Identification of Genes Involved in Aging
Introduction Genes involved in aging are targets for diagnostic, prognostic, and therapeutic products related to aging. This technology encompasses methods, reagents, and compounds that can be used either for the treatment of a life span disease or disorder or a disease or disorder associated with aging. Technology description Life span of yeast can be determined by measuring the number of mitotic divisions completed by a mother cell prior to senescence, defined as the replicative life span. To identify genes that regulate longevity in the budding yeast, a large-scale analysis of replicative life span was conducted with a set of 4800 single-gene–deletion strains. Business opportunity The US market for anti-aging products is an emerging industry, and yet is already in excess of $20 billion dollars a year. Currently, little is known about the underlying mechanisms of aging, and how to manipulate them. This technology offers exclusivity for products modulating genes involved in aging. Stage of development Genes involved in aging have been identified and confirmed. Additional screening is ongoing to identify additional genes. Animal models are being studied. Intellectual property position US non-provisional patent application has been filed. Related Publication(s)Kaeberlein et al. Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients. Science 310:1193-1196 (2005).
Type of Offer: Licensing
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