Polymerized Nanoparticle Therapeutics

APPLICATIONS OF TECHNOLOGY:

Drug delivery Therapeutic potential for inflammatory diseases such as:
Reperfusion injury Rheumatoid arthritis Adult respiratory distress syndrome Spetic shock

ADVANTAGES:

Easily polymerized High-purity, stable Carry specific biological ligands

ABSTRACT:

Carolyn Bertozzi and colleagues at Berkeley Lab have developed a method for creating high-purity, nano-sized polymer particles that display specific biological ligands on their surfaces. The material starts out as a synthetic membrane in the spherical form of a liposome that has self-assembled from monomers. A quick and efficient polymerization by light gives a solid shell. Monomers which bind to pathogens (such as influenza virus) or bind to disease sites in-vivo (inflammed tissue) are incorporated into the self-assembling mixture. The result is a hollow, spherical, polymerized liposome that binds to a biological target and can, in itself, be used as an inhibitor or be used for delivering a drug loaded in its interior. This technology forms the basis for a new class of materials that have great therapeutic potential.

Patents:
US 5,985,852
US 5,962,422
US 6,235,309

Inventor(s): Carolyn Bertozzi

Type of Offer: Licensing



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