Bicyclic Scaffold for Combinatorial Libraries
A new reaction for preparing a largely unexplored bicyclic scaffold is incorporated in a novel solid-supported combinatorial library synthesis. The compounds prepared with combinatorial synthesis are useful for screening in various applications such as drug lead discovery. This particular bicyclic scaffold is compact and contains up to eleven diversity sites so that many focused sub-libraries can be prepared using this new combinatorial synthesis technology. There are a maximum of six chiral cen ters in the compounds and control of their stereochemistry is accomplished by building the library using readily available chiral building blocks.
Categories: Materials & Chemicals
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