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Zinc-activated contrast agents

The present invention relates to contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to MRI contrast agents that are activated in the presence of zinc(II) (e.g., resulting in a brighter image)....
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Apparatus and methods for water treatment

An apparatus and method for treatment of water borne oxidized contaminants, using hydrogen as an electron donor for denitrification and reduction of other oxidized contaminants. Preliminary results reported here show that a biofilm of autotrophic denitrifiers accumulates rapidly in the wastewater se...
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Self-assembling Poly(diol Citrates)-protein Hydrogels

The present invention can be directed to poly(diol-citrate)-based copolymers, compositions thereof comprising protein components and methods of use and assembly....
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Solid phase host compositions

A new family of silicon-based polymers has been prepared in which organic host components are bound covalently. The polymer is a polysilsesquioxane matrix comprising, for example, hosts such as cyclodextrins (CD) or calixarenes (CX)....
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Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof

A novel coordination chemistry or metal ion binding approach to controlling the site-isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-i...
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Process for Continuous Solvent Production

A continuous process for production of solvents, particularly acetone-butanol-ethanol (ABE) using fermentation of solventogenic microorganisms and gas stripping is provided. The solventogenic microorganisms are inoculated in a nutrient medium containing assimilable carbohydrates (substrate) and opti...
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Hydroamination of Alkenes

A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. R1 is an organic group including a sp3 carbon atom bonded to CA. R2 is selected from the group consisting of hydrogen, methyl, and an...
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Apparatus and Method for Applying a Film on a Substrate

A system that incorporates teachings of the present disclosure may include, for example, an apparatus having a plurality of applicators, each applicator with an ingress opening to receive a liquid, and an egress opening to release the liquid, and a conductor positioned in a conduit of each of the pl...
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Water Repellent Metal-organic Frameworks, Process for Making and Uses Regarding Same

Microwave assisted synthesis may be used to produce water-repellent metallic organic frameworks (MOFs) molecules. The water-repellent MOFs contain non-polar functional groups, such as a trifluoromethoxy group, which has a strong water repellent effect. The water-repellent MOF, when exposed to water ...
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Slow Release of Organoboronic Acids in Cross-coupling Reactions

A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1-B-T; where R1 represents an organic group, T represents a ...
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Catalytic Compositions, Composition Production Methods, and Aqueous Solution Treatment Methods

Composition production methods are provided that can include providing PdO nanoparticles on a nitrogen-doped titanium oxide surface to form a catalytic mixture. Catalytic compositions and/or bactericides are provided that can include a substrate supporting Ti, O, N, and Pd. Water purification method...
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Method for Forming Allylic Alcohols

A method of performing a chemical reaction includes reacting an allyl donor and a substrate in a reaction mixture, and forming a homoallylic alcohol in the reaction mixture. The substrate may be an aldehyde or a hemiacetal. The reaction mixture includes a ruthenium catalyst, carbon monoxide at a lev...
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Highly Permeable Polymeric Membranes

Provided are substantially flat membranes that include a block or graft co-polymer and a water transport protein, such as Aquaporin-Z, or a synthetic mimic of such proteins. Also provided are methods of removing contaminants from a liquid, by contacting the liquid with a substantially flat membrane ...
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Solvent Removal and Recovery from Inorganic and Organic Solutions

A process for recovering solvents from inorganic and organic solutions is disclosed. The process utilizes a polymer capable of selectively extracting the solvent from the inorganic or organic solution. Introduction of the polymer into the solvent solution creates formation of a polymer-rich phase an...
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Method for the Synthesis of A-ring Aromatized Acetyl Minocyclines

The invention relates to a method for the production of A-ring aromatized acetyl minocyclines. The aim of the invention to provide a less complex method for the production of A-ring aromatized acetyl minocyclines of the formula (I), wherein R1 to R5 = acetyl and/or H, which can also be used on an in...
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Method for the Synthesis of A-ring Aromatized Acetyl Minocyclines

The invention relates to a process for production of A-ring aromatized acetyl-minocycline.The object of the invention, a resource-light process for the production of A-ring aromatized acetyl-Minocycline Formula $ F1 where R to R = acetyl and / or H to provide, it is also feasible on an industrial ...
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Directed Assembly of Three-dimensional Structures with Micron-scale Features

Polyelectrolyte inks comprising a solvent, a cationic polyelectrolyte dissolved in the solvent, and an anionic polyelectrolyte dissolved in the solvent, are described. The concentration of at least one of the polyelectrolytes in the solvent is in a semidilute regime....
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Selective Aliphatic C-H Oxidation

A composition including a complex of a metal, a tetradentate ligand, at least one ancillary ligand, and a counterion may be used for selective sp3 C-H bond oxidation. The tetradentate ligand may include a N-heterocyclic-N,N'-bis(pyridyl)-ethane-1,2-diamine group or a N,N'-bis(heterocyclic)-N,N'-bis(...
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Nicotinic Acetylcholine Receptor Ligands and the Uses Thereof

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an anim...
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Modified Polydicyclopentadienes

The present invention provides novel, modified polydicyclopentadienes and methods to prepare modified polydicyclopentadienes. The modified polydicyclopentadienes prepared by the methods of the invention are useful in many applications including new and useful solid phases for chromatography....
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Methods for the Preparation of Thiazolidinethione Indene-Based Chiral Auxiliaries

Methods for the preparation of indene-based thiazolidinethiones are provided comprising contacting 1-amino-2,3-dihydro-1H-inden-2-ol, or a substituted derivative thereof, with an acid under suitable reaction conditions to provide a first intermediate; and contacting the first intermediate with an al...
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Apparatus and Method for Carrying Out Multiple Reactions

The invention provides methods and an apparatus useful for site-isolating reagents or catalysts during chemical reactions. The methods and apparatus are useful for carrying out cascade or domino reactions....
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Spray Dried Microbes and Methods of Preparation and Use

The invention provides spray-dried preparations of microbes and methods of using those microbes....
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Bifunctional Lactide Monomer Derivative and Polymers and Materials Prepared Using the Same

The invention described herein provides a novel lactide monomer derivative and process for preparing the lactide monomer derivative. The monomer derivative of the invention is bifunctional in nature, and can be employed a variety of efficient synthesis processes to prepare various polymers. Further,...
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Polylactide Composites and Methods of Producing the Same

Embodiments of polylactide composites comprise a polylactide, and a polymerized natural oil dispersed inside the polylactide....
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Preparation of Solvent-borne Polymeric Bioactive Coatings

Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantiall...
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Non-thermal Plasma Synthesis with Carbon Component

The disclosure herein describes a method for producing ammonia by introducing N2, CO and water into a non-thermal plasma in the presence of a catalyst, the catalyst being effective to promote the disassociation of N2, CO and water to form reactants that in turn react to produce NH3 and CH4. This dis...
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Detection of Nucleic Acid Sequence Differences Using Coupled Ligase Detection and Polymerase Chain Reactions

The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain ...
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Solvent-borne Polymeric Bioactive Coatings for the Facilitated Removal of Bioorganic Stains

Protein-polymer composite materials are provided according to embodiments of the present invention that include an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins is mixed with the admixture. The emulsion is mixed with a...
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Hot-melt Adhesive and Method for the Manufacture Thereof

The invention relates to a hot-melt adhesive, comprising at least one polysaccharide ester (6) obtained through the reaction of a polysaccharide (5) with an imidazolide (3) in molten imidazole (1). The invention further relates to a method for manufacturing the hot-melt adhesive in which imidazole (...
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Tetrazine-based Bio-orthogonal Coupling Reagents and Methods

Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. Th...
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Method of Making Stable, Homogeneous Potassium Hydride Dispersions

A stable, homogeneous dispersion of potassium hydride is formed by reacting a mixture of wax and potassium metal with hydrogen....
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Reduced Dye Probes for the Detection of Radical Oxygen Species

Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes, such as deuteraled leuco dyes, capable of detecting one or more reactive oxygen species are described herein The reduced dyes are generally prepared by reducing the oxidized dye with a reducing agent, such as sodium ...
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PREPARATION OF SYNTHETIC NUCLEOSIDES VIA p-ALLYL TRANSITION METAL COMPLEX FORMATION

This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base ...
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Polyoxometalate Water Oxidation Catalysts and Methods of Use Thereof

Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment, the WOC is a polyoxometalate WOC which is hydrolytically stable, oxidatively stable, and thermally sta...
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Methods of Preparing 1-deoxy-sphingoid Bases and Derivatives Thereof

Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, re...
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Compounds, Intermediates, and Methods of Preparing the Same

The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds, methods of synthesizing the intermediate compounds, and the like....
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PROCESSES FOR PREPARING 5,7 DIAMINOPYRAZOLO[1,5-a] PYRIMIDINE COMPOUNDS

Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-a]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected 5-halo-7-aminopyrazolo[1,5-a]pyrimidine compound in solvent system comprising water and one or more organic solvents, optionally in the pres...
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Method of manufacture of 1,3-dioxolane and 1,3-oxathiolane nucleosides

Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be pro...
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Tridentate Platinum (II) Complexes

A platinum (II) complex of the general formula (I) or (II), in which Ar1, Ar2, and Ar3 are each independently aryl, heteroaryl, or heterocyclic. Ar1, Ar2, and Ar3 together form a tridentate ligand coordinated to the platinum through atoms X, Y, and Z, respectively, and X, Y, and Z are independently ...
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Platinum(II) Di(2-pyrazolyl)benzene Chloride Analogs and Uses

Synthesis of platinum(II) di(2-pyrazolyl)benzene chloride and analogs includes forming a 1,3-di-substituted benzene including two aromatic five-membered heterocycles, and reacting the 1,3-di-substituted benzene with an acidic platinum-containing solution to form a luminescent platinum(II) complex. T...
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Methods of Identifying Molecular Function

Disclosed herein are methods for identifying the molecular function of compounds, methods of iterative evolution of compounds, and a surface having high chemical diversity for performing the disclosed methods....
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Screening Method to Identify Molecules Having the Ability to Modulate the Activity of a Catalyst

The present invention provides methods in which to screen or identify molecules that can have catalytic activity or that can alter a catalyst's activity....
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Compound Arrays for Sample Profiling

The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds binding to components of the samples can be increased by forming arrays such that multivalent components of th...
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Bacterium for Production of Fatty Acids

A bacterium that produces fatty acids is disclosed. The bacteria further contains at least one modified polar cell layer....
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Fabricating Porous Materials Using Thixotropic Gels

Methods, apparatuses, and systems for fabricating porous materials using thixotropic gels. A shear force is applied to a thixotropic material causing the material to flow. Multiple components are added to the thixotropic material while applying the shear force causing the multiple components to be d...
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Tri-2-naphthylamines

The invention relates to tri-2-naphthylamines that can be useful in a variety of optical devices as hole-transport materials. For example, the tri-2-naphthylamines can be useful as hole-transport materials in organic light emitting diodes....
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Cyclopamine Analogs

The invention provides novel derivatives of cyclopamine having the following formula....
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Molecular Rectifiers Comprising Diamondoids

Provided is a molecular rectifier comprised of a diamondoid molecule and an electron acceptor attached to the diamondoid molecule. The electron acceptor is generally an electron accepting aromatic species which is covalently attached to the diamondoid....
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Preparing a colorless ionic liquid comprises reaction of heteroatom containing compound with quaternizing agent, where at least one heteroatom act as electron pair

Preparing a colorless ionic liquid (I) comprises: reaction of heteroatom containing compound, in which at least one heteroatom act as electron pair, with each of quaternizing agent under conditions that form anions and cation, where the reaction conditions are implemented in such a way that 85% of t...
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Glur2 Receptor Modulators

The present invention provides for compositions and methods for modulating the GluR2 receptor. It is based, at least in part, on the discovery, by X- ray crystallography, that a known GluR2 agonist binds to the receptor in two different orientations, thereby diminishing its potency. The present inve...
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Synthesis of Oligomeric Neolignans and their Use

Compounds having the structure formule (I) and their uses are described herein....
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On-demand Microfluidic Droplet Or Bubble Generation

Microfluidic systems and methods can dispense single or multiple fluid particles (such as a gas or other fluid bubble) or an encapsulated particle (e.g., a bead or biological cell) into a microchannel....
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Preparation of Functional Polymers

The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers we...
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Living Synthesis of Conducting Polymers Including Regioregular Polymers, Polythiophenes, and Block Copolymers

Regioregular poly(3-alkylthiophenes) and other polythiophenes can be prepared by living polymerization which have good solubility, processability and environmental stability. The polymerization method can afford regioregular poly(3-alkylthiophenes) in high yields. Kinetic study of polymerization rev...
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Improved Controlled Radical Polymerization Processes

A transition metal mediated chain transfer agent controlled polymerization process is described. The process combines the advantages of atom transfer radical polymerization (ATRP) and reversible addition fragmentation transfer (RAFT) polymerization. Synthesis of chain transfer agents useful in the d...
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Purification Methods and Purified Conjugated Polymers

Metal complexing agents are used to purify polymers including conducting polymers to provide very low metal content. The process comprises precipitating the polymer in solution into a solvent system comprising the metal complexing agent. Very low levels including undetectable levels of metals such a...
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Chiral Indole Intermediates and their Fluorescent Cyanine Dyes Containing Functional Groups

This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3'-dimethyl-3H-indole and its derivatives as intermediates for preparation of cyanine dyes, to methods of preparing these dyes and the dyes so prepared....
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Monolithic Polymer Crosslinked Composite Materials and Methods of Making

A bidentate free radical crosslinking initiator binds chemically to silica and silica rich surfaces and enables the free radical based polymerization of various materials such as styrene, divinylbenzene and methylmethacrylate onto silica and silica rich surfaces. When used in connection with aerogel...
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Pre-formed Assemblies of Solgel-derived Nanoparticles As 3-d Scaffolds for Composites and Aerogels

A composite material that includes a dopant comprised of pre-formed, three dimensional assemblies of skeletal structures that are comprised of solgel derived nanoparticles. The composite material includes a chemically bonded, in situ formed, polymer coating that at least partially coats mesoporous s...
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Soy-based Polyols

The invention provides B-sides of urethane formulations, wherein the B-sides comprise both alcohol and epoxy moieties. Also provided are urethane formulations comprising the B-side of the invention, as well as A-sides comprising isocyanate molecules....
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Method of Producing Lower Alcohols from Glycerol

This invention relates generally to a process for value-added processing of fats and oils to yield glycerol and glycerol derivatives. More particularly, the process converts glycerol to acetol and then acetol to propylene glycol to produce a propylene glycol with ultra-low amounts of ethylene glycol...
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Method of Producing Lower Alcohols from Glycerol

A reactive-separation process converts glycerin into lower alcohols, having boiling points less than 200 DEG C., at high yields. Conversion of natural glycerin to propylene glycol through an acetol intermediate is achieved at temperatures from 150 DEG to 250 DEG C. at a pressure ranging from 1 and 2...
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Functionalization of Organic Surfaces

The present invention relates to functionalizing a surface of an organic material. For example, surfaces of materials having C-H bonds, such as polymers having C-H bonds, can be functionalized. In certain embodiments, a heterobifunctional molecule having a photoactive anchor, a spacer, and a termina...
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Synthesis of Acenes and Hydroxy-acenes

A method comprising reducing an acenequinone to form an acenepolyhydrodiol by exposing the acenequinone to a reducing environment comprising an alkoxyaluminate....
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In situ Plating and Soldering of Materials Covered with a Surface Film

The disclosed subject matter provides systems and methods for etching and/or metal plating of substrate materials. An exemplary method in accordance with the disclosed subject matter for metal-plating or etching a substrate includes submerging portions of the substrate in a first bath of chemical so...
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Photolabile Compounds

The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In some embodiments, the Photolabile Compounds compr...
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Structures Having an Adjusted Mechanical Property

In various embodiments, the properties of a cross-linkable polymer can be changed by modifying the degree of cross-linking. The degree of cross-linking can be modified on a localized basis using lithographic patterns in which the cross-linkable polymer can be selectively and controllably subjected t...
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Substrate Laser Oxide Removal Process Followed By Electro Or Immersion Plating

Method of ablating the surface of a substrate including providing a dry substrate and an electrolyte source, ablating the surface of the dry substrate to at least partially remove a native oxide layer, and immersing the ablated dry substrate in the electrolyte source, in which the dry substrate is a...
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Surface-modified structures, useful e.g. in optical or catalytic applications, comprise substrate, e.g. of glass, silicate primary coating and secondary coating, e.g. of metal

A novel surface-modified structure (I) comprises (a) a substrate, (b) a silicate primary coating and (c) a secondary coating and/or particles containing element(s) other than silica and oxygen. The chemical composition of (b) differs from that of (a) and (c). Either (b) is located between (a) and (c...
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Method for the Determination of Intra- and Intermolecular Interactions in Aqueous Solution

The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, said method comprising the steps of: (a) determining the dehydration ([Delta]Gdehydration) of all atoms in the intermolecular interface, (b) adding the vacuum hydrogen bo...
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Method for the Stereoselective Synthesis of Phosphorus Compounds

The present invention relates to a method for the stereoselective synthesis of phosphorus compounds, wherein in the first reaction step a chiral auxiliary is covalently bound to the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride, the product from the first ...
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Process and Apparatus for Ion Channel Characterization

The present invention provides a process and an apparatus for performing the process, for ion channel characterisation, especially for determination of the impact of effector compounds onto the ion channel activity. For measuring, ion channels are comprised in lipid membrane vesicles. For detection,...
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Means for Treating Myosin-related Diseases

This invention relates to a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin....
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Methods for Identifying Nucleotide Ligands

Methods of identifying associations between nucleotide ligands and target molecules include amplifying a pool of non-random oligonucleotides to form libraries of oligonucleotides, contacting the library with a target molecule and separating the non-random oligonucleotides that associate with the tar...
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Mesoporous Inorganic Oxide Spheres and Method of Making Same

A method of preparing mesoporous inorganic oxide spherical particles includes providing a reaction mixture capable of producing mesoporous inorganic oxide spheres; heating the reaction mixture to produce mesostructured inorganic oxide particles and removing organic material from the mesostructured i...
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Curcumin Derivatives and their Use As Radioprotectors

Disclosed are compositions relating to analogues, derivatives, and metabolites of curcumin, methods of synthesis thereof, and methods for use of said compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the p...
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Hybrid Host Materials for Electrophosphorescent Devices

Compounds (including polymers) for use in hybrid host materials which can be used in electroluminescent devices. The compounds comprise at least one electron- transporting moiety and at least one hole-transporting moiety which are joined by a flexible linker. Hybrid host materials comprising the com...
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Method for the Sensitive Detection of Polyamino Acids and Other Macro-molecules

The invention relates to a method for the detection of an analyte containing polyamino acid. The object of the invention is to detect polyamino acids in a highly sensitive manner. The object is achieved in that an LM is coupled to a protein after chemical activation, and is complexed using a lanthan...
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Device and Method for Preparing and Performing Multiple Polymerase Chain Reactions

The present invention relates to methods, kits and devices with multiple open reaction chambers having multiple pre-deposited primer compositions, and a basic sample loading mechanism that utilizes an immiscible companion fluid for preparing and performing multiple Polymerase Chain Reactions...
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Trioxane Monomers and Dimers

Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, to...
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Thermally Stable Volatile Film Precursors

A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula MxLy where M is a metal and L is an amidrazone-derived ligand or an amidate-derived ligand. A process of forming a thin film using the precursors is also provided....
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New Rac1 Inhibitors As Potential Pharmacological Agents for Heart Failure Treatment

The present invention finds application in the field of medicine and, in particular, to new compounds particularly active in inhibiting Rac1 member of the Rho family. Pharmaceutical preparations containing them useful for the treatment and/or prevention of heart failure are disclosed as well....
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A Method for the Formation of Megamitochondria

The present invention relates to an in-vitro method for the formation of megamitochondria in cells, wherein the cells are grown in a suitable fermentation medium acidulated with lactic acid to pH values between 5.3 and 6.7. The invention further concerns H+ ionophores, ionophores which catalyze the ...
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Fluorinated Nanodiamond As a Precursor for Solid Substrate Surface Coating Using Wet Chemistry

The present invention is directed to nanodiamond (ND) surface coatings and methods of making same. Such coatings are formed by a covalent linkage of ND crystals to a particular surface via linker species. The methods described herein overcome many of the limitations of the prior art in that they can...
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Large Scale Microbial Culture Method

A new culture method for producing high levels of a metabolite, such as succinic acid uses oxygen rich culture without pH adjustment to increase the biomass, acclimation in under oxygen lean conditions having ...
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Fullernene Compositions and Methods for Photochemical Purification

In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible light. In some embodiments, the fullerene derivatives are aminofullerenes containing a plurality of a...
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Fluorescent fused-ring traizoles that inhibit cell proliferation and uses thereof

Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently d...
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Ligands Specific for Cannabinoid Receptor Subtype 2

A compound of Formula I: (I) has activity as a cannabinoid receptor antagonist. In Formula 1, R1 is unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted heteroaryl;...
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Vinyl Substituted Fatty Acids

Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein....
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Fluorous reaction systems

The present invention provides a method for carrying out a chemical reaction comprising the steps of forming an organic/fluorous solubilizing liquid phase comprising a solvent system. The solvent system is selected or adapted to substantially solubilize a fluorous reaction component or components (t...
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Fatty Acid Monomers to Reduce Emissions and Toughen Polymers

Novel fatty acid monomers and methods for their synthesis are provided for use in polymerization reactions. Fatty acid monomers are employed as reactive diluents in the polymerization of vinyl esters and polyesters for one or more purposes selected from improving the fracture resistance, lowering th...
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Production and Uses of Carbon Suboxides

Methods for the reduction of gaseous carbon dioxide emissions from combustion or oxidation reactions are provided. The various methods involve the formation of carbon suboxides and/or polymerized carbon suboxides (PCS), preferentially over gaseous carbon oxides to thereby reduce gaseous carbon dioxi...
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Poly(ethylene Glycol) and Poly(ethylene Oxide) By Initiated Chemical Vapor Deposition

A method for ionic polymerization of ethylene oxide. In the first step of the method, a gaseous monomer composition comprising ethylene oxide at a first flow rate is mixed with a gaseous ionic polymerization initiator at a second flow rate, thereby forming a mixture. The formed mixture is then heate...
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Crosslinked Hydrogels

The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alo...
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Lead sensor and methods of use

A fluorophore that forms a complex with Pb ions is disclosed. The fluorophore/lead complex fluoresces with an intensity greater than complexes formed by the fluorophore with other metals. The fluorophore may be used as a sensor/detector for lead ions in various samples. Methods for detecting and cal...
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Basic Acetophenones as Inhibitors of No-Synthases

Use of the substance characterized by general structural formula (I) for the preparation of an agent inhibiting the enzymatic activity of NO-synthase, R1, R2, R3, R4 and/or R5 being hydrogen, an alkyl group, an aryl group or a heterocyclic group and n equals 2 or 3....
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Inhibitors of Dimethylarginine Dimethylaminohydrolase

The invention relates to an inhibitor of dimethylarginine dimethylaminohydrolase (DDAH) of general structural formula (I), wherein B is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-sub...
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Derivate Von N

The invention relates to physically-chemically and pharmacokinetically enhanced N ?-hydroxy-L-arginine (NOHA) derivatives and a method for producing the NOHA derivatives having enhanced physical-chemical and pharmacokinetic properties according to the invention....
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Radio-opaque Polymer Biomaterials

Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, bioco...
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Apparatuses and Methods for Determining Protease Activity

The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease cleavage sequence, and linker for attaching the protease cleavage sequence to a solid support. Methods for d...
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Expression System Compositions and Methods

The present invention relates to novel expression systems and methods for preparing samples for 3D structure determination of a protein based on a protein expression vector, E. coli host, and specific growth media....
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System for Dehumidifying, Heating And/cooling of a Liquid

The invention relates to an absorber (1) or a regenerator. A liquid in said absorber (1) runs across an exchange surface to interact with a gas for the exchange of humidity. The liquid is supplied to the exchange surface by a distribution device (6) wherein the liquid, depending on the volume flow, ...
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Reservoir

The invention relates to a reservoir (1) for storing two pressureless fluids (2; 3). An insert (12) can be inserted into a reservoir base (6) of the reservoir. Said insert has a storage container (20) and conduits (21 to 24) having connections (29 to 32) via which a chamber (4) in the reservoir base...
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Device for Disinfecting Water By Means of Anodic Oxidation

The invention relates to a device for disinfecting water by means of anodic oxidation, wherein a reservoir (10) is provided for disinfected water, wherein a feed line (15) leads from the water to be disinfected into the reservoir (10), wherein a reactor (4) for the anodic reaction of the water is ar...
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Actuation Via Surface Chemistry Induced Surface Stress

A method of controlling macroscopic strain of a porous structure includes contacting a porous structure with a modifying agent which chemically adsorbs to a surface of the porous structure and modifies an existing surface stress of the porous structure. A device in one embodiment includes a porous m...
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Inorganic-organic Composite Fluorescent Substance

The present invention relates to a composite fluorescent substance, comprising an inorganic matrix and an organic fluorescent dye, wherein the inorganic matrix is constructed of an inorganic compound selected from the group of metal oxides, metal hydroxides, metal oxide hydroxides, metal phosphates,...
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Organo-cascade Catalysis: One-pot Production of Chemical Libraries

A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a c...
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Synthesis of Bio-functionalized Rare Earth Doped Upconverting Nanophosphors

Methods for preparing rare earth doped monodisperse, hexagonal phase upconverting nanophosphors, the steps of which include: dissolving one or more rare earth precursor compounds and one or more host metal fluoride compounds in a solvent containing a tri-substituted phosphine or a tri-substituted ph...
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Conversion of Carbon Dioxide to Organic Products

The invention relates to various embodiments of an environmentally beneficial method for reducing carbon dioxide. The methods in accordance with the invention include electrochemically or photoelectrochemically reducing the carbon dioxide in a divided electrochemical cell that includes an anode, e.g...
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Functionalized Graphene Sheets Having High Carbon to Oxygen Ratios

Functionalized graphene sheets having a carbon to oxygen molar ratio of at least about 23:1 and method of preparing the same....
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High-yield Activation of Polymer Surfaces for Covalent Attachment of Molecules

Polymer surfaces coated with organometallic layers, wherein the organometallic layers and polymer surfaces have functional groups that react to bond the organometallic layer to the polymer surface with organometallic functional groups remaining unreacted for the subsequent covalent attachment of org...
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Organic Vapor Jet Deposition Using an Exhaust

Methods and systems for organic vapor jet deposition are provided, where an exhaust is disposed between adjacent nozzles. One or more carrier gases may be provided and ejected from a plurality of nozzles. An exhaust may be provided to create a localized vacuum between nozzles. The exhaust may reduce...
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Device and Method for Organic Vapor Jet Deposition

A device and a method for facilitating the deposition and patterning of organic materials onto substrates utilizing the vapor transport mechanisms of organic vapor phase deposition is provided. The device includes one or more nozzles, and an apparatus integrally connected to the one or more nozzles,...
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Initiator-tightened Compositions

Disclosed herein are gel and plastic compositions comprising tightened layers of polymerized vinyl monomers, as well as methods of making the same, where the layers are tightened in having smaller pores. The tightened layers comprise tightened inner layers and exterior layers, and the compositions c...
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Betulinic Acid Derivatives and Methods of Use Thereof

This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment met...
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Hybrid Prokaryotic-eukaryotic Tubulins and Use Thereof

The present invention embraces hybrid Prosthecobacter- eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin....
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Functional Polysobutylene Based Macromonomers and Methods for Making and Using the Same

A method of synthesizing a functionalized polymer represented by the structural formula (I) comprising a step of reacting a polymer represented by structural formula (II) with a compound Nu1 -M to nucleophilically substitute moiety X1 with moiety Nu1. Values and preferred values of the variables in ...
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Thiophene-based Conjugated Polymers for Detection of Explosives

A device comprises a sensing element, wherein the sensing element includes a polymer or a copolymer having at least one unit of structural formula (I) having particular substituents for R' and R, formula (I): A method of detecting certain chemical compounds in a sample that includes exposing the dev...
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Polyisobutylene-based Polyurethanes

An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment compri...
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Modified Polymers and Methods for Making and Using the Same

The present invention provides block copolymers, e.g., thermoplastic elastomers, having at least one monomer that is covalently bonded to a sulfonate moiety. The present invention also provides block copolymers, e.g., thermoplastic elastomers, having at least one monomer that is covalently bonded to...
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Copolymers Having Polyisobutylene and Biodegradable Polymer Segments

The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspect...
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End-capped Polymer Chains and Products Thereof

Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moiety; (b) reacting the carbocationically terminated polymeric moiety with a heterocyclic compound of ...
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Polymerization of aromatic monomers using derivatives of hematin

Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts ...
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Functional Hydrocarbon Polymers and Process for Producing Same

A method of synthesizing a compound of formula (IIIe), comprising a step of reacting a compound of formula (IIIc): A functional polymer of formula (XXXa): The variables in formulas (IIIc), (IIIe), and (XXXa) are defined herein....
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Methods for forming copolymers comprising olefin and protected or unprotected hydroxystyrene units

Novel methods for forming copolymers, including block copolymers, which comprise one or more olefin units and one or more protected or unprotected hydroxystyrene units are provided....
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Methods and Apparatus for the Synthesis of Useful Compounds

The present invention relates to methods and apparatus for activation of a low reactivity, non-polar chemical compound, hi one example embodiment, the method comprises introducing the low reactivity chemical compound to a catalyst. At least one of (a) an oxidizing agent or a reducing agent and (b) a...
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Process Intensification in Microreactors

The present disclosure provides for a chemical reactor which includes elongate chambers defining an arrangement and including first, second, and third elongate chambers adapted to support respective distinct first, second, and third reactor functions associated with respective first, second, and thi...
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Glucose Sensors and Methods of Manufacture Thereof

Disclosed herein is a device that functions as a glucose sensor. The device has a reference electrode; a counter electrode, a working electrode; an electrically conducting membrane; an enzyme layer; a semi-permeable membrane; a first layer of a first hydrogel in operative communication with the work...
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Chemical Oxidization of Volatile Organic Compound

PROBLEM TO BE SOLVED: To effectively oxidize volatile organic compounds in the soil. ; SOLUTION: Volatile organic compounds are removed from the contaminated soil by introducing one or both of a water-soluble peroxygen compound, such as a persulfate, and a permanganate into the soil, either in situ ...
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Fully Crosslinked Chemically Structured Monolayers

The present invention relates to a structured monolayer, which is composed of low molecular weight aromatics and in the lateral direction of fully networked, with the mono-layer on one of the two surfaces of a pattern of functional groups, a method for producing such a structured monolayer and their...
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Odor Samples of Peroxidic Explosives

The invention relates to the use of a neutral ionic liquid for stabilizing peroxidic explosives and for producing stable solutions of peroxidic explosives. The invention further relates to stable compositions comprising a solution of a neutral ionic liquid having a detectable quantity of a peroxidic...
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Enantioselective production of alpha-hydroxy carbonyl compounds

The invention relates to a process for the regioselective and enantioselective preparation of +--hydroxy carbonyl compounds from +--ketocarbonyl compounds via enzymatic reduction....
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Methods and Compositions for Inhibiting Clostridium Difficile Spore Germination and Outgrowth

Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of C. difficile spores and/or the growth of C. difficile cells. The methods and compositions of the invention are useful for preventing and treating C. difficile-associated diseases, includ...
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Treating Catalysts

A method includes contacting a catalyst including a metal having an average particle size of approximately one nanometer or greater with SO2; and reducing the average particle size of the metal....
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Sulfur-tolerant Water-gas Shift Catalysts

A method for oxidizing carbon monoxide by a water-gas shift (WGS) reaction and a method for reducing carbon dioxide by a reverse water-gas shift (RWGS) reaction, both using a catalyst of the formula xMZLn2O2SOy, in which M, Ln, x, and y are as defined herein. Also disclosed are novel compositions fo...
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Heterocyclic Inhibitors of Necroptosis

The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-a) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-a induced necroptosis in FADD-deficient variant of hu...
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Method for de novo detection of sequences in nucleic acids:target sequencing by fragmentation

The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass of a fragment, the mass of any one...
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New substituted bisoxazoline ligands, useful as chiral catalyst in asymmetric organic synthesis, preferably nitroaldol reaction

Substituted bisoxazoline ligands (I) are new. Substituted bisoxazoline ligands of formula (I) are new.R1, R2, R3 = aryl, e.g. phenyl or alkyl, e.g. methyl, isopropyl or tert-butyl. Independent claims are also included for: (1) preparation of (I); (2) a polyglycerol bound bisoxazoline derivative of f...
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Polyoxadiazole polymers

Polyoxadiazole polymer (I), (II) or (III) is new. Polyoxadiazole polymer of formula (I), (II) or (III) is new. n : >= 1, preferably 6-10; m, p, q : integer; X : [1,3,4]oxadiazole derivative of formula (IV), substituted triazole derivative of formula (V) or (-(C(=O)-NH-NH-C(=O)-R 1>)-) (VI); Y 1>[1,3...
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Method for the Solid Phase-based Production of Phosphate-bridged Nucleoside Conjugates

The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles resul...
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Crosslinked Polycyclooctene

Chemically crosslinked polycyclooctene having excellent shape recovery properties is prepared by ring-opening metathesis polymerization of cis-cyclooctene followed by chemical crosslinking. The crosslinked polycyclooctene can be shaped, the shape memorized, a new shape imparted with the original sha...
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Polyesters with Grafted Zwitterions

The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-opening polymerisation and click chemistry, compositions and products comprising same, and related methods...
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Polymeric Compositions, Methods of Manufacture Thereof and Articles Comprising the Same

Disclosed herein is a polymeric composition comprising a polymeric composition comprising a first crosslinked network; and a second crosslinked network; wherein the first crosslinked network is crosslinked at a first stress and/or a first strain and the second crosslinked network is crosslinked at a...
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Rapid Cell Block Embedding Method and Apparatus

PROBLEM TO BE SOLVED: To provide a method and apparatus for rapidly embedding cells that utilizes a flow-through embedding technique. ; SOLUTION: The apparatus 10 includes a cell flow pathway 16 defined by an inflow tube 20 for delivering cell fragment from a cell sample 14 to a sample port 26. The ...
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Single Probe, Multiple Temperature, Nucleic Acid Detection Methods, Kits, and Compositions

Provided herein are methods, kits, and compositions related to nucleic acid detection assays that allow discrimination of multiple target sequences with a single probe. In particular, provided herein are methods kits, and compositions that include single-probe target sequence discrimination where di...
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Cross-linking of Superoxide Dismutase Monomers

A stabilized superoxide dismutase (SOD1 ) analogue, wherein the side chains of two amino acids on two different SOD1 monomers are connected is provided. A method of producing a stabilized superoxide disumutase (SOD1) analogue comprises reacting a first SOD 1 monomer, a second SOD1 monomer, and a cro...
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Conjugate Addition Reactions Using Bifunctional Cinchona-alkaloid-based Catalysts

One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene, comprising the step of: reacting a prochiral electron-defici...
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Amphiphilic Compositions and Methods for Preparing and Using Same

The invention relates to amphiphilic C-glycoside derivatives, to methods of using them and to processes for synthesizing them. Specifically, the invention relates to novel cyclic and linear enone-glycolipids and cyclic ketone-glycolipids....
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Chiral Stationary Phases Based on Xanthone Derivatives

The present invention relates to the development of new chiral stationary phases (CSPs), named chiral xanthone stationary phases (CXSPs), and to the use thereof for the enantiomeric resolution by high-performance liquid chromatography (HPLC). More specifically, it relates to the invention of new xan...
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Device to Separate Olefins from Paraffins and to Purify Olefins and Use Thereof

The present invention discloses a device, which uses membranes, capable of separating olefins from paraffins. The device (1) considers an ultramicroporous ceramic membrane module, zeolite or silicate based, containing a fixed carrier of copper I or silver ions (#-complexant ions) inserted by ion exc...
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Enzymatic Synthesis of Enantiomerically Enriched Derivatives of Cis- and Trans-cyclopentane-1,2-diamines

The invention relates to the enzymatic resolution of derivatives of cis- and trans-cyclopentane-1,2-diamines in order to obtain enantiomerically pure or enriched compounds, a method for preparing the starting materials for this method, the products of said method and the transformation thereof into ...
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Method for the Dehalogenation and Hydrogenation of Halogenated Aromatic Molecules

Method for the consecutive dehalogenation and hydrogenation of halogenated aromatic molecules under mild temperature and pressure conditions in the presence of a catalyst of rhodium complexes with bis(imino)pyridine ligands. Furthermore, the invention relates to said complexes....
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Two-zone Fluidised-bed Reactor

The invention relates to a fluidised-bed reactor (10, 20, 30, 40) comprising two zones (11,12, 21, 22; 31, 32; 41, 42), in which the upper zone (11, 21, 31, 41) has a different cross-section to the lower zone (12, 22, 32, 42). A zone with a reducing atmosphere is obtained in one of the two zones (11...
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Method for Obtaining Aromatic Hydrocarbons from Methane

The invention relates to a method for obtaining aromatic hydrocarbons from a stream containing at least one light hydrocarbon selected from the list comprising methane, ethane, ethylene, propane, propene, propylene, butane, butene or butadiene, in which the stream is brought into contact with a cata...
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Scalable Process for Producing Phycocyanine

The invention relates to a three-stage process for producing and purifying phycocyanine originating from microalgae of the genus Anabaena, said process being characterised by scalability and high yield. The first stage consists of a cell disruption by means of an osmotic shock which releases the cyt...
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Halogenated Derivatives of 2h-1,4-benzoxazin-3(4h)-one with C-2 Alkyl Chains Or N-4 Acyl Residues

The invention relates to halogenated derivatives of 2H-1,4-benzoxazin-3(4H)-one with C-2 alkyl chains or N-4 acyl residues. The invention belongs to the field of chemical compounds that can be used for agricultural pest control. The invention comprises a series of chemical compounds, together with t...
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Polymer Matrices Based on Polysaccharides and Cyclodextrins

The present invention relates to novel materials based on polymer matrices obtained from polysaccharides, to the methods for obtaining same and to the uses thereof. More particularly, the invention relates to the use of said materials based on starch, dextrin or cyclodextrins to sequester organic an...
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Method for the Preparation of Mero Sesquiterpenes from Labdane Diterpenes

The present invention describes a method for producing mero sesquiterpenes, more specifically drimenylbenzenes and drimenylnaphthoquinones, by means of a Diels-Alder reaction between a labdane diterpene and a dienophyl. Subsequently, a dehydrogenation yields the aromatized derivatives....
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N-benzyl Imidazole Derivatives

The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula (I) wherein R is (C1-3)alkyl, (C1-3)alkyloxy, halogen, nitro or cyano; R1 is formyl, (C1-6)alkyl, optionally substituted with OH, (C1-3)alkyloxy, (C1-3)alkylcarbonyloxy, (C1-3)alkyloxy- carbo...
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Method for Releasing and Labelling 0-glycans

The application describes a one-pot process for releasing and labelling O-glycans from glycoproteins, thereby facilitating analysis via LC-ESI-MS-MS. The process comprises contacting the glycoprotein with an amine, eg. methylamine, dimethylamine, or ammonia, NH3 in the presence of a labelling agent,...
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Copolymers

The invention provides a block copolypeptide comprising a hydrophilic heteropolypeptide block (A) and a hydrophobic homopolypeptide block (B). There is also provided a polymersome comprising a block copolypeptide of the invention. The invention further provides a method for preparing a copolymer com...
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Lanthanide Compounds

A compound, according to general formula 1: M( II )Ln(III) 1-p-q Ce(III) p Tb(III) q M'(III) 3 O 7 wherein M(II) represents a divalent metal selected from the group of Ca, Sr and mixtures thereof; Ln(III) is a trivalent metal selected from the group consisting of Y, Gd, La, Lu and mixtures thereof; ...
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Method for Producing Carboxylic Acids By Oxidative Cleavage of Unsaturated Compounds

The invention provides a method of oxidative cleavage of an unsaturated carbon-carbon bond, said method comprising contacting a reactant molecule containing a carbon-carbon unsaturated bond with a catalytic system comprising (i) either a mixture of tungstate salt and tungstic acid or a mixture of a ...
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Coordination Complex System Comprising Tautomeric Ligands

The invention relates to a coordination complex system comprising a ligand having the formula: R1-SO2-NH-P (XR2)2 (1a); or R1-SO2-N=PH (XR2)2 (1b); or R1-SO(OH)=N-P(XR2)2 (1c); wherein X is independently O, S, NH, or a bond; R1 and R2 are independently selected from hydrogen and substituted or unsub...
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Process for the Production of Phosphorous Compounds

The invention is directed to a process for the production of certain phosphorous, namely urea, thio-urea and sulphonamide phosphorous compounds. The present invention provides a process for the production of phosphorous compounds which process allows an easy and effective separation of the reaction ...
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Metal Catalysts Comprising Nitrogen-containing Aromatic Ligands and Use Thereof

The present invention discloses a method for the preparation of a polymer from vinyl group-containing monomers comprising the step of polymerizing the vinyl group-containing monomers in the presence of a metal catalyst having a moiety M(Y)4(X)2, wherein M is a transition metal selected from the grou...
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The Method of Glyceric Acid Selective Preparation and Catalysts for Its Realization

The present invention relates to chemical technology, particularly to the glyceric acid preparation method in process of selective glycerol oxidation in presence of new supported Pd catalyst. Object matter of this invention is increasing glyceric acid yield and selectivity of process using economica...
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Process for the Oxidative Cleavage of the Ethylenic Double Bonds of Vinylaromatics

The invention relates to a process for the oxidative cleavage of vinylaromatics of the formula (1), with the characteristic feature that compounds of the formula (1) are oxidized in accordance with the reaction scheme below to aldehydes or ketones of the formulae (2) and (3) in the presence of molec...
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Method for Producing Glucose Derivatives

The present invention relates to a method for producing 2-0- (a- D-glucopyranosyl) -glycerate from a glucosyl donor and a glucosyl acceptor comprising the steps: - providing a sucrose phosphorylase (EC 2.4.1.7), incubating said sucrose phosphorylase with a mixture comprising a glucosyl donor and gly...
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Non-leaching Heterogeneous Catalyst Systems for Coupling Reactions

Supported palladium containing catalyst systems comprising an inorganic support material, a modifying agent covalently attached to said inorganic support material through at least one first functional group FG1, such modifying agent comprising at least one second functional group FG2 for bonding a l...
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Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands

The invention relates to a method for preparation of ruthenium-based carbene catalysts with a chelating alkylidene ligand ("Hoveyda-type catalysts") by reacting a penta-coordinated ruthenium (II)-alkylidene complex of the type (L)(Py)X 1 X 2 Ru(alkylidene) with a suitable olefin derivative in a cros...
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Method for the Preparation of Reactive [18] F Fluoride

The present invention is related to a method to obtain reactive [18F] fluorides in an organic medium suitable for radiolabelling without any azeotropic evaporation step, by the use of a solid phase extraction column containing a modified non-ionic solid support....
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Inorganic-binding Peptides and Quality Control Methods Using Them

The present invention relates to quality control methods using inorganic binding peptides, wherein inorganic entities are identified using inorganic-binding peptides specifically binding to the inorganic entity of interest. In particular, the invention includes a method for the identification of def...
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Marked Peptides and Use Thereof for Assaying Circulating Irap

The invention relates to a method for assaying the circulating extracellular portion of the IRAP ("insulin-responsive aminopeptidase") protein, including at least one step of quantitatively assaying the released and purified extracellular portion of the IRAP using at least one marked peptide, said m...
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Method for screening and selecting ligands

The present invention provides a method for screening of ligands wherein the target is a membrane protein, which is reconstituted into a membrane environment, using the surface plasmon resonance (SPR) technology. In particular, the target is a VDAC protein....
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Extracellular Allosteric Inhibitor Binding Domain from a Tyrosine Kinase Receptor

The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specifically, the invention relates to an extracellular domain derived from a Fibroblast Growth Factor Recep...
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Cyclic Imidate Ligands

The present invention relates to a use of a cyclic imidate as a ligand for catalysis in which the ligand contains substructure (Y) as a minimal structural motive, wherein the carbon atoms and the nitrogen atom can be optionally substituted by a chemical substituent....
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Colorimetric Assay for the Visual Detection of Primary and Secondary Amines

The present invention concerns a novel method and kit system for the detection of solid-phase bound primary amines, secondary amines, or thiol groups comprising adding a fluid to said substrate and further comprising adding a novel reagents to said substrate and recording a colour reaction on said s...
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Improved cleaning of plasma chamber walls by adding of noble gas cleaning step

An improved reaction chamber and chamber cleaning process are disclosed able to remove water residues by making use of noble-gas plasma reactions. The chamber is easy to operate and the method is easily applicable and may be combined with standard cleaning procedure. A noble-gas plasma (e.g. He) tha...
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Low Temperature Direct Selective Methane to Methanol Conversion

Direct selective conversion of methane to methanol at low temperature (e.g. less than 300 degrees Celsius) is provided. The conversion is carried out at ambient pressure. An oxygen- activated catalyst is first created by heating a catalyst in an oxidizing environment. The oxygen-activated catalyst h...
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Method for Producing Hydrogen By Water Dissociation

The invention relates to a method for producing hydrogen from an aqueous medium containing an electron donor, a photosensitizer and a supported catalyst. The method is characterised in that the photosensitizer is a compound containing a porphyrin cycle bearing peripheral cationic groups non-conjugat...
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Method for Hybridizing Nucleic Acids

The invention relates a method for manipulating, isolating, detecting or amplifying a target nucleic acid in a sample by hybridization with an oligonucleotide-oligocation molecule, comprising allowing said nucleic acid to react with an oligonucleotide- oligocation of structure I A i B j H (I) wherei...
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Controlled Release of Active Aldehydes and Ketones from Equilibrated Dynamic Mixtures

The present invention concerns a dynamic mixture obtained by combining, in the presence of water, at least one diamine derivative, comprising at least one benzylamine moiety, with at least one active aldehyde or ketone. The invention's mixture is capable of releasing in a controlled and prolonged ma...
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Cyclitols and their Derivatives and their Therapeutic Applications

The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate deriva...
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Catalytic Phosphination Method

The invention relates to a double or triple catalytic phosphination method, essentially performed in a single step of injecting phosphine groups on a di-, tri- or tetra-halobiaryl compound....
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Apparatus and Processes for Generating Variable Concentration of Solutes in Microdroplets

The present invention relates to systems and methods for generating microdroplets with varying concentrations of a particular solute from a solution at fixed concentration....
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Method of Preparing an Adduct

A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, said molecular structure(s) each comprising one nucleotide chain onto which is hybridized at least one PNA-encoded molecule....
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Method for the Silanisation of Polysaccharides

The invention relates to a method for the silanisation of polysaccharides in a homogenous medium and in the presence of ionic liquids....
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Method for Synthesizing Hydroxy-bisphosphonic Acid Derivatives

The present invention relates to a method for preparing a hydroxy-bisphosphonic acid derivative or a salt thereof, from the corresponding carboxylic acid, comprising the following steps: - activation of the carboxylic acid function in the form of the boronate derivative thereof through the action of...
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Novel Compounds, Use Thereof As Medicaments, and Method for the Preparation Thereof

The invention relates to novel compounds having the following formula (I) in which: n is an integer from 1 to 12, in particular from 1 to 8, m and m' are, independently of one another, integers from 0 to 8, - q and q' are, independently of one another, integers from 0 to 2, p and p' are, independent...
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Thermoreversibly Crosslinked Elastic Bituminous Composition

The invention relates to a bituminous composition comprising at least one bitumen and at least one organogelling molecule taken alone or as a mixture, said organogelling molecule being represented by the following general formula (I): where: A represents an acyclic, cyclic or polycyclic, saturated o...
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Amphiphilic Block Copolymer and Method for Preparing Same

The invention relates to an amphiphilic block copolymer, to the preparation thereof, and to the use thereof in the form of a self-stabilizing latex. The copolymer has the formula R5O-[-CH2CH2-O-]n-C(=O)-CR3R4-[CH2CR6R7]m-S-C(=S)-S-R1 where: R1 is a straight or branched alkyl group, an alkenyl group ...
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Method for Synthesizing Polyesters in an Acidic Ionic Liquid Medium

The present invention relates to a method for synthesizing polyesters or copolyesters having a mean molar mass, in mass MW, greater than 10000, by means of a direct polyesterification reaction between a diacid, diester, hydroxyacid, or hydroxyester and a diol, or between hydroxyacids or hydroxyester...
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Processes for the Preparation of the Alpha Crystal Polymorph of Metal Phthalocyanines

Methods for producing a stabilised alpha copper phthalocyanine are described. More specifically such methods comprise forming a mixture of (a) a compound of the general formula (II), in which, R1 and R2 are independently -CN or -C(O)OH, or R1 and R2 together are -C(O)OC(O)-, -C(O)NHC(O)- or -C(NH)NH...
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A Process for Preparing Silica Microparticles

Silica core - shell microparticles are prepared by growing a porous silica shell from a silica precursor onto the surface of non- porous silica particle dispersed in a mixed surfactant solution under basic pH conditions. The particles are hydrothermally treating in an oil-in-water emulsion system an...
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Colorimetric anion sensor element

A sensor element suitable for colorimetric detection of anions in a sample, the sensor element comprising a water insoluble polymeric hydrogel having a polymer network defining a water permeable microvoid network, and an anion recognition dye (receptor) incorporated into the polymeric hydrogel. The ...
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Intermediates in the Enantioselective Synthesis of 3-(aminomethyl)-5-methyl-hexanoic Acid

(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are ...
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Conjugated Linoleic Acid Derivatives

A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10; and wherein the broken lines at positions 9 and 11, or at positions 10 and 12, are each double bonds separated by a single bond, and wherein the remaining broken line is a single bond....
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Alpha-GLYCOSYL THIOLS AND alpha-S-LINKED GLYCOLIPIDS

The present invention relates to stereoselective methods for the preparation of [alpha]-glycosyl thiols and [alpha]-S-linked glycosylceramides....
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pH sensor device comprising an ionogel

A pH sensor comprising an ionic liquid stabilised in a gel so as to form an ionogel; and a pH indicator salt. The ionic liquid may comprise a trihexyltetradecylphosphonium [P6,6,6,14]+ cation and one or more of a bis(trifluoromethanesulfonyl) amide [NTf2]-, dicyanoamide [dca]-, dodecylbenzenesulfona...
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Making a stationary phase for separations from electrochemically polymerised monomer

A method of fabricating the stationary phase of an analysis tool for subsequent use in analytical separations (e.g. chromatography), includes the steps of electrochemically growing the stationary phase from a material comprising an electroactive or conducting monomer by effecting electrochemical pol...
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Organosilane coating compositions and use thereof

A sol-gel coating composition comprising a hydrolysed organosilane, an arganometallic precursor and a corrosion inhibitor, wherein the corrosion inhibitor is a chelator for the organometallic precursor. The corrosion inhibitor and the organometellic precursor may form a nonoparticulate complex. The ...
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Biodegradable Solvents for the Chemical Industry

This invention relates to ionic liquid (ILs) solvents for chemical synthesis based on an alkyl - imidazolium cation core containing ionic liquids which have enhanced biodegradability and reduced toxicity relative to existing imidazolium bases ILs such as 1-butyl-3-methylimidazolium (bmmim) salts. Ma...
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Compositions and Methods for Expressing In-frame Multimeric Proteins

The present invention concerns methods and compositions for making and using multimeric, single chain proteins of a defined structure. The invention also includes nucleic acid expression systems for making such multimeric proteins, and methods for identifying modulators of such multimeric proteins. ...
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Method of Surface Treating Microfluidic Devices

The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment....
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Ionic Liquid Solvents

A chiral ionic compound comprising an alkyl substituted imidazolium or pyridinium cationic core having an alkyl ester side chain (-alkyl-C(O)O-) directly linked to the core and an associated counter anion, characterized in that the -O- atom of the ester side chain is linked to an alpha, a beta or a ...
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Identification of Phosphorylation Sites in Polypeptides By Employment of Uranyl Photocleavage

The present invention relates to a method of cleaving a polypeptide at one or more phosphorylated residues. Said cleavage is induced by irradiation and is dependent on the presence of uranyl. The method is useful for analysis of phosphoproteoms and also for protein purification. The method also rela...
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Method of Identifying Individuals At Risk of Thiopurine Drug Resistance and Intolerance

The present invention is directed to a method of screening individuals for the presence or absence of one or more polymorphisms associated with the risk of thiopurine resistance or intolerance....
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Prepolymer Composition

The present invention relates to a prepolymer composition comprising a polyester prepolymer, a vinyl-functional monomer having a vapour pressure which is less than styrene at 20 DEG C and an accelerator. The prepolymer composition can be combined with a promoter which causes the prepolymer compositi...
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Method for the Determination of the Position of Unsaturation in a Compound

A mass spectrometric method for determining the position of unsaturation in a compound is disclosed....
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Dye Composition for Use in Photoelectric Material

A dye composition for use in a photoelectric material, the dye composition comprising a plurality of dyes comprising a chromophore and at least one binding group for binding with a semiconductor (preferably a metal oxide semiconductor) wherein the plurality of dyes include a first dye wherein the bi...
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Polymer electrolytes and devices containing them

The application arises from studies that have shown that electrochemical cells containing SPEs including: (i) a non-volatile organic ionic salt; and (ii) an inorganic electrolyte salt have an improved conductivity across a range of temperatures, and are more stable to water compared to electrochemic...
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Synthesis of Ageladine a and Analogs Thereof

The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure RdCHO are condensed to form a condensation product. The resulting condensation product is then oxidized in ...
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Controlled Polymerisation Process

The present invention relates to a controlled metathesis-driven polymerisation process which is particularly useful for the synthesis of biological polymers such as peptides and polymers. The invention also provides metathesisable supports, groups and linkers for use in the process....
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Peptide Purification By Means of Metal Ion Affinity Chromatography

PROBLEM TO BE SOLVED: To provide an oligopeptide (tag) for purifying an objective protein and a polymer substrate for metal ion affinity chromatography. ; SOLUTION: The polymer substrate is functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group. The c...
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Contoxin Analogues and Methods for Synthesizing Same

According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides....
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Compositions and Uses Therefor

The invention is directed inter alia to the use of receptor-associated protein (RAP) polypeptide or a functional analog thereof to reduce amyloid oligomerisation and deposition and to reduce Ass associated neuropathologic features. Thus, the invention provides a composition comprising RAP or an anal...
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Molecularly Imprinted Polymers, Methods for their Production and Uses Thereof

The present invention relates to methods of preparing molecularly imprinted polymers (MIPs) which facilitate chemical hydrolysis and more particularly the hydrolysis of chemical substrates which possess hydrolytically labile bonds such as peptides and proteins. The present invention is thus directed...
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A Method for the N-demethylation of N-methyl Heterocycles

The present invention provides methods of N-demethylating, N-methylated heterocycles and N-methyl, N-oxide heterocycles using a transition metal with an oxidation state of zero, ferrocene or substituted derivatives thereof, or Cr 3+ .N-demethylated heterocycles prepared by the methods of the present...
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Antimalarial Agents That Are Inhibitors of Dihydroorotate Dehydrogenase

Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and...
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Novel Bismuth(III) Nsaid Compounds and Methods for their Use

The present invention relates to the field of non-specific anti inflammatory drugs (NSAIDs). In particular, the invention relates to bismuth(III) tris-carboxylate complexes having the formula [Bi(III)L3]n including its pharmaceutically acceptable salts and solvates, wherein, L is chosen from the gro...
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Affinity Ligands and Methods for Protein Purification

The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilise the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present i...
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Temperature-responsive Polymer Particles in Protein Separation Applications

The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particles functionalized with temperat...
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Peptide purification by means of hard metal ion affinity chromatography

A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group which comprises at least 3 nitrogen donor atoms in the ring of the cyclic group, at least one of the nitrogen atoms having an optionally substituted carboxy(lower alkyl) or opt...
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Terpene Synthases from Santalum

An isolated nucleic acid molecule that encodes a terpene synthase and is selected from among: a) a nucleic acid molecule comprising the sequence of nucleotides set forth in SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5; b) a nucleic acid molecule that is a fragment of (a); c) a nucleic acid molecule co...
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Method of Oxidising Organic Compounds

Disclosed herein is a method of oxidising an organic compound, wherein the oxidation is catalysed by nanoparticles of RuO2.Also disclosed are methods for forming the RuO2 nanoparticles....
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Organometallic Catalyst and Preparation Thereof

The present invention relates to a method for producing an organometallic catalyst and an organometallic catalyst when produced by the method. The method comprises the steps of combining a polycarboxylic acid or anhydride and a metal-oxide, metal-hydroxide or metal-salt with a solvent at a temperatu...
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Peptide and Phosphopeptide Synthesis Via Phosphate Assisted Ligation

Methods of preparing polypeptides and proteins. In particular, the invention has been developed as a method of preparing peptides and phosphopeptides through formation of a peptide bond via phosphate assisted peptide ligation...
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Surface polymerisation process and polymer product using RAFT agent

A method of polymerising monomer to form polymer at the surface of particulate material, said method comprising: providing a dispersion of said particulate material in a continuous liquid phase, said dispersion comprising a RAFT agent as a stabiliser for said particulate material, and said continuou...
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Tropoelastin Derivatives

The invention relates to derivatives of tropoelastin and variants of those derivatives. The invention further provides expression products and hybrid molecules of the derivatives and variants of the invention. The invention further provides methods for the production of the derivatives, variants, ex...
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Flotation Aids and Processes for Using the Same

This invention relates to particulate and/or liquid droplet separation processes from liquids containing the same and the use of specific chemical additives to control surface wetting, hydrophobicity and surface forces in such processes....
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Novel Compounds, Derivatives Thereof and their Use in Heterojunction Devices

The invention relates to novel polyaromatic and polyheteroaromatic compounds and derivatives thereof. The compounds display high solubility in organic solvents. A further aspect of the invention relates to the use of the novel compounds in the fabrication of organic film based heterojunction devices...
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Nitrogen-containing Macrocyclic Conjugates As Radiopharmaceuticals

The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated ...
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Process for the Preparation of Asymmetrical Bis(thiosemicarbazones)

The present invention relates to a method of making asymmetrical bis(thiosemicarbazones), compounds useful as synthetic intermediates in the method, new bis(thiosemicarbazones) that can be readily accessed by use of the method and methods of treatment and imaging utilising some of the new bis(thiose...
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Process for Generation of Protein and Uses Thereof

A method of generating a protein with an improved functional property, th e method comprising: (a) identifying at least one Target amino acid Residue in a first protein, wherein said Target amino acid Residue is associated wit h said functional property; (b) comparing at least one homologous second ...
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Immobilized Enzymes and Co-factors

The present invention is concerned with the immobilization of enzymes and their co-factors in a system which permits regeneration of the co-factors. Also included in the present invention are methods and devices which utilize such systems....
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Dinuclear, Quadruply-stranded Compounds Comprising Palladium Or Platinum

The invention relates to a compound of formula (M2L4 where: M = a palladium or platinum metal ion; L = X = -O-, -S-, -NH-, or (-CH2-)n, where n = 1, 2 or 3; R2, R4, R5, R6 are each independently selected from -H, -F, -Cl, -Br, -I, -methyl, -ethyl, -propyl, -O-methyl, -OH, -CH2OH, and - CH2CH2OH, R7,...
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Modified Plasminogen Activator Inhibitor Type-1 Molecule and Methods Based Thereon

The present invention relates to a modified plasminogen activator inhibitor type- 1 (PAI-1) molecule that displays an increased in vivo half-life of the active form of PAI- 1, but is deficient in one or more functional activities as compared to the wild-type PAI- 1 protein. The modified PAI-1 molecu...
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Method for Synthesizing Xanthohumol

A method is provided for synthesizing xanthohumol by inserting a prenyl-group onto the aryl-ring via a para-Claisen rearrangement after using a Mitsunobu reaction to establish the key prenylether precursor. A Claisen-Schmidt condensation is used to construct the chalcone scaffold followed by removal...
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Boron Selective Ionic Liquids and Polymeric Ionic Liquids, Methods of Making and Methods of Use Thereof

Boron selective ionic liquids and polymeric ionic liquids, methods of making and methods of using the same are disclosed....
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Muscarinic Receptor Agonist

PROBLEM TO BE SOLVED: To provide a muscarinic receptor agonist stimulating cholinergic activity. ; SOLUTION: There is provided a compound of formula (I), wherein R3is H, CH2CH3, COCH3or formula (II). ; COPYRIGHT: (C)2010,JPO&INPIT...
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Interface Polymer

A method of depositing an anion exchange polymer on an electrode substrate, said method comprising: a) contacting an electrode substrate with an anion exchange polymer in ionic form, wherein the polymer comprises a quaternary ammonium group as the anion exchange group, and b) treating the polymer, s...
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Capacitive Deionization

A process for separating organic compounds from an aqueous medium, said process comprising: adding surfactant to the aqueous medium, such that the organic compounds interact with the surfactant to form charged or polar entities; passing the aqueous medium between charged electrodes, whereby the char...
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A Method of Making a Hard Latex and a Hard Latex

A method of making a hard latex from a latex comprising an aqueous dispersion of a polymer, the method comprising the step of exposing the latex to infrared radiation....
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Photocatalytic Fluidized Bed Reactor with High Illumination Efficiency for Photocatalytic Oxidation Processes

The invention relates to the realization of synthesis of organic com not pounds or abatement of volatile organic compounds (VOCs) in gas-solid fluid- ised bed photocatalytic reactor with improved illumination efficiency. The photoreactor consists of a two-dimensional fluidized bed catalytic reactor ...
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Fully Crosslinked Chemically Structured Monolayers

The present invention relates to a structured monolayer which is made up of low molecular weight aromatics and is fully crosslinked in the lateral direction, where the monolayer has a pattern of functional groups on one of the two surfaces, a process for producing such a structured monolayer and als...
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Novel Sulfonium Borate Complex

A novel sulfonium borate complex, which can reduce the amount of fluorine ions produced during thermal cationic polymerization, and realize low-temperature, rapid curing properties in a thermal cationic polymerizable adhesive, is represented by the structure of the following formula (1). In the form...
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Bicyclic Monophosphines

A compound of formula (I): wherein: RP1 and RP2 are independently selected from C3-12 alkyl groups; RC is a C5-6 aryl group, optionally substituted by one or more groups selected from: C1-7 alkyl, C1-7 alkoxy, halo, NH2, C1-7alkylamino, di-C1-7alkylamino, and C5-6 aryl; RA1 and RA2 are independently...
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Aluminum Complexes and their Use in the Synthesis of Cyclic Carbonates

Dimeric aluminium catalysts of formula I: and their use in catalysing the synthesis of cyclic carbonates from epoxides and carbon dioxide....
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Formation of 18F and 19F Fluoroarenes Bearing Reactive Functionalities

An iodonium compound of formula (I): where RAR1 is a C5-6 aryl group, bearing at least one substituent selected from formyl, thionoacyl, acylamidocarboxy, thionoester, azo, C2-20 alkenyl, C2-20 alkynyl, and (CH2)nRc, where Rc is selected from ether, amino, azo and thioether; RAR2 is a C5 heteroaryl ...
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Method for Monitoring the Dehybridi Zation of Double Stranded Nucleic Acid

The present invention relates, in one aspect, to a method for monitoring the dehybridisation of double stranded nucleic acid, comprising the steps of: (a) providing a nucleic acid probe and a target nucleic acid; (b) forming a double stranded nucleic acid of which at least one of the strands of the ...
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Ammoximation Process

A redox ammoximation process in which a ketone or aldehyde is reacted with ammonia and oxygen in the presence of a catalyst, wherein: the catalyst is an aluminophosphate based redox catalyst having the qualitative general formula (I) M1M2AlPO-5 (I) in which M1 is at least one transition metal atom h...
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Methods of identifying modulators of CFTR/CK2 interaction

A method of identifying a compound capable of modulating CFTR/CK2 interaction and/or CFTR phosphorylation by CK2 comprising exposing CFTR and/or CK2 to a test compound and assessing the effect of the test compound on CFTR/CK2 interaction and/or CFTR phosphorylation by CK2. A method of screening for ...
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Polypeptides, Polynucleotides and Uses Thereof

A recombinant polynucleotide encoding migrating stimulating factor (MSF) or variants or fragments or derivatives or fusions thereof or fusions of said variants or fragments or derivatives. Reagents are disclosed which can distinguish MSF and fibronectin, and which can distinguish polynucleotides whi...
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Fluorescence Lifetime and Fluorescence Assays

The invention provides a method for determining a degree of phosphorylation of a substrate, for example a peptide substrate, using a fluorescence probe that acts alone or with another material and has a lifetime that varies when in proximity to a phosphate, the method comprising: causing the fluores...
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N-myristoyl Transferase Inhibitors

The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors....
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Wide Temperature-range Smectic Liquid Crystal Materials

A method of making a wide temperature-range smectic liquid crystal material comprises taking a wide temperature-range nematic mixture and doping this with a mesogenic silicon-containing material. Aspects of the invention provide wide temperature-range smectic materials and devices using the smectic ...
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Preparation of Halogen and Hydrogen Containing Alkenes Over Metal Fluoride Catalysts

Halogenated alkenes, especially fluorinated alkenes can be prepared from halogenated and fluorinated alkanes, respectively, by dehydrohalogenation or dehydrofluorination in the presence of a high-surface metal fluoride or oxifluoride. Preferably, trifluoroethylene, pentafluoropropene, tetrafluorobut...
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Method for Producing a Material Containing Zinc Oxide and a Semiconductor Element with a Material Containing Zinc Oxide

The invention relates, amongst other things to a method with the features given in the generic part of claim 1. According to the invention, a p-doped zinc oxide-containing material (30, 60, 125, 225, 325) is produced, wherein the p-doping is carried out during the growth of the material by a nitroge...
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Catalyst and Process

The invention is a method of dehydrogenating a hydrocarbon, especially an alkane, to form an unsaturated compound, especially an alkene, by contacting the alkane with a catalyst comprising a form of carbon which is catalytically active for the dehydrogenation reaction. The catalyst may be formed by ...
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Modulation of miRNA Activity

Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide wherein a test compound which alters the polyuridylation activity is useful in modulating miRNA activit...
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Probes Comprising Fluorescent Artificial Nucleobases and Use Thereof for Detection of Single Base Alteration

The present invention relates to forced intercalation probes (FIT-probes) comprising at least one nucleoside analogue which comprises at least a fluorescent artificial nucleobase directly bound to a carbon of a modified sugar moiety wherein said modified sugar moiety is a carba-sugar or an amino aci...
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A Composite Comprising At Least One Type of Perfluoroalkyl-perfluoro-phthalocyanine

The present invention relates to a composite comprising at least one type of perfluoroalkyl-perfluoro-phthalocyanine, and to a method of producing such composite. The present invention also relates to a method of generating singlet oxygen, a method of killing eukaryotic or prokaryotic cells and a me...
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Fluorescent Dyes and Complexes

A fluorescent dye comprising a xanthene-derived fluorophore having the formula (I) wherein R1, R2, R3, R4, R5 and R6 are independently selected from H, alkyl, alkoxy, alcohol, ether, alkenyl, alkenoxy, aryl, aralkyl and amido, except that R1, R4 and/or R5 is not H when bonded to Y, Y1 or Y2, respect...
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Dimethylthiofoxins and azafoxins which may be useful as ligands for G-protein coupled receptors

The invention provides compounds of general formulae (II) or (III), or pharmaceutically acceptable salts thereof. X is -CO-(Y)k-(Z)nor -SO2-(Y)k-(Z)nwherein k is 0 or 1, each Y is a cycloalkyl, polycycloalkyl, cycloalkenyl or polycycloalkenyl group, n is an integer from 1 to the maximum number of su...
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Conductive Polymer Compositions in Opto-Electrical Devices

A conductive polymer composition comprising: a polymer having a HOMO level greater than or equal to -5.7 eV and a dopant having a LUMO level less than -4.3 eV....
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Ultrahydrophobic Surfaces and Methods for their Production

The present invention relates to a method of producing an ultrahydrophobic surface, the method comprising providing a mixture comprising low surface energy material and a sacrificial material, forming a layer from the mixture wherein the layer contains particles of the sacrificial material, treating...
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Polypeptides Including Modified Constant Regions

Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an Fc[gamma]R, which processes comprise modifying the polypeptides by substitution of the amino acid at position 268 of a human IgG CH2 region for a non-native polar or charged amino a...
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Compounds and their use in detecting an amino acid and/or latent fingerprint

The present invention relates to compounds of amino acids and/or latent fingerprints of formula:[Het]-CHOwherein Het is a nitrogen containing heterocyclic system in which a nitrogen atomis substituted by a substituted or unsubstituted alkyl group, aryl group, aralkyl group or alkaryl group, and -CHO...
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Method for extending the life of chemical sensors

The method is described for extending the life of chemical sensors for determining individual components in the gas phase, the contact between fluoride-ion conductor and metal electrode being heated once or repeatedly under the conditions of the gas to be measured briefly to temperatures between 300...
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Capillary arrangement used in electro-spraying ionization processes in mass spectrometry, e.g. for converting molecules having a high molecular mass (e.g. DNA) from a solution into ions has an electri

Capillary arrangement (10) has an electrically conducting metal oxide layer (4) for contacting a sample fluid in the arrangement. An Independent claim is also included for a process for the production of the capillary arrangement....
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Procedures and cutlery for the digestion of cells and the preservation and extraction of nucleic acids from living cells or tissues

The invention relates to a method for sample fixation, sample preservation, for cell disruption and extraction of nucleic acids in living cells, cell aggregates and tissue samples, and a working set for the implementation of the procedure. The method is to use living cells or tissue fragments of a n...
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Method for Detecting Target Nucleic Acids Using Template Catalyzed Transfer Reactions

The present invention relates to the detection and quantification of nucleic acid sequences and to the sequence determination of nucleic acids using template catalyzed transfer reactions. The invention also relates to methods, reagents, and kits for detecting and quantifying nucleic acid sequences a...
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Preparing mineral organic fertilizer from process water of hydrothermal carbonization of plant material comprises separating carbon and organic residual components from process water and isolating min

Preparing mineral organic fertilizer from process water of the hydrothermal carbonization of plant material, comprises separating carbon and organic residual components from the process water and isolating the mineral components from the process water by drying. An independent claim is included for ...
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Polymer Micelle Complex Including Nucleic Acid

It is an object of the present invention to provide: a polyion complex that sufficiently retains a photosensitizing substance in serum and is excellent in terms of structural stability; a nucleic acid polyplex as a constituent thereof; and a device and a kit for delivering a nucleic acid into a cell...
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ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-CROSS-LINKED POLYMERIC MICELLE

Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical...
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Organic-inorganic Hybrid Nano Particle Composed of Nucleic Acid Conjugate Having Polyethylene Glycol Bound Thereto and Calcium Phosphate

Disclosed is an organic-inorganic hybrid nano particle comprising a conjugate of a nucleic acid and a polyethylene glycol chain bound covalently to the nucleic acid and a calcium ion (Ca2+) and a phosphate ion (PO4 3-). The particle can be used as an effective delivery system for delivering a nuclei...
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Cationic Poly (Amino Acids) and Uses Thereof

Provided is an efficient delivery system for nucleic acids. Provided specifically are cationic poly(amino acids) that have a side chain having different amine functional groups in a portion that includes a cationic group and wherein a hydrophobic group has been introduced into a part of the side cha...
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Polyion Complex of Double-stranded Ribonucleic Acid

PROBLEM TO BE SOLVED: To provide a delivery system useful for delivering a double-stranded ribonucleic acid that achieves gene silencing in glomeruli, particularly mesangial cells or other cells to the tissues or cells; and others. ; SOLUTION: A polyion complex is in the form of a non-polymeric mice...
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Contrast Medium-containing Organic-inorganic Hybrid Particle

PROBLEM TO BE SOLVED: To provide a carrier for stably delivering an MRI contrast medium to a target site. ; SOLUTION: The organic-inorganic hybrid particle comprises a block copolymer containing an unchargeable hydrophilic polymer chain segment and a polymer chain segment containing a repeating unit...
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Copolymer Including Uncharged Hydrophilic Block and Cationic Polyamino Acid Block Having Hydrophobic Group in Part of Side Chains, and Use Thereof

The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is covalently bound to one end of the main chain of the polyamino acid chain block, and the hydrophobic gr...
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Charge Conversional Ternary Polyplex

Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive c...
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Esterases for Monitoring Protein Biosynthesis in Vitro

The present invention relates to the use of an esterase for monitoring and/or tracking the synthesis of a protein, polypeptide or peptide in a cell-free translation system or in an in vivo expression system in which the synthesis of a protein, polypeptide or peptide can occur, wherein said monitorin...
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Expression vector for Bacillus species

The present invention is related to the use of the gsiB promoter as an inducible promoter in an expression system, whereby the promoter can be induced by a measure selected from the group comprising decrease in pH, increase in temperature, addition of alcohol, preferably ethanol, exhaustion of nutri...
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Imidazo[1,5-B]pyridazinamido Ligands and their Complexes

The invention relates to novel NN(R) ligands of the formula 1 (imidazo[1,5-b]pyridazine-substituted amino ligands) in uncharged or anionic form and catalysts which can be produced therewith, in particular for asymemtric catalysis, and a process for producing such ligands and catalysts....
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Triorgano(amino)borates: Activation of Alkali Metal Amides, Converting Alkali Metal Amides Into Hydrocarbon-soluble Reagents

The invention relates to triorgamo(amino)borates and to the production and use thereof. Object of the invention is it to make a chemical compound available those the synthesis of new chemical products allowed and/or. with their assistance existing, aufwändige or less inefficient reaction processe...
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Surface-treated Copper Foil and Copper-clad Laminate

To provide a surface treated copper foil satisfying all of the bonding strength to polyimide film, chemical resistance, and etching property, and to provide a CCL using the surface treated copper foil, a surface treated copper foil is formed being comprising an untreated copper foil on at least one ...
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Superior Liquid Uptake Resins for Polymer-supported Synthesis (SLURPS)

Background Solid phase synthesis, or polymer-supported synthesis, is a technique for chemical transformations in which molecules are bound to a solid, such as a polymer bead, during the reaction and hence are easier to separate afterwards. The main benefit lies in the fact that these supports, b...
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Processing and Application of Cereal Processing Byproduct-Based Adhesives

Tech ID: 11321 / UC Case 2004-311-0 Abstract Processing and Application of Cereal Processing Byproduct-based Adhesives Full Description A novel processing and application method for cereal processing byproduct-based adhesives has been developed by researchers at the University of California,...
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Scratch Resistant Polymer Blends

This invention relates to polypropylene-based polymer blends exhibiting enhanced scratch resistance. Polypropylene-based materials such as TPO’s are used in a broad range of applications, including automotive parts, appliances, and construction materials. One critical deficiency of these materials...
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Cost-Efficient, Biodegradable Microspheres with Control of Diameter, Density, Color and Surface Chemistry

BACKGROUND: Currently commercialized microspheres for flow measurement and bioscience applications are manufactured via polymerization processes that are costly or impossible to customize and require handling of hazardous materials. Further, the resulting microspheres contain hazardous or non-biodeg...
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Solid Base Transesterification Catalysts for Biodiesel Production

BACKGROUND: Biodiesel presents physical-chemical properties similar to petro-diesel, and can be used directly in the motor with no further significant mechanical modifications or expenditure in maintenance. The base catalyzed transesterification of triglycerides produces a non-toxic, biodegradable, ...
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Use of Magnetic Nanoparticles to remove Dispersed Nanoparticles from Aqueous Solutions

BACKGROUND: Carbon nanotubes (CNTs) are important structural blocks for the preparation of composites with unique optical, electrical, and mechanical properties and their production is expected to increase significantly in the years to come. CNTs are extremely hydrophobic and prone to aggregation, a...
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Novel Enantiomeric Chiral Alcohols

DESCRIPTION: University of California, Merced (UC Merced) researchers have synthesized novel enantiomeric chiral alcohols, derivatives of a phenyl isobutanol. These compounds feature a conformationally restrictive methyl group on the phenyl group adjacent to the alcohol functionality. APPLICATION...
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Improved Physical Methods for Increasing Stereoselectivity

BACKGROUND: Since 1988, the Food & Drug Administration has required that the enantiomeric composition of all drugs be known, making stereoselective reactions essential for the pharmaceuticals industry. However, the reactions used to establish chirality at one or more stereocenters often are not suff...
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Sequential Sampling within a Portable Computing Environment

BACKGROUND: In industrial, agricultural, and warehouse/retail settings, there are many situations where sequential sampling and hypothesis testing could markedly improve productivity and quality control. However, the underlying mathematics can be very complicated, leading to very high computing requ...
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Heterogeneous Copper Catalysts

BACKGROUND: The development of effective asymmetric reactions that enable the enantioselective formation of one chiral center over another continues to be an important area of research. A second important area of research relates to the development of water-soluble organometallic catalysts. Conventi...
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Organic Multi-Photon Absorbing Molecules

BACKGROUND: Two-photon or other multi-photon absorbing molecules have been designed in a variety of technologies involving such subjects as optical data storage, 3-D microfabrication techniques, frequency upconverted lasing, optical power limiting, photodynamic therapy, and multi-photon fluorescenc...
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A Novel Class of Pre-Emergent Herbicides

The University of California is seeking industrial partners to commercialize a novel class of herbicidal compounds, the DHC’s. The DHC’s were developed by a major producer of ag chemicals. This company decided to follow different leads and recently donated patents applications claiming the DHC’s as ...
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Nanoparticle Assembled Hollow Spheres

BACKGROUND: Nanoparticles with very small diameters (...
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Bifunctional Catalysts and Methods for Synthesis of Impermeable and Semipermeable Coatings

BACKGROUND: Fields that involve the handling of sensitive materials, such as electronics, chemicals, and biological agents need a means of safely isolating these items to protect them or the outside environment from contamination. Current methods for coating, sealing, or encapsulating these materia...
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Searching Composition Space in Combinatorial Chemistry by Monte Carlo Methods

BACKGROUND: Combinatorial chemistry involves searching a large compositional space for compounds with a high figure of merit in order to find a molecule with a given property. However, current methods of searching only apply to relatively small libraries of compounds, with limited numbers of composi...
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Modular Adhesives and Energy-Dissipating Materials

BACKGROUND: Natural materials are renowned for their strength and toughness. Spider dragline silk has a breakage energy per unit weight two orders of magnitude greater than high tensile steel, and is representative of many other strong natural fibers. The abalone shell, a composite of calcium carbon...
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A Chemical Enhancer of Net Photosynthesis

A University of California researcher has isolated genes (described in PCT application #WO00029607A1) from the soil bacterium Sinorhizobium meliloti (a symbiont naturally found with alfalfa) that produce a molecule that increases net photosynthesis by 25% to 30% within 20 hours after being applied t...
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A Methyl Bromide Substitute for Agricultural Use

Methyl bromide is extremely important to United States and World agriculture (64,000,000 lbs. used in the U.S. in 1990), and is the most widely used and efficacious general-purpose fumigant in the world. It has extensive applications in soil fumigation, quarantine treatment of exports and imports, ...
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One-Pot Organocopper Chemistry and Stereospecific Nucleoside Formation

A researcher at the University of California has made several inventions related to organic syntheses involving higher-order cuprates. Higher-order organocuprates are reagents containing copper atoms to which are bound multiple negatively-charged ligands in ethereal solvents, and have been successfu...
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Safe and Powerful Reductant

Researchers at the University of California have synthesized a family of compounds which have very strong reduction properties and are also inexpensive and exceptionally safe. Since 1947 the standard high-powered reductant available has been lithium aluminum hydride, but its violent reaction wit...
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Synthesis of Beta-Amino Alcohols

Enantiomerically pure .-amino alcohols play an increasingly important role in both the treatment of a wide variety of human disorders and as chiral auxiliaries in organic synthesis. The importance of enantiomeric purity in pharmaceuticals has been amply demonstrated by the debilitating and sometime...
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Poly(2-Methoxy,g-(2'Ethyl-Hexyloxy)-P-Phenylene Vinylene), MEH-PPV, and Methods for Use

BACKGROUND: The possibility of combining the important electronic and optical properties of semiconductors and metals with the attractive mechanical properties and processing advantages of polymers has existed since the discovery of conducting polymers in the late 1970's. However, early attempts res...
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A Monoclonal Antibody Assay for Detecting Cyclodiene Insecticides

Researchers at the University of California (UC) have produced a mouse hybridoma cell line, which secretes monoclonal antibodies directed against the most common and persistent polychlorinated cyclodiene insecticides. The monoclonal antibodies are the basis of a competition enzyme-linked immunosorb...
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Novel Chromogenic Ionophores

Ionophores selectively complex with specific ions in sample solutions, and are widely used for measuring ion concentrations in such solutions in conjunction with ion-selective electrodes. University of California researchers have developed new classes of ionophores, called chromogenic hemispherands...
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Novel Self-Doped Polymers

PATENT ABSTRACT: A self-doped conducting polymer having along its backbone a .pi.- electron conjugated system which comprises a plurality of monomer units, between about 0.01 and 100 mole % of the units having covalently linked thereto at least one Bronsted acid group. The conductive zwitterionic po...
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Novel Conductive Polymers

POLYISOTHIANAPHTENE, A NEW CONDUCTING POLYMER UC Case No. 1984-044-2 U.S. Patent 4,640,748 Patent Abstract: A polymer having an isothianaphthene structure represented by the formula (Ia) and/or Ib): wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or a hydrocarbon residue having ...
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Prevention of Browning in Fruits and Vegetables

Bruising or other mechanical wounding of fruits and vegetables cause many post-harvest problems; including the browning of injured and adjacent tissue. Currently, the only way to control browning induced by mechanical wounding is with refrigeration or chemical treatment. While these treatments slow ...
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Tough, Self-Healing Silicone Materials

Siloxane- and organosiloxane-based materials (collectively termed "silicones") are ubiquitous in commercially available goods and high technology applications, often in the form of oils, rubbers, resins, and hard solids. Their general usefulness is due to their broad and tunable range of beneficial ...
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Amide Forming Chemical Ligation under Mild Reagent-Free Conditions

BACKGROUND: Despite the importance of amide (peptide) bonds, there are currently few methods for their preparation. The synthesis of amide bonds is generally limited to methods requiring the use of excess coupling reagents and side chain protected amino acid residues. These processes are inefficien...
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Compositions and Methods for in Vitro Molecular Sorting Compartmentalization in Double (W/O/W) Emulsions

The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water...
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Raman Spectroscopy Apparatus and Method for Continuous Chemical Analysis of Fluid Streams

The present invention provides apparatus and methods for analyzing the chemical composition of fluid streams using Raman spectroscopy. The apparatus includes a laser source for producing light having an excitation wavelength. The light is introduced into a bundle of optical fibers connected to a tub...
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Use of Drosophila Embryos for Delivery and High-throughput Screening of Chemical Compounds

Present-day drug discovery frequently involves screening hundreds of thousands of compounds for biological activity against a target molecule. Compound screening is typically preformed using cell-based systems because they promise accurate, whole-cell data representative of the physiological conditi...
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Quantitative Analysis of Unresolved Isomers and Isobars by Tandem Mass Spectrometry

This novel and improved deconvolution method allows high-throughput, quantitative analysis of isobars from unresolved chromatographic peaks, and accurate quantification of isomers or isobars in a complex mixture. Tandem mass spectrometry is attractive for many applications due to its high selectivi...
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Electrochemical Reduction of Ferric Ions Using Hydrogen Gas

Solvent extraction/electrowinning (SXEW) is a growing segment of the copper industry, producing some of the best quality copper in the market. Electrowinning of copper is a highly energy-intensive process that oxidizes water, producing oxygen and an acid mist that may be hazardous to both humans and...
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Chemical Vapor Synthesis of Uniform Mixtures of Fine Powders

Producing homogeneous mixtures of fine powders using conventional methods can be a challenging task, especially when the mixture is a composite powder. This technology describes a process of synthesizing fine powder mixtures from reactions in the gas phase followed by condensation and surface deposi...
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A Virtual Electrochemical Laboratory

This software-based invention simulates a laboratory environment that enables students to understand how common electrochemical experiments are performed. Easily installed on a Microsoft Windows platform, the virtual lab allows students to explore a research environment, conduct experiments by tria...
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Wastewater Treatment Igloos or "Poo-Gloos" for the Removal of Ammonia

Wastewater treatment lagoons are one of the most widespread treatment technologies in the United States and are suited for small to medium sized rural communities, animal feedlot operations, as well as some industries. Lagoons are effective at removing organic material and suspended solids, provided...
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Magnetic Activated Carbon Particles for Gold Recovery, Water Treatment and other Applications

This invention describes the process of mixing a magnetic material homogeneously with an activated carbon material. Activated carbon is commonly used to remove a number of materials from liquids and gases, for recovery of values or for purification. The magnetic carbon from this invention is of fi...
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Direct Reading, Quantitative Biosensors for Measuring Chemical Concentrations

Bioluminescence and chemiluminescence are chemical oxidation processes that result in photon emission. Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NADH) are two molecules that play unique and central roles in biology and are the basic coupling agents of cellular metabolism. M...
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Novel Synthesis of Indoles

Technology This technology offers two main opportunities. First, it can produce a number of new 2-substituted Indoles that cannot be realized by the Fisher synthesis, and which can be used the starting material to new therapeutic agents. Secondly, it provides a significant improvement over cu...
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Polymerizable Beta-Diketones for MIPs of Divalent or Trivalent D and F Block Metals

A process for preparing vinyl substituted beta-diketones includes reacting a halogen-containing beta-diketone with an olefin in a reaction zone under Heck coupling reaction conditions in the presence of a catalyst, a base, and an organic phosphine to provide a vinyl substituted beta-diketone product...
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Soluble, Processible Molecularly Imprinted Macromolecules

The scientific community's excitement for the use of molecularly imprinted polymers (MIPS) for sensors and filters is rising at an almost exponential rate, with the practical realization that plastics holding impressions of molecules could revolutionize many important aspects of drug discovery, medi...
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Vessel for Solid Phase Micro-Extraction (SPME) Chemical Sampling

Researchers at the Johns Hopkins University, Applied Physics Laboratory (JHU/APL) have further developed the Solid Phase Micro-Extraction (SPME) process. This a process whereby chemicals of interest are selectively and competitively adsorbed onto a silica fiber coated by a stationary chemical phase....
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Fluid Sampling Interface for a Submerged Water-Borne Vehicle

It is unsafe and often impossible for humans to directly assess potentially hazardous environments. Today, unmanned vehicles and robots are often used to perform activities that are difficult, dangerous, or impossible for humans. Unmanned vehicles are very successful obtaining materials that need to...
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Dual-Sided Microchannel Plate Detector Mount for Coaxial Time-of-Flight Mass Spectrometers

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland Security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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Polymer Based Lanthanide Luminescent Sensors for the Detection of Organophosphorous Compounds

A number of organophosphorus compounds are used in nerve agents, including the chemically similar organo-fluorophosphorus compounds found in nerve gasses such as Sarin and Soman. Detection and quantification of these highly toxic compounds by remote sensors at very low levels are critical. Although ...
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Automated Propellant Blending (MSC-22757)

Abstract: Innovators at NASA Johnson Space Center have developed a safer, more consistent and economical way in which to blend propellants. Used mainly for the production of Zirconium Potassium Perchlorate (ZPP) propellant, this automated blending apparatus and process has produced compositions tha...
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Ammonia Monitor Including Solid Phase pH Conditioning and a Liquid-Liquid Exchange Module (MSC-22270)

Abstract: The Ammonia Monitor Including Solid Phase pH Conditioning and a Liquid-Liquid Exchange Module is a new kind of analytical instrument that measures ammonia dissolved in water. It provides continuous, real-time determination of the concentration of ammonia and ammonium in an aqueous process...
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UV-Curable Polyimides ()

Abstract: The National Aeronautics and Space Administration seeks to transfer technology for the development and production of polyimides using ultraviolet light, rather than heat, to effect polymerization....
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Lightweight Ceramic Insulation and Method (MSC-20782)

Abstract: NASA has introduced an alternative approach to the fabrication of ceramic insulation that is capable of withstanding temperatures up to 1600 degrees C. The process takes water-soluble salts, such as sodium carbonate and aluminum sulfate, and converts them into a powder of porous particles...
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Low-Temperature Oxidation Catalysts (TOP1-466)

Abstract: NASA Langley Research Center is actively seeking partnerships and collaborations to commercialize its Low-Temperature Oxidation Catalysts technology. Several licensees are developing commercial applications...
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Low-Temperature Oxidation Catalysts (TOP1-466)

Abstract: NASA Langley Research Center has developed a family of catalysts for low-temperature oxidation of carbon monoxide and other gases. These oxidation catalysts have high activity at low temperatures. Both carbon monoxide and formaldehyde can be readily oxidized in air at typical room tempera...
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Thermostable Purified Endoglucanases from Thermophilic Bacterium Acidothermus Cellulyticius

U.S. Patent 5,275,944 Technology Description A purified low molecular weight cellulase endoglucanase I having a molecular weight of between about 57,420 to about 74,580 daltons from Acidothermus cellulolyticus (ATCC 43068). The cellulase is water soluble, possesses both C.sub.1 and C.sub.x type...
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Process for Selection of Oxygen-tolerant Algal Mutants that Produce H.sub.2

U.S. Patent 5,871,952 Technology Description A process for selection of oxygen-tolerant, H.sub.2 -producing algal mutant cells comprising:(a) growing algal cells photoautotrophically under fluorescent light to mid log phase;(b) inducing algal cells grown photoautrophically under fluorescent lig...
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Hydrogen Producting Using Hydrogenase-Containing Oxygenic Photosynthetic Organisms

U.S. Patent 6,989,252 Technology Description This invention relates to photosynthetic hydrogen production and specifically to a biophotolysis process, which can be cycled, for the temporal separation of oxygen evolution and hydrogen production in algae....
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Fluorescence technique for on-line monitoring of state of hydrogen-producing microorganisms

U.S. Patent 7,229,785 Technology Description In situ fluorescence method to monitor state of sulfur-deprived algal culture's ability to produce H.sub.2 under sulfur depletion, comprising: a) providing sulfur-deprived algal culture; b) illuminating culture; c) measuring onset of H.sub.2 percenta...
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Solar-Induced Chemical Vapor Deposition of Diamond-Type Carbon Films

U.S. Patent 5,346,729 Technology Description An improved chemical vapor deposition method for depositing transparent continuous coatings of sp.sup.3 -bonded diamond-type carbon films, comprising: a) providing a volatile hydrocarbon gas/H.sub.2 reactant mixture in a cold wall vacuum/chemical vap...
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Process for Selection of Oxygen-tolerant Algal Mutants that Produce H.sub.2

U.S. Patent 5,871,952 Technology Description A process for selection of oxygen-tolerant, H.sub.2 -producing algal mutant cells comprising:(a) growing algal cells photoautotrophically under fluorescent light to mid log phase;(b) inducing algal cells grown photoautrophically under fluorescent lig...
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Plasma Enhanced Chemical Vapor Depositions (PECVD) Method of Forming Vanadium Oxide Films and Vanadium Oxide Thin-Films Prepared Thereby

U.S. Patent 6,156,395 Technology Description A method is disclosed of forming a vanadium oxide film on a substrate utilizing plasma enhanced chemical vapor deposition. The method includes positioning a substrate within a plasma reaction chamber and then forming a precursor gas comprised of a va...
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Photoenhanced Anaerobic Digestion of Organic Acids

U.S. Patent 4,919,813 Technology Description A process is described for rapid conversion of organic acids and alcohols anaerobic digesters into hydrogen and carbon dioxide, the optimal precursor substrates for production of methane. The process includes addition of photosynthetic bacteria to th...
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Using liquid desiccant as a regenerable filter for capturing and deactivating contaminants

Technology Description A method, and systems for implementing such method, for purifying and conditioning air of weaponized contaminants. The method includes wetting a filter packing media with a salt-based liquid desiccant, such as water with a high concentration of lithium chloride. Air is passed ...
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Solid Lithium-Ion Electrolyte

Technology Description The present invention relates to the composition of a solid lithium-ion electrolyte based on the Li.sub.2 O--CeO.sub.2 --SiO.sub.2 system having good transparent characteristics and high ion conductivity suitable for uses in lithium batteries, electrochromic devices and other ...
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Method and System for Simulating Heat and Mass Transfer in CoolingTowers

Technology Description The present invention is a system and method for simulating the performance of a cooling tower. More precisely, the simulator of the present invention predicts values related to the heat and mass transfer from a liquid (e.g., water) to a gas (e.g., air) when provided with inpu...
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Solar Hydrogen Generation

Background The establishment of the hydrogen economy will require a non-fossil fuel source of hydrogen. One of the most promising alternatives is to use solar energy to generate hydrogen. Currently, this can be done with conventional solar cells coupled to water electrolysis cells, but the approach ...
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Microporous Mixed Matrix Membranes

Background Dense mixed matrix membranes have been researched for many years since they are easier to produce than zeolite membranes, they are durable and flexible, and they offer a performance enhancement over polymer membranes. However, dense mixed matrix membranes have limited improved selectivity...
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Lanthanide-Containing Conducting Polymers as Emissive Materials

Background This technology represents a novel method of assembling emissive materials with potential applications that include: hybrid, organic, and polymer light-emitting diodes (LEDs), flexible screens and displays, and chemical sensors. A new class of electropolymerizable lanthanide-containing co...
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Inexpensive, efficient method for manufacturing organic photovoltaics and LEDs

Background The incorporation of active components such as semiconductor nanoparticles into conducting polymer matrices has many potential applications, including electronic materials, photovoltaic cells, luminescent devices, and sensor arrays. By judiciously placing seed points within the conducting...
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Electrochromic Material Based on a Conducting Ladder Polymer

Background Electrochromism is the phenomenon displayed when some type of matter reversibly changes color when a burst of charge is applied. Recent applications of electrochromic materials include electrochromic windows which darken when voltage is added and are transparent when voltage is taken away...
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Detection of Single Nanoparticle Collisions by Electrocatalytic Amplification and its Analytical Applications in Nanotechnology and Biotechnology

Background Current detector/sensor technology has been used to detect the presence of molecules in substances quickly and with relatively high sensitivity. For example, the average diabetic is able to quickly test his blood with the prick of a finger. Conventional technology allows for this quick an...
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Carbon Dioxide Capture by Aqueous Piperazine

Background The conventional process for CO2 absorption/stripping uses aqueous amines such as monoethanolamine (MEA). Piperazine has previously been identified as a very reactive amine. It is an attractive alternative to MEA because it reacts with CO2 thirty times faster than MEA. However, piperazine...
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A New Method for Anion Metathesis

Background Organic salts are essential reactants in a number of important applications, including the preparation of reaction media, catalysts, precatalysts, analytical materials, solvent, and sensory materials. The properties of organic salts greatly depend on the nature of the associated anion. Me...
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Phenolate Constrained Geometry Polymerization Catalyst and Methods for Preparing ( 96053)

Scientists at Northwestern University have created a unique constrained geometry catalyst (CGC) for olefin polymerization by a simple cost effective one step-synthesis. Upon activation with strong Lewis acid cocatalysts efficient polymerization of ethylene, propylene and styrene is realized. ADV...
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Silyl-Terminated Polymer and Method for Preparing Silyl-Terminated Polyolefins ( 96055)

A new class of a-olefin polymerization catalysts has been developed at Northwestern University. The catalysts in the presence of silanes efficiently produce silyl-capped polyolefins with controlled molecular weight and polydispersity. The Ziegler-Natta type catalysts reduce process cocatalyst requir...
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Perfluoronapthyl Substituted Boron Containing Catalyst Activator ( 96101

A novel Ziegler-Natta polymerization activator has been created at Northwestern University. Tris (b-perfluoronapthyl) borane (PNB) cocatalyzes Group 4 metal complexes into a powerful a-olefin polymerization system. PNB promotes efficient ethylene polymerization with a variety of Zr and Ti Ziegler-Na...
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NOx Reduction Catalyst ( 97039)

The invention relates to a method for the reduction of nitrogen oxides in gaseous streams such as the exhaust emission from a lean burn internal combustion. U.S. Patent No. 6,143,681...
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Supported Organometallic Catalysts for Hydrogenation and Olefin Polymerization ( 98038)

Northwestern University scientists have prepared a new class of olefin / arene hydrogenation and olefin polymerization heterogeneous catalysts that exhibit high conversion rates under ambient conditions. The novel catalysts are supported on sulfate-modified zirconia, which provide exceptional Lewis ...
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Organosilicon Compounds and Uses Thereof ( 99043/99008)

Researchers at Northwestern University developed a series of novel silicone-based linkages as tools for the solid-phase synthesis of compounds containing a benzene ring. U.S. Patent No. 6,416,861...
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Chemical CO2 Fixation: Cr(III) and Co(III) Salen Complexes as Highly Efficient Catalysts for the Coupling of CO2 and Epoxides (21048)

New highly active Cr(III)- and Co(III) catalyst systems for the coupling of CO2 and terminal epoxides to cyclic carbonates under extremely mild conditions. Carbon dioxide is an attractive and economical C1 building block in organic synthesis and carbonates are versatile chemical intermediates. Howev...
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Method for the Preparation of Monodisperse High Molecular Weight Polymers (21062)

A novel method has been developed whereby monodisperse high molecular weight polymers (> 500,000 g/mol) can be prepared from a variety of synthetic, normally disperse high molecular weight polymers. This mechanical process is applied directly to the polymer and does not involve synthetic or chemica...
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Solid Phase Organic Silicate Host Compositions (21075)

A new class of solid organic host – silicon (polysilsesquioxane) matrix polymers have been created. Inorganic silicates, which provide mesoporous cavities, and organic shape / size template molecules are combined to create a novel family of materials capable of tailored separation, catalytic, and s...
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Method of Producing an Exfoliated Polymer-Clay Nanocomposite Through Solid-State Shear Pulverization (22089)

Well dispersed polymer-clay nanocomposites are readily produced with continuous solid state shear pulverization (S3P). Process affords polymer hybrid nanocomposites with enhanced properties in the absence of compatabilizing agents. ADVANTAGES: A general process affording highly dispersed polymer...
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Catalytic Synthesis of High Energy Density Nanocomposite Dielectric Materials (26136)

A process affording homogeneously dispersed ceramic nanoparticles within the matrix of processable, high-strength polymers. The high energy density polymer-metal oxide composites provide effective high energy storage in capacitor and insulator applications. ADVANTAGES: Polymer-metal oxide composi...
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Enhanced Polymer Properties by Solid State Shear Pulverization (28003

Northwestern’s solid state shear pulverization (S3P) process improves the physical properties of a variety of homopolymers. Enhanced polymer crystallinity, mechanical and oxygen barrier properties are achieved with S3P processing. ADVANTAGES: S3P polymer treatment significantly enhances polymer ...
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Neutral Bimetallic Transition Metal Napthldioxydiiminato Catalysts and Related Polymerization Methods (28037)

New bimetallic Ni olefin polymerization catalyst system. ADVANTAGE: Bimetallic olefin polymerization catalysts with increased activity, degree of and selectivity for methyl group branching, and comonomer incorporation versus mononuclear analogues under mild process conditions. The catalysts als...
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Polymer-Cellulose Composites via Solid-State Shear Pulverization (28135

Process for producing polymer-cellulose composites with enhanced properties. ADVANTAGES: A scalable process to produce well dispersed polymer-cellulose composites having enhanced properties, without need of compatibilizing agents. SUMMARY: Cellulose provides many opportunities to improve the...
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Surface-Immobilized Antimicrobial Peptoids (28138)

Northwestern researchers have developed peptoid mimics of antimicrobial peptides that can be immobilized onto surfaces, rendering these surfaces capable of compromising the membranes of attached bacteria. ADVANTAGES: Peptoids afford promising alternatives to conventional antimicrobials because o...
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Selective Inhibitors of Nitric Oxide Synthases (21036/98009)

This discovery presents two series of compounds that demonstrate very high selectivity for inhibition of neuronal nitric oxide synthase (nNOS) over the inducible nitric oxide synthase (iNOS) enzymes, crucial in the treatment of neurological diseased states. These inhibitors offer the potential for t...
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Facile Direct Conjugation of Peptides, Peptide Modified Polymers and Therapeutic Agents to Tissue Surfaces. (27127)

Synthetic peptide-polymer conjugates are enzymatically coupled to cartilage under mild conditions through the formation of isopeptide bonds between the peptides and extra cellular matrix (ECM) proteins. The system provides a general means of drug delivery, tissue engineering and repair or bioadhesiv...
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Oligo(p-phenylene vinylene) amphiphiles and methods for self-assembly

INVENTION: Amphiphilic oligo(p-phenylene vinylene) compounds and methods of use en route to self-assembled composites and device fabrication. Accordingly, it is an object of the present invention to provide OPV compounds and/or methods for assembly, thereby overcoming various deficiencies and sh...
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Novel Ion Exchange Materials for Heavy Metals Removal

INVENTION: The novel ion exchange materials are metal sulfide based materials. They are made of inexpensive, non-toxic elements. They can be prepared by solid state or hydrothermal synthesis and are chemically and thermally stable. The current production scale is on the order of grams, however the c...
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Polymer-Cellulose Composites via Solid-State Shear Pulverization

INVENTION: Process for producing polymer-cellulose composites with enhanced properties. ADVANTAGES: A scalable process to produce well dispersed polymer-cellulose composites having enhanced properties, without need of compatibilizing agents. SUMMARY: Cellulose provides many opportunities to ...
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Chlorine-Resistant Reverse-Osmosis Membrane

Current state-of-the-art technology for reverse osmosis filtration of water has one major flaw: the addition of chlorine can cause the membrane to degrade. However, when treating saltwater or brackish water, it is necessary to introduce chlorine for sanitation and disinfection purposes. Unfortunatel...
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Centrifuge Permeameter for Unsaturated Soils System

Current testing methods cannot measure the unsaturated hydraulic properties of granular materials simultaneously, and require long testing periods. They are impractical and involve the use of several granular specimens as well as destructive or intrusive measurements of the relevant testing variable...
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Centrifuge Permeameter for Unsaturated Soils System

Background Current testing methods cannot measure the unsaturated hydraulic properties of granular materials simultaneously, and require long testing periods. They are impractical and involve the use of several granular specimens as well as destructive or intrusive measurements of the relevant testi...
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Centrifuge Permeameter for Unsaturated Soils System

Current testing methods cannot measure the unsaturated hydraulic properties of granular materials simultaneously, and require long testing periods. They are impractical and involve the use of several granular specimens as well as destructive or intrusive measurements of the relevant testing variable...
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Binder Compositions for Laser Sintering Processes

Background Rapid prototyping has developed steadily as an industry over the past two decades. The leading four companies in the field had aggregate sales estimated at $387 million in 2007, approximately a 10% increase over 2006. However, currently there is no binder capable of providing the structur...
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Advanced Polymer Membranes for the Purification of Hydrogen and Other Gases

Background Current methods for carbon dioxide removal and hydrogen purification are not only very expensive but also cause large losses of gas and use toxic chemicals. The hydrogen required in the refining business is generated through costly, toxic, and inefficient systems like steam methane reform...
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Additive technology to eliminate bio-fouling in membranes; e.g., desalinization

Background One of the major roadblocks to widespread use of membranes for water purification is membrane fouling. Fouling occurs when certain impurities in water are deposited on the surface of a membrane or in its internal pore structure. This deposition leads to a dramatic reduction in water flux,...
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A New Method for Anion Metathesis

vBackground Organic salts are essential reactants in a number of important applications, including the preparation of reaction media, catalysts, precatalysts, analytical materials, solvent, and sensory materials. The properties of organic salts greatly depend on the nature of the associated anion. M...
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Highly Efficient and Specific Oxidation of Nucleic Acids with Dinuclear Copper Complexes

The present invention is related to a novel method for splitting nucleic acids at specific points on a complementary nucleic acid segment using a dinuclear copper-based compound of Formula I. Additionally, the present invention is related to a novel treatment of cancer, tumors, and cancer cells usin...
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Abstract Tungstated Zirconia Nanocatalysts

Preparation of tungstated zirconia solid acid catalyst with enhanced activity Advantages . Enhanced activity relative to solid acid catalysts . Enhanced selectivity, thermal stability, and resistance to deactivation . Environmentally friendly; Low environmental impact relative to liquid catal...
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Method for Producing Tetrapodal Nanoparticles with High Selectivity

Large-scale production of tetrapodal CdSe nanoparticles Advantages . Method produces tetrapodal CdSe nanoparticles of uniform size with high selectivity . Production costs (relative to existing methods) reduced approximately 200-fold . Method does not require use of highly toxic alkyl phosphonat...
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Group IV monolithic column

In present chromatography products, silica based and organic polymers are used to fabricate monolithic columns. While some of these stationary phases have pH and temperature limitations, zirconia offers superior pH and temperature characteristics. One company has commercialized zirconia based produc...
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Temporally Addressable Biochemical Sensor Arrays

Chemical sensor arrays are low cost, compact, robust and versatile alternatives to large analytical tools and hence drive the need to rapidly fabricate reusable chemical sensor arrays for simultaneous multi-analyte quantification. This invention includes the rapid fabrication of reusable chemica...
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Protein Imprinted Xerogels with Integrated Emission Sites (PIXIES)

Chemical sensor arrays are low cost, compact, robust and versatile alternatives to large analytical tools and hence drive the need to rapidly fabricate reusable chemical sensor arrays for simultaneous multi-analyte quantification. This invention includes the rapid fabrication of reusable chemica...
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Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re...
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Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. The pores are small enough that clarity of the plastic is unaffected, and because of the po...
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Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistance and low absorption rates. This thermoplastic’s many qualities make it an exceptional candidate for...
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Methods for Detecting and Extracting Gold

Introduction Gold is found in various forms on earth. It can be found in rocks, ore deposits, eluvial deposits, alluvial deposits, placer deposits etc. Gold is also recovered from secondary sources such as electronic scrap and waste electroplating solutions. Most methods of extracting gold are extre...
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Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively...
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Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact strength of any thermoplastic, has a high resistance to corrosion, moisture, and abrasion, and has ...
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Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re...
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Polymer Solar Cells using Self-Assembled Monolayer modified Zinc Oxide/Metal as Cathodes

Introduction Conjugated polymer-based organic solar cells are considered an essential source of inexpensive renewable energy due to their advantages of being fabricated by low-cost and large-area printing and coating techniques on light-weight flexible substrates. Bulk heterojunction (BHJ) solar cel...
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Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. The pores are small enough that clarity of the plastic is unaffected, and because of the po...
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Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistance and low absorption rates. This thermoplastic’s many qualities make it an exceptional candidate for...
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Method and Apparatus for Fluid Dispersion

Summary The invention is a microfluidic device for focusing and/or breaking fluid sections and drops. The subject fluid flows in the device's central channel as the dispersing fluid flows in the two outer channels. The outer fluid exerts pressure and viscous stresses that focus the inner fluid into ...
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Electrostatic Steering of Charged Droplets in Microfluidic Devices

Summary The invention consists of means of charging droplets and then using that charge to choose which channel a droplet will enter at a bifurcation. There is a need to have fast, accurate means of precisely sorting and directing materials in an automated way on a microfluidic device. Examples o...
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Method and Apparatus for Forming Multiple Emulsions

Summary Everyday emulsions have drops of one liquid dispersed in an immiscible continuous liquid. A multiple emulsion has immiscible droplets dispersed in drops dispersed in an immiscible continuous liquid (double emulsion). The IP describes a simple apparatus that can make multiple emulsions with a...
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Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host’s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel of this immune response pathway are the so-called Major Histocompatibility Complex (MHC) molecu...
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Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain

Summary Background: Although peptides have shown some promise in clinical trials as therapeutic agents, their success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity resulting from conformational inflex...
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Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel of this immune response pathway are the so-called Major Histocompatibility Complex (MHC) molecules....
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A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates

Summary Background: Molecular studies of the genomic organization of HIV-1 show that it encodes a number of genes common to all retroviruses, such as the gag, pol, and env genes. The env gene of HIV-1 produces a cleaved envelope glycoprotein (gp120) that is expressed on the exterior viral envelope s...
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Production of Digitized Stereoscopic Polarizing Images by Inkjet Printing

Summary The Technology The Stereo Imaging Research Group developed methods, materials and applications for stereoscopic hardcopy. The group's StereoJet process forms polarizing images by inkjet printing, using commercial desktop printers without modification. Key inventions include specialized su...
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Production of Digitized Stereoscopic Polarizing Images by Inkjet Printing

Summary The Technology The Stereo Imaging Research Group developed methods, materials and applications for stereoscopic hardcopy. The group's StereoJet process forms polarizing images by inkjet printing, using commercial desktop printers without modification. Key inventions include specialized su...
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Creating Nano-Wrinkles of Virtually any Design on the Surface of Polymers

Summary Creating Nano-Wrinkles of Virtually any Design on the Surface of Polymers Elevator pitch: A new method has been developed at Harvard to design and create virtually any type of nano-wrinkle patterns on the surfaces of polymers. Anticipated applications for these hard-skin nano-wrinkled s...
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Uniform Non-Spherical Colloidal Particles with Tunable Shapes

Summary Background: Non-spherical colloidal particles are useful in advanced applications beyond those that regular spherical colloidal particles exhibit. For example they are useful for modifying optical properties, controlling suspension rheology, and engineering colloidal composites. However c...
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Portable and Inexpensive Chemical and Biological Sensors

Summary The broadly tunable quantum cascade laser (QCL) described in this invention enables the production of a small, portable chemical and biological sensor that can detect a range of molecules within a single, compact device. Quantum Cascade Lasers (QCLs) are intraband semiconductor lasers that c...
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Microfabricated, Chip-Based, Low-Power Optical Tweezers

Summary Since they were first demonstrated over twenty years ago, optical tweezers have been widely used for the manipulation and measurement of many microscale particles, particularly in the biological sciences. However, many of these systems require large, high-powered laser systems along with bul...
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Scaleable Hydrogen Production via Bioengineered Yeast Systems

Summary A new synthetic biology approach is proposed for producing hydrogen from bioengineered yeast strains. The invention applies aggressive engineering of metabolic pathways and reducing complexes to create a yeast microenvironment capable of producing hydrogen from glucose at theoretical maximum...
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Specific Targeting of Cell Division (and Cancer): Small molecule inhibitors of Eg5 Hold Potential for Enhanced Safety

Summary Prof. Mitchison’s group at Harvard was the first to show, very elegantly, that it is possible to specifically target cell division proteins other than tubulin by using a small molecule, monastrol, which targets Eg5 and leads to mitotic arrest. Eg5 is responsible for establishing and mainta...
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Novel Anti-CMV Small Molecules

Summary Five structurally diverse small molecules have been discovered that inhibit human cytomegalovirus (CMV) replication with sub- to low micro-molar potency and at concentrations of up to 500-fold lower than those exhibiting cytotoxicity. These molecules represent a distinct departure from conte...
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Novel Clinical Stage Treatments for Epilepsy and Pain

Summary The principal investigator has discovered that Huperzine A (HupA) is characterized by extremely potent therapeutic activity against epilepsy and chronic pain. HupA was tested in a formalin model of pain, in which it produced complete inhibition of pain behavior in all treated mice, with a do...
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HBPA Photoaffinity Probe

Summary This invention describes a photolabeling reagent p-(4-hydroxybenzoyl)phenylalanine (HBPA) which overcomes many difficulties associated with BPA. Patent protection includes this compound's synthesis and use in photolabeling. Harvard's intellectual property portfolio includes the following ...
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On Bead Tagging and Decoding for Combinatorial Synthesis

Summary Pharmaceutical drug discovery has been greatly impacted by the development of novel approaches to the rapid synthesis of novel compounds, including combinatorial synthesis approaches. A common problem in combinatorial synthesis is that the compounds are frequently produced as mixed pools att...
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Techniques for high yield synthesis of macrocyclic compounds

Summary Many useful pharmaceuticals, including natural products, have a macrocyclic structure that can be a challenge when exploring synthesis methods. The Walsh Laboratory has discovered a new process using of a solid-phase resin to synthesize macrocycle compounds, including polyketide synthase (PK...
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Method of Creating Self-Assembled, Selectively-Permeable Colloidosome Structures

Summary Colloidosomes are spherical shells of micron-sized particles made by the simple technique of self-assembly onto emulsion droplets. These hollow, elastic capsules are ideal for efficiently encapsulating active agents for selective and timed release because they are highly controllable in stre...
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Production of Digitized Stereoscopic Polarizing Images by Inkjet Printing

Summary The Technology The Stereo Imaging Research Group developed methods, materials and applications for stereoscopic hardcopy. The group's StereoJet process forms polarizing images by inkjet printing, using commercial desktop printers without modification. Key inventions include specialized su...
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Using Electro-magnetically Induced Transparency in Photonic Crystal Cavities to

Summary This invention describes a photonic crystal system which uses electro-magnetically induced transparency (EIT) as the non-linear medium in photonic crystal cavities to obtain devices of unprecedent non-linear sensitivity, with operating power requirements many orders of magnitude smaller than...
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Method and Apparatus for Fluid Dispersion

Summary The invention is a microfluidic device for focusing and/or breaking fluid sections and drops. The subject fluid flows in the device's central channel as the dispersing fluid flows in the two outer channels. The outer fluid exerts pressure and viscous stresses that focus the inner fluid into ...
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Electrostatic Steering of Charged Droplets in Microfluidic Devices

Summary The invention consists of means of charging droplets and then using that charge to choose which channel a droplet will enter at a bifurcation. There is a need to have fast, accurate means of precisely sorting and directing materials in an automated way on a microfluidic device. Examples o...
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Method and Apparatus for Forming Multiple Emulsions

Summary Everyday emulsions have drops of one liquid dispersed in an immiscible continuous liquid. A multiple emulsion has immiscible droplets dispersed in drops dispersed in an immiscible continuous liquid (double emulsion). The IP describes a simple apparatus that can make multiple emulsions with a...
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Engineering 3D and Free Standing Tissue Structures

Summary Background: Efforts to build biosynthetic materials or engineered tissues that recapitulate the structure-function relationships of natural processes often fail because of an inability to replicate the proper in vivo conditions. For example, engineering a functional muscle tissue requires th...
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Novel Surfactants for Stabilizing Emulsions of Water or Hydrocarbon Oil-Based Droplets in a Fluorocarbon Oil Continuous Phase

Summary Emulsions—dispersions of two immiscible fluids—have many applications in industry and everyday life. These range from paints, to crop protection, chemical synthesis, and production of latices. They are also increasingly attractive for analytical applications. Traditional emulsions consis...
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"MoleProbe": a Real-Time Molecular Diagnostic Device

Summary A novel engineering method for generation of freestanding 2-D and 3-D tissue structures. Biopolymers (proteins, carbohydrates, lipids, nucleic acids or combinations thereof) are deposited onto a transitional polymer surface with a patterning technique that allows for nanometer-to-millimeter-...
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Native Anti-corrosion Coatings for Metals

Summary The need: Corrosion of metals hamper the performance and safety of products ranging from medical implants to large-scale naval vessels, aircraft, bridges, and oil pipeline structures. A 2002 study of the US Federal Highway Administration estimated the cost of corrosion of metallic materials ...
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A novel bioplastic

Summary A novel bioplastic, poly ((3R,5R)-3,5-dihydroxyhexanoic acid (poly(3,5-DHH), has been discovered. This molecule may be manufactured biosynthetically and offers significant advantages over current bio-plastics standards, such as high solubility and ease of chemical modification. Bioplastics b...
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Novel Synthetic Mechanism to b-Lactone and Analogs: Lead Compounds for the Treatment of Proteasome-Related Diseases

Summary Background: Proteasome inhibition offers considerable promise in the therapy of a number of types of diseases, such as cancer and neurodegenerative diseases. One such proteasome inhibtor, Velcade, is currently marketed for treatment of multiple myeloma by Millennium Pharmaceuticals. Despite ...
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Improved Method of Expression Cloning

Summary The human genome will soon be completely sequenced, presenting a vast new array of targets against which pharmaceutical agents can potentially be designed. However, to capitalize on this new information, the cellular function and medical significance of each of these genes will need to be de...
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HBPA Photoaffinity Probe

Summary This invention describes a photolabeling reagent p-(4-hydroxybenzoyl)phenylalanine (HBPA) which overcomes many difficulties associated with BPA. Patent protection includes this compound's synthesis and use in photolabeling. Harvard's intellectual property portfolio includes the following ...
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Bilins as anticancer agents

Summary A remarkable discovery at Harvard Medical School has led to the recognition that a naturally-occurring small molecule and analogs thereof possess potent anticancer properties through their ability to control cell differentiation. According to the invention, bilins are administered to induce ...
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Inhibitors of Protein-Processivity Factor

Summary Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal interaction between known Pol family members and other cellular factors. Unlike most protein-protein interactions, the target site is uniquely suited to small m...
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Method of Detecting Compounds Utilizing Genetically Modified Lambdoid Bacterioph

Summary This invention describes a method to detet a molecule of interest in a given solution, and a method of selecting or screening for cell lines that can continuously produce desired compounds. This method uses a genetically and chemically modified lambdoid bacteriophage that has a target molecu...
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Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)

Summary This invention comprises methods for non-homologous random recombination (NRR) of nucleic acids, and their use to develop and select nucleic acids or polypeptides with novel structure and function. This technology is distinct from previous DNA shuffling methods in that it provides more compr...
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Modular Conditional Knockout: Precise Temporal Control of Protein Degradation in Living Cells

Summary Polyubiquitinated proteins in eukaryotes are directed to the proteasome for degradation. It is generally accepted that proteasome-mediated proteolysis depends strictly upon ubiquitination, as disruption of that process has been observed to halt proteolytic activity of the proteasome. Researc...
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Affinity grids in preparing single particle specimens for Electron Microscopy

Summary Immobilized metal affinity chromatography has been used extensively to isolate macromolecular complexes for structural studies. This is facilitated by the high affinity interaction between a short continuous stretch of histidine residues and nickel cations chelated by nitrilotriacetic acid (...
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Crosslinkable Hole Transporting Materials for Organic Lightemitting Diodes

Introduction High-performance organic or polymer light-emitting diodes comprise multilayer configurations having hole-transporting, emissive and electron-transporting layers to balance the injection and transport of both holes and electrons. In general, holetransporting material is the first applied...
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Nanocomposite Photovoltaic Cells

Introduction Photovoltaic cells based on polymer semiconductors are of great interest as a low cost approach to solar energy conversion into electricity. The most efficient polymer solar cells are based on binary blends, in which polymers function as electrondonors and fullerenes as electron-accepto...
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Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively...
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Fabrication of Gold Nanocages and Cubic Nanoframes for Biomedical Treatment through Etching Nanoboxes

Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive research because of their unique and tunable surface plasmon resonance (SPR) properties. Because of...
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Production of Palladium Nanostructures with Shape Selection by Adding Bromide

Introduction Single-crystal, one-dimensional nanostructures of palladium are attractive as interconnects for fabricating nanoscale electronic devices. Polycrystalline, mesoscopic wires made of palladium have been utilized for resistance-based detection of hydrogen gas. However, polycrystalline wires...
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Copper Chloride-mediated Synthesis of Silver Nanowires

Introduction Owing to the high electrical and thermal conductivity of bulk silver, the synthesis of Ag nanowires has been and continues to be an area of active research. The properties and applications of the nanostructures are determined by the shape, size, structure, and composition of the nanostr...
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Electrospray Evaporative Spray Cooling (EESC)

Introduction As electronic devices get increasingly more powerful and more compact, there are an increasing number of semiconductor components that emit an increasing amount of heat. In order to ensure that these devices remain long-lived and reliable, more efficient methods of dissipating heat buil...
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Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Introduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and supercapacitors. Nevertheless, the synthesis of well-defined carbon nanotubes of 50 to 100-nm diameter has ...
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Integrated Platform for Chemical Profiling of Ultrasmall Subcellular Compartments from a Single Cell

Introduction The ability to analyze biological and chemical activity at the subcellular level is limited by the tools that are currently available. Typically a choice between the spatial fidelity of imaging techniques or the detailed chemical and biological information available using various separa...
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Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTPA complexes approved for clinical use are cleared within a few minutes and do not provide sufficient...
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Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact strength of any thermoplastic, has a high resistance to corrosion, moisture, and abrasion, and has ...
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Production of Palladium Nanostructures with Shape Selection by Adding Bromide

Introduction Single-crystal, one-dimensional nanostructures of palladium are attractive as interconnects for fabricating nanoscale electronic devices. Polycrystalline, mesoscopic wires made of palladium have been utilized for resistance-based detection of hydrogen gas. However, polycrystalline wires...
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Copper Chloride-mediated Synthesis of Silver Nanowires

Introduction Owing to the high electrical and thermal conductivity of bulk silver, the synthesis of Ag nanowires has been and continues to be an area of active research. The properties and applications of the nanostructures are determined by the shape, size, structure, and composition of the nanostr...
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A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys...
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Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p...
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Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively...
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Signal Amplification Method for SPR-based Chemical Detection

Introduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versatile platform for the observation and quantitation of chemical reactions and intermolecular binding at...
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3-D Tissue Culture Chamber

Introduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in tissue are not just autonomous masses but consist of many interdependent cell types and their surrou...
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Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p...
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Preparative Separation of Mixtures by Mass Spectrometry

Introduction With the average development cost for new pharmaceutical products in the hundreds of millions and continuing to increase, there is a pressing need to identify successful therapeutic compounds at the earliest stage possible. Combinatorial chemistry provides the drug discovery process wit...
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Design of Thermal Interface Material Based on High Temperature Shape Memory Alloy for Connecting Two Thermoelectric Legs

Introduction Efficient heat management is crucial for electronics to optimize performance and to avoid premature component deterioration. An area of primary concern is at the interface of adjoining thermal components, such as with heatsink interfaces and with connections between thermoelectric legs....
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Design of Active Materials and Structures based on Composites of Shape Memory Alloy and Shape Memory Polymer

Introduction Shape memory alloys (SMA) and shape memory polymers (SMP) have shown tremendous promise for a wide variety of applications because of their ability to “remember” a previous state when heated. However, they can only remember a single shape. The ability to remember two shapes would make t...
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Method of Detecting, Characterizing, and Quantifying Bulk, Light- Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those containing nitrogen and carbon, are too low in energy to penetrate significant distances into enclosing ...
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Precision coating of macromolecules on Surfaces

Introduction Production of chemically modified surfaces by ion deposition allows for unique chemistries on those surfaces, providing functionalities that are critical to medical devices such as stents and vascular grafts. Sophisticated materials are now required for complex medical applications such...
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Shockwave Reactor

Introduction Ethylene is a commercially important chemical with many applications, and it is especially important as a building block for other, more complex molecules. It is typically made by cracking various larger hydrocarbons using pyrolysis. The hydrocarbon feedstock for these reactions varies ...
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Novel Compound Semiconductor Use as a Buffer Layer for Controlled Oxide Growth on Silicon

Introduction An area of research that has gained increasing importance in recent years is the controlled growth of oxides other than SiO2 on silicon. Technology description Researchers at the UW have developed the use of Ga2Se3 as a novel buffer layer preventing SiOx and silicide formation during th...
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Electroactive Polymer Using Shape Memory Alloy

Introduction Shape memory polymers have shown tremendous promise for a wide variety of applications for their ability to “remember” a previous state when heated. Unfortunately, they have been slow to develop commercial availability. Many of these polymers also have small compression ratios. However,...
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Droplet Compartmentalization for Chemical Separations and On-Line Sampling

Introduction The ability to separate complex mixtures of chemicals and biomolecules is an important component of any chemical synthesis or biological processing. To date, there is no technology available to combine the high resolution of analytical separations with monodisperse droplet generation. I...
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Copper Chloride-mediated Synthesis of Silver Nanowires

Introduction Owing to the high electrical and thermal conductivity of bulk silver, the synthesis of Ag nanowires has been and continues to be an area of active research. The properties and applications of the nanostructures are determined by the shape, size, structure, and composition of the nanostr...
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Catch and Release Method for Charged Particle Concentration

Introduction Cell separation in a microfluidic device can be difficult at times. One difficulty researchers face is the ability to capture and separate charged particles when carried in an aqueous solution. Technology description Our researchers have developed a microfluidic method and device to cap...
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A Method and Design for Performing Rapid Parallel Microfluidic Molecular Affinity Assays

Introduction Point-of-care diagnostic testing, or testing performed at the patient bedside, allows physicians to diagnose patients more rapidly than traditional laboratory-based testing. Rapid results can enable better patient management decisions, improved patient outcomes, and a reduction in the o...
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Method for Deconvolving Single-Molecule Intensity Distributions for Quantitative Biological Measurements

Introduction Fluorescence microscopy images of cells often contain puncta, or clusters of fluorescence signal. To measure the concentration of labeled proteins in a puncta, calibration typically needs to be performed for each fluorescence species. Traditional calibration techniques only provide aver...
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Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Introduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and supercapacitors. Nevertheless, the synthesis of well-defined carbon nanotubes of 50 to 100-nm diameter has ...
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Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Introduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and supercapacitors. Nevertheless, the synthesis of well-defined carbon nanotubes of 50 to 100-nm diameter has ...
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Advanced Biomimetic Surfaces for Surface-Enhanced Raman Biomimetic Surfaces for Surface-Enhanced Raman

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subj...
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Advanced Biomimetic Surfaces for Surface-Enhanced Raman Biomimetic Surfaces for Surface-Enhanced Raman

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subj...
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Air-Stable p-Type Semiconducting Polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re...
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Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal action. These variations are especially pronounced in coastal and estuarine waters where seawater int...
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Exciplex™a Highly Sensitive Nucleic Acid Fluorescent Detection System

BACKGROUND Conventional fluorescent dyes used in nucleic acid detection methods suffer from a number of limitations. High backgrounds result in false positives and a reduction in sensitivity. The small Stokes shift (difference between excitation and emission wavelengths) often requires optical filte...
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Monomer for 'one-part' Crosslinkable Water-borne Coatings (HESS)

BACKGROUND Water-borne latex-based coatings have been in commercial use for well over five decades. For chemical and polymer suppliers, the inherently easier and safer manufacturing/ handling associated with water-borne latex-based coatings is a major advantage and a strong reason for expanding thei...
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pH modified UV treatment of water pesticidal and pharmaceutical

The Invention The invention consists of introducing a pH influenced polychromatic ultra-violet (UV) photolysis process for disinfection of water contaminated by several organic components (alone or in a mixture of contaminants), where the pH to enhance contaminant breakdown is optimized by correlat...
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Use of Photosensitized Epon Epoxy Resin 1002F for MEMS and BioMEMS Applications

Background: Microelectrical-mechanical systems (MEMS) are miniature mechanical devices intended to perform non-electronic functions such as sensing or actuation. These devices are typically built from silicon using lithographic techniques borrowed from the semiconductor industry. Some examples of t...
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A Chemical Compound with Possible p53 Cancer Mutant Rescue Activity

Background: Mutants of the tumor suppressor protein are frequently found in human cancers. About three quarters of them have a single amino acid change in the core domain of p53 that is needed to bind to p53 DNA binding cites. There is great interest for identifying chemical compounds that can rest...
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One-Step Direct Synthesis of LaPO4

Background: Monazite is an important ceramic material for several potential applications including composite ceramics, machineable ceramics, nuclear waste storage, fluorescent materials, electrochemical substrates, and as an electrolyte in solid oxide fuel cells. Monazite forms weak interfaces with...
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A Microfabrication Process for Vertical Microelectrodes inside Polymer Microchannels

Background: For microfluidic applications, different electrodes inside the microfluidic channels may be patterned by metal evaporation methods such as thermal evaporation, electric beam evaporation, and sputtering. Since most of the deposition methods only deposit very thin layers of metal (e.g., u...
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A New PET Radiotracer for Serotonin 5HT1A Receptors

Background: Serotonin 5-HT1A receptors are implicated in Alzheimers disease, dementia, anxiety, schizophrenia, and depression, and significant efforts have been undertaken to develop various compounds that bind to these receptors for potential use in diagnosis and therapy of disorders associated wi...
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New Protein Resistant and Biodegradable Biopolymer

Background: The ability to resist nonspecific protein adsorption (protein resistance) is an indicator of a material's biological inertness or biocompatibility. Protein resistant biomaterials such as the commonly used poly(ethylene glycol) (PEG) have been used in a number of applications such as pro...
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High-Isolation Tunable MEMS Capacitive Switch

Background: For a typical MEMS switch, the resonant frequency is around 20 to 30 GHz which can not be employed by commercial wireless systems operating at a frequency band of 2 to 8 GHz. This resonant frequency can be tuned by changing the inductance of the switch membrane. When inductance is incre...
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Depth Profiling of the Skin Structure in Vivo

University researchers have developed a photoacoustic probe contained within a handpiece for use in contact with the skin. The laser pulses generate acoustic waves at the subsurface absorption sites. It is believed that no known use of photoacoustics has been used for this purpose in the past. Previ...
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Fabrication Method for Polymer Thin Films

University researchers have developed a method that allows for the synthesis of a wide variety of polymer thin films, the fabrication method of which can be combined with photolithography to create surface patterns. Thin film thickness is controlled from 1 nm to the submicron range. The method also ...
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Molecular Imprinting for the Recognition of Peptides in Aqueous Solution

Molecular imprinting is a process for synthesizing materials that contain highly specific recognition sites for smaller molecules. Today, molecular imprinting is used for many purposes, including the creation of macromolecular binding and catalytic sites and as binding sites for the separation or re...
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Aluminum - Lithium Alloy Metal Matrix Composites

For high temperature aerospace application, Ti alloys are often utilized to produce structural parts. However, the cost has often been the drawback. Finding an alternative has motivated the development of advanced aluminum alloys to satisfy the requirement of titanium alloys. Researchers of the Univ...
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Emulsified Zero-Valent Iron (EZVI) (KSC-12246)

Emulsified Zero-Valent Iron is a versatile technology that can be used at many of these locations. Applicable sites may include: dye and paint manufacturers;dry cleaners; chemical manufacturers; metal cleaning and degreasing facilities; leather-tanning facilities; pharmaceutical manufacturers; adhes...
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Hydrocarbon Oxidation for Manufacturing Chemicals

APPLICATION OF TECHNOLOGY: Chemical manufacturing Hydrocarbon oxidation ADVANTAGES: Works at ambient temperature Highly selective Energy-efficient process Environmentally benign ABSTRACT: Heinz Frei, Fritz Blatter and Hai Sun have developed a selective thermal or photochemical oxidation pro...
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Using liquid desiccant as a regenerable filter for capturing and deactivating contaminants

A method, and systems for implementing such method, for purifying and conditioning air of weaponized contaminants. The method includes wetting a filter packing media with a salt-based liquid desiccant, such as water with a high concentration of lithium chloride. Air is passed through the wetted filt...
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Device and method of positionally accurate implantation of individual particles in a substrate surface

A device and a method for positionally accurate implantation of individual particles in a substrate surface (1a) are described. A diaphragm for a particle beam to be directed onto the substrate surface (1a) and a detector provided thereon in the form of a p-n junction for determining a secondary ele...
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Biological Production of Polymer Monomers

EJIB-2541 APPLICATIONS OF TECHNOLOGY: Producing a wide variety dicarboxylic acids for the manufacture of commercial polymers, e.g. polyesters, polyamides, polyurethanes ADVANTAGES: Starting material is renewable, cellulosic or other biomass instead of petroleum Enzymes can be modified to...
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Microfluidic device forming enhanced spatial and temporal gradients

Microfluidic device improving on current chemical gradient-generation designs in the forming of spatial and temporal gradients in a compact structure TECH FIELD(S) Microfluidic devices FEATURES Available is an improved microfluidic design for generating spatial and temporal chemical gradi...
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Device for Controlled Placement of Effluents from Mechanically or Electrically Driven Separations

TECH FIELD(S) Analytical Chemistry, Mass Spectrometry, Proteomics FEATURES The analysis of samples utilizing analytical chemistry techniques frequently requires the samples to be subjected to a number of successive techniques in order to obtain the desired information. This is particularly tru...
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Process for Thermo Catalytic Cracking (TCC) of heavy oils feeds to increase production of light olefins (Ethylene-Propylene) at low Temperature

Solution / invention summary : TCC Process is operated in existing steam cracking reactors and uses a novel catalyst material to increase the production of Ethylene-Propylene at a lower cracking temperature and with heavy hydrocarbon feed materials. TCC is very selective to light olefins. Catalyst ...
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Surface Patterning

Surface Patterning – Simultaneous functionalization and patterning of surfaces by scribing or scoring in the presence of reactive species. This technique has been done on silicon wafers using a diamond tipped pencil but it can be used on other materials using other scribes. General Information ...
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Hydrophobic Coatings on Polymer Surfaces

A permanent water and oil resistant coating for polymer/plastic/organic material has been developed by the Chemistry Department ay BYU. The material bonds permanently with nylon and other polymeric and organic materials making them more resistant to water and oil. The coating is applied through chem...
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Monolithic Column Technology for Strong

Monolithic Column Technology for Strong Cation-Exchange Liquid Chromatography - Improves chromatography technology by eliminating the need to add organic solvents to decrease the hydrophobic character of the column. General Information Ion exchange chromatography is a process that separates ions...
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Electrically Actuated Micropumps

Electrically actuated micropumps enable microchip liquid chromatography separations to be carried out rapidly and with miniaturized instrumentation. The micropumps can be powered with a battery, using potentials in the tens of volts, while generating adequate pressures for liquid chromatographic sep...
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