BACE1 siRNA reduces A-Beta peptides in vivo

Summary BACE1 is a beta-secretase shown to cleave precursor molecules leading to the formation of amyloid proteins and plaques in Alzheimers patients. Dr. Li-huei Tsai and her collaborator Ken Kosik, MD (Brigham) have developed a method that inhibits BACE1 using siRNA. In tissue culture using neuronal cells from an animal model that overexpresses human amyloid precursor protein, this approach markedly reduced secreted amyloid peptides.

Applications Alzheimer's therapy. For Further Information Please Contact the Director of Business Development Michal Preminger Email: [email protected] Telephone: (617) 432-0920

Inventor(s): Tsai, Li-Huei

Type of Offer: Licensing



« More Medical Patents

---