Membrane Microarrays for Cell Manipulation

APPLICATIONS OF TECHNOLOGY:

Front-end screening Drug discovery Diagnostic and therapeutic applications Directed evolution of desirable cell recognition/adhesion characteristics

ADVANTAGES:

Allows manipulation and sorting of parallel living cells

ABSTRACT:

Berkeley Lab researchers have created a novel form of membrane microarray technology to be applied to the manipulation and sorting of living cells. Jay Groves, Lara Mahal and Carolyn Bertozzi have solved technical problems relating to the production of sterile membrane microarrays suitable for cell culture, the actual culture of cells on the membrane, and the development of suitable membrane compositions. For the first time, using this technique, natural lipid membrane surfaces that have been fabricated into chip-based microarrays can be used for massively parallel live cell screening and behavior modulation. Membrane microarrays are likely to find broad use in applications including: front-end screening; drug discovery, diagnostic and therapeutic applications (e.g., removing autoimmune cells from a patient’s blood to control the progression of diseases such as diabetes or arthritis); and directed evolution of desirable cell recognition/adhesion characteristics (e.g., cultivation of NK cells for directed tumor attack).

Attached files:


Type of Offer: Licensing



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