IL-8R and STAT-3 Modulation: Targeting Glioblastoma Multiforme and Other Brain Tumors

Summary There is an unmet need for better therapies against high grade anaplastic astrocytoma and glioblastoma multiforme. Recent results suggest that that inhibiting IL-8 receptor activity and enhancing STAT3 activity may be used as a novel therapy against brain tumors. Cell-based assays validated the IL-8R/STAT3 targets using RNAi knockdown studies, immunoassays, and a battery of tumor proliferation and invasiveness assays. In-vivo data was captured by implanting STAT-3 transfected glioblastoma cells into a SCID mouse model. Compared with controls, it was found that enhanced STAT3 expression significantly reduced both tumor size and mass, suggesting a powerful new treatment approach against brain tumors.

Applications It is expected that modulation of IL-8R and STAT3 will be relevant to both tumors of the CNS and brain tumors originating from non-CNS cancer sites. The discovery will facilitate the development and application of new anti-tumor compounds for brain cancer patients. For Further Information Please Contact the Director of Business Development Michal Preminger Email: [email protected] Telephone: (617) 432-0920

Inventor(s): Bonni, Azad

Type of Offer: Licensing



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