Monoclonal antibody to RGS9

Introduction RGS9 is a member of the RGS family of GTPase accelerating proteins (GAPs) and is the predominant source of GAP activity in rod outer segments. Because of its pivotal position in the inactivation phase of the light response, RGS9, found predominately in vertebrate cone and rod photoreceptors, is a useful model for understanding how rapid recovery kinetics of the light responses in retinal photoreceptors take place. Technology description Researchers at the University of Washington have developed a monoclonal (clone D7)
antibody against RGS9 (MAb RGS9). Mice were immunized against full-length bacterially expressed RGS9. MAb RGS9 recognizes an epitope encompassing the carboxyl terminal end of the RGS domain and the amino terminal end of the C-terminal and has been successfully tested in Western Blot and immunohistochemistry. Related Publication(s)
J Biol Chem. 2003 Mar 7;278(10):8316-25. J Biol Chem. 2001 Jun 22;276(25):22287-95. Gene. 1999 Nov 15;240(1):23-34. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5351-6. For more information on this technology contact:
Ariadna Santander Agreements Manager Technology Licensing [email protected] 206-543-1138

Type of Offer: Licensing



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