Recoverable Solid Supported Catalyst for Asymmetric Synthesis

The “chirality” of molecules often determines the effectiveness of reaction constituents in several chemical, biochemical and industrial processes. An earlier technology (# 5722) described a catalyst, viz., a coordination polymer with a metallic (Rho dium) center that could be employed to synthesize chiral molecules in an accelerated manner. The catalyst exhibited high selectivity, required low energy and created minimal waste. This invention extends the catalyzing chemistry above in that it perf orms it on polymer supports. The resultant recycling means that catalyst usage costs are reduced owing to the extremely low quantities needed. Other advantages of this new approach are:

a) Cleaner methods: cross-linked polymers are insoluble, non- volatile, odorless and non-toxic (environment friendly). Highly toxic chemicals can be rendered inert and harmless through attachment to a polymer support - no toxic materials can be released to the atmosphere. This lowers waste generation. b) Pote ntial for automated synthesis and testing using high-throughput screens: polymer-supported chemistry readily lends itself to the development of automated techniques. c) Simplified product isolation and recovery: following completion of a reaction, the desired target and the insoluble polymer-supported reagent can be separated simply by filtration of the insoluble polymer support d) Encapsulation of the existing homogeneous catalyst to an inert is done through non-covalent bonding.

The te chnology scores high on selectivity (almost 90%), specificity and purity of the enantiomer created. The technology also allows for the possibility of running up to 5 different reactions (or 15 cycles).

Employing this catalyst, racemic mixtures o

Categories: Materials & Chemicals

Patents Issues: 6,962,891

Type of Offer: Licensing

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