Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")
Summary Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrices (see Harvard Case No. 1438). The present invention extends the polony technology to provided miniaturized, high-density, bead-based nucleic acid arrays and improved methods for array-based sequencing of nucleic acids. High feature resolution enables identification and isolation of clonal sequences present on microparticles in both research and diagnostics applications.
The invention is available for non-exclusive license for (i) internal research use and (ii) the commercial distribution of clinical diagnostic, food testing and environmental testing products and services. U.S. and foreign patent rights are available.
Applications Clinical diagnostics; food and environmental testing; research use (genomics; drug development; general biology). For Further Information Please Contact the Director of Business Development Maryanne Fenerjian Email: firstname.lastname@example.org Telephone: (617) 432-0920
Church, George M.
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