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Multilayer Silk Protein Films

The present invention is directed to a method of forming multilayer silk protein films and a multilayer film obtained therefrom. The invention is further directed to various materials, products and compositions containing said multilayer film and to the use of Said multilayer film in several applica...
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Haptics and Virtual Reality

Licensing of Software and/or Hardware technologies covering high performance collocated virtual reality and haptics, applicable to a number of fields....
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Plasma Discharge Self-cleaning Filtration System

The present invention is directed to a novel method for cleaning a filter surface using a plasma discharge self-cleaning filtration system. The method involves utilizing plasma discharges to induce short electric pulses of nanoseconds duration at high voltages. These electrical pulses generate stron...
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Device, Instrument and Process for Detecting Magnetically Labeled Analytes

The present invention is directed to a device for quantitative analysis of an analyte in a liquid sample by detecting a magnetic label, an instrument for controlling the analysis process and displaying the results and a method for performing said analysis with said device and said instrument....
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Sensitive Paints

A sensitive paint being sensitive with respect to a physical parameter, preferably pressure, temperature, CO2 concentration, etc., comprises a luminophor being incorporated into polymeric beads and having at least one luminescence property, e.g. intensity or decay, which depends on said physical par...
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Dielectric Sensor

It is very important to accurately measure the thickness of thin layered films, which are used in many scientific fields. There are several techniques available for non-invasive estimation of film thickness. However most of them are limited to certain type of films, or may not be suitable for making...
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Sample Retrieval Device for Environmental Aerosol Collection Used in Conjunction with a Field-Portable Time-of-Flight Mass Spectrometer

The remote collection of chemical and biological samples has become increasingly important in recent years. JHU/APL has developed a series of Field-Portable Time–of–Flight Mass Spectrometers to rapidly (...
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Industrial, Medical and Art Restoration Applications of Surface Texturing (TOP3-00071)

Abstract: The National Aeronautics and Space Administration (NASA) seeks to transfer technologies that can produce surface textures which enhance heat transfer, cell attachment, and other surface properties, as well as provide surface cleaning for delicate objects....
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Optimized Image Compression (DCTune) (ARC-12015)

Abstract: The DCTune technology represents a fundamental improvement on existing optimization techniques known as Quantization. Quantization selectively increases or decreases the amount of information used to render a picture. The image compression uses a DCT and each DCT coefficient yielded by th...
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NASA Smart Materials and Structures ()

Abstract: The Morphing Project seeks to integrate smart, biologically inspired, or other unconventional approaches to lead to aggressive improvements in the efficiency, versatility and safety of future air and spacecraft. The foundation of this multi-disciplinary project is research on smart materi...
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Global Qualitative Flow Path Modeling for Local State Determination (MSC-22618)

Abstract: The technology supports reconfigurable models needed for analysis and simulation of industrial process automation where operations change the active flow paths in the system. The technology can be used to validate advanced process automation designs and software, where the active system s...
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A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys...
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Design of Thermal Interface Material Based on High Temperature Shape Memory Alloy for Connecting Two Thermoelectric Legs

Introduction Efficient heat management is crucial for electronics to optimize performance and to avoid premature component deterioration. An area of primary concern is at the interface of adjoining thermal components, such as with heatsink interfaces and with connections between thermoelectric legs....
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Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal action. These variations are especially pronounced in coastal and estuarine waters where seawater int...
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Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those containing nitrogen and carbon, are too low in energy to penetrate significant distances into enclosing ...
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Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact strength of any thermoplastic, has a high resistance to corrosion, moisture, and abrasion, and has ...
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Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re...
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Nav1.2/β1/contactin cell line

Introduction Mammalian Na+ channels are heteromultimeric structures that include the poreforming α subunit in association with auxiliary β subunits. Contactin is a neuronal cell adhesion molecule of the immunoglobulin superfamily. Numerous lines of evidence indicate a role for contactin in regulati...
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Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventional techniques have significant drawbacks: for instance, electrochemical techniques have low sensiti...
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Retinoic Acid Activated Reporter

Introduction Retinoic Acid Receptors (RARs) are transcription factors that are involved in many cellular processes. Upon binding of activators such as Retinoic Acid, a derivative of Vitamin A, RARs bind a consensus DNA sequence, termed the Retinoic Acid Response Element (RARE), and initiate transcri...
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Phospholipase C-γ1 Fusion Protein Constructs

Introduction Phosphoinositide phospholipase C (PLC) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. PLCs participate in phosphatidylinositol bisphosphate (PIP2) metabolism and lipid signaling pathways in a calcium-dependent manner. Phosph...
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Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. The pores are small enough that clarity of the plastic is unaffected, and because of the po...
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Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistance and low absorption rates. This thermoplastic’s many qualities make it an exceptional candidate for...
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BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediates the efflux transport of a broad spectrum of substrates, including many drugs routinely administere...
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Application of Grating Light Reflection Spectroscopy in Analytical Sensors

Introduction There are a number of methods for measuring bulk fluid compositions in statics and flow by visible light reflection characteristics from the optically inhomogeneous wall of a vessel. Surface Plasmon Spectroscopy (SPS) on gratings and randomly rough surfaces has proven to be especially s...
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A New and More Accurate Mouse Model for Alzheimer’s disease

Introduction Alzheimer’s Disease (AD) is a neurogenerative disease with two cardinal features: the senile plaque consisting of an amyloid core surrounded by dystrophic neuritic and glial processes; and the neurofibrillary tangle (NFT) composed largely of filamentous hyperphosphorylated tau. A diseas...
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Electrospray Evaporative Spray Cooling (EESC)

Introduction As electronic devices get increasingly more powerful and more compact, there are an increasing number of semiconductor components that emit an increasing amount of heat. In order to ensure that these devices remain long-lived and reliable, more efficient methods of dissipating heat buil...
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Recombinant Baculovirus that Produces Human Topoisomerase I

Introduction Eukaryotic topoisomerase I (Topo I) is capable of relaxing both negatively and positively supercoiled DNA. The enzyme catalyzes changes in the superhelical state of duplex DNA by transiently breaking a single strand. Technology description Dr James Champoux’s laboratory has generated re...
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Dice1.1 and Dice1.2 congenic mice

Technology description Dice1.1 and Dice1.2 inbred congenic mouse strains were produced on a BALB/c background and contain discrete non-overlapping chromosome 16 congenic intervals inherited from B10.D2. These congenic intervals contain genetic loci that control the propensity of CD4+ helper T cells ...
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Droplet Compartmentalization for Chemical Separations and On-Line Sampling

Introduction The ability to separate complex mixtures of chemicals and biomolecules is an important component of any chemical synthesis or biological processing. To date, there is no technology available to combine the high resolution of analytical separations with monodisperse droplet generation. I...
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The Gene Encoding the Drosophila Muscarinic Acetylcholine Receptor & Its Expression in Mammalian Cells

Introduction Muscarinic acetylcholine receptors are involved in the activation of various signal transduction pathways through their interaction with G protein. They play a major role in regulating the functions of the target organs of the parasympathetic nervous system of mammals. Acethylcholine is...
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Clonal Cell Lines Expressing Sodium Channel RIIA (Nav1.2) and Subunits

Introduction Voltage-gated sodium channels are responsible for action potential initiation and propagation, placing them in ideal position to regulate firing and conduction in neurons. Nav1.2 (rat brain type IIa) represents a highly tetrodotoxin (TTX)–sensitive sodium channel that is broadly express...
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Monoclonal antibody to RGS9

Introduction RGS9 is a member of the RGS family of GTPase accelerating proteins (GAPs) and is the predominant source of GAP activity in rod outer segments. Because of its pivotal position in the inactivation phase of the light response, RGS9, found predominately in vertebrate cone and rod photorecep...
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A novel mouse model to screen compounds for the treatment of neurodegenerative disorders

Introduction Protein misfolding and aggregation are thought to play a central role in the pathogenesis of many, if not most, neurodegenerative disorders. The pharmaceutical industry has recently invested significant effort to identify small molecule inhibitors of protein misfolding and aggregation, ...
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Cell line stably expressing rat cardiac sodium channel α subunits (Nav1.5)

Introduction The Nav1.5 sodium ion channel protein is an integral membrane protein and tetrodotoxinresistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Def...
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3-D Tissue Culture Chamber

Introduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in tissue are not just autonomous masses but consist of many interdependent cell types and their surrou...
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Genetically Encoded Cell Death Reporter

Introduction Determining cell viability is critical to a wide variety of scientific disciplines. Currently, cell viability is assessed by incubating the cells of interest with a chemical dye or stain that reacts differently with living cells compared to dead cells. The stained cells are then analyze...
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Type 1 X Type 8 Adenylyl Cyclase double Knockout Mice (DKO strain)

Introduction Production of cAMP by adenylyl cyclase (AC) provides an important mechanism for the regulation of neuronal physiology. The calcium-stimulated AC isoforms have been strongly implicated in the alteration of neuronal function. Targeted inactivation of the calciumstimulated AC type I (AC1) ...
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SV2A Knockout Mouse

Introduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it evolved as a part of complex signaling systems. SV2A was shown to be the binding site for the antiep...
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A New p53 Cell-Based Assay

Summary Harvard researchers developed a reliable, high-throughput screening assay to identify activators and inhibitors of p53. This cell-based luminescence assay measures the level of a reporter gene product under the control of a promoter containing a p53-binding site. P53 is a transcription fa...
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A New p53 Cell-Based Assay

Summary Harvard researchers developed a reliable, high-throughput screening assay to identify activators and inhibitors of p53. This cell-based luminescence assay measures the level of a reporter gene product under the control of a promoter containing a p53-binding site. P53 is a transcription fa...
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"Teabag" Processing: an Automated, High Throughput Method for Affinity Purification

Summary A high throughput system for protein purification has been developed, whereby a “tea-bag” structure is used to house microspheres for targeted protein binding and elution. The microspheres are compatible with any solid-phase protein purification, which includes coupling of Ni++/Histidine...
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Crosslinkable Hole Transporting Materials for Organic Lightemitting Diodes

Introduction High-performance organic or polymer light-emitting diodes comprise multilayer configurations having hole-transporting, emissive and electron-transporting layers to balance the injection and transport of both holes and electrons. In general, holetransporting material is the first applied...
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Purified Compositions of Stem Cell Derived Differentiating Cells

Introduction Stem cells have a capacity for both self-renewal and the generation of differentiated cell types. Embryonic Stem (ES) cells are derived from cultures of inner cell mass (ICM) cells, and have the property of participating as totipotent cells when placed into host blastocysts. The develop...
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A Three-Dimensional Distributed Sensor using an integrated Optical Waveguide Array

Introduction A flexible shear and pressure sensor array has been developed by researchers at the University of Washington. The sensors are fiber optic-based, and are imbedded in a thin polymer sheet to allow their use in a wide range of pressure & shear sensing applications. Technology description A...
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A New Protocol of Diels-Alder Lattice Hardening for Highly Efficient Electro-optic Materials Showing Outstanding Temporal Stability over 200 Degrees C

Introduction Organic electro-optic (EO) materials have attracted much interest in the past two decades because of their extensive potential applications in various fields, ranging from waveguides, switches, emitters, and detectors. Though EO materials have a huge potential in Photonics and Electroni...
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Larger Area Pressure and Shear Measurement Using Optical Time Domain Reflectometer (OTDR)

Introduction Lower limb complications associated with diabetes include the development of plantar ulcers that can lead to infection and subsequent amputation. Several authors have postulated that shear stress is an important component of ulcer development. While it is known from force plate analyses...
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Novel Methods of Creating a True Smart Structure for Stress Monitoring and Active Mechanical Support on Footwear

Introduction Investigation of strain sensing has been an active research area for the past 60 years and has the potential to affect a large number of industries and disciplines. The characteristics of all strain sensors depend, to some degree, on the properties of the deformable contact materials. E...
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Design of Surface Plasmon Biosensor Based on Self-Referencing and Digital Window System

Introduction Surface Plasmon resonance (SPR) has attracted strong attention as a biosensor in the past two decades because it can provide label-free, real-time detection with high sensitivity. Technology description Researchers at the UW have developed an SPR biosensor with increased accurate refere...
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Polymer based bendloss waveguide sensor for shear and pressure measurement

Introduction Lower limb complications associated with diabetes include the development of plantar ulcers that can lead to infection and subsequent amputation. Several authors have postulated that shear stress is an important component of ulcer development. While it is known from force plate analyses...
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Extrusion of Microcellular Foams and Foam Composites

Introduction Conventional extrusion of microcellular foams using supercritical carbon dioxide as a blowing agent needs expensive equipment or specialized modification in order to operate. High pressure and high temperature seals are required on the extruder barrel at the injection for the supercriti...
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A flexible polymer based smart skin

Introduction For some applications, it is essential to obtain the real time 2-D profiling of certain physical parameters such as temperature, force, pressure, and shear stress on a 3-D object. If the surface of the object is flat, one can use a monolithic MEMS device with large amounts of sensors. H...
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Programmable Ultrasound Back-End System Using Multi-Core Processor

Introduction Ultrasonography is a noninvasive medical imaging technique, which utilizes ultrasonic waves to visualize soft tissue within the body, and advances in this technology have led to various therapies, including those that utilize high-intensity focused ultrasound (HIFU) capable of rapidly ...
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Tissue-Engineered Urinary Bladder Using Autologous Cells

Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladders tend to suffer from critical complications, such as inadequate performance, infection, and adverse h...
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A Polymer-Based Integrated Optical Image Acquisition and Display System

Introduction Imaging devices are used in a variety of roles from medical imaging to barcode reading, and as these devices get smaller, their number of potential applications only increases. Endoscopes, for example, allow for real-time imaging inside the body; conventional versions, however, are limi...
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Novel Adsorbent Systems for Water Purification Using Metal Oxide Bound to Substrate and Heated Metal Oxide Particles

Introduction There is an ever increasing need for potable water. Improvements in conventional purification technologies allow for savings in both time and money and ensure that clean water is available in areas that need it. Technology Description Professor Benjamin at the University of Washington h...
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Novel Adsorbent Systems for Water Purification Using Metal Oxide Bound to Substrate and Heated Metal Oxide Particles

Introduction There is an ever increasing need for potable water. Improvements in conventional purification technologies allow for savings in both time and money and ensure that clean water is available in areas that need it. Technology Description Professor Benjamin at the University of Washington h...
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Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those containing nitrogen and carbon, are too low in energy to penetrate significant distances into enclosing ...
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Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact strength of any thermoplastic, has a high resistance to corrosion, moisture, and abrasion, and has ...
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Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufacturing requirements and allowing for larger, more flexible, and more robust materials that are more re...
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Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final plastic. The pores are small enough that clarity of the plastic is unaffected, and because of the po...
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Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistance and low absorption rates. This thermoplastic’s many qualities make it an exceptional candidate for...
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Thulium-Doped Fiber Laser Amplifier at 1762 nm

Introduction The role of a fiber amplifier is to increase the signal from an optical source, such as a laser, and this function is vital for effective telecommunications. In practice, this fiberoptic component is pumped with energy corresponding to a specific wavelength range, and the original optic...
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Design of Thermal Interface Material Based on High Temperature Shape Memory Alloy for Connecting Two Thermoelectric Legs

Introduction Efficient heat management is crucial for electronics to optimize performance and to avoid premature component deterioration. An area of primary concern is at the interface of adjoining thermal components, such as with heatsink interfaces and with connections between thermoelectric legs....
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Toughening Structural Adhesives Using Novel Core-Shell Thermoplastic Nanoparticles

Introduction Structural Adhesives are increasingly replacing traditional fastening methods such as welding, bolts and rivets, in industrial applications. They are used to bond many different material types including ceramics, metals, glass, plastics and composites, and are designed for high strength...
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3-D Tissue Culture Chamber

UW Ref# 7654 Introduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in tissue are not just autonomous masses but consist of many interdependent cell types and...
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Methods for Production of Thick Microcellular Sheets and Composite Structures

Introduction Microcellular manufacturing processes have been developed largely for production of thin films (thickness ...
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Microcellular Poly (vinyl Chloride) Structures

Introduction A novel process for continuous production of microcellular foams has been developed and applied to make microcellular profiles from PVC. Technology description Researchers at the UW have developed microcellular poly (vinyl) chloride polymeric structures made in an extrusion or injection...
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A novel graded-modulus-interphase material for polymeric composites

Introduction Filler- (e.g., particulate or fiber) reinforced structural polymers or polymeric composites have changed the way things are made. Today, they are found, for example, in air/ground transportation vehicles, sporting goods, ballistic barrier applications and weapons, electronic packaging, ...
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Novel Compound Semiconductor Use as a Buffer Layer for Controlled Oxide Growth on Silicon

Introduction An area of research that has gained increasing importance in recent years is the controlled growth of oxides other than SiO2 on silicon. Technology description Researchers at the UW have developed the use of Ga2Se3 as a novel buffer layer preventing SiOx and silicide formation during th...
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Biochemical Sensor in Open Nanochannel

Introduction Micro and nano-sized biochips are convenient for exploring molecular interactions because of their small feature size. The small size of the chips allows for sensitive detection on the molecular level while reducing testing time and sample volumes. Technology description Researchers at ...
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Ferromagnetic Shape Memory Alloys

Introduction Shape Memory Alloys (SMA) are metals which return to their original shape after deformation. Conventional SMAs are thermally activated, requiring heat to change the metal’s crystal structure and allow it to resume its pre-deformation shape. Technology description Material scientists at ...
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Super-low Fouling Zwitterionic-based Materials

Introduction Tin-based antifouling paints are being phased out due to marine pollution concerns. Non-toxic silicone and fluorinated coatings are under development, but these are easy release coatings rather than antifouling. PEG is the most commonly used antifouling polymer coating, but its suscepti...
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Nanocellular, Microcellular, and Macrocellular Foams from TPU’s and TPE’s and their Method of Manufacture

Introduction Thermoplastic Elastomers (TPE’s) are a class of flexible materials with a wide range of applications. To date TPE’s, and a subclass of these materials, Thermoplastic Urethanes (TPU’s), have been difficult to foam by conventional means. Technology description Researchers at the UW have d...
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Production of Thick Microcellular & Thermoplastic Sheets and Components

Introduction Thick microcellular plastics for lightweight, energy efficient building materials and other applications have been developed. Up to 70% reduction in relative density of the materials has been achieved. Technology description Researchers at the UW have developed a process to make thick, ...
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Crosslinkable Hole Transporting Materials for Organic Light emitting

Introduction High-performance organic or polymer light-emitting diodes comprise multilayer configurations having hole-transporting, emissive and electron-transporting layers to balance the injection and transport of both holes and electrons. In general, holetransporting material is the first applied...
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Energy Harvesting Composite Made of Piezoelectric Energy Harvesting Composite Made of Piezoelectric

Introduction Shape memory alloy (SMA) materials are easily deformed at low temperature and return to their original configuration by heating. Via the piezoelectric effect, some materials will produce an electric potential as a result of stress from changes in temperature. The alternating current (AC...
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Design of Active Materials and Structures based on Composites of Shape Memory Alloy and Shape Memory Polymer

Introduction Shape memory alloys (SMA) and shape memory polymers (SMP) have shown tremendous promise for a wide variety of applications because of their ability to “remember” a previous state when heated. However, they can only remember a single shape. The ability to remember two shapes would make t...
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Advanced Biomimetic Surfaces for Surface-Enhanced Raman Spectroscopy (SERS)

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subj...
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Design of Bio-Actuator for Medical Treatment Based on Ferromagnetic Shape Memory Alloy Helical Spring

Introduction FSMA (ferromagnetic shape memory alloy) materials provide fast speed of actuation using magnetic fields and large strain and stress capability. Technology description Researchers at the University of Washington have developed applications for FSMA devices in stents encapsulated with mic...
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Design of coiled ferromagnetic composite plate spring

Introduction In general, motors are constructed by both electro and permanent magnets, and move due to the attractive magnet using force, which originates from these magnets. The motors rotate infinitely in principal; however the output torque is limited. Technology description Researchers at the UW...
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Intracellular Delivery Vector

Introduction Some drugs require cellular uptake to be effective and methods to increase cellular uptake are desired to improve on the efficacy and reduce the side-effects of certain drugs. One way to increase cellular uptake of a drug is by attaching it to a cellpenetrating peptide (CPP). CPPs, such...
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Production of Palladium Nanostructures with Shape Selection by Adding Bromide

Introduction Single-crystal, one-dimensional nanostructures of palladium are attractive as interconnects for fabricating nanoscale electronic devices. Polycrystalline, mesoscopic wires made of palladium have been utilized for resistance-based detection of hydrogen gas. However, polycrystalline wires...
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A New Protocol of Diels-Alder Lattice Hardening for Highly Efficient Electro-optic Materials Showing Outstanding Temporal Stability over 200 Degrees C

Introduction Organic electro-optic (EO) materials have attracted much interest in the past two decades because of their extensive potential applications in various fields, ranging from waveguides, switches, emitters, and detectors. Though EO materials have a huge potential in Photonics and Electroni...
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Microfluidic Device and Method for Detection and Separation of Particles by Isoelectric Focusing

Introduction Electrophoresis and isoelectric focusing techniques are well suited to rapid isolation and detection of biological particles. Microfluidic devices are particularly amenable to electrophoresis-based applications, offering advantages such as low reagent and sample consumption, reduced ene...
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Methods and Apparatus for Force Reduction in the Self-Piercing Riveting Process with Resistance Heating and Multi-Step Punching

Introduction Self-piercing riveting (SPR) requires a very high processing force to finish its piercing and riveting actions. U.S. auto manufacturers are hesitant to adopt SPR because of this particular disadvantage. Reducing the processing force is therefore a key factor in eventually adopting SPR f...
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Concentration and Selectivity of Nucleic Acids using a Nano needle

Introduction There is a need in the medical industry for cost-effective, non-invasive methods of sampling biological fluids that often contain bio-markers such as nucleic acids, which can be indicative of disease states; thus, sensitive and specific diagnostic tests to locate bio-markers are needed....
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Thermo-reversibly Crosslinked Cladding Materials with Highly Tunable Conductivity for Nonlinear Optical Polymer-based Devices

Introduction A typical electro-optic waveguide device includes a lower electrode layer, a lower cladding layer, an active guiding layer, an upper cladding layer, and an upper electrode layer. The purpose of the cladding layers in an electro-optic device is to confine light in the active guiding laye...
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A method for quantitative, proteome-wide analysis of protein phosphorylation

Introduction Protein phosphorylation is one of the most important regulatory events in cells. The state of activity of numerous enzymes and processes and the association of specific proteins into functional complexes are frequently controlled by reversible protein phosphorylation. Because cellular p...
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Method for Fast Crosslinking of Silicone Compounds at Low Temperature By in Situ Water Generation

Introduction Deposition of small amounts of functional materials has recently become a matter of intensive research. Inkjet printing technology is a promising and widely used technique for the fabrication of small parts with specific functionalities into welldefined locations. The limits of this tec...
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Episodic Monitor

Introduction Epilepsy affects over three million Americans and is characterized by recurring seizures, which typically involve problems with motor, sensory, and/or cognitive functions. These seizures may occur with or without loss of consciousness. One of the hazards of having a seizure, especially ...
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Novel Stabilization Scheme for Obtaining Single Longitudinal Mode (SLM) Radiation from a Pulsed Nd:Yag laser

Background: Pulsed, q-switched solid-state lasers are an almost ubiquitous light source for powerful, short laser pulses, as used in industry and research labs. Typically, a simple free running cavity design is employed, while more demanding applications require seeded lasers. In that case a narrow...
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Emulsified Zero-Valent Iron (EZVI) (KSC-12246)

Emulsified Zero-Valent Iron is a versatile technology that can be used at many of these locations. Applicable sites may include: dye and paint manufacturers;dry cleaners; chemical manufacturers; metal cleaning and degreasing facilities; leather-tanning facilities; pharmaceutical manufacturers; adhes...
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Control System for Prosthetic Devices (MSC-21941)

Although many prosthetic devices have been developed, including computer controlled "bionic" or hydraulically actuated devices, these devices do not provide user feedback. Additionally, below-the-elbow amputees favor some derivation of the traditional hook-and-cable harness system developed in th...
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Proton-Transfer-Reaction/Ion-Mobility-Spectrometer (PTR-IMS) (NPO-21187)

A small, portable detector with high sensitivity suitable for detection of trace amounts of organic compounds, PTR-IMS does not suffer from problems associated with commonly used gas chromatography/mass spectrometry-based instruments (GC/MS) such as limited sensitivity, fragmentation of large organi...
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Rapid Low-Temperature Epitaxial Growth Using a Hot-Element Assisted Chemical Vapor Deposition Process

The invention provides a process for depositing an epitaxial layer on a crystalline substrate, comprising the steps of providing a chamber having an element capable of heating, introducing the substrate into the chamber, heating the element at a temperature sufficient to decompose a source gas, pass...
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Reactive Codoping of GaAlInP Compound Semiconductors

A GaAlInP compound semiconductor and a method of producing a GaAlInP compound semiconductor are provided. The apparatus and method comprises a GaAs crystal substrate in a metal organic vapor deposition reactor. Al, Ga, and In vapors are prepared by thermally decomposing organometallic compounds. P v...
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Method of Preparing Nitrogen Containing Semiconductor Material

A method of combining group III elements with group V elements that incorporates at least nitrogen from a nitrogen halide for use in semiconductors and in particular semiconductors in photovoltaic cells....
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Using liquid desiccant as a regenerable filter for capturing and deactivating contaminants

A method, and systems for implementing such method, for purifying and conditioning air of weaponized contaminants. The method includes wetting a filter packing media with a salt-based liquid desiccant, such as water with a high concentration of lithium chloride. Air is passed through the wetted filt...
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Purification of Caprolactam from Recycled Nylon

A method of removing 1,11-diamino-6-undecanone from the pyrolysis product of nylon comprising: a) pyrolyzing nylon-6 to form a pyrolyzate containing a caprolactam mixture;b) dissolving the caprolactam mixture in a solvent to form a solution;c) passing carbon dioxide gas through the solution to form ...
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Process for the Conversion of and Aqueous Biomass Hydrolyzate into Fuels or Chemicals by the Selective Removal of fermentation Inhibitors

A process of making a fuel or chemical from a biomass hydrolyzate is provided which comprises the steps of providing a biomass hydrolyzate, adjusting the pH of the hydrolyzate, contacting a metal oxide having an affinity for guaiacyl or syringyl functional groups, or both and the hydrolyzate for a t...
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Pretreatment of Microbial Sludges

Methods are described for pretreating microbial sludges to break cells and disrupt organic matter. One method involves the use of sonication, and another method involves the use of shear forces. The pretreatment of sludge enhances bioconversion of the organic fraction. This allows for efficient dewa...
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Interdigitalized Photovoltaic Power Conversion Device

A photovoltaic power conversion device has a top surface adapted to receive impinging radiation. The device includes at least two adjacent, serially connected cells. Each cell includes a semi-insulating substrate and a lateral conductivity layer of a first doped electrical conductivity disposed on t...
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High Efficiency Low Cost Thin Film Silicon Solar Cell Design and Method for Making

A semiconductor device having a substrate, a conductive intermediate layer deposited onto said substrate, wherein the intermediate layer serves as a back electrode, an optical reflector, and an interface for impurity gettering, and a semiconductor layer deposited onto said intermediate layer, wherei...
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Electrical Isolation of Component Cells in Monolithically Interconnected Modules

A monolithically interconnected photovoltaic module having cells which are electrically connected which comprises a substrate, a plurality of cells formed over the substrate, each cell including a primary absorber layer having a light receiving surface and a p-region, formed with a p-type dopant, an...
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Crystallization from High-Temperature Solutions of Si in Copper

A liquid phase epitaxy method for forming thin crystalline layers of device quality silicon having less than 5X10.sup.16 Cu atoms/cc impurity, comprising: preparing a saturated liquid solution melt of Si in Cu at about 16% to about 90% wt. Si at a temperature range of about 800.degree. C. to about 1...
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Controlled Metal-Semiconductor Sintering/Alloying by One-directional Reverse Illumination

Metal strips deposited on a top surface of a semiconductor substrate are sintered at one temperature simultaneously with alloying a metal layer on the bottom surface at a second, higher temperature. This simultaneous sintering of metal strips and alloying a metal layer on opposite surfaces of the su...
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Welding/Sealing Glass Enclosed Space in a Vacuum

A method of welding and sealing the edges of two juxtaposed glass sheets together to seal a vacuum space between the sheets comprises the steps of positioning a radiation absorbant material, such as FeO, VO.sub.2, or NiO, between the radiation transmissive glass sheets adjacent the edges and then ir...
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Thin Film Method of Conductin Lithium-Ions

The present invention relates to the composition of a solid lithium-ion electrolyte based on the Li.sub.2 O--CeO.sub.2 --SiO.sub.2 system having good transparent characteristics and high ion conductivity suitable for uses in lithium batteries, electrochromic devices and other electrochemical applica...
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Stand-Alone Photovoltaic (PV) Powered Electrochromic Window

A variable transmittance double pane window includes an electrochromic material that has been deposited on one pane of the window in conjunction with an array of photovoltaic cells deposited along an edge of the pane to produce the required electric power necessary to vary the effective transmittanc...
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Solid Lithium-Ion Electrolyte

The present invention relates to the composition of a solid lithium-ion electrolyte based on the Li.sub.2 O--CeO.sub.2 --SiO.sub.2 system having good transparent characteristics and high ion conductivity suitable for uses in lithium batteries, electrochromic devices and other electrochemical applica...
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Solar-Induced Chemical Vapor Deposition of Diamond-Type Carbon Films

An improved chemical vapor deposition method for depositing transparent continuous coatings of sp.sup.3 -bonded diamond-type carbon films, comprising: a) providing a volatile hydrocarbon gas/H.sub.2 reactant mixture in a cold wall vacuum/chemical vapor deposition chamber containing a suitable substr...
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Self Bleaching Photoelectrochemical-Electrochromic Device

A photoelectrochemical-electrochromic device comprising a first transparent electrode and a second transparent electrode in parallel, spaced relation to each other. The first transparent electrode is electrically connected to the second transparent electrode. An electrochromic material is applied to...
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Redox Polymer Electrodes for Advanced Batteries

Advanced batteries having a long cycle lifetime are provided. More specifically, the present invention relates to electrodes made from redox polymer films and batteries in which either the positive electrode, the negative electrode, or both, comprise redox polymers. Suitable redox polymers for this ...
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Preparation of Superconductor Precursor Powders

A process for the preparation of a precursor metallic powder composition for use in the subsequent formation of a superconductor. The process comprises the steps of providing an electrodeposition bath comprising an electrolyte medium and a cathode substrate electrode, and providing to the bath one o...
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Plasma Enhanced Chemical Vapor Depositions (PECVD) Method of Forming Vanadium Oxide Films and Vanadium Oxide Thin-Films Prepared Thereby

A method is disclosed of forming a vanadium oxide film on a substrate utilizing plasma enhanced chemical vapor deposition. The method includes positioning a substrate within a plasma reaction chamber and then forming a precursor gas comprised of a vanadium-containing chloride gas in an inert carrier...
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Photoenhanced Anaerobic Digestion of Organic Acids

A process is described for rapid conversion of organic acids and alcohols anaerobic digesters into hydrogen and carbon dioxide, the optimal precursor substrates for production of methane. The process includes addition of photosynthetic bacteria to the digester and exposure of the bacteria to radiant...
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Photoconversion of Gasified Organic Materials Into Biologically Degradable Plastics

A process is described for converting organic materials (such as biomass wastes) into a bioplastic suitable for use as a biodegradable plastic. In a preferred embodiment the process involves thermally gasifying the organic material into primarily carbon monoxide and hydrogen, followed by photosynthe...
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PD/NI-WO3 Anodic Double Layer Gasochromic Device

An anodic double layer gasochromic sensor structure for optical detection of hydrogen in improved response time and with improved optical absorption real time constants, comprising: a glass substrate; a tungsten-doped nickel oxide layer coated on the glass substrate; and a palladium layer coated on ...
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Molecular Water-Oxidation Catalyst

A dimeric composition of the formula: ##STR1## wherein L', L", L'", and L"" are each a bidentate ligand having at least one functional substituent, the ligand selected from bipyridine, phenanthroline, 2-phenylpyridine, bipyrimidine, and bipyrazyl and the functional substituent selected from carboxyl...
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Microwave Impregnation of Porous Materials with Thermal Energy Storage Materials

A method for impregnating a porous, non-metallic construction material with a solid phase-change material is described. The phase-change material in finely divided form is spread onto the surface of the porous material, after which the porous material is exposed to microwave energy for a time suffic...
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Method of High-Purity Silane Preparation

A process for the preparation of high purity silane, suitable for forming thin layer silicon structures in various semiconductor devices and high purity poly- and single crystal silicon for a variety of applications, is provided. Synthesis of high-purity silane starts with a temperature assisted rea...
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Method and Apparatus for Rapid Biohydrogen Phenotypic Screening of Microorganisms Using a Chemochromic Sensor

The invention provides an assay system for identifying a hydrogen-gas-producing organism, including a sensor film having a first layer comprising a transition metal oxide or oxysalt and a second layer comprising hydrogen-dissociative catalyst metal, the first and second layers having an inner and an...
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Method for Improving the Durability of Ion Insertion Materials

The invention provides a method of protecting an ion insertion material from the degradative effects of a liquid or gel-type electrolyte material by disposing a protective, solid ion conducting, electrically insulating, layer between the ion insertion layer and the liquid or gel-type electrolyte mat...
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Method for Charging a Hydrogen Getter

A method for charging a sample of either a permanent or reversible getter material with a high concentration of hydrogen while maintaining a base pressure below 10.sup.-4 torr at room temperature involves placing the sample of hydrogen getter material in a chamber, activating the sample of hydrogen ...
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Zymomonas Pentose-Sugar Fermenting Strains and Uses Thereof

Disclosed in the present invention is a Zymomonas integrant and derivatives of these integrants that posess the ability to ferment pentose into ethanol. The genetic sequences encoding for the pentose-fermenting enzymes are integrated into the Zymomonas in a two-integration event of homologous recomb...
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Low Thermal Resistance Power Module Assembly

A power module assembly with low thermal resistance and enhanced heat dissipation to a cooling medium. The assembly includes a heat sink or spreader plate with passageways or openings for coolant that extend through the plate from a lower surface to an upper surface. A circuit substrate is provided ...
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Increasing Jet Entrainment, Mixing and Spreading

A free jet of air is disturbed at a frequency that substantially matches natural turbulences in the free jet to increase the entrainment, mixing, and spreading of air by the free jet, for example in a room or other enclosure. The disturbances are created by pulsing the flow of air that creates the f...
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High Rate Chemical Vapor Deposition of Carbon Films Using Fluorinated Gases

A high rate, low-temperature deposition of amorphous carbon films is produced by PE-CVD in the presence of a fluorinated or other halide gas. The deposition can be performed at less than 100.degree. C., including ambient room temperature, with a radio frequency plasma assisted chemical vapor deposit...
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Fiber Optic Device for Sensing the Presence of Gas

A fiber-optic device for sensing the presence of a gas in an environment is provided. The device comprises a light source for directing a light beam to a layer system having a first surface and a second surface opposite the first surface. The first surface is exposable to the light beam and the seco...
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Electrochromic Projection and Writing Device

A display and projection apparatus includes an electrochromic material and a photoconductive material deposited in tandem used in conjunction with a light filtering means for filtering light transmitted through the electrochromic material. When an electric field is applied across the electrochromic ...
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Electrochromic-Photovoltaic Film for Light-Sensitive Control of Optical Transmittance

A variable transmittance optical component includes an electrochromic material and a photovoltaic device-type thin film solar cell deposited in a tandem type, monolithic single coating over the component. A bleed resistor of a predetermined value is connected in series across the electrochromic mate...
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Isolation of Levoglucosan from Pyrolysis Oil Derived from Cellulose

High purity levoglucosan is obtained from pyrolysis oil derived from cellulose by: mixing pyrolysis oil with water and a basic metal hydroxide, oxide, or salt in amount sufficient to elevate pH values to a range of from about 12 to about 12.5, and adding an amount of the hydroxide, oxide, or salt in...
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Direct printing of thin-film conductors using metal-chelate inks

A process for forming an electrical conductor on a substrate is provided, consisting essentially of providing an ink comprised of a metallic chelate, printing directly thereon the ink, and decomposing the ink wherein the metal-chelate is converted to a solid metal conductor on the substrate....
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Buried anode lithium thin film battery and process

A reverse configuration, lithium thin film battery (300) having a buried lithium anode layer (305) and process for making the same. The present invention is formed from a precursor composite structure (200) made by depositing electrolyte layer (204) onto substrate (201), followed by sequential depos...
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